Amino acid dipepetide frequency for Siculibacillus lacustris

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	23.684AlaAla: 23.684 ± 0.236	1.1AlaCys: 1.1 ± 0.032	8.184AlaAsp: 8.184 ± 0.085	8.54AlaGlu: 8.54 ± 0.1	4.869AlaPhe: 4.869 ± 0.059	12.337AlaGly: 12.337 ± 0.101	2.559AlaHis: 2.559 ± 0.049	6.924AlaIle: 6.924 ± 0.063	3.561AlaLys: 3.561 ± 0.065	14.329AlaLeu: 14.329 ± 0.18	3.321AlaMet: 3.321 ± 0.053	2.287AlaAsn: 2.287 ± 0.035	6.696AlaPro: 6.696 ± 0.092	3.074AlaGln: 3.074 ± 0.048	10.861AlaArg: 10.861 ± 0.117	6.167AlaSer: 6.167 ± 0.082	8.181AlaThr: 8.181 ± 0.112	11.512AlaVal: 11.512 ± 0.104	1.717AlaTrp: 1.717 ± 0.037	2.307AlaTyr: 2.307 ± 0.042	0.001AlaXaa: 0.001 ± 0.001
Cys	0.887CysAla: 0.887 ± 0.027	0.098CysCys: 0.098 ± 0.01	0.539CysAsp: 0.539 ± 0.02	0.383CysGlu: 0.383 ± 0.016	0.283CysPhe: 0.283 ± 0.014	0.977CysGly: 0.977 ± 0.026	0.219CysHis: 0.219 ± 0.015	0.296CysIle: 0.296 ± 0.015	0.13CysLys: 0.13 ± 0.009	0.766CysLeu: 0.766 ± 0.026	0.138CysMet: 0.138 ± 0.01	0.188CysAsn: 0.188 ± 0.012	0.47CysPro: 0.47 ± 0.02	0.151CysGln: 0.151 ± 0.011	0.739CysArg: 0.739 ± 0.023	0.423CysSer: 0.423 ± 0.017	0.352CysThr: 0.352 ± 0.017	0.585CysVal: 0.585 ± 0.024	0.098CysTrp: 0.098 ± 0.009	0.134CysTyr: 0.134 ± 0.01	0.001CysXaa: 0.001 ± 0.001
Asp	7.503AspAla: 7.503 ± 0.076	0.465AspCys: 0.465 ± 0.019	3.45AspAsp: 3.45 ± 0.056	3.272AspGlu: 3.272 ± 0.054	2.184AspPhe: 2.184 ± 0.038	5.859AspGly: 5.859 ± 0.076	1.379AspHis: 1.379 ± 0.036	2.295AspIle: 2.295 ± 0.039	1.384AspLys: 1.384 ± 0.037	7.101AspLeu: 7.101 ± 0.085	0.988AspMet: 0.988 ± 0.024	0.889AspAsn: 0.889 ± 0.028	4.072AspPro: 4.072 ± 0.059	1.398AspGln: 1.398 ± 0.036	5.433AspArg: 5.433 ± 0.075	1.721AspSer: 1.721 ± 0.037	2.593AspThr: 2.593 ± 0.043	4.728AspVal: 4.728 ± 0.062	0.925AspTrp: 0.925 ± 0.028	1.163AspTyr: 1.163 ± 0.032	0.001AspXaa: 0.001 ± 0.001
Glu	8.052GluAla: 8.052 ± 0.082	0.296GluCys: 0.296 ± 0.015	2.32GluAsp: 2.32 ± 0.053	2.585GluGlu: 2.585 ± 0.054	1.514GluPhe: 1.514 ± 0.034	3.86GluGly: 3.86 ± 0.064	0.998GluHis: 0.998 ± 0.029	3.839GluIle: 3.839 ± 0.057	1.767GluLys: 1.767 ± 0.045	4.704GluLeu: 4.704 ± 0.057	1.348GluMet: 1.348 ± 0.029	1.115GluAsn: 1.115 ± 0.029	2.757GluPro: 2.757 ± 0.05	1.375GluGln: 1.375 ± 0.033	5.153GluArg: 5.153 ± 0.07	2.203GluSer: 2.203 ± 0.037	3.576GluThr: 3.576 ± 0.054	4.219GluVal: 4.219 ± 0.057	0.615GluTrp: 0.615 ± 0.021	0.696GluTyr: 0.696 ± 0.024	0.001GluXaa: 0.001 ± 0.001
Phe	5.238PheAla: 5.238 ± 0.068	0.345PheCys: 0.345 ± 0.017	2.744PheAsp: 2.744 ± 0.049	2.037PheGlu: 2.037 ± 0.04	1.351PhePhe: 1.351 ± 0.035	3.749PheGly: 3.749 ± 0.061	0.756PheHis: 0.756 ± 0.023	1.133PheIle: 1.133 ± 0.028	0.771PheLys: 0.771 ± 0.024	3.422PheLeu: 3.422 ± 0.056	0.62PheMet: 0.62 ± 0.025	0.756PheAsn: 0.756 ± 0.025	1.524PhePro: 1.524 ± 0.033	0.884PheGln: 0.884 ± 0.023	2.375PheArg: 2.375 ± 0.041	1.803PheSer: 1.803 ± 0.034	1.817PheThr: 1.817 ± 0.039	3.394PheVal: 3.394 ± 0.054	0.47PheTrp: 0.47 ± 0.021	0.746PheTyr: 0.746 ± 0.021	0.0PheXaa: 0.0 ± 0.0
Gly	10.627GlyAla: 10.627 ± 0.101	0.871GlyCys: 0.871 ± 0.024	4.864GlyAsp: 4.864 ± 0.054	4.678GlyGlu: 4.678 ± 0.063	3.793GlyPhe: 3.793 ± 0.051	7.9GlyGly: 7.9 ± 0.105	2.052GlyHis: 2.052 ± 0.039	4.391GlyIle: 4.391 ± 0.066	2.531GlyLys: 2.531 ± 0.052	10.253GlyLeu: 10.253 ± 0.116	1.834GlyMet: 1.834 ± 0.039	1.766GlyAsn: 1.766 ± 0.05	3.938GlyPro: 3.938 ± 0.06	2.014GlyGln: 2.014 ± 0.038	8.073GlyArg: 8.073 ± 0.1	4.571GlySer: 4.571 ± 0.068	4.98GlyThr: 4.98 ± 0.11	6.907GlyVal: 6.907 ± 0.079	1.447GlyTrp: 1.447 ± 0.035	1.872GlyTyr: 1.872 ± 0.042	0.001GlyXaa: 0.001 ± 0.001
His	2.488HisAla: 2.488 ± 0.043	0.218HisCys: 0.218 ± 0.014	1.296HisAsp: 1.296 ± 0.037	0.952HisGlu: 0.952 ± 0.028	0.784HisPhe: 0.784 ± 0.023	2.041HisGly: 2.041 ± 0.044	0.567HisHis: 0.567 ± 0.024	0.681HisIle: 0.681 ± 0.024	0.341HisLys: 0.341 ± 0.016	2.24HisLeu: 2.24 ± 0.04	0.425HisMet: 0.425 ± 0.015	0.357HisAsn: 0.357 ± 0.016	1.441HisPro: 1.441 ± 0.036	0.467HisGln: 0.467 ± 0.019	1.718HisArg: 1.718 ± 0.034	0.747HisSer: 0.747 ± 0.024	0.828HisThr: 0.828 ± 0.023	1.639HisVal: 1.639 ± 0.036	0.3HisTrp: 0.3 ± 0.014	0.413HisTyr: 0.413 ± 0.017	0.001HisXaa: 0.001 ± 0.001
Ile	7.94IleAla: 7.94 ± 0.097	0.415IleCys: 0.415 ± 0.016	3.917IleAsp: 3.917 ± 0.054	3.348IleGlu: 3.348 ± 0.052	1.479IlePhe: 1.479 ± 0.035	5.532IleGly: 5.532 ± 0.062	0.861IleHis: 0.861 ± 0.025	1.418IleIle: 1.418 ± 0.039	1.131IleLys: 1.131 ± 0.035	4.424IleLeu: 4.424 ± 0.062	0.702IleMet: 0.702 ± 0.023	1.015IleAsn: 1.015 ± 0.034	2.149IlePro: 2.149 ± 0.04	0.976IleGln: 0.976 ± 0.026	3.39IleArg: 3.39 ± 0.043	2.221IleSer: 2.221 ± 0.047	2.35IleThr: 2.35 ± 0.047	4.725IleVal: 4.725 ± 0.053	0.553IleTrp: 0.553 ± 0.02	0.847IleTyr: 0.847 ± 0.027	0.001IleXaa: 0.001 ± 0.001
Lys	3.546LysAla: 3.546 ± 0.057	0.137LysCys: 0.137 ± 0.011	1.299LysAsp: 1.299 ± 0.037	1.101LysGlu: 1.101 ± 0.03	0.758LysPhe: 0.758 ± 0.022	2.152LysGly: 2.152 ± 0.045	0.391LysHis: 0.391 ± 0.018	1.697LysIle: 1.697 ± 0.041	1.015LysLys: 1.015 ± 0.038	2.53LysLeu: 2.53 ± 0.05	0.598LysMet: 0.598 ± 0.022	0.648LysAsn: 0.648 ± 0.025	1.621LysPro: 1.621 ± 0.038	0.658LysGln: 0.658 ± 0.021	1.91LysArg: 1.91 ± 0.039	1.508LysSer: 1.508 ± 0.031	1.749LysThr: 1.749 ± 0.039	2.227LysVal: 2.227 ± 0.047	0.288LysTrp: 0.288 ± 0.015	0.5LysTyr: 0.5 ± 0.02	0.001LysXaa: 0.001 ± 0.001
Leu	16.612LeuAla: 16.612 ± 0.129	0.74LeuCys: 0.74 ± 0.02	6.61LeuAsp: 6.61 ± 0.082	5.077LeuGlu: 5.077 ± 0.07	3.529LeuPhe: 3.529 ± 0.062	9.216LeuGly: 9.216 ± 0.088	1.794LeuHis: 1.794 ± 0.044	4.903LeuIle: 4.903 ± 0.059	2.936LeuLys: 2.936 ± 0.047	8.703LeuLeu: 8.703 ± 0.102	2.053LeuMet: 2.053 ± 0.039	1.767LeuAsn: 1.767 ± 0.04	5.589LeuPro: 5.589 ± 0.066	2.089LeuGln: 2.089 ± 0.044	6.697LeuArg: 6.697 ± 0.073	5.458LeuSer: 5.458 ± 0.119	5.916LeuThr: 5.916 ± 0.138	8.811LeuVal: 8.811 ± 0.093	1.208LeuTrp: 1.208 ± 0.031	1.758LeuTyr: 1.758 ± 0.037	0.001LeuXaa: 0.001 ± 0.001
Met	2.704MetAla: 2.704 ± 0.049	0.146MetCys: 0.146 ± 0.01	0.913MetAsp: 0.913 ± 0.027	0.799MetGlu: 0.799 ± 0.025	0.631MetPhe: 0.631 ± 0.025	1.531MetGly: 1.531 ± 0.033	0.325MetHis: 0.325 ± 0.017	1.269MetIle: 1.269 ± 0.032	0.795MetLys: 0.795 ± 0.028	1.944MetLeu: 1.944 ± 0.037	0.51MetMet: 0.51 ± 0.026	0.617MetAsn: 0.617 ± 0.02	1.338MetPro: 1.338 ± 0.038	0.531MetGln: 0.531 ± 0.019	1.624MetArg: 1.624 ± 0.034	1.418MetSer: 1.418 ± 0.032	1.818MetThr: 1.818 ± 0.039	1.782MetVal: 1.782 ± 0.036	0.189MetTrp: 0.189 ± 0.012	0.246MetTyr: 0.246 ± 0.012	0.001MetXaa: 0.001 ± 0.001
Asn	2.447AsnAla: 2.447 ± 0.054	0.195AsnCys: 0.195 ± 0.012	1.027AsnAsp: 1.027 ± 0.028	0.798AsnGlu: 0.798 ± 0.024	0.728AsnPhe: 0.728 ± 0.024	1.783AsnGly: 1.783 ± 0.054	0.395AsnHis: 0.395 ± 0.016	0.938AsnIle: 0.938 ± 0.026	0.475AsnLys: 0.475 ± 0.019	2.165AsnLeu: 2.165 ± 0.038	0.397AsnMet: 0.397 ± 0.017	0.42AsnAsn: 0.42 ± 0.019	1.507AsnPro: 1.507 ± 0.033	0.551AsnGln: 0.551 ± 0.021	1.475AsnArg: 1.475 ± 0.031	0.845AsnSer: 0.845 ± 0.03	0.948AsnThr: 0.948 ± 0.032	1.602AsnVal: 1.602 ± 0.039	0.301AsnTrp: 0.301 ± 0.014	0.457AsnTyr: 0.457 ± 0.02	0.0AsnXaa: 0.0 ± 0.0
Pro	7.464ProAla: 7.464 ± 0.104	0.331ProCys: 0.331 ± 0.015	3.58ProAsp: 3.58 ± 0.055	3.413ProGlu: 3.413 ± 0.053	2.004ProPhe: 2.004 ± 0.039	4.726ProGly: 4.726 ± 0.064	1.139ProHis: 1.139 ± 0.031	2.845ProIle: 2.845 ± 0.047	1.621ProLys: 1.621 ± 0.039	4.761ProLeu: 4.761 ± 0.061	1.217ProMet: 1.217 ± 0.031	1.113ProAsn: 1.113 ± 0.028	3.298ProPro: 3.298 ± 0.075	1.287ProGln: 1.287 ± 0.029	3.578ProArg: 3.578 ± 0.056	2.831ProSer: 2.831 ± 0.041	3.198ProThr: 3.198 ± 0.051	4.389ProVal: 4.389 ± 0.063	0.752ProTrp: 0.752 ± 0.022	0.988ProTyr: 0.988 ± 0.027	0.001ProXaa: 0.001 ± 0.001
Gln	3.101GlnAla: 3.101 ± 0.05	0.151GlnCys: 0.151 ± 0.011	0.988GlnAsp: 0.988 ± 0.029	1.013GlnGlu: 1.013 ± 0.033	0.821GlnPhe: 0.821 ± 0.025	1.835GlnGly: 1.835 ± 0.036	0.425GlnHis: 0.425 ± 0.018	1.658GlnIle: 1.658 ± 0.083	0.766GlnLys: 0.766 ± 0.028	2.113GlnLeu: 2.113 ± 0.063	0.637GlnMet: 0.637 ± 0.021	0.567GlnAsn: 0.567 ± 0.022	1.212GlnPro: 1.212 ± 0.029	0.699GlnGln: 0.699 ± 0.026	1.742GlnArg: 1.742 ± 0.039	1.335GlnSer: 1.335 ± 0.032	1.432GlnThr: 1.432 ± 0.036	1.873GlnVal: 1.873 ± 0.05	0.281GlnTrp: 0.281 ± 0.015	0.425GlnTyr: 0.425 ± 0.018	0.0GlnXaa: 0.0 ± 0.0
Arg	9.875ArgAla: 9.875 ± 0.106	0.576ArgCys: 0.576 ± 0.021	4.454ArgAsp: 4.454 ± 0.068	3.812ArgGlu: 3.812 ± 0.059	3.213ArgPhe: 3.213 ± 0.053	5.421ArgGly: 5.421 ± 0.061	1.892ArgHis: 1.892 ± 0.037	4.341ArgIle: 4.341 ± 0.061	1.673ArgLys: 1.673 ± 0.038	9.485ArgLeu: 9.485 ± 0.099	1.765ArgMet: 1.765 ± 0.036	1.437ArgAsn: 1.437 ± 0.029	4.81ArgPro: 4.81 ± 0.074	1.939ArgGln: 1.939 ± 0.037	7.986ArgArg: 7.986 ± 0.101	3.929ArgSer: 3.929 ± 0.059	3.639ArgThr: 3.639 ± 0.051	5.678ArgVal: 5.678 ± 0.07	1.066ArgTrp: 1.066 ± 0.029	1.284ArgTyr: 1.284 ± 0.032	0.002ArgXaa: 0.002 ± 0.001
Ser	5.936SerAla: 5.936 ± 0.08	0.354SerCys: 0.354 ± 0.017	2.672SerAsp: 2.672 ± 0.041	2.301SerGlu: 2.301 ± 0.046	1.86SerPhe: 1.86 ± 0.043	5.129SerGly: 5.129 ± 0.086	0.967SerHis: 0.967 ± 0.026	2.489SerIle: 2.489 ± 0.049	1.249SerLys: 1.249 ± 0.035	5.086SerLeu: 5.086 ± 0.068	1.061SerMet: 1.061 ± 0.029	1.065SerAsn: 1.065 ± 0.03	2.78SerPro: 2.78 ± 0.044	1.124SerGln: 1.124 ± 0.03	3.374SerArg: 3.374 ± 0.053	2.668SerSer: 2.668 ± 0.074	2.797SerThr: 2.797 ± 0.085	3.687SerVal: 3.687 ± 0.055	0.669SerTrp: 0.669 ± 0.023	0.94SerTyr: 0.94 ± 0.025	0.0SerXaa: 0.0 ± 0.0
Thr	7.555ThrAla: 7.555 ± 0.102	0.43ThrCys: 0.43 ± 0.018	2.833ThrAsp: 2.833 ± 0.047	2.593ThrGlu: 2.593 ± 0.048	1.951ThrPhe: 1.951 ± 0.039	5.381ThrGly: 5.381 ± 0.089	1.038ThrHis: 1.038 ± 0.027	3.05ThrIle: 3.05 ± 0.069	1.21ThrLys: 1.21 ± 0.033	6.245ThrLeu: 6.245 ± 0.09	1.076ThrMet: 1.076 ± 0.03	1.142ThrAsn: 1.142 ± 0.056	3.532ThrPro: 3.532 ± 0.053	1.249ThrGln: 1.249 ± 0.122	3.992ThrArg: 3.992 ± 0.065	2.746ThrSer: 2.746 ± 0.061	3.495ThrThr: 3.495 ± 0.162	5.143ThrVal: 5.143 ± 0.078	0.766ThrTrp: 0.766 ± 0.026	1.015ThrTyr: 1.015 ± 0.027	0.0ThrXaa: 0.0 ± 0.0
Val	12.992ValAla: 12.992 ± 0.107	0.666ValCys: 0.666 ± 0.02	5.186ValAsp: 5.186 ± 0.069	4.853ValGlu: 4.853 ± 0.065	2.94ValPhe: 2.94 ± 0.049	7.047ValGly: 7.047 ± 0.071	1.57ValHis: 1.57 ± 0.033	3.979ValIle: 3.979 ± 0.056	2.14ValLys: 2.14 ± 0.047	7.952ValLeu: 7.952 ± 0.086	1.795ValMet: 1.795 ± 0.036	1.534ValAsn: 1.534 ± 0.037	4.207ValPro: 4.207 ± 0.063	1.704ValGln: 1.704 ± 0.035	5.399ValArg: 5.399 ± 0.066	3.95ValSer: 3.95 ± 0.061	5.054ValThr: 5.054 ± 0.077	8.208ValVal: 8.208 ± 0.104	0.993ValTrp: 0.993 ± 0.026	1.376ValTyr: 1.376 ± 0.03	0.0ValXaa: 0.0 ± 0.0
Trp	1.41TrpAla: 1.41 ± 0.031	0.126TrpCys: 0.126 ± 0.009	0.685TrpAsp: 0.685 ± 0.022	0.499TrpGlu: 0.499 ± 0.018	0.524TrpPhe: 0.524 ± 0.019	1.041TrpGly: 1.041 ± 0.029	0.268TrpHis: 0.268 ± 0.014	0.667TrpIle: 0.667 ± 0.021	0.39TrpLys: 0.39 ± 0.019	1.452TrpLeu: 1.452 ± 0.031	0.302TrpMet: 0.302 ± 0.014	0.377TrpAsn: 0.377 ± 0.017	0.707TrpPro: 0.707 ± 0.024	0.403TrpGln: 0.403 ± 0.019	1.187TrpArg: 1.187 ± 0.033	0.847TrpSer: 0.847 ± 0.026	0.828TrpThr: 0.828 ± 0.027	0.945TrpVal: 0.945 ± 0.029	0.243TrpTrp: 0.243 ± 0.013	0.26TrpTyr: 0.26 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.15TyrAla: 2.15 ± 0.041	0.195TyrCys: 0.195 ± 0.011	1.244TyrAsp: 1.244 ± 0.029	0.938TyrGlu: 0.938 ± 0.025	0.719TyrPhe: 0.719 ± 0.022	1.847TyrGly: 1.847 ± 0.041	0.346TyrHis: 0.346 ± 0.017	0.581TyrIle: 0.581 ± 0.02	0.447TyrLys: 0.447 ± 0.019	1.79TyrLeu: 1.79 ± 0.036	0.341TyrMet: 0.341 ± 0.017	0.394TyrAsn: 0.394 ± 0.018	0.882TyrPro: 0.882 ± 0.025	0.5TyrGln: 0.5 ± 0.022	1.572TyrArg: 1.572 ± 0.04	0.818TyrSer: 0.818 ± 0.021	0.895TyrThr: 0.895 ± 0.025	1.49TyrVal: 1.49 ± 0.034	0.279TyrTrp: 0.279 ± 0.016	0.439TyrTyr: 0.439 ± 0.019	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.001	0.001XaaCys: 0.001 ± 0.001	0.001XaaAsp: 0.001 ± 0.001	0.001XaaGlu: 0.001 ± 0.001	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.004XaaPro: 0.004 ± 0.002	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.001	0.0XaaSer: 0.0 ± 0.0	0.001XaaThr: 0.001 ± 0.001	0.001XaaVal: 0.001 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4425 proteins (1441686 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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