Amino acid dipepetide frequency for Sulfurovum sp. UBA12169

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.328AlaAla: 6.328 ± 0.142
0.819AlaCys: 0.819 ± 0.047
3.757AlaAsp: 3.757 ± 0.089
3.835AlaGlu: 3.835 ± 0.089
3.668AlaPhe: 3.668 ± 0.084
5.385AlaGly: 5.385 ± 0.12
1.725AlaHis: 1.725 ± 0.06
6.209AlaIle: 6.209 ± 0.109
6.943AlaLys: 6.943 ± 0.145
8.863AlaLeu: 8.863 ± 0.155
2.544AlaMet: 2.544 ± 0.074
3.211AlaAsn: 3.211 ± 0.077
2.211AlaPro: 2.211 ± 0.063
3.037AlaGln: 3.037 ± 0.077
2.688AlaArg: 2.688 ± 0.082
4.746AlaSer: 4.746 ± 0.098
3.858AlaThr: 3.858 ± 0.093
5.16AlaVal: 5.16 ± 0.104
0.629AlaTrp: 0.629 ± 0.042
3.082AlaTyr: 3.082 ± 0.079
0.0AlaXaa: 0.0 ± 0.0
Cys
0.743CysAla: 0.743 ± 0.044
0.092CysCys: 0.092 ± 0.013
0.66CysAsp: 0.66 ± 0.039
0.734CysGlu: 0.734 ± 0.047
0.337CysPhe: 0.337 ± 0.023
0.805CysGly: 0.805 ± 0.038
0.33CysHis: 0.33 ± 0.029
0.642CysIle: 0.642 ± 0.031
0.652CysLys: 0.652 ± 0.034
0.61CysLeu: 0.61 ± 0.032
0.215CysMet: 0.215 ± 0.019
0.374CysAsn: 0.374 ± 0.027
0.443CysPro: 0.443 ± 0.034
0.287CysGln: 0.287 ± 0.02
0.365CysArg: 0.365 ± 0.027
0.644CysSer: 0.644 ± 0.034
0.466CysThr: 0.466 ± 0.028
0.546CysVal: 0.546 ± 0.034
0.062CysTrp: 0.062 ± 0.009
0.379CysTyr: 0.379 ± 0.025
0.0CysXaa: 0.0 ± 0.0
Asp
4.7AspAla: 4.7 ± 0.103
0.411AspCys: 0.411 ± 0.029
2.738AspAsp: 2.738 ± 0.078
4.697AspGlu: 4.697 ± 0.106
2.888AspPhe: 2.888 ± 0.07
3.394AspGly: 3.394 ± 0.089
0.91AspHis: 0.91 ± 0.044
4.922AspIle: 4.922 ± 0.099
4.252AspLys: 4.252 ± 0.085
4.771AspLeu: 4.771 ± 0.084
1.551AspMet: 1.551 ± 0.054
2.062AspAsn: 2.062 ± 0.067
1.895AspPro: 1.895 ± 0.064
1.411AspGln: 1.411 ± 0.057
2.067AspArg: 2.067 ± 0.068
2.571AspSer: 2.571 ± 0.068
3.28AspThr: 3.28 ± 0.074
3.181AspVal: 3.181 ± 0.07
0.369AspTrp: 0.369 ± 0.028
1.959AspTyr: 1.959 ± 0.065
0.0AspXaa: 0.0 ± 0.0
Glu
6.012GluAla: 6.012 ± 0.108
0.668GluCys: 0.668 ± 0.037
3.518GluAsp: 3.518 ± 0.079
5.972GluGlu: 5.972 ± 0.151
2.706GluPhe: 2.706 ± 0.083
4.523GluGly: 4.523 ± 0.094
1.52GluHis: 1.52 ± 0.06
5.995GluIle: 5.995 ± 0.11
6.537GluLys: 6.537 ± 0.126
6.293GluLeu: 6.293 ± 0.123
2.044GluMet: 2.044 ± 0.062
3.622GluAsn: 3.622 ± 0.07
1.739GluPro: 1.739 ± 0.057
2.528GluGln: 2.528 ± 0.067
2.86GluArg: 2.86 ± 0.072
3.672GluSer: 3.672 ± 0.084
3.436GluThr: 3.436 ± 0.074
4.472GluVal: 4.472 ± 0.104
0.61GluTrp: 0.61 ± 0.036
2.633GluTyr: 2.633 ± 0.065
0.0GluXaa: 0.0 ± 0.0
Phe
3.736PheAla: 3.736 ± 0.087
0.461PheCys: 0.461 ± 0.026
3.241PheAsp: 3.241 ± 0.074
3.502PheGlu: 3.502 ± 0.078
2.578PhePhe: 2.578 ± 0.08
3.683PheGly: 3.683 ± 0.093
0.801PheHis: 0.801 ± 0.039
3.523PheIle: 3.523 ± 0.093
3.103PheLys: 3.103 ± 0.077
4.53PheLeu: 4.53 ± 0.112
1.277PheMet: 1.277 ± 0.05
1.894PheAsn: 1.894 ± 0.066
1.25PhePro: 1.25 ± 0.043
1.0PheGln: 1.0 ± 0.043
1.541PheArg: 1.541 ± 0.047
3.317PheSer: 3.317 ± 0.081
2.411PheThr: 2.411 ± 0.057
3.246PheVal: 3.246 ± 0.081
0.488PheTrp: 0.488 ± 0.031
1.904PheTyr: 1.904 ± 0.064
0.0PheXaa: 0.0 ± 0.0
Gly
5.128GlyAla: 5.128 ± 0.112
0.853GlyCys: 0.853 ± 0.044
3.399GlyAsp: 3.399 ± 0.079
4.163GlyGlu: 4.163 ± 0.087
3.633GlyPhe: 3.633 ± 0.089
4.752GlyGly: 4.752 ± 0.12
1.353GlyHis: 1.353 ± 0.051
5.613GlyIle: 5.613 ± 0.094
5.105GlyLys: 5.105 ± 0.098
5.769GlyLeu: 5.769 ± 0.091
2.021GlyMet: 2.021 ± 0.055
2.495GlyAsn: 2.495 ± 0.074
1.154GlyPro: 1.154 ± 0.051
1.801GlyGln: 1.801 ± 0.064
2.509GlyArg: 2.509 ± 0.073
3.846GlySer: 3.846 ± 0.083
3.548GlyThr: 3.548 ± 0.102
4.746GlyVal: 4.746 ± 0.096
0.677GlyTrp: 0.677 ± 0.035
2.949GlyTyr: 2.949 ± 0.068
0.0GlyXaa: 0.0 ± 0.0
His
1.605HisAla: 1.605 ± 0.053
0.259HisCys: 0.259 ± 0.023
0.97HisAsp: 0.97 ± 0.044
1.324HisGlu: 1.324 ± 0.052
1.188HisPhe: 1.188 ± 0.049
1.399HisGly: 1.399 ± 0.053
0.58HisHis: 0.58 ± 0.038
1.856HisIle: 1.856 ± 0.055
1.406HisLys: 1.406 ± 0.046
2.002HisLeu: 2.002 ± 0.059
0.527HisMet: 0.527 ± 0.031
0.778HisAsn: 0.778 ± 0.04
1.099HisPro: 1.099 ± 0.047
0.755HisGln: 0.755 ± 0.034
0.911HisArg: 0.911 ± 0.049
1.213HisSer: 1.213 ± 0.046
1.268HisThr: 1.268 ± 0.053
0.996HisVal: 0.996 ± 0.044
0.197HisTrp: 0.197 ± 0.021
0.988HisTyr: 0.988 ± 0.04
0.0HisXaa: 0.0 ± 0.0
Ile
7.078IleAla: 7.078 ± 0.113
0.702IleCys: 0.702 ± 0.031
5.349IleAsp: 5.349 ± 0.098
6.397IleGlu: 6.397 ± 0.113
3.621IlePhe: 3.621 ± 0.092
5.312IleGly: 5.312 ± 0.099
1.534IleHis: 1.534 ± 0.052
5.601IleIle: 5.601 ± 0.128
6.176IleLys: 6.176 ± 0.109
7.122IleLeu: 7.122 ± 0.121
1.711IleMet: 1.711 ± 0.058
3.337IleAsn: 3.337 ± 0.073
2.901IlePro: 2.901 ± 0.077
2.395IleGln: 2.395 ± 0.063
2.778IleArg: 2.778 ± 0.085
4.851IleSer: 4.851 ± 0.098
4.018IleThr: 4.018 ± 0.098
5.376IleVal: 5.376 ± 0.124
0.573IleTrp: 0.573 ± 0.034
2.761IleTyr: 2.761 ± 0.069
0.0IleXaa: 0.0 ± 0.0
Lys
6.025LysAla: 6.025 ± 0.116
0.571LysCys: 0.571 ± 0.034
3.94LysAsp: 3.94 ± 0.089
8.06LysGlu: 8.06 ± 0.155
2.443LysPhe: 2.443 ± 0.077
4.133LysGly: 4.133 ± 0.088
1.663LysHis: 1.663 ± 0.058
6.757LysIle: 6.757 ± 0.128
7.369LysLys: 7.369 ± 0.167
6.652LysLeu: 6.652 ± 0.122
2.436LysMet: 2.436 ± 0.061
4.457LysAsn: 4.457 ± 0.092
2.573LysPro: 2.573 ± 0.067
2.748LysGln: 2.748 ± 0.061
3.285LysArg: 3.285 ± 0.093
4.262LysSer: 4.262 ± 0.095
4.511LysThr: 4.511 ± 0.089
4.482LysVal: 4.482 ± 0.099
0.599LysTrp: 0.599 ± 0.036
2.606LysTyr: 2.606 ± 0.069
0.0LysXaa: 0.0 ± 0.0
Leu
7.401LeuAla: 7.401 ± 0.129
0.899LeuCys: 0.899 ± 0.041
5.41LeuAsp: 5.41 ± 0.104
6.734LeuGlu: 6.734 ± 0.112
5.073LeuPhe: 5.073 ± 0.115
6.335LeuGly: 6.335 ± 0.11
2.129LeuHis: 2.129 ± 0.06
6.491LeuIle: 6.491 ± 0.118
7.672LeuLys: 7.672 ± 0.143
9.871LeuLeu: 9.871 ± 0.18
2.626LeuMet: 2.626 ± 0.077
3.876LeuAsn: 3.876 ± 0.081
3.573LeuPro: 3.573 ± 0.087
3.433LeuGln: 3.433 ± 0.083
3.564LeuArg: 3.564 ± 0.079
6.808LeuSer: 6.808 ± 0.119
4.631LeuThr: 4.631 ± 0.09
5.16LeuVal: 5.16 ± 0.109
0.814LeuTrp: 0.814 ± 0.04
3.571LeuTyr: 3.571 ± 0.084
0.0LeuXaa: 0.0 ± 0.0
Met
2.254MetAla: 2.254 ± 0.07
0.19MetCys: 0.19 ± 0.018
1.399MetAsp: 1.399 ± 0.057
1.672MetGlu: 1.672 ± 0.054
1.129MetPhe: 1.129 ± 0.053
1.975MetGly: 1.975 ± 0.062
0.66MetHis: 0.66 ± 0.033
2.344MetIle: 2.344 ± 0.066
2.326MetLys: 2.326 ± 0.072
2.904MetLeu: 2.904 ± 0.082
0.906MetMet: 0.906 ± 0.046
1.188MetAsn: 1.188 ± 0.041
1.278MetPro: 1.278 ± 0.05
1.211MetGln: 1.211 ± 0.048
1.119MetArg: 1.119 ± 0.044
1.619MetSer: 1.619 ± 0.054
1.353MetThr: 1.353 ± 0.049
1.78MetVal: 1.78 ± 0.052
0.163MetTrp: 0.163 ± 0.017
0.725MetTyr: 0.725 ± 0.037
0.0MetXaa: 0.0 ± 0.0
Asn
3.388AsnAla: 3.388 ± 0.082
0.335AsnCys: 0.335 ± 0.025
2.378AsnAsp: 2.378 ± 0.072
3.073AsnGlu: 3.073 ± 0.071
1.902AsnPhe: 1.902 ± 0.057
2.665AsnGly: 2.665 ± 0.075
0.918AsnHis: 0.918 ± 0.042
4.062AsnIle: 4.062 ± 0.08
3.099AsnLys: 3.099 ± 0.072
3.986AsnLeu: 3.986 ± 0.087
1.106AsnMet: 1.106 ± 0.046
1.823AsnAsn: 1.823 ± 0.068
2.027AsnPro: 2.027 ± 0.066
1.348AsnGln: 1.348 ± 0.052
1.729AsnArg: 1.729 ± 0.059
2.28AsnSer: 2.28 ± 0.067
2.328AsnThr: 2.328 ± 0.072
2.615AsnVal: 2.615 ± 0.068
0.316AsnTrp: 0.316 ± 0.029
1.621AsnTyr: 1.621 ± 0.055
0.0AsnXaa: 0.0 ± 0.0
Pro
2.112ProAla: 2.112 ± 0.061
0.293ProCys: 0.293 ± 0.024
1.738ProAsp: 1.738 ± 0.058
2.218ProGlu: 2.218 ± 0.064
1.872ProPhe: 1.872 ± 0.055
1.713ProGly: 1.713 ± 0.064
0.846ProHis: 0.846 ± 0.041
2.466ProIle: 2.466 ± 0.067
2.707ProLys: 2.707 ± 0.081
3.598ProLeu: 3.598 ± 0.091
0.902ProMet: 0.902 ± 0.039
1.356ProAsn: 1.356 ± 0.051
0.913ProPro: 0.913 ± 0.044
1.321ProGln: 1.321 ± 0.052
1.037ProArg: 1.037 ± 0.04
2.22ProSer: 2.22 ± 0.065
1.7ProThr: 1.7 ± 0.053
2.355ProVal: 2.355 ± 0.07
0.305ProTrp: 0.305 ± 0.024
1.434ProTyr: 1.434 ± 0.055
0.0ProXaa: 0.0 ± 0.0
Gln
2.477GlnAla: 2.477 ± 0.064
0.243GlnCys: 0.243 ± 0.02
1.392GlnAsp: 1.392 ± 0.051
2.817GlnGlu: 2.817 ± 0.08
1.2GlnPhe: 1.2 ± 0.045
1.842GlnGly: 1.842 ± 0.059
0.624GlnHis: 0.624 ± 0.036
2.901GlnIle: 2.901 ± 0.082
3.656GlnLys: 3.656 ± 0.097
2.527GlnLeu: 2.527 ± 0.069
1.163GlnMet: 1.163 ± 0.044
2.121GlnAsn: 2.121 ± 0.06
0.863GlnPro: 0.863 ± 0.037
1.11GlnGln: 1.11 ± 0.052
1.413GlnArg: 1.413 ± 0.053
2.078GlnSer: 2.078 ± 0.065
2.067GlnThr: 2.067 ± 0.068
1.541GlnVal: 1.541 ± 0.054
0.284GlnTrp: 0.284 ± 0.025
1.083GlnTyr: 1.083 ± 0.046
0.0GlnXaa: 0.0 ± 0.0
Arg
2.633ArgAla: 2.633 ± 0.069
0.399ArgCys: 0.399 ± 0.027
2.06ArgAsp: 2.06 ± 0.063
2.766ArgGlu: 2.766 ± 0.079
2.055ArgPhe: 2.055 ± 0.063
2.28ArgGly: 2.28 ± 0.069
0.858ArgHis: 0.858 ± 0.04
3.004ArgIle: 3.004 ± 0.077
2.615ArgLys: 2.615 ± 0.074
3.722ArgLeu: 3.722 ± 0.09
1.177ArgMet: 1.177 ± 0.049
1.557ArgAsn: 1.557 ± 0.051
1.119ArgPro: 1.119 ± 0.053
1.236ArgGln: 1.236 ± 0.044
1.559ArgArg: 1.559 ± 0.062
2.133ArgSer: 2.133 ± 0.069
1.803ArgThr: 1.803 ± 0.07
2.585ArgVal: 2.585 ± 0.07
0.342ArgTrp: 0.342 ± 0.027
2.009ArgTyr: 2.009 ± 0.058
0.0ArgXaa: 0.0 ± 0.0
Ser
4.479SerAla: 4.479 ± 0.09
0.578SerCys: 0.578 ± 0.031
3.074SerAsp: 3.074 ± 0.07
3.369SerGlu: 3.369 ± 0.07
3.229SerPhe: 3.229 ± 0.087
4.479SerGly: 4.479 ± 0.094
1.285SerHis: 1.285 ± 0.05
4.697SerIle: 4.697 ± 0.097
4.56SerLys: 4.56 ± 0.102
5.995SerLeu: 5.995 ± 0.113
1.658SerMet: 1.658 ± 0.06
2.363SerAsn: 2.363 ± 0.066
1.833SerPro: 1.833 ± 0.061
2.154SerGln: 2.154 ± 0.061
2.381SerArg: 2.381 ± 0.07
4.034SerSer: 4.034 ± 0.098
2.952SerThr: 2.952 ± 0.075
3.899SerVal: 3.899 ± 0.09
0.58SerTrp: 0.58 ± 0.028
2.402SerTyr: 2.402 ± 0.072
0.0SerXaa: 0.0 ± 0.0
Thr
3.895ThrAla: 3.895 ± 0.086
0.379ThrCys: 0.379 ± 0.03
2.603ThrAsp: 2.603 ± 0.078
2.621ThrGlu: 2.621 ± 0.061
2.58ThrPhe: 2.58 ± 0.058
3.527ThrGly: 3.527 ± 0.095
1.193ThrHis: 1.193 ± 0.051
4.307ThrIle: 4.307 ± 0.098
3.823ThrLys: 3.823 ± 0.08
5.975ThrLeu: 5.975 ± 0.118
1.326ThrMet: 1.326 ± 0.053
2.034ThrAsn: 2.034 ± 0.071
2.433ThrPro: 2.433 ± 0.073
2.108ThrGln: 2.108 ± 0.065
1.713ThrArg: 1.713 ± 0.057
2.846ThrSer: 2.846 ± 0.078
2.679ThrThr: 2.679 ± 0.074
3.583ThrVal: 3.583 ± 0.083
0.372ThrTrp: 0.372 ± 0.027
1.956ThrTyr: 1.956 ± 0.066
0.0ThrXaa: 0.0 ± 0.0
Val
5.053ValAla: 5.053 ± 0.102
0.754ValCys: 0.754 ± 0.042
3.589ValAsp: 3.589 ± 0.082
4.154ValGlu: 4.154 ± 0.081
2.945ValPhe: 2.945 ± 0.077
4.108ValGly: 4.108 ± 0.089
1.262ValHis: 1.262 ± 0.042
4.766ValIle: 4.766 ± 0.097
4.358ValLys: 4.358 ± 0.093
6.154ValLeu: 6.154 ± 0.118
1.784ValMet: 1.784 ± 0.06
2.495ValAsn: 2.495 ± 0.063
2.202ValPro: 2.202 ± 0.072
1.833ValGln: 1.833 ± 0.059
2.337ValArg: 2.337 ± 0.059
4.319ValSer: 4.319 ± 0.078
3.229ValThr: 3.229 ± 0.083
4.504ValVal: 4.504 ± 0.107
0.647ValTrp: 0.647 ± 0.035
2.255ValTyr: 2.255 ± 0.067
0.0ValXaa: 0.0 ± 0.0
Trp
0.551TrpAla: 0.551 ± 0.034
0.117TrpCys: 0.117 ± 0.015
0.41TrpAsp: 0.41 ± 0.025
0.502TrpGlu: 0.502 ± 0.029
0.436TrpPhe: 0.436 ± 0.027
0.667TrpGly: 0.667 ± 0.046
0.229TrpHis: 0.229 ± 0.018
0.764TrpIle: 0.764 ± 0.042
0.5TrpLys: 0.5 ± 0.033
0.899TrpLeu: 0.899 ± 0.042
0.332TrpMet: 0.332 ± 0.026
0.363TrpAsn: 0.363 ± 0.027
0.149TrpPro: 0.149 ± 0.017
0.335TrpGln: 0.335 ± 0.029
0.333TrpArg: 0.333 ± 0.022
0.507TrpSer: 0.507 ± 0.032
0.369TrpThr: 0.369 ± 0.027
0.551TrpVal: 0.551 ± 0.031
0.11TrpTrp: 0.11 ± 0.015
0.319TrpTyr: 0.319 ± 0.025
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.103TyrAla: 3.103 ± 0.077
0.363TyrCys: 0.363 ± 0.03
2.408TyrAsp: 2.408 ± 0.076
2.75TyrGlu: 2.75 ± 0.074
2.002TyrPhe: 2.002 ± 0.059
2.539TyrGly: 2.539 ± 0.073
0.902TyrHis: 0.902 ± 0.044
2.672TyrIle: 2.672 ± 0.068
2.715TyrLys: 2.715 ± 0.076
3.826TyrLeu: 3.826 ± 0.094
0.887TyrMet: 0.887 ± 0.037
1.592TyrAsn: 1.592 ± 0.055
1.45TyrPro: 1.45 ± 0.049
1.349TyrGln: 1.349 ± 0.047
1.722TyrArg: 1.722 ± 0.067
2.035TyrSer: 2.035 ± 0.064
2.044TyrThr: 2.044 ± 0.062
1.97TyrVal: 1.97 ± 0.059
0.307TyrTrp: 0.307 ± 0.026
1.573TyrTyr: 1.573 ± 0.064
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1860 proteins (564002 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski