Amino acid dipepetide frequency for [Collinsella] massiliensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.163AlaAla: 17.163 ± 0.284	2.291AlaCys: 2.291 ± 0.068	7.374AlaAsp: 7.374 ± 0.128	8.239AlaGlu: 8.239 ± 0.145	4.451AlaPhe: 4.451 ± 0.088	10.498AlaGly: 10.498 ± 0.151	2.507AlaHis: 2.507 ± 0.064	5.675AlaIle: 5.675 ± 0.1	3.395AlaLys: 3.395 ± 0.091	12.449AlaLeu: 12.449 ± 0.223	3.006AlaMet: 3.006 ± 0.073	2.756AlaAsn: 2.756 ± 0.069	5.445AlaPro: 5.445 ± 0.142	4.047AlaGln: 4.047 ± 0.097	9.112AlaArg: 9.112 ± 0.183	6.727AlaSer: 6.727 ± 0.112	6.018AlaThr: 6.018 ± 0.118	8.994AlaVal: 8.994 ± 0.141	1.452AlaTrp: 1.452 ± 0.06	3.358AlaTyr: 3.358 ± 0.079	0.0AlaXaa: 0.0 ± 0.0
Cys	1.965CysAla: 1.965 ± 0.058	0.248CysCys: 0.248 ± 0.021	1.044CysAsp: 1.044 ± 0.044	0.934CysGlu: 0.934 ± 0.042	0.502CysPhe: 0.502 ± 0.03	1.661CysGly: 1.661 ± 0.05	0.266CysHis: 0.266 ± 0.024	0.761CysIle: 0.761 ± 0.039	0.328CysLys: 0.328 ± 0.022	1.066CysLeu: 1.066 ± 0.05	0.387CysMet: 0.387 ± 0.025	0.305CysAsn: 0.305 ± 0.024	0.857CysPro: 0.857 ± 0.052	0.332CysGln: 0.332 ± 0.024	0.851CysArg: 0.851 ± 0.038	0.815CysSer: 0.815 ± 0.037	0.88CysThr: 0.88 ± 0.038	1.125CysVal: 1.125 ± 0.046	0.112CysTrp: 0.112 ± 0.014	0.383CysTyr: 0.383 ± 0.024	0.0CysXaa: 0.0 ± 0.0
Asp	9.449AspAla: 9.449 ± 0.165	0.727AspCys: 0.727 ± 0.036	4.274AspAsp: 4.274 ± 0.111	5.704AspGlu: 5.704 ± 0.096	2.292AspPhe: 2.292 ± 0.057	5.917AspGly: 5.917 ± 0.185	1.029AspHis: 1.029 ± 0.035	3.431AspIle: 3.431 ± 0.076	1.566AspLys: 1.566 ± 0.063	5.384AspLeu: 5.384 ± 0.098	1.547AspMet: 1.547 ± 0.044	1.354AspAsn: 1.354 ± 0.067	3.197AspPro: 3.197 ± 0.075	1.283AspGln: 1.283 ± 0.043	3.655AspArg: 3.655 ± 0.088	2.504AspSer: 2.504 ± 0.064	3.154AspThr: 3.154 ± 0.09	4.894AspVal: 4.894 ± 0.088	0.668AspTrp: 0.668 ± 0.032	1.86AspTyr: 1.86 ± 0.062	0.0AspXaa: 0.0 ± 0.0
Glu	8.141GluAla: 8.141 ± 0.146	0.654GluCys: 0.654 ± 0.033	4.006GluAsp: 4.006 ± 0.113	4.88GluGlu: 4.88 ± 0.106	1.969GluPhe: 1.969 ± 0.051	5.128GluGly: 5.128 ± 0.103	1.833GluHis: 1.833 ± 0.057	3.027GluIle: 3.027 ± 0.092	1.992GluLys: 1.992 ± 0.066	7.494GluLeu: 7.494 ± 0.129	1.712GluMet: 1.712 ± 0.059	1.906GluAsn: 1.906 ± 0.068	3.191GluPro: 3.191 ± 0.086	2.736GluGln: 2.736 ± 0.068	6.567GluArg: 6.567 ± 0.129	2.767GluSer: 2.767 ± 0.059	3.229GluThr: 3.229 ± 0.08	5.053GluVal: 5.053 ± 0.093	0.527GluTrp: 0.527 ± 0.027	1.648GluTyr: 1.648 ± 0.054	0.0GluXaa: 0.0 ± 0.0
Phe	3.984PheAla: 3.984 ± 0.085	0.701PheCys: 0.701 ± 0.037	2.949PheAsp: 2.949 ± 0.069	2.49PheGlu: 2.49 ± 0.061	1.392PhePhe: 1.392 ± 0.05	3.363PheGly: 3.363 ± 0.08	0.665PheHis: 0.665 ± 0.031	1.943PheIle: 1.943 ± 0.061	1.069PheLys: 1.069 ± 0.048	2.847PheLeu: 2.847 ± 0.074	0.94PheMet: 0.94 ± 0.045	1.023PheAsn: 1.023 ± 0.048	1.314PhePro: 1.314 ± 0.046	0.933PheGln: 0.933 ± 0.043	1.689PheArg: 1.689 ± 0.048	2.298PheSer: 2.298 ± 0.067	2.343PheThr: 2.343 ± 0.102	2.742PheVal: 2.742 ± 0.062	0.377PheTrp: 0.377 ± 0.024	1.015PheTyr: 1.015 ± 0.041	0.0PheXaa: 0.0 ± 0.0
Gly	9.954GlyAla: 9.954 ± 0.163	1.465GlyCys: 1.465 ± 0.052	4.813GlyAsp: 4.813 ± 0.109	5.312GlyGlu: 5.312 ± 0.113	3.173GlyPhe: 3.173 ± 0.078	6.44GlyGly: 6.44 ± 0.144	1.536GlyHis: 1.536 ± 0.056	5.214GlyIle: 5.214 ± 0.093	3.183GlyLys: 3.183 ± 0.084	7.054GlyLeu: 7.054 ± 0.128	2.615GlyMet: 2.615 ± 0.067	2.136GlyAsn: 2.136 ± 0.077	1.926GlyPro: 1.926 ± 0.057	1.978GlyGln: 1.978 ± 0.058	5.024GlyArg: 5.024 ± 0.089	5.122GlySer: 5.122 ± 0.121	5.212GlyThr: 5.212 ± 0.139	6.743GlyVal: 6.743 ± 0.102	0.96GlyTrp: 0.96 ± 0.04	2.695GlyTyr: 2.695 ± 0.062	0.0GlyXaa: 0.0 ± 0.0
His	2.409HisAla: 2.409 ± 0.064	0.222HisCys: 0.222 ± 0.02	1.317HisAsp: 1.317 ± 0.047	1.401HisGlu: 1.401 ± 0.046	0.622HisPhe: 0.622 ± 0.031	1.89HisGly: 1.89 ± 0.051	0.42HisHis: 0.42 ± 0.026	1.063HisIle: 1.063 ± 0.045	0.433HisLys: 0.433 ± 0.027	1.648HisLeu: 1.648 ± 0.057	0.452HisMet: 0.452 ± 0.026	0.45HisAsn: 0.45 ± 0.026	1.145HisPro: 1.145 ± 0.041	0.407HisGln: 0.407 ± 0.028	1.141HisArg: 1.141 ± 0.044	0.793HisSer: 0.793 ± 0.035	0.991HisThr: 0.991 ± 0.041	1.7HisVal: 1.7 ± 0.053	0.165HisTrp: 0.165 ± 0.015	0.522HisTyr: 0.522 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	6.935IleAla: 6.935 ± 0.119	0.812IleCys: 0.812 ± 0.038	4.165IleAsp: 4.165 ± 0.084	4.171IleGlu: 4.171 ± 0.097	1.609IlePhe: 1.609 ± 0.049	3.955IleGly: 3.955 ± 0.09	0.848IleHis: 0.848 ± 0.036	2.692IleIle: 2.692 ± 0.087	1.52IleLys: 1.52 ± 0.049	3.733IleLeu: 3.733 ± 0.087	1.337IleMet: 1.337 ± 0.051	1.302IleAsn: 1.302 ± 0.045	2.533IlePro: 2.533 ± 0.068	1.23IleGln: 1.23 ± 0.051	2.595IleArg: 2.595 ± 0.067	2.967IleSer: 2.967 ± 0.067	3.007IleThr: 3.007 ± 0.09	4.687IleVal: 4.687 ± 0.099	0.444IleTrp: 0.444 ± 0.027	1.318IleTyr: 1.318 ± 0.044	0.0IleXaa: 0.0 ± 0.0
Lys	3.206LysAla: 3.206 ± 0.089	0.259LysCys: 0.259 ± 0.022	1.573LysAsp: 1.573 ± 0.061	1.683LysGlu: 1.683 ± 0.055	0.808LysPhe: 0.808 ± 0.037	2.285LysGly: 2.285 ± 0.065	0.603LysHis: 0.603 ± 0.03	1.675LysIle: 1.675 ± 0.063	1.551LysLys: 1.551 ± 0.071	3.061LysLeu: 3.061 ± 0.086	0.781LysMet: 0.781 ± 0.041	1.049LysAsn: 1.049 ± 0.046	1.603LysPro: 1.603 ± 0.065	1.078LysGln: 1.078 ± 0.044	2.575LysArg: 2.575 ± 0.076	1.528LysSer: 1.528 ± 0.061	1.929LysThr: 1.929 ± 0.061	2.283LysVal: 2.283 ± 0.069	0.213LysTrp: 0.213 ± 0.021	0.831LysTyr: 0.831 ± 0.035	0.0LysXaa: 0.0 ± 0.0
Leu	12.332LeuAla: 12.332 ± 0.187	1.338LeuCys: 1.338 ± 0.042	6.453LeuAsp: 6.453 ± 0.107	6.042LeuGlu: 6.042 ± 0.127	3.298LeuPhe: 3.298 ± 0.091	7.772LeuGly: 7.772 ± 0.134	1.625LeuHis: 1.625 ± 0.051	4.583LeuIle: 4.583 ± 0.104	2.793LeuLys: 2.793 ± 0.071	7.786LeuLeu: 7.786 ± 0.151	2.611LeuMet: 2.611 ± 0.072	2.194LeuAsn: 2.194 ± 0.055	4.378LeuPro: 4.378 ± 0.093	2.04LeuGln: 2.04 ± 0.057	5.402LeuArg: 5.402 ± 0.107	5.652LeuSer: 5.652 ± 0.107	5.039LeuThr: 5.039 ± 0.11	7.362LeuVal: 7.362 ± 0.139	0.779LeuTrp: 0.779 ± 0.036	2.229LeuTyr: 2.229 ± 0.061	0.0LeuXaa: 0.0 ± 0.0
Met	3.073MetAla: 3.073 ± 0.068	0.36MetCys: 0.36 ± 0.024	1.456MetAsp: 1.456 ± 0.051	1.396MetGlu: 1.396 ± 0.05	0.769MetPhe: 0.769 ± 0.038	2.317MetGly: 2.317 ± 0.067	0.51MetHis: 0.51 ± 0.029	1.156MetIle: 1.156 ± 0.051	0.949MetLys: 0.949 ± 0.045	2.62MetLeu: 2.62 ± 0.069	0.7MetMet: 0.7 ± 0.035	0.87MetAsn: 0.87 ± 0.038	1.445MetPro: 1.445 ± 0.047	0.802MetGln: 0.802 ± 0.035	1.942MetArg: 1.942 ± 0.06	1.611MetSer: 1.611 ± 0.046	1.375MetThr: 1.375 ± 0.05	1.785MetVal: 1.785 ± 0.061	0.23MetTrp: 0.23 ± 0.018	0.53MetTyr: 0.53 ± 0.026	0.0MetXaa: 0.0 ± 0.0
Asn	3.023AsnAla: 3.023 ± 0.07	0.299AsnCys: 0.299 ± 0.024	1.513AsnAsp: 1.513 ± 0.066	1.652AsnGlu: 1.652 ± 0.053	0.861AsnPhe: 0.861 ± 0.038	2.216AsnGly: 2.216 ± 0.073	0.488AsnHis: 0.488 ± 0.027	1.461AsnIle: 1.461 ± 0.049	0.847AsnLys: 0.847 ± 0.037	2.539AsnLeu: 2.539 ± 0.061	0.681AsnMet: 0.681 ± 0.031	0.72AsnAsn: 0.72 ± 0.045	1.778AsnPro: 1.778 ± 0.053	0.678AsnGln: 0.678 ± 0.036	1.49AsnArg: 1.49 ± 0.046	1.165AsnSer: 1.165 ± 0.051	1.329AsnThr: 1.329 ± 0.063	2.11AsnVal: 2.11 ± 0.068	0.276AsnTrp: 0.276 ± 0.023	0.695AsnTyr: 0.695 ± 0.038	0.0AsnXaa: 0.0 ± 0.0
Pro	6.071ProAla: 6.071 ± 0.152	0.586ProCys: 0.586 ± 0.031	3.046ProAsp: 3.046 ± 0.064	4.052ProGlu: 4.052 ± 0.086	1.762ProPhe: 1.762 ± 0.052	3.759ProGly: 3.759 ± 0.084	0.824ProHis: 0.824 ± 0.039	2.073ProIle: 2.073 ± 0.057	1.375ProLys: 1.375 ± 0.057	3.739ProLeu: 3.739 ± 0.085	0.884ProMet: 0.884 ± 0.036	1.099ProAsn: 1.099 ± 0.046	1.181ProPro: 1.181 ± 0.055	1.309ProGln: 1.309 ± 0.045	2.493ProArg: 2.493 ± 0.07	2.401ProSer: 2.401 ± 0.064	2.335ProThr: 2.335 ± 0.066	3.943ProVal: 3.943 ± 0.068	0.544ProTrp: 0.544 ± 0.026	1.416ProTyr: 1.416 ± 0.048	0.0ProXaa: 0.0 ± 0.0
Gln	3.649GlnAla: 3.649 ± 0.083	0.248GlnCys: 0.248 ± 0.023	1.447GlnAsp: 1.447 ± 0.051	1.718GlnGlu: 1.718 ± 0.057	0.919GlnPhe: 0.919 ± 0.042	2.17GlnGly: 2.17 ± 0.056	0.516GlnHis: 0.516 ± 0.029	1.625GlnIle: 1.625 ± 0.05	0.951GlnLys: 0.951 ± 0.041	2.798GlnLeu: 2.798 ± 0.071	0.79GlnMet: 0.79 ± 0.038	0.879GlnAsn: 0.879 ± 0.04	1.262GlnPro: 1.262 ± 0.049	1.069GlnGln: 1.069 ± 0.042	2.02GlnArg: 2.02 ± 0.069	1.174GlnSer: 1.174 ± 0.045	1.435GlnThr: 1.435 ± 0.053	2.19GlnVal: 2.19 ± 0.058	0.257GlnTrp: 0.257 ± 0.017	0.655GlnTyr: 0.655 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	8.688ArgAla: 8.688 ± 0.168	0.951ArgCys: 0.951 ± 0.045	4.168ArgAsp: 4.168 ± 0.09	4.761ArgGlu: 4.761 ± 0.106	2.511ArgPhe: 2.511 ± 0.059	4.561ArgGly: 4.561 ± 0.1	1.283ArgHis: 1.283 ± 0.051	3.598ArgIle: 3.598 ± 0.094	1.896ArgLys: 1.896 ± 0.061	5.897ArgLeu: 5.897 ± 0.119	1.922ArgMet: 1.922 ± 0.052	1.499ArgAsn: 1.499 ± 0.052	2.551ArgPro: 2.551 ± 0.074	1.671ArgGln: 1.671 ± 0.054	5.076ArgArg: 5.076 ± 0.122	3.37ArgSer: 3.37 ± 0.071	3.358ArgThr: 3.358 ± 0.078	5.018ArgVal: 5.018 ± 0.095	0.666ArgTrp: 0.666 ± 0.035	2.136ArgTyr: 2.136 ± 0.055	0.0ArgXaa: 0.0 ± 0.0
Ser	6.024SerAla: 6.024 ± 0.111	0.873SerCys: 0.873 ± 0.052	3.28SerAsp: 3.28 ± 0.073	3.069SerGlu: 3.069 ± 0.075	2.448SerPhe: 2.448 ± 0.063	4.908SerGly: 4.908 ± 0.091	0.933SerHis: 0.933 ± 0.042	3.062SerIle: 3.062 ± 0.067	1.743SerLys: 1.743 ± 0.055	4.855SerLeu: 4.855 ± 0.103	1.479SerMet: 1.479 ± 0.048	1.479SerAsn: 1.479 ± 0.059	2.283SerPro: 2.283 ± 0.049	1.473SerGln: 1.473 ± 0.047	3.073SerArg: 3.073 ± 0.067	3.343SerSer: 3.343 ± 0.087	3.016SerThr: 3.016 ± 0.076	4.053SerVal: 4.053 ± 0.087	0.689SerTrp: 0.689 ± 0.037	1.877SerTyr: 1.877 ± 0.061	0.0SerXaa: 0.0 ± 0.0
Thr	5.624ThrAla: 5.624 ± 0.115	0.876ThrCys: 0.876 ± 0.04	3.265ThrAsp: 3.265 ± 0.095	2.987ThrGlu: 2.987 ± 0.083	2.28ThrPhe: 2.28 ± 0.1	5.036ThrGly: 5.036 ± 0.122	1.055ThrHis: 1.055 ± 0.039	2.945ThrIle: 2.945 ± 0.084	1.591ThrLys: 1.591 ± 0.07	5.125ThrLeu: 5.125 ± 0.1	1.3ThrMet: 1.3 ± 0.046	1.412ThrAsn: 1.412 ± 0.075	3.265ThrPro: 3.265 ± 0.064	1.416ThrGln: 1.416 ± 0.049	2.914ThrArg: 2.914 ± 0.065	2.9ThrSer: 2.9 ± 0.067	3.016ThrThr: 3.016 ± 0.099	4.917ThrVal: 4.917 ± 0.116	0.619ThrTrp: 0.619 ± 0.037	1.859ThrTyr: 1.859 ± 0.106	0.0ThrXaa: 0.0 ± 0.0
Val	9.236ValAla: 9.236 ± 0.14	1.315ValCys: 1.315 ± 0.054	5.154ValAsp: 5.154 ± 0.098	5.364ValGlu: 5.364 ± 0.091	2.899ValPhe: 2.899 ± 0.074	5.63ValGly: 5.63 ± 0.111	1.412ValHis: 1.412 ± 0.048	4.082ValIle: 4.082 ± 0.101	2.308ValLys: 2.308 ± 0.07	7.578ValLeu: 7.578 ± 0.135	1.894ValMet: 1.894 ± 0.061	2.211ValAsn: 2.211 ± 0.058	3.928ValPro: 3.928 ± 0.084	1.92ValGln: 1.92 ± 0.061	5.235ValArg: 5.235 ± 0.112	4.886ValSer: 4.886 ± 0.092	4.5ValThr: 4.5 ± 0.124	6.619ValVal: 6.619 ± 0.144	0.749ValTrp: 0.749 ± 0.039	2.105ValTyr: 2.105 ± 0.063	0.0ValXaa: 0.0 ± 0.0
Trp	0.885TrpAla: 0.885 ± 0.037	0.211TrpCys: 0.211 ± 0.017	0.628TrpAsp: 0.628 ± 0.034	0.692TrpGlu: 0.692 ± 0.032	0.449TrpPhe: 0.449 ± 0.029	0.784TrpGly: 0.784 ± 0.033	0.21TrpHis: 0.21 ± 0.017	0.482TrpIle: 0.482 ± 0.027	0.335TrpLys: 0.335 ± 0.02	1.018TrpLeu: 1.018 ± 0.04	0.317TrpMet: 0.317 ± 0.021	0.34TrpAsn: 0.34 ± 0.025	0.363TrpPro: 0.363 ± 0.024	0.421TrpGln: 0.421 ± 0.027	0.726TrpArg: 0.726 ± 0.038	0.57TrpSer: 0.57 ± 0.03	0.476TrpThr: 0.476 ± 0.031	0.75TrpVal: 0.75 ± 0.038	0.173TrpTrp: 0.173 ± 0.016	0.332TrpTyr: 0.332 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.144TyrAla: 3.144 ± 0.076	0.387TyrCys: 0.387 ± 0.024	1.966TyrAsp: 1.966 ± 0.074	1.914TyrGlu: 1.914 ± 0.055	1.061TyrPhe: 1.061 ± 0.04	2.268TyrGly: 2.268 ± 0.063	0.628TyrHis: 0.628 ± 0.035	1.312TyrIle: 1.312 ± 0.042	0.75TyrLys: 0.75 ± 0.04	3.02TyrLeu: 3.02 ± 0.071	0.541TyrMet: 0.541 ± 0.029	0.836TyrAsn: 0.836 ± 0.041	1.248TyrPro: 1.248 ± 0.044	0.946TyrGln: 0.946 ± 0.035	2.001TyrArg: 2.001 ± 0.053	1.367TyrSer: 1.367 ± 0.052	1.756TyrThr: 1.756 ± 0.083	2.056TyrVal: 2.056 ± 0.06	0.265TyrTrp: 0.265 ± 0.019	0.936TyrTyr: 0.936 ± 0.043	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 1896 proteins (653081 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---