Amino acid dipepetide frequency for Dyella tabacisoli

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
15.395AlaAla: 15.395 ± 0.16
1.113AlaCys: 1.113 ± 0.032
6.438AlaAsp: 6.438 ± 0.067
6.081AlaGlu: 6.081 ± 0.086
3.736AlaPhe: 3.736 ± 0.058
9.928AlaGly: 9.928 ± 0.113
2.692AlaHis: 2.692 ± 0.052
5.542AlaIle: 5.542 ± 0.073
3.685AlaLys: 3.685 ± 0.076
14.151AlaLeu: 14.151 ± 0.14
3.051AlaMet: 3.051 ± 0.06
3.572AlaAsn: 3.572 ± 0.09
5.708AlaPro: 5.708 ± 0.078
5.461AlaGln: 5.461 ± 0.071
7.403AlaArg: 7.403 ± 0.093
6.93AlaSer: 6.93 ± 0.095
6.48AlaThr: 6.48 ± 0.122
8.056AlaVal: 8.056 ± 0.09
1.824AlaTrp: 1.824 ± 0.043
2.886AlaTyr: 2.886 ± 0.062
0.0AlaXaa: 0.0 ± 0.0
Cys
0.987CysAla: 0.987 ± 0.029
0.109CysCys: 0.109 ± 0.009
0.464CysAsp: 0.464 ± 0.02
0.431CysGlu: 0.431 ± 0.02
0.303CysPhe: 0.303 ± 0.015
0.816CysGly: 0.816 ± 0.028
0.244CysHis: 0.244 ± 0.013
0.378CysIle: 0.378 ± 0.016
0.199CysLys: 0.199 ± 0.012
0.828CysLeu: 0.828 ± 0.029
0.176CysMet: 0.176 ± 0.012
0.249CysAsn: 0.249 ± 0.013
0.379CysPro: 0.379 ± 0.018
0.234CysGln: 0.234 ± 0.013
0.533CysArg: 0.533 ± 0.023
0.515CysSer: 0.515 ± 0.018
0.459CysThr: 0.459 ± 0.019
0.639CysVal: 0.639 ± 0.023
0.119CysTrp: 0.119 ± 0.009
0.238CysTyr: 0.238 ± 0.013
0.0CysXaa: 0.0 ± 0.0
Asp
7.452AspAla: 7.452 ± 0.107
0.421AspCys: 0.421 ± 0.02
3.092AspAsp: 3.092 ± 0.056
3.009AspGlu: 3.009 ± 0.057
2.106AspPhe: 2.106 ± 0.042
5.232AspGly: 5.232 ± 0.093
1.317AspHis: 1.317 ± 0.034
2.602AspIle: 2.602 ± 0.041
1.676AspLys: 1.676 ± 0.041
5.527AspLeu: 5.527 ± 0.078
1.119AspMet: 1.119 ± 0.03
1.611AspAsn: 1.611 ± 0.045
3.162AspPro: 3.162 ± 0.051
1.869AspGln: 1.869 ± 0.038
3.379AspArg: 3.379 ± 0.054
3.014AspSer: 3.014 ± 0.05
3.006AspThr: 3.006 ± 0.052
3.936AspVal: 3.936 ± 0.052
0.989AspTrp: 0.989 ± 0.027
1.705AspTyr: 1.705 ± 0.041
0.0AspXaa: 0.0 ± 0.0
Glu
5.623GluAla: 5.623 ± 0.09
0.341GluCys: 0.341 ± 0.016
2.057GluAsp: 2.057 ± 0.043
1.971GluGlu: 1.971 ± 0.051
1.502GluPhe: 1.502 ± 0.031
3.286GluGly: 3.286 ± 0.059
1.608GluHis: 1.608 ± 0.039
2.383GluIle: 2.383 ± 0.055
1.539GluLys: 1.539 ± 0.044
5.984GluLeu: 5.984 ± 0.107
0.973GluMet: 0.973 ± 0.028
1.258GluAsn: 1.258 ± 0.028
2.274GluPro: 2.274 ± 0.044
2.86GluGln: 2.86 ± 0.054
4.452GluArg: 4.452 ± 0.085
2.535GluSer: 2.535 ± 0.056
2.404GluThr: 2.404 ± 0.047
3.419GluVal: 3.419 ± 0.058
0.605GluTrp: 0.605 ± 0.018
1.125GluTyr: 1.125 ± 0.033
0.0GluXaa: 0.0 ± 0.0
Phe
4.09PheAla: 4.09 ± 0.06
0.311PheCys: 0.311 ± 0.018
2.612PheAsp: 2.612 ± 0.046
1.848PheGlu: 1.848 ± 0.046
1.28PhePhe: 1.28 ± 0.036
3.295PheGly: 3.295 ± 0.056
0.79PheHis: 0.79 ± 0.023
1.399PheIle: 1.399 ± 0.035
0.993PheLys: 0.993 ± 0.027
2.851PheLeu: 2.851 ± 0.059
0.698PheMet: 0.698 ± 0.022
1.325PheAsn: 1.325 ± 0.033
1.446PhePro: 1.446 ± 0.033
1.071PheGln: 1.071 ± 0.025
1.958PheArg: 1.958 ± 0.045
2.227PheSer: 2.227 ± 0.042
1.919PheThr: 1.919 ± 0.046
2.563PheVal: 2.563 ± 0.051
0.48PheTrp: 0.48 ± 0.019
0.913PheTyr: 0.913 ± 0.026
0.0PheXaa: 0.0 ± 0.0
Gly
8.468GlyAla: 8.468 ± 0.114
0.771GlyCys: 0.771 ± 0.027
4.471GlyAsp: 4.471 ± 0.062
4.192GlyGlu: 4.192 ± 0.066
3.062GlyPhe: 3.062 ± 0.059
6.91GlyGly: 6.91 ± 0.107
2.14GlyHis: 2.14 ± 0.042
4.085GlyIle: 4.085 ± 0.057
3.29GlyLys: 3.29 ± 0.046
8.222GlyLeu: 8.222 ± 0.079
2.156GlyMet: 2.156 ± 0.045
2.925GlyAsn: 2.925 ± 0.096
2.957GlyPro: 2.957 ± 0.047
3.395GlyGln: 3.395 ± 0.065
5.174GlyArg: 5.174 ± 0.067
5.344GlySer: 5.344 ± 0.111
4.637GlyThr: 4.637 ± 0.117
6.268GlyVal: 6.268 ± 0.078
1.517GlyTrp: 1.517 ± 0.035
2.701GlyTyr: 2.701 ± 0.047
0.0GlyXaa: 0.0 ± 0.0
His
3.158HisAla: 3.158 ± 0.049
0.247HisCys: 0.247 ± 0.014
1.426HisAsp: 1.426 ± 0.033
1.208HisGlu: 1.208 ± 0.035
0.947HisPhe: 0.947 ± 0.029
2.411HisGly: 2.411 ± 0.046
0.694HisHis: 0.694 ± 0.027
1.053HisIle: 1.053 ± 0.031
0.561HisLys: 0.561 ± 0.02
2.369HisLeu: 2.369 ± 0.041
0.541HisMet: 0.541 ± 0.02
0.594HisAsn: 0.594 ± 0.023
1.47HisPro: 1.47 ± 0.035
0.887HisGln: 0.887 ± 0.031
1.637HisArg: 1.637 ± 0.045
1.312HisSer: 1.312 ± 0.036
1.175HisThr: 1.175 ± 0.028
1.677HisVal: 1.677 ± 0.039
0.508HisTrp: 0.508 ± 0.019
0.796HisTyr: 0.796 ± 0.021
0.0HisXaa: 0.0 ± 0.0
Ile
6.467IleAla: 6.467 ± 0.086
0.385IleCys: 0.385 ± 0.019
3.526IleAsp: 3.526 ± 0.046
3.131IleGlu: 3.131 ± 0.058
1.267IlePhe: 1.267 ± 0.031
4.53IleGly: 4.53 ± 0.068
0.983IleHis: 0.983 ± 0.025
1.503IleIle: 1.503 ± 0.038
1.341IleLys: 1.341 ± 0.036
3.179IleLeu: 3.179 ± 0.052
0.589IleMet: 0.589 ± 0.025
1.605IleAsn: 1.605 ± 0.045
2.165IlePro: 2.165 ± 0.041
1.396IleGln: 1.396 ± 0.031
2.627IleArg: 2.627 ± 0.044
2.798IleSer: 2.798 ± 0.054
2.654IleThr: 2.654 ± 0.06
3.465IleVal: 3.465 ± 0.055
0.535IleTrp: 0.535 ± 0.019
1.198IleTyr: 1.198 ± 0.026
0.0IleXaa: 0.0 ± 0.0
Lys
3.442LysAla: 3.442 ± 0.067
0.139LysCys: 0.139 ± 0.009
1.584LysAsp: 1.584 ± 0.037
1.24LysGlu: 1.24 ± 0.036
0.823LysPhe: 0.823 ± 0.031
2.169LysGly: 2.169 ± 0.044
0.734LysHis: 0.734 ± 0.027
1.38LysIle: 1.38 ± 0.034
1.063LysLys: 1.063 ± 0.044
3.507LysLeu: 3.507 ± 0.061
0.593LysMet: 0.593 ± 0.02
0.919LysAsn: 0.919 ± 0.03
2.142LysPro: 2.142 ± 0.053
1.488LysGln: 1.488 ± 0.033
2.058LysArg: 2.058 ± 0.046
1.719LysSer: 1.719 ± 0.041
1.703LysThr: 1.703 ± 0.042
2.218LysVal: 2.218 ± 0.04
0.298LysTrp: 0.298 ± 0.016
0.701LysTyr: 0.701 ± 0.025
0.0LysXaa: 0.0 ± 0.0
Leu
13.722LeuAla: 13.722 ± 0.133
1.012LeuCys: 1.012 ± 0.027
6.58LeuAsp: 6.58 ± 0.091
4.745LeuGlu: 4.745 ± 0.08
3.558LeuPhe: 3.558 ± 0.059
8.577LeuGly: 8.577 ± 0.094
2.662LeuHis: 2.662 ± 0.051
4.772LeuIle: 4.772 ± 0.072
3.456LeuLys: 3.456 ± 0.062
11.901LeuLeu: 11.901 ± 0.15
2.09LeuMet: 2.09 ± 0.044
3.127LeuAsn: 3.127 ± 0.068
6.588LeuPro: 6.588 ± 0.098
4.161LeuGln: 4.161 ± 0.074
7.799LeuArg: 7.799 ± 0.109
7.19LeuSer: 7.19 ± 0.089
5.853LeuThr: 5.853 ± 0.092
6.932LeuVal: 6.932 ± 0.082
1.447LeuTrp: 1.447 ± 0.041
2.424LeuTyr: 2.424 ± 0.045
0.0LeuXaa: 0.0 ± 0.0
Met
2.579MetAla: 2.579 ± 0.055
0.148MetCys: 0.148 ± 0.011
1.049MetAsp: 1.049 ± 0.027
0.845MetGlu: 0.845 ± 0.028
0.67MetPhe: 0.67 ± 0.024
1.401MetGly: 1.401 ± 0.037
0.584MetHis: 0.584 ± 0.02
0.902MetIle: 0.902 ± 0.026
0.788MetLys: 0.788 ± 0.025
2.639MetLeu: 2.639 ± 0.049
0.428MetMet: 0.428 ± 0.018
0.723MetAsn: 0.723 ± 0.022
1.383MetPro: 1.383 ± 0.034
1.019MetGln: 1.019 ± 0.025
1.619MetArg: 1.619 ± 0.04
1.581MetSer: 1.581 ± 0.032
1.325MetThr: 1.325 ± 0.03
1.496MetVal: 1.496 ± 0.036
0.213MetTrp: 0.213 ± 0.013
0.429MetTyr: 0.429 ± 0.019
0.0MetXaa: 0.0 ± 0.0
Asn
3.64AsnAla: 3.64 ± 0.091
0.237AsnCys: 0.237 ± 0.014
1.752AsnAsp: 1.752 ± 0.048
1.375AsnGlu: 1.375 ± 0.026
1.087AsnPhe: 1.087 ± 0.032
3.167AsnGly: 3.167 ± 0.094
0.689AsnHis: 0.689 ± 0.022
1.404AsnIle: 1.404 ± 0.042
0.793AsnLys: 0.793 ± 0.027
2.948AsnLeu: 2.948 ± 0.07
0.581AsnMet: 0.581 ± 0.024
1.115AsnAsn: 1.115 ± 0.059
1.917AsnPro: 1.917 ± 0.045
1.172AsnGln: 1.172 ± 0.041
1.727AsnArg: 1.727 ± 0.033
1.629AsnSer: 1.629 ± 0.061
1.85AsnThr: 1.85 ± 0.067
2.224AsnVal: 2.224 ± 0.056
0.463AsnTrp: 0.463 ± 0.021
1.01AsnTyr: 1.01 ± 0.037
0.0AsnXaa: 0.0 ± 0.0
Pro
6.684ProAla: 6.684 ± 0.091
0.366ProCys: 0.366 ± 0.018
3.148ProAsp: 3.148 ± 0.052
2.713ProGlu: 2.713 ± 0.057
1.74ProPhe: 1.74 ± 0.038
4.386ProGly: 4.386 ± 0.062
1.172ProHis: 1.172 ± 0.032
2.189ProIle: 2.189 ± 0.044
1.449ProLys: 1.449 ± 0.031
5.653ProLeu: 5.653 ± 0.09
1.258ProMet: 1.258 ± 0.033
1.546ProAsn: 1.546 ± 0.041
2.717ProPro: 2.717 ± 0.066
2.174ProGln: 2.174 ± 0.038
2.868ProArg: 2.868 ± 0.053
3.248ProSer: 3.248 ± 0.06
2.803ProThr: 2.803 ± 0.049
3.877ProVal: 3.877 ± 0.054
0.833ProTrp: 0.833 ± 0.025
1.311ProTyr: 1.311 ± 0.034
0.0ProXaa: 0.0 ± 0.0
Gln
5.497GlnAla: 5.497 ± 0.078
0.284GlnCys: 0.284 ± 0.018
1.592GlnAsp: 1.592 ± 0.035
1.397GlnGlu: 1.397 ± 0.035
1.269GlnPhe: 1.269 ± 0.029
3.052GlnGly: 3.052 ± 0.055
1.128GlnHis: 1.128 ± 0.033
1.873GlnIle: 1.873 ± 0.04
1.025GlnLys: 1.025 ± 0.026
4.943GlnLeu: 4.943 ± 0.082
0.883GlnMet: 0.883 ± 0.027
1.063GlnAsn: 1.063 ± 0.038
2.398GlnPro: 2.398 ± 0.047
2.366GlnGln: 2.366 ± 0.06
3.528GlnArg: 3.528 ± 0.066
2.359GlnSer: 2.359 ± 0.05
2.079GlnThr: 2.079 ± 0.05
3.171GlnVal: 3.171 ± 0.054
0.722GlnTrp: 0.722 ± 0.026
0.937GlnTyr: 0.937 ± 0.033
0.0GlnXaa: 0.0 ± 0.0
Arg
6.766ArgAla: 6.766 ± 0.093
0.535ArgCys: 0.535 ± 0.019
3.711ArgAsp: 3.711 ± 0.064
3.893ArgGlu: 3.893 ± 0.081
2.571ArgPhe: 2.571 ± 0.046
4.497ArgGly: 4.497 ± 0.067
1.966ArgHis: 1.966 ± 0.044
3.546ArgIle: 3.546 ± 0.056
1.921ArgLys: 1.921 ± 0.037
7.689ArgLeu: 7.689 ± 0.11
1.682ArgMet: 1.682 ± 0.039
1.805ArgAsn: 1.805 ± 0.039
3.027ArgPro: 3.027 ± 0.058
2.914ArgGln: 2.914 ± 0.055
4.863ArgArg: 4.863 ± 0.093
3.735ArgSer: 3.735 ± 0.058
3.159ArgThr: 3.159 ± 0.05
4.679ArgVal: 4.679 ± 0.069
1.218ArgTrp: 1.218 ± 0.035
2.177ArgTyr: 2.177 ± 0.044
0.0ArgXaa: 0.0 ± 0.0
Ser
6.766SerAla: 6.766 ± 0.094
0.477SerCys: 0.477 ± 0.019
3.179SerAsp: 3.179 ± 0.055
2.581SerGlu: 2.581 ± 0.047
2.368SerPhe: 2.368 ± 0.049
5.727SerGly: 5.727 ± 0.105
1.414SerHis: 1.414 ± 0.033
2.796SerIle: 2.796 ± 0.05
1.804SerLys: 1.804 ± 0.039
6.403SerLeu: 6.403 ± 0.079
1.447SerMet: 1.447 ± 0.035
2.017SerAsn: 2.017 ± 0.064
2.983SerPro: 2.983 ± 0.043
2.179SerGln: 2.179 ± 0.047
3.555SerArg: 3.555 ± 0.053
3.922SerSer: 3.922 ± 0.091
3.571SerThr: 3.571 ± 0.085
4.343SerVal: 4.343 ± 0.059
0.939SerTrp: 0.939 ± 0.029
1.869SerTyr: 1.869 ± 0.062
0.0SerXaa: 0.0 ± 0.0
Thr
6.384ThrAla: 6.384 ± 0.121
0.393ThrCys: 0.393 ± 0.017
2.995ThrAsp: 2.995 ± 0.072
2.257ThrGlu: 2.257 ± 0.046
1.721ThrPhe: 1.721 ± 0.039
4.653ThrGly: 4.653 ± 0.087
1.354ThrHis: 1.354 ± 0.029
2.341ThrIle: 2.341 ± 0.049
1.239ThrLys: 1.239 ± 0.034
6.63ThrLeu: 6.63 ± 0.119
1.053ThrMet: 1.053 ± 0.028
1.495ThrAsn: 1.495 ± 0.064
3.74ThrPro: 3.74 ± 0.064
2.274ThrGln: 2.274 ± 0.064
3.265ThrArg: 3.265 ± 0.048
3.157ThrSer: 3.157 ± 0.082
3.291ThrThr: 3.291 ± 0.098
4.442ThrVal: 4.442 ± 0.112
0.737ThrTrp: 0.737 ± 0.027
1.599ThrTyr: 1.599 ± 0.08
0.0ThrXaa: 0.0 ± 0.0
Val
8.564ValAla: 8.564 ± 0.11
0.645ValCys: 0.645 ± 0.022
4.188ValAsp: 4.188 ± 0.06
3.623ValGlu: 3.623 ± 0.062
2.449ValPhe: 2.449 ± 0.052
5.287ValGly: 5.287 ± 0.068
1.537ValHis: 1.537 ± 0.034
3.535ValIle: 3.535 ± 0.055
1.977ValLys: 1.977 ± 0.04
8.186ValLeu: 8.186 ± 0.099
1.6ValMet: 1.6 ± 0.035
2.37ValAsn: 2.37 ± 0.064
3.66ValPro: 3.66 ± 0.051
2.641ValGln: 2.641 ± 0.045
4.553ValArg: 4.553 ± 0.078
4.578ValSer: 4.578 ± 0.065
4.263ValThr: 4.263 ± 0.105
5.555ValVal: 5.555 ± 0.085
0.914ValTrp: 0.914 ± 0.025
1.722ValTyr: 1.722 ± 0.036
0.0ValXaa: 0.0 ± 0.0
Trp
1.241TrpAla: 1.241 ± 0.029
0.153TrpCys: 0.153 ± 0.011
0.663TrpAsp: 0.663 ± 0.025
0.496TrpGlu: 0.496 ± 0.019
0.599TrpPhe: 0.599 ± 0.025
0.925TrpGly: 0.925 ± 0.029
0.436TrpHis: 0.436 ± 0.02
0.686TrpIle: 0.686 ± 0.024
0.456TrpLys: 0.456 ± 0.019
2.206TrpLeu: 2.206 ± 0.056
0.416TrpMet: 0.416 ± 0.017
0.56TrpAsn: 0.56 ± 0.022
0.718TrpPro: 0.718 ± 0.025
0.869TrpGln: 0.869 ± 0.026
1.274TrpArg: 1.274 ± 0.033
1.016TrpSer: 1.016 ± 0.027
0.782TrpThr: 0.782 ± 0.029
0.955TrpVal: 0.955 ± 0.028
0.28TrpTrp: 0.28 ± 0.016
0.368TrpTyr: 0.368 ± 0.015
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.21TyrAla: 3.21 ± 0.044
0.211TyrCys: 0.211 ± 0.012
1.694TyrAsp: 1.694 ± 0.088
1.164TyrGlu: 1.164 ± 0.031
1.011TyrPhe: 1.011 ± 0.028
2.434TyrGly: 2.434 ± 0.048
0.53TyrHis: 0.53 ± 0.019
0.977TyrIle: 0.977 ± 0.024
0.667TyrLys: 0.667 ± 0.021
2.777TyrLeu: 2.777 ± 0.047
0.483TyrMet: 0.483 ± 0.022
0.901TyrAsn: 0.901 ± 0.038
1.305TyrPro: 1.305 ± 0.032
1.137TyrGln: 1.137 ± 0.036
2.084TyrArg: 2.084 ± 0.043
1.529TyrSer: 1.529 ± 0.04
1.607TyrThr: 1.607 ± 0.063
1.932TyrVal: 1.932 ± 0.035
0.455TyrTrp: 0.455 ± 0.018
0.791TyrTyr: 0.791 ± 0.03
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4066 proteins (1484847 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski