Amino acid dipepetide frequency for Streptococcus phage Javan143

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.634AlaAla: 3.634 ± 1.153
0.433AlaCys: 0.433 ± 0.198
3.98AlaAsp: 3.98 ± 0.66
5.105AlaGlu: 5.105 ± 0.834
2.163AlaPhe: 2.163 ± 0.463
3.807AlaGly: 3.807 ± 0.873
0.865AlaHis: 0.865 ± 0.278
5.278AlaIle: 5.278 ± 0.685
6.402AlaLys: 6.402 ± 1.133
6.229AlaLeu: 6.229 ± 1.355
1.73AlaMet: 1.73 ± 0.4
3.547AlaAsn: 3.547 ± 0.801
1.817AlaPro: 1.817 ± 0.447
3.893AlaGln: 3.893 ± 0.776
3.374AlaArg: 3.374 ± 0.615
5.018AlaSer: 5.018 ± 1.235
2.769AlaThr: 2.769 ± 0.452
3.634AlaVal: 3.634 ± 0.734
0.433AlaTrp: 0.433 ± 0.193
2.076AlaTyr: 2.076 ± 0.452
0.0AlaXaa: 0.0 ± 0.0
Cys
0.173CysAla: 0.173 ± 0.132
0.0CysCys: 0.0 ± 0.0
0.173CysAsp: 0.173 ± 0.126
1.125CysGlu: 1.125 ± 0.456
0.173CysPhe: 0.173 ± 0.117
0.433CysGly: 0.433 ± 0.243
0.087CysHis: 0.087 ± 0.096
0.692CysIle: 0.692 ± 0.246
0.346CysLys: 0.346 ± 0.19
0.087CysLeu: 0.087 ± 0.086
0.0CysMet: 0.0 ± 0.0
0.173CysAsn: 0.173 ± 0.156
0.087CysPro: 0.087 ± 0.081
0.087CysGln: 0.087 ± 0.081
0.346CysArg: 0.346 ± 0.185
0.26CysSer: 0.26 ± 0.143
0.173CysThr: 0.173 ± 0.102
0.346CysVal: 0.346 ± 0.188
0.087CysTrp: 0.087 ± 0.078
0.26CysTyr: 0.26 ± 0.195
0.0CysXaa: 0.0 ± 0.0
Asp
3.374AspAla: 3.374 ± 0.534
0.433AspCys: 0.433 ± 0.207
4.845AspAsp: 4.845 ± 0.905
5.624AspGlu: 5.624 ± 0.718
3.461AspPhe: 3.461 ± 0.586
4.326AspGly: 4.326 ± 0.82
0.606AspHis: 0.606 ± 0.241
5.364AspIle: 5.364 ± 0.864
7.354AspLys: 7.354 ± 0.77
6.056AspLeu: 6.056 ± 0.853
1.817AspMet: 1.817 ± 0.366
3.634AspAsn: 3.634 ± 0.468
1.557AspPro: 1.557 ± 0.348
2.076AspGln: 2.076 ± 0.313
1.557AspArg: 1.557 ± 0.443
4.672AspSer: 4.672 ± 0.515
3.115AspThr: 3.115 ± 0.519
3.634AspVal: 3.634 ± 0.641
1.384AspTrp: 1.384 ± 0.292
3.547AspTyr: 3.547 ± 0.657
0.0AspXaa: 0.0 ± 0.0
Glu
5.364GluAla: 5.364 ± 1.343
0.692GluCys: 0.692 ± 0.251
3.807GluAsp: 3.807 ± 0.542
7.181GluGlu: 7.181 ± 1.015
2.682GluPhe: 2.682 ± 0.592
3.461GluGly: 3.461 ± 0.6
1.211GluHis: 1.211 ± 0.311
6.056GluIle: 6.056 ± 0.651
6.489GluLys: 6.489 ± 0.694
8.392GluLeu: 8.392 ± 0.739
2.25GluMet: 2.25 ± 0.565
2.596GluAsn: 2.596 ± 0.479
1.817GluPro: 1.817 ± 0.448
3.374GluGln: 3.374 ± 0.572
3.807GluArg: 3.807 ± 0.518
5.018GluSer: 5.018 ± 0.529
4.499GluThr: 4.499 ± 0.679
6.489GluVal: 6.489 ± 0.922
1.125GluTrp: 1.125 ± 0.323
2.423GluTyr: 2.423 ± 0.612
0.0GluXaa: 0.0 ± 0.0
Phe
1.644PheAla: 1.644 ± 0.368
0.0PheCys: 0.0 ± 0.0
4.239PheAsp: 4.239 ± 0.782
3.374PheGlu: 3.374 ± 0.65
1.211PhePhe: 1.211 ± 0.33
2.855PheGly: 2.855 ± 0.562
0.519PheHis: 0.519 ± 0.207
2.769PheIle: 2.769 ± 0.486
4.499PheLys: 4.499 ± 0.57
2.769PheLeu: 2.769 ± 0.464
1.298PheMet: 1.298 ± 0.272
2.336PheAsn: 2.336 ± 0.548
0.692PhePro: 0.692 ± 0.303
0.779PheGln: 0.779 ± 0.245
2.163PheArg: 2.163 ± 0.379
2.25PheSer: 2.25 ± 0.473
2.596PheThr: 2.596 ± 0.455
2.163PheVal: 2.163 ± 0.507
0.087PheTrp: 0.087 ± 0.084
1.99PheTyr: 1.99 ± 0.444
0.0PheXaa: 0.0 ± 0.0
Gly
3.461GlyAla: 3.461 ± 0.673
0.433GlyCys: 0.433 ± 0.21
3.807GlyAsp: 3.807 ± 0.744
4.326GlyGlu: 4.326 ± 0.583
3.028GlyPhe: 3.028 ± 0.582
2.942GlyGly: 2.942 ± 0.521
0.865GlyHis: 0.865 ± 0.249
3.461GlyIle: 3.461 ± 0.454
5.191GlyLys: 5.191 ± 0.541
6.489GlyLeu: 6.489 ± 0.867
2.076GlyMet: 2.076 ± 0.392
3.807GlyAsn: 3.807 ± 0.481
1.298GlyPro: 1.298 ± 0.466
3.115GlyGln: 3.115 ± 0.631
2.769GlyArg: 2.769 ± 0.474
2.336GlySer: 2.336 ± 0.469
3.288GlyThr: 3.288 ± 0.806
3.028GlyVal: 3.028 ± 0.693
1.125GlyTrp: 1.125 ± 0.336
2.769GlyTyr: 2.769 ± 0.633
0.0GlyXaa: 0.0 ± 0.0
His
0.779HisAla: 0.779 ± 0.338
0.087HisCys: 0.087 ± 0.09
1.038HisAsp: 1.038 ± 0.339
0.952HisGlu: 0.952 ± 0.26
0.26HisPhe: 0.26 ± 0.149
1.125HisGly: 1.125 ± 0.229
0.346HisHis: 0.346 ± 0.173
1.038HisIle: 1.038 ± 0.424
0.952HisLys: 0.952 ± 0.356
0.952HisLeu: 0.952 ± 0.335
0.173HisMet: 0.173 ± 0.112
0.952HisAsn: 0.952 ± 0.297
0.519HisPro: 0.519 ± 0.196
0.433HisGln: 0.433 ± 0.241
0.433HisArg: 0.433 ± 0.229
0.865HisSer: 0.865 ± 0.333
0.692HisThr: 0.692 ± 0.221
1.211HisVal: 1.211 ± 0.373
0.173HisTrp: 0.173 ± 0.112
0.692HisTyr: 0.692 ± 0.338
0.0HisXaa: 0.0 ± 0.0
Ile
5.191IleAla: 5.191 ± 0.683
0.433IleCys: 0.433 ± 0.201
6.229IleAsp: 6.229 ± 0.693
5.364IleGlu: 5.364 ± 0.639
2.855IlePhe: 2.855 ± 0.45
4.239IleGly: 4.239 ± 0.571
1.211IleHis: 1.211 ± 0.334
3.634IleIle: 3.634 ± 0.647
7.614IleLys: 7.614 ± 0.939
4.759IleLeu: 4.759 ± 0.784
1.125IleMet: 1.125 ± 0.341
3.547IleAsn: 3.547 ± 0.498
2.336IlePro: 2.336 ± 0.378
1.99IleGln: 1.99 ± 0.41
3.028IleArg: 3.028 ± 0.48
4.326IleSer: 4.326 ± 0.574
4.499IleThr: 4.499 ± 0.617
4.153IleVal: 4.153 ± 0.541
0.433IleTrp: 0.433 ± 0.186
3.201IleTyr: 3.201 ± 0.563
0.0IleXaa: 0.0 ± 0.0
Lys
6.835LysAla: 6.835 ± 0.832
0.346LysCys: 0.346 ± 0.186
6.835LysAsp: 6.835 ± 0.737
7.441LysGlu: 7.441 ± 0.863
2.596LysPhe: 2.596 ± 0.411
5.451LysGly: 5.451 ± 0.888
1.038LysHis: 1.038 ± 0.256
7.96LysIle: 7.96 ± 0.946
7.181LysLys: 7.181 ± 0.99
7.441LysLeu: 7.441 ± 0.765
1.903LysMet: 1.903 ± 0.478
6.143LysAsn: 6.143 ± 0.736
1.903LysPro: 1.903 ± 0.398
4.499LysGln: 4.499 ± 0.729
3.98LysArg: 3.98 ± 0.646
5.364LysSer: 5.364 ± 0.645
4.586LysThr: 4.586 ± 0.673
6.229LysVal: 6.229 ± 0.962
0.952LysTrp: 0.952 ± 0.309
2.596LysTyr: 2.596 ± 0.499
0.0LysXaa: 0.0 ± 0.0
Leu
6.489LeuAla: 6.489 ± 0.938
0.173LeuCys: 0.173 ± 0.124
5.624LeuAsp: 5.624 ± 0.787
6.835LeuGlu: 6.835 ± 0.722
2.855LeuPhe: 2.855 ± 0.602
5.537LeuGly: 5.537 ± 0.818
0.779LeuHis: 0.779 ± 0.263
5.191LeuIle: 5.191 ± 0.755
9.863LeuLys: 9.863 ± 0.863
7.008LeuLeu: 7.008 ± 0.854
1.298LeuMet: 1.298 ± 0.389
4.326LeuAsn: 4.326 ± 0.727
2.769LeuPro: 2.769 ± 0.48
3.634LeuGln: 3.634 ± 0.61
3.807LeuArg: 3.807 ± 0.656
6.229LeuSer: 6.229 ± 0.603
6.316LeuThr: 6.316 ± 0.901
4.586LeuVal: 4.586 ± 0.551
0.692LeuTrp: 0.692 ± 0.171
2.942LeuTyr: 2.942 ± 0.456
0.0LeuXaa: 0.0 ± 0.0
Met
1.211MetAla: 1.211 ± 0.318
0.0MetCys: 0.0 ± 0.0
1.038MetAsp: 1.038 ± 0.333
2.596MetGlu: 2.596 ± 0.41
1.125MetPhe: 1.125 ± 0.377
1.125MetGly: 1.125 ± 0.281
0.0MetHis: 0.0 ± 0.0
2.509MetIle: 2.509 ± 0.494
1.73MetLys: 1.73 ± 0.4
1.817MetLeu: 1.817 ± 0.484
0.865MetMet: 0.865 ± 0.304
1.038MetAsn: 1.038 ± 0.305
0.519MetPro: 0.519 ± 0.192
1.125MetGln: 1.125 ± 0.329
1.211MetArg: 1.211 ± 0.382
1.903MetSer: 1.903 ± 0.383
1.73MetThr: 1.73 ± 0.372
1.038MetVal: 1.038 ± 0.329
0.433MetTrp: 0.433 ± 0.212
0.606MetTyr: 0.606 ± 0.284
0.0MetXaa: 0.0 ± 0.0
Asn
3.288AsnAla: 3.288 ± 0.825
0.606AsnCys: 0.606 ± 0.243
2.682AsnAsp: 2.682 ± 0.447
3.201AsnGlu: 3.201 ± 0.454
2.682AsnPhe: 2.682 ± 0.533
3.374AsnGly: 3.374 ± 0.543
0.779AsnHis: 0.779 ± 0.214
2.942AsnIle: 2.942 ± 0.51
3.288AsnLys: 3.288 ± 0.567
4.326AsnLeu: 4.326 ± 0.705
1.817AsnMet: 1.817 ± 0.425
2.163AsnAsn: 2.163 ± 0.499
2.163AsnPro: 2.163 ± 0.436
3.028AsnGln: 3.028 ± 0.595
3.115AsnArg: 3.115 ± 0.434
3.288AsnSer: 3.288 ± 0.623
2.682AsnThr: 2.682 ± 0.51
2.942AsnVal: 2.942 ± 0.508
0.692AsnTrp: 0.692 ± 0.226
3.288AsnTyr: 3.288 ± 0.624
0.0AsnXaa: 0.0 ± 0.0
Pro
1.557ProAla: 1.557 ± 0.371
0.173ProCys: 0.173 ± 0.138
2.076ProAsp: 2.076 ± 0.497
2.336ProGlu: 2.336 ± 0.344
1.211ProPhe: 1.211 ± 0.306
0.865ProGly: 0.865 ± 0.219
0.173ProHis: 0.173 ± 0.128
2.076ProIle: 2.076 ± 0.464
2.855ProLys: 2.855 ± 0.47
1.644ProLeu: 1.644 ± 0.404
0.606ProMet: 0.606 ± 0.296
1.211ProAsn: 1.211 ± 0.396
0.346ProPro: 0.346 ± 0.161
1.384ProGln: 1.384 ± 0.455
1.125ProArg: 1.125 ± 0.39
1.99ProSer: 1.99 ± 0.492
1.557ProThr: 1.557 ± 0.318
1.384ProVal: 1.384 ± 0.284
0.087ProTrp: 0.087 ± 0.086
0.692ProTyr: 0.692 ± 0.211
0.0ProXaa: 0.0 ± 0.0
Gln
3.201GlnAla: 3.201 ± 0.442
0.346GlnCys: 0.346 ± 0.153
2.25GlnAsp: 2.25 ± 0.47
3.115GlnGlu: 3.115 ± 0.432
1.817GlnPhe: 1.817 ± 0.464
1.99GlnGly: 1.99 ± 0.562
0.865GlnHis: 0.865 ± 0.3
3.115GlnIle: 3.115 ± 0.602
4.499GlnLys: 4.499 ± 0.728
5.105GlnLeu: 5.105 ± 0.888
0.433GlnMet: 0.433 ± 0.21
3.028GlnAsn: 3.028 ± 0.526
0.779GlnPro: 0.779 ± 0.29
1.384GlnGln: 1.384 ± 0.381
1.817GlnArg: 1.817 ± 0.437
4.066GlnSer: 4.066 ± 0.571
2.076GlnThr: 2.076 ± 0.456
2.509GlnVal: 2.509 ± 0.516
0.173GlnTrp: 0.173 ± 0.14
1.125GlnTyr: 1.125 ± 0.404
0.0GlnXaa: 0.0 ± 0.0
Arg
3.115ArgAla: 3.115 ± 0.6
0.173ArgCys: 0.173 ± 0.133
3.115ArgAsp: 3.115 ± 0.602
3.634ArgGlu: 3.634 ± 0.663
1.73ArgPhe: 1.73 ± 0.342
2.25ArgGly: 2.25 ± 0.491
0.779ArgHis: 0.779 ± 0.282
3.893ArgIle: 3.893 ± 0.711
3.115ArgLys: 3.115 ± 0.538
4.066ArgLeu: 4.066 ± 0.601
1.384ArgMet: 1.384 ± 0.259
1.644ArgAsn: 1.644 ± 0.442
1.298ArgPro: 1.298 ± 0.315
2.682ArgGln: 2.682 ± 0.409
2.423ArgArg: 2.423 ± 0.627
1.73ArgSer: 1.73 ± 0.459
2.336ArgThr: 2.336 ± 0.4
2.509ArgVal: 2.509 ± 0.441
0.692ArgTrp: 0.692 ± 0.261
2.855ArgTyr: 2.855 ± 0.511
0.0ArgXaa: 0.0 ± 0.0
Ser
4.413SerAla: 4.413 ± 0.686
0.087SerCys: 0.087 ± 0.098
5.191SerAsp: 5.191 ± 0.609
4.932SerGlu: 4.932 ± 0.751
3.115SerPhe: 3.115 ± 0.471
4.326SerGly: 4.326 ± 0.705
1.125SerHis: 1.125 ± 0.404
3.72SerIle: 3.72 ± 0.757
5.364SerLys: 5.364 ± 0.76
5.624SerLeu: 5.624 ± 0.679
1.211SerMet: 1.211 ± 0.315
3.807SerAsn: 3.807 ± 0.702
1.557SerPro: 1.557 ± 0.484
2.942SerGln: 2.942 ± 0.541
3.288SerArg: 3.288 ± 0.43
3.547SerSer: 3.547 ± 0.645
2.855SerThr: 2.855 ± 0.462
3.98SerVal: 3.98 ± 0.62
0.26SerTrp: 0.26 ± 0.134
1.644SerTyr: 1.644 ± 0.386
0.0SerXaa: 0.0 ± 0.0
Thr
4.326ThrAla: 4.326 ± 1.079
0.346ThrCys: 0.346 ± 0.206
3.374ThrAsp: 3.374 ± 0.558
3.893ThrGlu: 3.893 ± 0.539
2.423ThrPhe: 2.423 ± 0.508
5.451ThrGly: 5.451 ± 0.649
0.433ThrHis: 0.433 ± 0.179
3.893ThrIle: 3.893 ± 0.669
4.845ThrLys: 4.845 ± 0.489
4.759ThrLeu: 4.759 ± 0.635
0.692ThrMet: 0.692 ± 0.289
2.596ThrAsn: 2.596 ± 0.469
1.644ThrPro: 1.644 ± 0.378
2.163ThrGln: 2.163 ± 0.446
1.817ThrArg: 1.817 ± 0.34
3.201ThrSer: 3.201 ± 0.54
4.239ThrThr: 4.239 ± 0.873
3.201ThrVal: 3.201 ± 0.534
0.519ThrTrp: 0.519 ± 0.236
2.25ThrTyr: 2.25 ± 0.47
0.0ThrXaa: 0.0 ± 0.0
Val
5.105ValAla: 5.105 ± 0.718
0.087ValCys: 0.087 ± 0.084
4.499ValAsp: 4.499 ± 0.667
4.326ValGlu: 4.326 ± 0.565
2.509ValPhe: 2.509 ± 0.422
3.028ValGly: 3.028 ± 0.447
0.779ValHis: 0.779 ± 0.254
3.893ValIle: 3.893 ± 0.617
5.105ValLys: 5.105 ± 0.538
4.326ValLeu: 4.326 ± 0.504
1.73ValMet: 1.73 ± 0.382
3.115ValAsn: 3.115 ± 0.53
1.038ValPro: 1.038 ± 0.311
2.509ValGln: 2.509 ± 0.526
3.028ValArg: 3.028 ± 0.562
4.326ValSer: 4.326 ± 0.564
4.326ValThr: 4.326 ± 0.723
4.239ValVal: 4.239 ± 0.613
0.606ValTrp: 0.606 ± 0.2
1.99ValTyr: 1.99 ± 0.492
0.0ValXaa: 0.0 ± 0.0
Trp
0.346TrpAla: 0.346 ± 0.167
0.173TrpCys: 0.173 ± 0.153
0.692TrpAsp: 0.692 ± 0.27
0.692TrpGlu: 0.692 ± 0.218
0.433TrpPhe: 0.433 ± 0.226
0.692TrpGly: 0.692 ± 0.199
0.26TrpHis: 0.26 ± 0.143
0.779TrpIle: 0.779 ± 0.255
1.211TrpLys: 1.211 ± 0.359
1.125TrpLeu: 1.125 ± 0.339
0.173TrpMet: 0.173 ± 0.13
0.779TrpAsn: 0.779 ± 0.279
0.0TrpPro: 0.0 ± 0.0
0.692TrpGln: 0.692 ± 0.229
0.606TrpArg: 0.606 ± 0.216
0.519TrpSer: 0.519 ± 0.197
0.433TrpThr: 0.433 ± 0.205
0.519TrpVal: 0.519 ± 0.222
0.087TrpTrp: 0.087 ± 0.087
0.346TrpTyr: 0.346 ± 0.201
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.682TyrAla: 2.682 ± 0.496
0.087TyrCys: 0.087 ± 0.089
2.942TyrAsp: 2.942 ± 0.487
2.682TyrGlu: 2.682 ± 0.509
1.903TyrPhe: 1.903 ± 0.387
2.336TyrGly: 2.336 ± 0.505
0.952TyrHis: 0.952 ± 0.31
1.903TyrIle: 1.903 ± 0.596
3.374TyrLys: 3.374 ± 0.588
3.98TyrLeu: 3.98 ± 0.682
0.952TyrMet: 0.952 ± 0.309
1.903TyrAsn: 1.903 ± 0.415
1.211TyrPro: 1.211 ± 0.321
1.99TyrGln: 1.99 ± 0.479
1.73TyrArg: 1.73 ± 0.406
2.076TyrSer: 2.076 ± 0.422
1.298TyrThr: 1.298 ± 0.373
2.769TyrVal: 2.769 ± 0.684
0.519TyrTrp: 0.519 ± 0.225
1.73TyrTyr: 1.73 ± 0.419
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 55 proteins (11559 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski