Amino acid dipepetide frequency for Erysipelothrix larvae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.474AlaAla: 3.474 ± 0.097	0.774AlaCys: 0.774 ± 0.035	2.637AlaAsp: 2.637 ± 0.065	2.553AlaGlu: 2.553 ± 0.063	3.287AlaPhe: 3.287 ± 0.075	3.522AlaGly: 3.522 ± 0.079	1.548AlaHis: 1.548 ± 0.045	5.492AlaIle: 5.492 ± 0.093	3.666AlaLys: 3.666 ± 0.083	7.54AlaLeu: 7.54 ± 0.112	1.884AlaMet: 1.884 ± 0.057	2.709AlaAsn: 2.709 ± 0.072	1.691AlaPro: 1.691 ± 0.054	2.587AlaGln: 2.587 ± 0.064	2.257AlaArg: 2.257 ± 0.067	4.471AlaSer: 4.471 ± 0.088	3.58AlaThr: 3.58 ± 0.107	4.293AlaVal: 4.293 ± 0.083	0.515AlaTrp: 0.515 ± 0.027	2.766AlaTyr: 2.766 ± 0.069	0.0AlaXaa: 0.0 ± 0.0
Cys	0.626CysAla: 0.626 ± 0.031	0.097CysCys: 0.097 ± 0.012	0.661CysAsp: 0.661 ± 0.032	0.591CysGlu: 0.591 ± 0.028	0.424CysPhe: 0.424 ± 0.025	0.788CysGly: 0.788 ± 0.032	0.183CysHis: 0.183 ± 0.018	0.794CysIle: 0.794 ± 0.035	0.446CysLys: 0.446 ± 0.028	0.783CysLeu: 0.783 ± 0.035	0.206CysMet: 0.206 ± 0.019	0.381CysAsn: 0.381 ± 0.023	0.283CysPro: 0.283 ± 0.02	0.207CysGln: 0.207 ± 0.017	0.286CysArg: 0.286 ± 0.019	0.557CysSer: 0.557 ± 0.03	0.447CysThr: 0.447 ± 0.026	0.909CysVal: 0.909 ± 0.036	0.045CysTrp: 0.045 ± 0.007	0.362CysTyr: 0.362 ± 0.023	0.0CysXaa: 0.0 ± 0.0
Asp	4.463AspAla: 4.463 ± 0.089	0.527AspCys: 0.527 ± 0.028	3.595AspAsp: 3.595 ± 0.087	4.381AspGlu: 4.381 ± 0.09	2.976AspPhe: 2.976 ± 0.061	3.841AspGly: 3.841 ± 0.088	1.32AspHis: 1.32 ± 0.05	4.967AspIle: 4.967 ± 0.085	3.37AspLys: 3.37 ± 0.067	5.626AspLeu: 5.626 ± 0.1	1.566AspMet: 1.566 ± 0.046	2.508AspAsn: 2.508 ± 0.069	1.93AspPro: 1.93 ± 0.057	1.997AspGln: 1.997 ± 0.052	2.147AspArg: 2.147 ± 0.054	3.418AspSer: 3.418 ± 0.078	3.59AspThr: 3.59 ± 0.091	4.85AspVal: 4.85 ± 0.105	0.447AspTrp: 0.447 ± 0.027	2.727AspTyr: 2.727 ± 0.064	0.0AspXaa: 0.0 ± 0.0
Glu	4.644GluAla: 4.644 ± 0.095	0.526GluCys: 0.526 ± 0.032	3.828GluAsp: 3.828 ± 0.085	4.212GluGlu: 4.212 ± 0.121	2.46GluPhe: 2.46 ± 0.06	3.82GluGly: 3.82 ± 0.076	1.406GluHis: 1.406 ± 0.046	5.528GluIle: 5.528 ± 0.089	4.247GluLys: 4.247 ± 0.095	5.865GluLeu: 5.865 ± 0.107	1.923GluMet: 1.923 ± 0.06	3.515GluAsn: 3.515 ± 0.075	1.782GluPro: 1.782 ± 0.05	1.923GluGln: 1.923 ± 0.058	2.575GluArg: 2.575 ± 0.056	4.111GluSer: 4.111 ± 0.084	4.415GluThr: 4.415 ± 0.138	4.739GluVal: 4.739 ± 0.081	0.455GluTrp: 0.455 ± 0.028	2.374GluTyr: 2.374 ± 0.064	0.0GluXaa: 0.0 ± 0.0
Phe	2.773PheAla: 2.773 ± 0.068	0.389PheCys: 0.389 ± 0.023	3.425PheAsp: 3.425 ± 0.075	3.483PheGlu: 3.483 ± 0.07	2.015PhePhe: 2.015 ± 0.057	3.289PheGly: 3.289 ± 0.081	0.733PheHis: 0.733 ± 0.04	3.772PheIle: 3.772 ± 0.092	2.933PheLys: 2.933 ± 0.056	3.649PheLeu: 3.649 ± 0.084	1.324PheMet: 1.324 ± 0.041	2.491PheAsn: 2.491 ± 0.06	1.261PhePro: 1.261 ± 0.048	1.174PheGln: 1.174 ± 0.045	1.418PheArg: 1.418 ± 0.045	3.351PheSer: 3.351 ± 0.057	2.785PheThr: 2.785 ± 0.068	3.625PheVal: 3.625 ± 0.08	0.336PheTrp: 0.336 ± 0.025	1.767PheTyr: 1.767 ± 0.056	0.0PheXaa: 0.0 ± 0.0
Gly	3.783GlyAla: 3.783 ± 0.084	0.671GlyCys: 0.671 ± 0.034	3.325GlyAsp: 3.325 ± 0.073	3.439GlyGlu: 3.439 ± 0.1	3.377GlyPhe: 3.377 ± 0.078	4.144GlyGly: 4.144 ± 0.099	1.334GlyHis: 1.334 ± 0.042	5.599GlyIle: 5.599 ± 0.101	3.813GlyLys: 3.813 ± 0.073	6.142GlyLeu: 6.142 ± 0.099	1.772GlyMet: 1.772 ± 0.051	2.882GlyAsn: 2.882 ± 0.09	1.394GlyPro: 1.394 ± 0.041	1.895GlyGln: 1.895 ± 0.049	2.264GlyArg: 2.264 ± 0.064	4.236GlySer: 4.236 ± 0.084	3.746GlyThr: 3.746 ± 0.077	5.3GlyVal: 5.3 ± 0.103	0.626GlyTrp: 0.626 ± 0.048	3.243GlyTyr: 3.243 ± 0.075	0.0GlyXaa: 0.0 ± 0.0
His	1.448HisAla: 1.448 ± 0.046	0.237HisCys: 0.237 ± 0.018	1.54HisAsp: 1.54 ± 0.049	1.579HisGlu: 1.579 ± 0.05	1.06HisPhe: 1.06 ± 0.043	1.41HisGly: 1.41 ± 0.052	0.699HisHis: 0.699 ± 0.035	1.65HisIle: 1.65 ± 0.053	1.222HisLys: 1.222 ± 0.041	1.968HisLeu: 1.968 ± 0.055	0.522HisMet: 0.522 ± 0.029	1.032HisAsn: 1.032 ± 0.035	0.949HisPro: 0.949 ± 0.041	0.935HisGln: 0.935 ± 0.037	0.904HisArg: 0.904 ± 0.039	1.057HisSer: 1.057 ± 0.044	1.191HisThr: 1.191 ± 0.042	1.558HisVal: 1.558 ± 0.048	0.158HisTrp: 0.158 ± 0.017	1.014HisTyr: 1.014 ± 0.041	0.0HisXaa: 0.0 ± 0.0
Ile	5.627IleAla: 5.627 ± 0.113	0.766IleCys: 0.766 ± 0.033	5.457IleAsp: 5.457 ± 0.089	5.906IleGlu: 5.906 ± 0.095	3.148IlePhe: 3.148 ± 0.08	5.103IleGly: 5.103 ± 0.106	1.85IleHis: 1.85 ± 0.054	6.248IleIle: 6.248 ± 0.114	4.874IleLys: 4.874 ± 0.085	7.784IleLeu: 7.784 ± 0.11	2.025IleMet: 2.025 ± 0.053	4.178IleAsn: 4.178 ± 0.08	3.116IlePro: 3.116 ± 0.075	3.139IleGln: 3.139 ± 0.08	3.123IleArg: 3.123 ± 0.068	5.748IleSer: 5.748 ± 0.102	4.921IleThr: 4.921 ± 0.106	6.202IleVal: 6.202 ± 0.088	0.484IleTrp: 0.484 ± 0.028	2.892IleTyr: 2.892 ± 0.063	0.0IleXaa: 0.0 ± 0.0
Lys	3.948LysAla: 3.948 ± 0.078	0.364LysCys: 0.364 ± 0.026	4.11LysAsp: 4.11 ± 0.077	5.001LysGlu: 5.001 ± 0.101	1.758LysPhe: 1.758 ± 0.056	3.76LysGly: 3.76 ± 0.078	1.661LysHis: 1.661 ± 0.048	4.33LysIle: 4.33 ± 0.087	4.433LysLys: 4.433 ± 0.084	5.079LysLeu: 5.079 ± 0.089	1.774LysMet: 1.774 ± 0.054	3.329LysAsn: 3.329 ± 0.069	2.17LysPro: 2.17 ± 0.056	2.601LysGln: 2.601 ± 0.07	3.289LysArg: 3.289 ± 0.058	3.748LysSer: 3.748 ± 0.085	4.189LysThr: 4.189 ± 0.08	4.104LysVal: 4.104 ± 0.081	0.457LysTrp: 0.457 ± 0.034	2.357LysTyr: 2.357 ± 0.07	0.0LysXaa: 0.0 ± 0.0
Leu	5.52LeuAla: 5.52 ± 0.094	0.949LeuCys: 0.949 ± 0.04	6.042LeuAsp: 6.042 ± 0.1	6.514LeuGlu: 6.514 ± 0.108	4.515LeuPhe: 4.515 ± 0.098	6.035LeuGly: 6.035 ± 0.086	1.6LeuHis: 1.6 ± 0.057	7.766LeuIle: 7.766 ± 0.114	6.613LeuLys: 6.613 ± 0.091	8.468LeuLeu: 8.468 ± 0.119	2.827LeuMet: 2.827 ± 0.068	5.575LeuAsn: 5.575 ± 0.098	3.027LeuPro: 3.027 ± 0.069	2.747LeuGln: 2.747 ± 0.064	3.58LeuArg: 3.58 ± 0.082	7.628LeuSer: 7.628 ± 0.122	5.347LeuThr: 5.347 ± 0.095	6.776LeuVal: 6.776 ± 0.094	0.74LeuTrp: 0.74 ± 0.033	3.45LeuTyr: 3.45 ± 0.083	0.0LeuXaa: 0.0 ± 0.0
Met	1.592MetAla: 1.592 ± 0.047	0.21MetCys: 0.21 ± 0.018	1.648MetAsp: 1.648 ± 0.049	1.386MetGlu: 1.386 ± 0.044	1.162MetPhe: 1.162 ± 0.041	1.788MetGly: 1.788 ± 0.052	0.509MetHis: 0.509 ± 0.024	2.544MetIle: 2.544 ± 0.065	2.339MetLys: 2.339 ± 0.055	2.449MetLeu: 2.449 ± 0.061	0.911MetMet: 0.911 ± 0.04	1.891MetAsn: 1.891 ± 0.051	0.869MetPro: 0.869 ± 0.038	0.781MetGln: 0.781 ± 0.027	1.232MetArg: 1.232 ± 0.041	1.949MetSer: 1.949 ± 0.049	1.516MetThr: 1.516 ± 0.04	1.801MetVal: 1.801 ± 0.052	0.144MetTrp: 0.144 ± 0.016	0.781MetTyr: 0.781 ± 0.032	0.0MetXaa: 0.0 ± 0.0
Asn	3.382AsnAla: 3.382 ± 0.086	0.379AsnCys: 0.379 ± 0.022	2.975AsnAsp: 2.975 ± 0.062	3.264AsnGlu: 3.264 ± 0.071	1.967AsnPhe: 1.967 ± 0.057	3.406AsnGly: 3.406 ± 0.111	1.375AsnHis: 1.375 ± 0.05	4.08AsnIle: 4.08 ± 0.071	3.04AsnLys: 3.04 ± 0.064	4.472AsnLeu: 4.472 ± 0.078	1.214AsnMet: 1.214 ± 0.044	2.615AsnAsn: 2.615 ± 0.09	2.483AsnPro: 2.483 ± 0.11	2.359AsnGln: 2.359 ± 0.067	2.26AsnArg: 2.26 ± 0.06	2.651AsnSer: 2.651 ± 0.082	3.075AsnThr: 3.075 ± 0.087	3.724AsnVal: 3.724 ± 0.072	0.402AsnTrp: 0.402 ± 0.028	2.019AsnTyr: 2.019 ± 0.07	0.0AsnXaa: 0.0 ± 0.0
Pro	1.547ProAla: 1.547 ± 0.054	0.226ProCys: 0.226 ± 0.016	1.717ProAsp: 1.717 ± 0.053	2.256ProGlu: 2.256 ± 0.097	1.715ProPhe: 1.715 ± 0.051	1.765ProGly: 1.765 ± 0.088	0.799ProHis: 0.799 ± 0.036	2.747ProIle: 2.747 ± 0.067	1.847ProLys: 1.847 ± 0.062	3.078ProLeu: 3.078 ± 0.065	0.823ProMet: 0.823 ± 0.033	1.778ProAsn: 1.778 ± 0.058	0.622ProPro: 0.622 ± 0.028	1.27ProGln: 1.27 ± 0.044	0.986ProArg: 0.986 ± 0.043	2.169ProSer: 2.169 ± 0.067	2.216ProThr: 2.216 ± 0.111	2.295ProVal: 2.295 ± 0.058	0.299ProTrp: 0.299 ± 0.024	1.431ProTyr: 1.431 ± 0.047	0.0ProXaa: 0.0 ± 0.0
Gln	2.343GlnAla: 2.343 ± 0.064	0.32GlnCys: 0.32 ± 0.02	2.016GlnAsp: 2.016 ± 0.066	2.707GlnGlu: 2.707 ± 0.072	1.691GlnPhe: 1.691 ± 0.055	2.071GlnGly: 2.071 ± 0.049	0.744GlnHis: 0.744 ± 0.036	2.594GlnIle: 2.594 ± 0.06	2.397GlnLys: 2.397 ± 0.055	3.178GlnLeu: 3.178 ± 0.07	0.97GlnMet: 0.97 ± 0.036	1.854GlnAsn: 1.854 ± 0.051	0.987GlnPro: 0.987 ± 0.036	1.222GlnGln: 1.222 ± 0.055	1.696GlnArg: 1.696 ± 0.064	2.453GlnSer: 2.453 ± 0.065	2.242GlnThr: 2.242 ± 0.061	2.108GlnVal: 2.108 ± 0.056	0.323GlnTrp: 0.323 ± 0.023	1.479GlnTyr: 1.479 ± 0.05	0.0GlnXaa: 0.0 ± 0.0
Arg	2.102ArgAla: 2.102 ± 0.054	0.347ArgCys: 0.347 ± 0.022	2.332ArgAsp: 2.332 ± 0.058	2.418ArgGlu: 2.418 ± 0.06	2.077ArgPhe: 2.077 ± 0.061	1.939ArgGly: 1.939 ± 0.055	0.839ArgHis: 0.839 ± 0.037	3.535ArgIle: 3.535 ± 0.077	2.776ArgLys: 2.776 ± 0.065	3.865ArgLeu: 3.865 ± 0.086	1.088ArgMet: 1.088 ± 0.039	2.174ArgAsn: 2.174 ± 0.063	1.112ArgPro: 1.112 ± 0.045	1.261ArgGln: 1.261 ± 0.043	1.75ArgArg: 1.75 ± 0.061	2.284ArgSer: 2.284 ± 0.055	2.006ArgThr: 2.006 ± 0.053	2.927ArgVal: 2.927 ± 0.074	0.337ArgTrp: 0.337 ± 0.026	1.963ArgTyr: 1.963 ± 0.059	0.0ArgXaa: 0.0 ± 0.0
Ser	3.605SerAla: 3.605 ± 0.079	0.54SerCys: 0.54 ± 0.031	3.848SerAsp: 3.848 ± 0.087	3.866SerGlu: 3.866 ± 0.08	3.474SerPhe: 3.474 ± 0.084	4.474SerGly: 4.474 ± 0.093	1.425SerHis: 1.425 ± 0.045	6.183SerIle: 6.183 ± 0.109	4.351SerLys: 4.351 ± 0.086	6.788SerLeu: 6.788 ± 0.1	1.991SerMet: 1.991 ± 0.052	3.435SerAsn: 3.435 ± 0.077	1.664SerPro: 1.664 ± 0.05	2.434SerGln: 2.434 ± 0.063	2.411SerArg: 2.411 ± 0.054	4.306SerSer: 4.306 ± 0.101	3.676SerThr: 3.676 ± 0.091	5.087SerVal: 5.087 ± 0.099	0.596SerTrp: 0.596 ± 0.033	2.565SerTyr: 2.565 ± 0.066	0.0SerXaa: 0.0 ± 0.0
Thr	2.976ThrAla: 2.976 ± 0.079	0.44ThrCys: 0.44 ± 0.026	2.903ThrAsp: 2.903 ± 0.08	2.759ThrGlu: 2.759 ± 0.066	2.955ThrPhe: 2.955 ± 0.084	3.811ThrGly: 3.811 ± 0.113	1.603ThrHis: 1.603 ± 0.053	5.259ThrIle: 5.259 ± 0.112	3.151ThrLys: 3.151 ± 0.069	7.243ThrLeu: 7.243 ± 0.118	1.497ThrMet: 1.497 ± 0.05	2.779ThrAsn: 2.779 ± 0.08	2.525ThrPro: 2.525 ± 0.108	2.771ThrGln: 2.771 ± 0.068	2.178ThrArg: 2.178 ± 0.061	3.798ThrSer: 3.798 ± 0.081	3.344ThrThr: 3.344 ± 0.088	4.213ThrVal: 4.213 ± 0.1	0.556ThrTrp: 0.556 ± 0.031	2.613ThrTyr: 2.613 ± 0.09	0.0ThrXaa: 0.0 ± 0.0
Val	4.31ValAla: 4.31 ± 0.084	0.83ValCys: 0.83 ± 0.039	4.819ValAsp: 4.819 ± 0.112	4.705ValGlu: 4.705 ± 0.09	3.604ValPhe: 3.604 ± 0.068	4.736ValGly: 4.736 ± 0.1	1.373ValHis: 1.373 ± 0.046	5.822ValIle: 5.822 ± 0.1	4.245ValLys: 4.245 ± 0.077	7.359ValLeu: 7.359 ± 0.109	2.077ValMet: 2.077 ± 0.051	3.705ValAsn: 3.705 ± 0.081	2.166ValPro: 2.166 ± 0.054	2.15ValGln: 2.15 ± 0.062	2.596ValArg: 2.596 ± 0.068	5.795ValSer: 5.795 ± 0.096	4.075ValThr: 4.075 ± 0.092	5.737ValVal: 5.737 ± 0.1	0.556ValTrp: 0.556 ± 0.027	2.914ValTyr: 2.914 ± 0.065	0.0ValXaa: 0.0 ± 0.0
Trp	0.402TrpAla: 0.402 ± 0.024	0.079TrpCys: 0.079 ± 0.012	0.44TrpAsp: 0.44 ± 0.029	0.457TrpGlu: 0.457 ± 0.026	0.461TrpPhe: 0.461 ± 0.026	0.578TrpGly: 0.578 ± 0.033	0.147TrpHis: 0.147 ± 0.013	0.761TrpIle: 0.761 ± 0.03	0.45TrpLys: 0.45 ± 0.029	0.774TrpLeu: 0.774 ± 0.034	0.247TrpMet: 0.247 ± 0.021	0.416TrpAsn: 0.416 ± 0.03	0.18TrpPro: 0.18 ± 0.018	0.265TrpGln: 0.265 ± 0.019	0.278TrpArg: 0.278 ± 0.019	0.471TrpSer: 0.471 ± 0.027	0.46TrpThr: 0.46 ± 0.031	0.606TrpVal: 0.606 ± 0.039	0.109TrpTrp: 0.109 ± 0.013	0.355TrpTyr: 0.355 ± 0.024	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.679TyrAla: 2.679 ± 0.061	0.406TyrCys: 0.406 ± 0.025	2.928TyrAsp: 2.928 ± 0.074	2.872TyrGlu: 2.872 ± 0.069	1.867TyrPhe: 1.867 ± 0.054	2.704TyrGly: 2.704 ± 0.07	0.984TyrHis: 0.984 ± 0.037	2.92TyrIle: 2.92 ± 0.063	2.25TyrLys: 2.25 ± 0.06	3.608TyrLeu: 3.608 ± 0.077	0.857TyrMet: 0.857 ± 0.036	1.896TyrAsn: 1.896 ± 0.052	1.375TyrPro: 1.375 ± 0.05	1.679TyrGln: 1.679 ± 0.059	1.902TyrArg: 1.902 ± 0.046	2.517TyrSer: 2.517 ± 0.071	2.556TyrThr: 2.556 ± 0.11	2.718TyrVal: 2.718 ± 0.07	0.352TyrTrp: 0.352 ± 0.024	1.764TyrTyr: 1.764 ± 0.064	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2225 proteins (709240 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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