Amino acid dipepetide frequency for Klebsiella phage Kund-ULIP54

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.095AlaAla: 9.095 ± 0.989
0.724AlaCys: 0.724 ± 0.24
6.68AlaAsp: 6.68 ± 0.8
4.99AlaGlu: 4.99 ± 0.795
3.139AlaPhe: 3.139 ± 0.513
7.243AlaGly: 7.243 ± 1.023
1.529AlaHis: 1.529 ± 0.313
4.266AlaIle: 4.266 ± 0.531
6.6AlaLys: 6.6 ± 0.758
7.807AlaLeu: 7.807 ± 0.91
2.656AlaMet: 2.656 ± 0.621
4.346AlaAsn: 4.346 ± 0.444
3.139AlaPro: 3.139 ± 0.728
3.702AlaGln: 3.702 ± 0.65
5.312AlaArg: 5.312 ± 0.586
5.553AlaSer: 5.553 ± 0.743
4.105AlaThr: 4.105 ± 0.515
5.553AlaVal: 5.553 ± 0.611
1.046AlaTrp: 1.046 ± 0.351
3.139AlaTyr: 3.139 ± 0.456
0.0AlaXaa: 0.0 ± 0.0
Cys
0.644CysAla: 0.644 ± 0.242
0.08CysCys: 0.08 ± 0.088
0.724CysAsp: 0.724 ± 0.318
0.644CysGlu: 0.644 ± 0.255
0.402CysPhe: 0.402 ± 0.201
0.563CysGly: 0.563 ± 0.202
0.322CysHis: 0.322 ± 0.146
0.644CysIle: 0.644 ± 0.266
0.402CysLys: 0.402 ± 0.233
0.966CysLeu: 0.966 ± 0.319
0.0CysMet: 0.0 ± 0.0
0.161CysAsn: 0.161 ± 0.133
0.483CysPro: 0.483 ± 0.195
0.322CysGln: 0.322 ± 0.159
0.644CysArg: 0.644 ± 0.318
0.644CysSer: 0.644 ± 0.212
0.483CysThr: 0.483 ± 0.263
0.724CysVal: 0.724 ± 0.256
0.161CysTrp: 0.161 ± 0.124
0.322CysTyr: 0.322 ± 0.187
0.0CysXaa: 0.0 ± 0.0
Asp
5.714AspAla: 5.714 ± 0.694
0.402AspCys: 0.402 ± 0.208
3.863AspAsp: 3.863 ± 0.506
3.702AspGlu: 3.702 ± 0.557
2.897AspPhe: 2.897 ± 0.503
6.358AspGly: 6.358 ± 0.608
0.885AspHis: 0.885 ± 0.294
2.495AspIle: 2.495 ± 0.415
4.507AspLys: 4.507 ± 0.644
4.024AspLeu: 4.024 ± 0.612
2.173AspMet: 2.173 ± 0.417
2.656AspAsn: 2.656 ± 0.405
2.656AspPro: 2.656 ± 0.494
2.334AspGln: 2.334 ± 0.451
3.058AspArg: 3.058 ± 0.437
3.622AspSer: 3.622 ± 0.478
4.024AspThr: 4.024 ± 0.458
4.427AspVal: 4.427 ± 0.469
1.046AspTrp: 1.046 ± 0.321
2.093AspTyr: 2.093 ± 0.375
0.0AspXaa: 0.0 ± 0.0
Glu
7.485GluAla: 7.485 ± 0.977
0.724GluCys: 0.724 ± 0.343
4.668GluAsp: 4.668 ± 0.671
5.714GluGlu: 5.714 ± 1.227
2.736GluPhe: 2.736 ± 0.468
5.553GluGly: 5.553 ± 0.852
1.529GluHis: 1.529 ± 0.477
3.058GluIle: 3.058 ± 0.534
3.3GluLys: 3.3 ± 0.77
6.278GluLeu: 6.278 ± 0.898
1.61GluMet: 1.61 ± 0.6
2.093GluAsn: 2.093 ± 0.381
2.575GluPro: 2.575 ± 0.596
2.978GluGln: 2.978 ± 0.717
4.105GluArg: 4.105 ± 0.897
4.105GluSer: 4.105 ± 0.684
3.541GluThr: 3.541 ± 0.498
4.909GluVal: 4.909 ± 0.622
0.644GluTrp: 0.644 ± 0.221
3.3GluTyr: 3.3 ± 0.483
0.0GluXaa: 0.0 ± 0.0
Phe
2.575PheAla: 2.575 ± 0.42
0.322PheCys: 0.322 ± 0.152
2.575PheAsp: 2.575 ± 0.573
2.012PheGlu: 2.012 ± 0.389
1.127PhePhe: 1.127 ± 0.306
3.541PheGly: 3.541 ± 0.663
0.563PheHis: 0.563 ± 0.265
1.771PheIle: 1.771 ± 0.584
2.495PheLys: 2.495 ± 0.396
2.817PheLeu: 2.817 ± 0.604
0.966PheMet: 0.966 ± 0.25
2.093PheAsn: 2.093 ± 0.39
1.449PhePro: 1.449 ± 0.441
1.368PheGln: 1.368 ± 0.322
1.932PheArg: 1.932 ± 0.544
2.093PheSer: 2.093 ± 0.397
2.414PheThr: 2.414 ± 0.446
2.254PheVal: 2.254 ± 0.469
0.322PheTrp: 0.322 ± 0.151
1.207PheTyr: 1.207 ± 0.322
0.0PheXaa: 0.0 ± 0.0
Gly
7.082GlyAla: 7.082 ± 0.989
0.805GlyCys: 0.805 ± 0.278
5.231GlyAsp: 5.231 ± 0.492
6.036GlyGlu: 6.036 ± 0.771
2.656GlyPhe: 2.656 ± 0.374
6.519GlyGly: 6.519 ± 1.168
1.207GlyHis: 1.207 ± 0.335
4.507GlyIle: 4.507 ± 0.818
5.312GlyLys: 5.312 ± 0.938
5.875GlyLeu: 5.875 ± 0.7
1.61GlyMet: 1.61 ± 0.425
2.817GlyAsn: 2.817 ± 0.481
1.449GlyPro: 1.449 ± 0.428
2.897GlyGln: 2.897 ± 0.398
4.346GlyArg: 4.346 ± 0.496
6.197GlySer: 6.197 ± 0.833
5.07GlyThr: 5.07 ± 1.148
5.151GlyVal: 5.151 ± 0.851
1.771GlyTrp: 1.771 ± 0.382
2.978GlyTyr: 2.978 ± 0.486
0.0GlyXaa: 0.0 ± 0.0
His
1.046HisAla: 1.046 ± 0.296
0.402HisCys: 0.402 ± 0.167
1.127HisAsp: 1.127 ± 0.298
1.368HisGlu: 1.368 ± 0.452
0.805HisPhe: 0.805 ± 0.261
1.449HisGly: 1.449 ± 0.331
0.483HisHis: 0.483 ± 0.22
0.724HisIle: 0.724 ± 0.277
1.046HisLys: 1.046 ± 0.254
1.449HisLeu: 1.449 ± 0.382
0.644HisMet: 0.644 ± 0.227
0.241HisAsn: 0.241 ± 0.119
0.644HisPro: 0.644 ± 0.205
0.483HisGln: 0.483 ± 0.225
0.724HisArg: 0.724 ± 0.332
0.805HisSer: 0.805 ± 0.255
0.724HisThr: 0.724 ± 0.232
1.851HisVal: 1.851 ± 0.392
0.161HisTrp: 0.161 ± 0.101
0.966HisTyr: 0.966 ± 0.197
0.0HisXaa: 0.0 ± 0.0
Ile
4.588IleAla: 4.588 ± 0.459
0.724IleCys: 0.724 ± 0.209
3.461IleAsp: 3.461 ± 0.559
3.219IleGlu: 3.219 ± 0.533
0.724IlePhe: 0.724 ± 0.269
4.024IleGly: 4.024 ± 0.592
0.966IleHis: 0.966 ± 0.294
2.173IleIle: 2.173 ± 0.482
2.817IleLys: 2.817 ± 0.487
3.541IleLeu: 3.541 ± 0.478
1.046IleMet: 1.046 ± 0.314
2.334IleAsn: 2.334 ± 0.567
2.414IlePro: 2.414 ± 0.454
2.012IleGln: 2.012 ± 0.444
3.783IleArg: 3.783 ± 0.605
3.139IleSer: 3.139 ± 0.486
2.495IleThr: 2.495 ± 0.583
2.817IleVal: 2.817 ± 0.412
0.483IleTrp: 0.483 ± 0.201
1.851IleTyr: 1.851 ± 0.386
0.0IleXaa: 0.0 ± 0.0
Lys
7.807LysAla: 7.807 ± 1.026
0.322LysCys: 0.322 ± 0.186
3.219LysAsp: 3.219 ± 0.689
5.392LysGlu: 5.392 ± 0.743
2.334LysPhe: 2.334 ± 0.424
6.117LysGly: 6.117 ± 0.954
1.449LysHis: 1.449 ± 0.322
2.495LysIle: 2.495 ± 0.445
3.461LysLys: 3.461 ± 0.814
5.795LysLeu: 5.795 ± 0.656
1.771LysMet: 1.771 ± 0.375
2.736LysAsn: 2.736 ± 0.43
2.736LysPro: 2.736 ± 0.553
2.414LysGln: 2.414 ± 0.452
3.783LysArg: 3.783 ± 0.638
3.38LysSer: 3.38 ± 0.605
2.897LysThr: 2.897 ± 0.379
5.312LysVal: 5.312 ± 0.709
0.805LysTrp: 0.805 ± 0.297
1.771LysTyr: 1.771 ± 0.406
0.0LysXaa: 0.0 ± 0.0
Leu
7.887LeuAla: 7.887 ± 0.933
0.322LeuCys: 0.322 ± 0.207
4.909LeuAsp: 4.909 ± 0.609
7.002LeuGlu: 7.002 ± 1.017
2.656LeuPhe: 2.656 ± 0.413
4.909LeuGly: 4.909 ± 0.626
0.966LeuHis: 0.966 ± 0.328
3.702LeuIle: 3.702 ± 0.551
6.439LeuLys: 6.439 ± 0.707
5.875LeuLeu: 5.875 ± 0.81
2.334LeuMet: 2.334 ± 0.304
3.783LeuAsn: 3.783 ± 0.465
3.219LeuPro: 3.219 ± 0.525
3.622LeuGln: 3.622 ± 0.457
5.151LeuArg: 5.151 ± 0.647
4.668LeuSer: 4.668 ± 0.564
4.909LeuThr: 4.909 ± 0.628
4.507LeuVal: 4.507 ± 0.549
1.288LeuTrp: 1.288 ± 0.402
2.334LeuTyr: 2.334 ± 0.442
0.0LeuXaa: 0.0 ± 0.0
Met
3.3MetAla: 3.3 ± 0.521
0.161MetCys: 0.161 ± 0.138
1.851MetAsp: 1.851 ± 0.403
1.61MetGlu: 1.61 ± 0.352
0.966MetPhe: 0.966 ± 0.269
1.529MetGly: 1.529 ± 0.338
0.402MetHis: 0.402 ± 0.2
1.288MetIle: 1.288 ± 0.343
1.127MetLys: 1.127 ± 0.304
2.656MetLeu: 2.656 ± 0.436
0.483MetMet: 0.483 ± 0.223
0.724MetAsn: 0.724 ± 0.197
0.805MetPro: 0.805 ± 0.221
2.012MetGln: 2.012 ± 0.47
1.207MetArg: 1.207 ± 0.33
1.449MetSer: 1.449 ± 0.326
1.932MetThr: 1.932 ± 0.393
1.771MetVal: 1.771 ± 0.499
0.0MetTrp: 0.0 ± 0.0
0.724MetTyr: 0.724 ± 0.262
0.0MetXaa: 0.0 ± 0.0
Asn
3.783AsnAla: 3.783 ± 0.616
0.483AsnCys: 0.483 ± 0.207
2.173AsnAsp: 2.173 ± 0.326
2.897AsnGlu: 2.897 ± 0.576
1.449AsnPhe: 1.449 ± 0.34
4.266AsnGly: 4.266 ± 0.67
0.402AsnHis: 0.402 ± 0.215
2.897AsnIle: 2.897 ± 0.494
2.093AsnLys: 2.093 ± 0.408
3.139AsnLeu: 3.139 ± 0.447
0.885AsnMet: 0.885 ± 0.287
1.529AsnAsn: 1.529 ± 0.335
2.093AsnPro: 2.093 ± 0.362
1.449AsnGln: 1.449 ± 0.31
1.529AsnArg: 1.529 ± 0.428
2.978AsnSer: 2.978 ± 0.55
2.254AsnThr: 2.254 ± 0.547
2.897AsnVal: 2.897 ± 0.555
0.805AsnTrp: 0.805 ± 0.298
1.932AsnTyr: 1.932 ± 0.544
0.0AsnXaa: 0.0 ± 0.0
Pro
3.139ProAla: 3.139 ± 0.44
0.402ProCys: 0.402 ± 0.211
2.012ProAsp: 2.012 ± 0.39
4.427ProGlu: 4.427 ± 0.677
1.449ProPhe: 1.449 ± 0.218
2.414ProGly: 2.414 ± 0.444
0.322ProHis: 0.322 ± 0.151
1.127ProIle: 1.127 ± 0.322
2.575ProLys: 2.575 ± 0.508
2.414ProLeu: 2.414 ± 0.45
0.644ProMet: 0.644 ± 0.222
2.012ProAsn: 2.012 ± 0.465
0.885ProPro: 0.885 ± 0.321
1.368ProGln: 1.368 ± 0.34
1.932ProArg: 1.932 ± 0.441
2.254ProSer: 2.254 ± 0.364
2.012ProThr: 2.012 ± 0.47
2.897ProVal: 2.897 ± 0.355
0.805ProTrp: 0.805 ± 0.197
1.851ProTyr: 1.851 ± 0.363
0.0ProXaa: 0.0 ± 0.0
Gln
3.783GlnAla: 3.783 ± 0.529
0.241GlnCys: 0.241 ± 0.15
2.656GlnAsp: 2.656 ± 0.359
2.736GlnGlu: 2.736 ± 0.406
1.851GlnPhe: 1.851 ± 0.351
2.736GlnGly: 2.736 ± 0.426
0.241GlnHis: 0.241 ± 0.15
1.932GlnIle: 1.932 ± 0.418
3.058GlnLys: 3.058 ± 0.501
4.105GlnLeu: 4.105 ± 0.533
1.61GlnMet: 1.61 ± 0.49
1.288GlnAsn: 1.288 ± 0.278
1.69GlnPro: 1.69 ± 0.281
3.38GlnGln: 3.38 ± 0.659
2.173GlnArg: 2.173 ± 0.463
2.414GlnSer: 2.414 ± 0.462
2.093GlnThr: 2.093 ± 0.514
2.978GlnVal: 2.978 ± 0.511
0.724GlnTrp: 0.724 ± 0.273
1.69GlnTyr: 1.69 ± 0.394
0.0GlnXaa: 0.0 ± 0.0
Arg
5.392ArgAla: 5.392 ± 0.776
0.805ArgCys: 0.805 ± 0.255
3.461ArgAsp: 3.461 ± 0.547
3.944ArgGlu: 3.944 ± 0.536
2.093ArgPhe: 2.093 ± 0.441
4.024ArgGly: 4.024 ± 0.567
0.885ArgHis: 0.885 ± 0.277
3.541ArgIle: 3.541 ± 0.634
3.944ArgLys: 3.944 ± 0.547
4.507ArgLeu: 4.507 ± 0.699
1.529ArgMet: 1.529 ± 0.347
2.334ArgAsn: 2.334 ± 0.429
2.012ArgPro: 2.012 ± 0.355
2.897ArgGln: 2.897 ± 0.463
2.656ArgArg: 2.656 ± 0.446
3.702ArgSer: 3.702 ± 0.427
2.897ArgThr: 2.897 ± 0.603
3.461ArgVal: 3.461 ± 0.653
1.127ArgTrp: 1.127 ± 0.329
1.127ArgTyr: 1.127 ± 0.299
0.0ArgXaa: 0.0 ± 0.0
Ser
4.346SerAla: 4.346 ± 0.643
0.644SerCys: 0.644 ± 0.241
4.185SerAsp: 4.185 ± 0.598
4.185SerGlu: 4.185 ± 0.613
2.897SerPhe: 2.897 ± 0.503
4.829SerGly: 4.829 ± 0.712
1.529SerHis: 1.529 ± 0.31
2.978SerIle: 2.978 ± 0.488
4.266SerLys: 4.266 ± 0.523
4.829SerLeu: 4.829 ± 0.746
1.368SerMet: 1.368 ± 0.306
2.254SerAsn: 2.254 ± 0.644
1.932SerPro: 1.932 ± 0.38
3.219SerGln: 3.219 ± 0.488
3.461SerArg: 3.461 ± 0.662
2.254SerSer: 2.254 ± 0.552
4.266SerThr: 4.266 ± 0.646
4.185SerVal: 4.185 ± 0.572
0.724SerTrp: 0.724 ± 0.204
2.254SerTyr: 2.254 ± 0.498
0.0SerXaa: 0.0 ± 0.0
Thr
4.507ThrAla: 4.507 ± 0.705
0.885ThrCys: 0.885 ± 0.301
3.219ThrAsp: 3.219 ± 0.481
3.38ThrGlu: 3.38 ± 0.469
2.093ThrPhe: 2.093 ± 0.446
4.909ThrGly: 4.909 ± 0.751
1.207ThrHis: 1.207 ± 0.276
3.38ThrIle: 3.38 ± 0.461
4.829ThrLys: 4.829 ± 0.679
5.392ThrLeu: 5.392 ± 0.82
1.449ThrMet: 1.449 ± 0.316
2.093ThrAsn: 2.093 ± 0.533
2.656ThrPro: 2.656 ± 0.411
2.173ThrGln: 2.173 ± 0.416
2.656ThrArg: 2.656 ± 0.431
4.024ThrSer: 4.024 ± 0.785
3.058ThrThr: 3.058 ± 0.782
3.702ThrVal: 3.702 ± 0.637
0.483ThrTrp: 0.483 ± 0.205
1.368ThrTyr: 1.368 ± 0.374
0.0ThrXaa: 0.0 ± 0.0
Val
5.553ValAla: 5.553 ± 0.602
0.402ValCys: 0.402 ± 0.193
3.622ValAsp: 3.622 ± 0.378
4.346ValGlu: 4.346 ± 0.611
2.093ValPhe: 2.093 ± 0.498
4.829ValGly: 4.829 ± 0.522
1.046ValHis: 1.046 ± 0.357
3.38ValIle: 3.38 ± 0.595
4.588ValLys: 4.588 ± 0.552
5.553ValLeu: 5.553 ± 0.653
1.368ValMet: 1.368 ± 0.316
4.024ValAsn: 4.024 ± 0.628
2.575ValPro: 2.575 ± 0.453
2.334ValGln: 2.334 ± 0.362
4.507ValArg: 4.507 ± 0.583
4.829ValSer: 4.829 ± 0.916
5.312ValThr: 5.312 ± 0.677
4.507ValVal: 4.507 ± 0.744
0.724ValTrp: 0.724 ± 0.356
2.254ValTyr: 2.254 ± 0.512
0.0ValXaa: 0.0 ± 0.0
Trp
0.644TrpAla: 0.644 ± 0.201
0.322TrpCys: 0.322 ± 0.155
0.644TrpAsp: 0.644 ± 0.218
1.127TrpGlu: 1.127 ± 0.277
0.402TrpPhe: 0.402 ± 0.189
0.563TrpGly: 0.563 ± 0.219
0.402TrpHis: 0.402 ± 0.213
0.644TrpIle: 0.644 ± 0.277
1.368TrpLys: 1.368 ± 0.36
1.368TrpLeu: 1.368 ± 0.409
0.322TrpMet: 0.322 ± 0.167
0.724TrpAsn: 0.724 ± 0.222
0.241TrpPro: 0.241 ± 0.13
0.724TrpGln: 0.724 ± 0.269
0.805TrpArg: 0.805 ± 0.211
1.207TrpSer: 1.207 ± 0.416
0.724TrpThr: 0.724 ± 0.262
1.288TrpVal: 1.288 ± 0.364
0.241TrpTrp: 0.241 ± 0.125
0.161TrpTyr: 0.161 ± 0.115
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.254TyrAla: 2.254 ± 0.455
0.161TyrCys: 0.161 ± 0.127
2.656TyrAsp: 2.656 ± 0.505
2.173TyrGlu: 2.173 ± 0.425
1.127TyrPhe: 1.127 ± 0.274
3.139TyrGly: 3.139 ± 0.386
0.805TyrHis: 0.805 ± 0.281
1.61TyrIle: 1.61 ± 0.44
1.771TyrLys: 1.771 ± 0.338
2.093TyrLeu: 2.093 ± 0.332
1.449TyrMet: 1.449 ± 0.442
1.771TyrAsn: 1.771 ± 0.44
1.288TyrPro: 1.288 ± 0.374
1.69TyrGln: 1.69 ± 0.482
2.575TyrArg: 2.575 ± 0.486
1.288TyrSer: 1.288 ± 0.382
2.254TyrThr: 2.254 ± 0.553
2.656TyrVal: 2.656 ± 0.455
0.563TyrTrp: 0.563 ± 0.232
0.805TyrTyr: 0.805 ± 0.346
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 46 proteins (12426 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski