Amino acid dipepetide frequency for Cafeteria roenbergensis virus (strain BV-PW1) (CroV)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
1.919AlaAla: 1.919 ± 0.367
0.389AlaCys: 0.389 ± 0.055
1.454AlaAsp: 1.454 ± 0.159
1.189AlaGlu: 1.189 ± 0.098
1.206AlaPhe: 1.206 ± 0.08
1.352AlaGly: 1.352 ± 0.144
0.584AlaHis: 0.584 ± 0.061
2.082AlaIle: 2.082 ± 0.108
2.146AlaLys: 2.146 ± 0.172
2.222AlaLeu: 2.222 ± 0.134
0.546AlaMet: 0.546 ± 0.077
1.508AlaAsn: 1.508 ± 0.097
0.957AlaPro: 0.957 ± 0.176
0.8AlaGln: 0.8 ± 0.078
0.8AlaArg: 0.8 ± 0.084
2.157AlaSer: 2.157 ± 0.177
1.86AlaThr: 1.86 ± 0.149
1.417AlaVal: 1.417 ± 0.125
0.162AlaTrp: 0.162 ± 0.026
1.173AlaTyr: 1.173 ± 0.081
0.0AlaXaa: 0.0 ± 0.0
Cys
0.373CysAla: 0.373 ± 0.052
0.292CysCys: 0.292 ± 0.043
0.887CysAsp: 0.887 ± 0.077
0.616CysGlu: 0.616 ± 0.062
0.66CysPhe: 0.66 ± 0.059
0.708CysGly: 0.708 ± 0.078
0.238CysHis: 0.238 ± 0.036
0.93CysIle: 0.93 ± 0.08
1.135CysLys: 1.135 ± 0.092
1.0CysLeu: 1.0 ± 0.08
0.184CysMet: 0.184 ± 0.03
1.114CysAsn: 1.114 ± 0.091
0.557CysPro: 0.557 ± 0.057
0.357CysGln: 0.357 ± 0.044
0.335CysArg: 0.335 ± 0.046
0.914CysSer: 0.914 ± 0.073
0.557CysThr: 0.557 ± 0.058
0.546CysVal: 0.546 ± 0.061
0.162CysTrp: 0.162 ± 0.036
0.925CysTyr: 0.925 ± 0.089
0.0CysXaa: 0.0 ± 0.0
Asp
1.379AspAla: 1.379 ± 0.109
0.687AspCys: 0.687 ± 0.067
3.774AspAsp: 3.774 ± 0.187
4.109AspGlu: 4.109 ± 0.227
3.779AspPhe: 3.779 ± 0.129
2.303AspGly: 2.303 ± 0.122
0.622AspHis: 0.622 ± 0.055
6.104AspIle: 6.104 ± 0.216
6.185AspLys: 6.185 ± 0.233
5.088AspLeu: 5.088 ± 0.178
1.022AspMet: 1.022 ± 0.071
5.731AspAsn: 5.731 ± 0.24
1.265AspPro: 1.265 ± 0.147
1.249AspGln: 1.249 ± 0.083
1.189AspArg: 1.189 ± 0.084
3.293AspSer: 3.293 ± 0.155
3.514AspThr: 3.514 ± 0.155
2.179AspVal: 2.179 ± 0.123
0.427AspTrp: 0.427 ± 0.048
3.087AspTyr: 3.087 ± 0.146
0.0AspXaa: 0.0 ± 0.0
Glu
1.676GluAla: 1.676 ± 0.128
0.681GluCys: 0.681 ± 0.067
3.714GluAsp: 3.714 ± 0.263
4.471GluGlu: 4.471 ± 0.211
2.99GluPhe: 2.99 ± 0.134
2.222GluGly: 2.222 ± 0.129
1.006GluHis: 1.006 ± 0.066
6.812GluIle: 6.812 ± 0.236
6.304GluLys: 6.304 ± 0.229
6.136GluLeu: 6.136 ± 0.186
1.314GluMet: 1.314 ± 0.103
6.19GluAsn: 6.19 ± 0.237
2.103GluPro: 2.103 ± 0.533
1.909GluGln: 1.909 ± 0.117
1.189GluArg: 1.189 ± 0.093
3.33GluSer: 3.33 ± 0.179
3.244GluThr: 3.244 ± 0.148
2.087GluVal: 2.087 ± 0.134
0.643GluTrp: 0.643 ± 0.061
2.963GluTyr: 2.963 ± 0.136
0.0GluXaa: 0.0 ± 0.0
Phe
0.984PheAla: 0.984 ± 0.081
0.66PheCys: 0.66 ± 0.063
3.174PheAsp: 3.174 ± 0.141
2.714PheGlu: 2.714 ± 0.131
2.033PhePhe: 2.033 ± 0.104
2.898PheGly: 2.898 ± 0.258
1.07PheHis: 1.07 ± 0.091
5.277PheIle: 5.277 ± 0.209
5.525PheLys: 5.525 ± 0.217
4.028PheLeu: 4.028 ± 0.158
1.108PheMet: 1.108 ± 0.079
6.828PheAsn: 6.828 ± 0.347
1.508PhePro: 1.508 ± 0.094
1.146PheGln: 1.146 ± 0.08
1.319PheArg: 1.319 ± 0.077
3.017PheSer: 3.017 ± 0.126
2.892PheThr: 2.892 ± 0.139
1.887PheVal: 1.887 ± 0.118
0.422PheTrp: 0.422 ± 0.054
2.957PheTyr: 2.957 ± 0.142
0.0PheXaa: 0.0 ± 0.0
Gly
1.535GlyAla: 1.535 ± 0.21
0.687GlyCys: 0.687 ± 0.068
2.292GlyAsp: 2.292 ± 0.134
2.184GlyGlu: 2.184 ± 0.127
1.881GlyPhe: 1.881 ± 0.093
2.519GlyGly: 2.519 ± 0.186
0.816GlyHis: 0.816 ± 0.076
3.33GlyIle: 3.33 ± 0.153
3.687GlyLys: 3.687 ± 0.146
3.168GlyLeu: 3.168 ± 0.154
0.897GlyMet: 0.897 ± 0.113
3.033GlyAsn: 3.033 ± 0.165
0.908GlyPro: 0.908 ± 0.073
0.86GlyGln: 0.86 ± 0.083
1.184GlyArg: 1.184 ± 0.103
2.53GlySer: 2.53 ± 0.142
2.287GlyThr: 2.287 ± 0.134
1.984GlyVal: 1.984 ± 0.107
0.476GlyTrp: 0.476 ± 0.053
2.082GlyTyr: 2.082 ± 0.122
0.0GlyXaa: 0.0 ± 0.0
His
0.497HisAla: 0.497 ± 0.054
0.287HisCys: 0.287 ± 0.037
0.752HisAsp: 0.752 ± 0.066
0.86HisGlu: 0.86 ± 0.066
1.276HisPhe: 1.276 ± 0.096
0.616HisGly: 0.616 ± 0.059
0.476HisHis: 0.476 ± 0.057
1.681HisIle: 1.681 ± 0.096
1.8HisLys: 1.8 ± 0.082
2.379HisLeu: 2.379 ± 0.15
0.33HisMet: 0.33 ± 0.045
1.741HisAsn: 1.741 ± 0.088
0.968HisPro: 0.968 ± 0.074
0.903HisGln: 0.903 ± 0.063
0.433HisArg: 0.433 ± 0.055
1.265HisSer: 1.265 ± 0.108
1.168HisThr: 1.168 ± 0.092
0.724HisVal: 0.724 ± 0.058
0.178HisTrp: 0.178 ± 0.029
1.065HisTyr: 1.065 ± 0.073
0.0HisXaa: 0.0 ± 0.0
Ile
1.881IleAla: 1.881 ± 0.112
1.222IleCys: 1.222 ± 0.084
6.326IleAsp: 6.326 ± 0.213
6.953IleGlu: 6.953 ± 0.265
4.666IlePhe: 4.666 ± 0.165
3.406IleGly: 3.406 ± 0.147
1.584IleHis: 1.584 ± 0.099
11.5IleIle: 11.5 ± 0.361
12.078IleLys: 12.078 ± 0.312
9.245IleLeu: 9.245 ± 0.32
1.881IleMet: 1.881 ± 0.115
11.294IleAsn: 11.294 ± 0.357
3.682IlePro: 3.682 ± 0.171
2.655IleGln: 2.655 ± 0.125
2.39IleArg: 2.39 ± 0.12
6.25IleSer: 6.25 ± 0.187
5.498IleThr: 5.498 ± 0.213
3.412IleVal: 3.412 ± 0.147
0.714IleTrp: 0.714 ± 0.066
5.466IleTyr: 5.466 ± 0.203
0.0IleXaa: 0.0 ± 0.0
Lys
1.99LysAla: 1.99 ± 0.148
1.292LysCys: 1.292 ± 0.106
5.055LysAsp: 5.055 ± 0.225
6.558LysGlu: 6.558 ± 0.235
5.142LysPhe: 5.142 ± 0.174
2.92LysGly: 2.92 ± 0.154
2.211LysHis: 2.211 ± 0.102
12.451LysIle: 12.451 ± 0.35
10.332LysLys: 10.332 ± 0.36
10.635LysLeu: 10.635 ± 0.293
2.136LysMet: 2.136 ± 0.108
10.889LysAsn: 10.889 ± 0.267
2.557LysPro: 2.557 ± 0.128
3.347LysGln: 3.347 ± 0.225
2.173LysArg: 2.173 ± 0.126
5.78LysSer: 5.78 ± 0.204
5.671LysThr: 5.671 ± 0.233
4.325LysVal: 4.325 ± 0.244
1.552LysTrp: 1.552 ± 0.216
6.812LysTyr: 6.812 ± 0.249
0.0LysXaa: 0.0 ± 0.0
Leu
2.514LeuAla: 2.514 ± 0.159
1.054LeuCys: 1.054 ± 0.081
5.958LeuAsp: 5.958 ± 0.19
6.574LeuGlu: 6.574 ± 0.231
3.99LeuPhe: 3.99 ± 0.163
3.563LeuGly: 3.563 ± 0.16
1.59LeuHis: 1.59 ± 0.099
9.532LeuIle: 9.532 ± 0.282
9.991LeuLys: 9.991 ± 0.264
8.234LeuLeu: 8.234 ± 0.291
1.811LeuMet: 1.811 ± 0.107
8.829LeuAsn: 8.829 ± 0.346
4.109LeuPro: 4.109 ± 0.227
3.044LeuGln: 3.044 ± 0.129
2.141LeuArg: 2.141 ± 0.102
6.185LeuSer: 6.185 ± 0.171
7.693LeuThr: 7.693 ± 0.5
4.271LeuVal: 4.271 ± 0.156
0.627LeuTrp: 0.627 ± 0.054
4.104LeuTyr: 4.104 ± 0.145
0.0LeuXaa: 0.0 ± 0.0
Met
0.8MetAla: 0.8 ± 0.086
0.216MetCys: 0.216 ± 0.037
1.227MetAsp: 1.227 ± 0.064
1.417MetGlu: 1.417 ± 0.094
0.984MetPhe: 0.984 ± 0.064
1.011MetGly: 1.011 ± 0.093
0.173MetHis: 0.173 ± 0.031
1.719MetIle: 1.719 ± 0.114
2.06MetLys: 2.06 ± 0.133
1.59MetLeu: 1.59 ± 0.106
0.519MetMet: 0.519 ± 0.063
1.487MetAsn: 1.487 ± 0.085
0.643MetPro: 0.643 ± 0.073
0.389MetGln: 0.389 ± 0.053
0.476MetArg: 0.476 ± 0.05
1.508MetSer: 1.508 ± 0.091
1.168MetThr: 1.168 ± 0.077
1.0MetVal: 1.0 ± 0.091
0.124MetTrp: 0.124 ± 0.026
0.849MetTyr: 0.849 ± 0.075
0.0MetXaa: 0.0 ± 0.0
Asn
1.508AsnAla: 1.508 ± 0.095
0.941AsnCys: 0.941 ± 0.083
4.298AsnAsp: 4.298 ± 0.165
4.677AsnGlu: 4.677 ± 0.197
5.369AsnPhe: 5.369 ± 0.206
2.622AsnGly: 2.622 ± 0.136
1.73AsnHis: 1.73 ± 0.093
11.629AsnIle: 11.629 ± 0.362
11.64AsnLys: 11.64 ± 0.354
10.37AsnLeu: 10.37 ± 0.361
1.757AsnMet: 1.757 ± 0.09
10.873AsnAsn: 10.873 ± 0.449
2.59AsnPro: 2.59 ± 0.132
4.541AsnGln: 4.541 ± 0.306
1.854AsnArg: 1.854 ± 0.099
5.385AsnSer: 5.385 ± 0.184
5.044AsnThr: 5.044 ± 0.183
3.92AsnVal: 3.92 ± 0.204
0.784AsnTrp: 0.784 ± 0.074
5.882AsnTyr: 5.882 ± 0.251
0.0AsnXaa: 0.0 ± 0.0
Pro
1.049ProAla: 1.049 ± 0.226
0.373ProCys: 0.373 ± 0.045
2.06ProAsp: 2.06 ± 0.117
3.093ProGlu: 3.093 ± 0.507
1.779ProPhe: 1.779 ± 0.099
1.254ProGly: 1.254 ± 0.112
0.806ProHis: 0.806 ± 0.075
3.968ProIle: 3.968 ± 0.266
3.195ProLys: 3.195 ± 0.173
3.022ProLeu: 3.022 ± 0.13
0.622ProMet: 0.622 ± 0.069
2.492ProAsn: 2.492 ± 0.141
1.254ProPro: 1.254 ± 0.109
0.973ProGln: 0.973 ± 0.071
0.838ProArg: 0.838 ± 0.076
2.682ProSer: 2.682 ± 0.17
2.184ProThr: 2.184 ± 0.123
1.59ProVal: 1.59 ± 0.101
0.243ProTrp: 0.243 ± 0.037
1.654ProTyr: 1.654 ± 0.079
0.0ProXaa: 0.0 ± 0.0
Gln
0.919GlnAla: 0.919 ± 0.093
0.26GlnCys: 0.26 ± 0.04
1.514GlnAsp: 1.514 ± 0.103
2.363GlnGlu: 2.363 ± 0.151
1.714GlnPhe: 1.714 ± 0.092
1.022GlnGly: 1.022 ± 0.071
0.557GlnHis: 0.557 ± 0.059
3.228GlnIle: 3.228 ± 0.14
2.914GlnLys: 2.914 ± 0.179
2.93GlnLeu: 2.93 ± 0.132
0.654GlnMet: 0.654 ± 0.06
2.99GlnAsn: 2.99 ± 0.152
1.979GlnPro: 1.979 ± 0.26
1.325GlnGln: 1.325 ± 0.086
0.746GlnArg: 0.746 ± 0.069
1.898GlnSer: 1.898 ± 0.141
1.979GlnThr: 1.979 ± 0.14
1.6GlnVal: 1.6 ± 0.088
0.292GlnTrp: 0.292 ± 0.04
1.281GlnTyr: 1.281 ± 0.093
0.0GlnXaa: 0.0 ± 0.0
Arg
0.697ArgAla: 0.697 ± 0.068
0.46ArgCys: 0.46 ± 0.05
1.595ArgAsp: 1.595 ± 0.125
1.557ArgGlu: 1.557 ± 0.133
1.46ArgPhe: 1.46 ± 0.093
0.995ArgGly: 0.995 ± 0.078
0.465ArgHis: 0.465 ± 0.053
2.206ArgIle: 2.206 ± 0.119
2.482ArgLys: 2.482 ± 0.131
2.109ArgLeu: 2.109 ± 0.117
0.535ArgMet: 0.535 ± 0.054
1.833ArgAsn: 1.833 ± 0.094
0.768ArgPro: 0.768 ± 0.072
0.8ArgGln: 0.8 ± 0.065
0.941ArgArg: 0.941 ± 0.084
1.152ArgSer: 1.152 ± 0.104
1.243ArgThr: 1.243 ± 0.098
1.146ArgVal: 1.146 ± 0.083
0.205ArgTrp: 0.205 ± 0.037
1.233ArgTyr: 1.233 ± 0.095
0.0ArgXaa: 0.0 ± 0.0
Ser
1.752SerAla: 1.752 ± 0.162
0.724SerCys: 0.724 ± 0.062
3.563SerAsp: 3.563 ± 0.144
3.011SerGlu: 3.011 ± 0.126
3.222SerPhe: 3.222 ± 0.14
2.433SerGly: 2.433 ± 0.162
1.395SerHis: 1.395 ± 0.105
5.796SerIle: 5.796 ± 0.19
6.823SerLys: 6.823 ± 0.259
7.164SerLeu: 7.164 ± 0.392
1.119SerMet: 1.119 ± 0.08
5.812SerAsn: 5.812 ± 0.232
1.973SerPro: 1.973 ± 0.135
1.903SerGln: 1.903 ± 0.134
1.698SerArg: 1.698 ± 0.119
5.169SerSer: 5.169 ± 0.303
3.801SerThr: 3.801 ± 0.165
2.39SerVal: 2.39 ± 0.129
0.589SerTrp: 0.589 ± 0.056
2.99SerTyr: 2.99 ± 0.149
0.0SerXaa: 0.0 ± 0.0
Thr
1.492ThrAla: 1.492 ± 0.12
0.73ThrCys: 0.73 ± 0.066
3.249ThrAsp: 3.249 ± 0.178
3.217ThrGlu: 3.217 ± 0.169
3.893ThrPhe: 3.893 ± 0.24
2.341ThrGly: 2.341 ± 0.143
1.562ThrHis: 1.562 ± 0.133
5.044ThrIle: 5.044 ± 0.197
5.59ThrLys: 5.59 ± 0.213
6.001ThrLeu: 6.001 ± 0.32
0.946ThrMet: 0.946 ± 0.077
5.352ThrAsn: 5.352 ± 0.216
2.536ThrPro: 2.536 ± 0.142
1.887ThrGln: 1.887 ± 0.103
1.411ThrArg: 1.411 ± 0.099
4.239ThrSer: 4.239 ± 0.207
3.958ThrThr: 3.958 ± 0.281
2.206ThrVal: 2.206 ± 0.132
0.53ThrTrp: 0.53 ± 0.054
2.379ThrTyr: 2.379 ± 0.121
0.0ThrXaa: 0.0 ± 0.0
Val
1.476ValAla: 1.476 ± 0.146
0.606ValCys: 0.606 ± 0.059
2.59ValAsp: 2.59 ± 0.134
2.714ValGlu: 2.714 ± 0.169
1.795ValPhe: 1.795 ± 0.11
1.865ValGly: 1.865 ± 0.112
0.73ValHis: 0.73 ± 0.067
3.73ValIle: 3.73 ± 0.162
4.395ValLys: 4.395 ± 0.224
3.628ValLeu: 3.628 ± 0.189
0.773ValMet: 0.773 ± 0.068
3.33ValAsn: 3.33 ± 0.14
1.773ValPro: 1.773 ± 0.124
1.016ValGln: 1.016 ± 0.076
1.087ValArg: 1.087 ± 0.086
3.017ValSer: 3.017 ± 0.135
1.919ValThr: 1.919 ± 0.117
1.698ValVal: 1.698 ± 0.103
0.411ValTrp: 0.411 ± 0.049
1.952ValTyr: 1.952 ± 0.097
0.0ValXaa: 0.0 ± 0.0
Trp
0.26TrpAla: 0.26 ± 0.043
0.119TrpCys: 0.119 ± 0.023
0.578TrpAsp: 0.578 ± 0.067
0.422TrpGlu: 0.422 ± 0.049
0.416TrpPhe: 0.416 ± 0.048
0.287TrpGly: 0.287 ± 0.041
0.119TrpHis: 0.119 ± 0.027
0.762TrpIle: 0.762 ± 0.056
0.87TrpLys: 0.87 ± 0.07
0.627TrpLeu: 0.627 ± 0.055
0.227TrpMet: 0.227 ± 0.034
0.806TrpAsn: 0.806 ± 0.07
1.189TrpPro: 1.189 ± 0.288
0.195TrpGln: 0.195 ± 0.032
0.26TrpArg: 0.26 ± 0.036
0.541TrpSer: 0.541 ± 0.061
0.438TrpThr: 0.438 ± 0.063
0.389TrpVal: 0.389 ± 0.052
0.092TrpTrp: 0.092 ± 0.024
0.47TrpTyr: 0.47 ± 0.051
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.222TyrAla: 1.222 ± 0.093
0.811TyrCys: 0.811 ± 0.072
2.925TyrAsp: 2.925 ± 0.115
2.287TyrGlu: 2.287 ± 0.105
3.195TyrPhe: 3.195 ± 0.145
2.006TyrGly: 2.006 ± 0.111
1.665TyrHis: 1.665 ± 0.093
4.32TyrIle: 4.32 ± 0.21
4.671TyrLys: 4.671 ± 0.195
6.239TyrLeu: 6.239 ± 0.259
0.973TyrMet: 0.973 ± 0.076
5.282TyrAsn: 5.282 ± 0.216
1.811TyrPro: 1.811 ± 0.107
2.865TyrGln: 2.865 ± 0.168
1.417TyrArg: 1.417 ± 0.106
3.022TyrSer: 3.022 ± 0.139
2.444TyrThr: 2.444 ± 0.112
1.735TyrVal: 1.735 ± 0.1
0.433TyrTrp: 0.433 ± 0.05
3.947TyrTyr: 3.947 ± 0.208
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 544 proteins (184963 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski