Amino acid dipepetide frequency for Leptospira borgpetersenii str. 200701203

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.627AlaAla: 3.627 ± 0.076	0.562AlaCys: 0.562 ± 0.026	2.72AlaAsp: 2.72 ± 0.05	3.792AlaGlu: 3.792 ± 0.072	2.712AlaPhe: 2.712 ± 0.057	4.362AlaGly: 4.362 ± 0.064	0.849AlaHis: 0.849 ± 0.028	4.331AlaIle: 4.331 ± 0.065	3.946AlaLys: 3.946 ± 0.069	5.666AlaLeu: 5.666 ± 0.078	1.212AlaMet: 1.212 ± 0.035	2.457AlaAsn: 2.457 ± 0.056	1.747AlaPro: 1.747 ± 0.044	1.561AlaGln: 1.561 ± 0.045	2.521AlaArg: 2.521 ± 0.054	4.009AlaSer: 4.009 ± 0.073	2.648AlaThr: 2.648 ± 0.052	3.696AlaVal: 3.696 ± 0.065	0.606AlaTrp: 0.606 ± 0.025	1.831AlaTyr: 1.831 ± 0.042	0.0AlaXaa: 0.0 ± 0.0
Cys	0.409CysAla: 0.409 ± 0.022	0.085CysCys: 0.085 ± 0.01	0.366CysAsp: 0.366 ± 0.018	0.498CysGlu: 0.498 ± 0.023	0.596CysPhe: 0.596 ± 0.023	0.751CysGly: 0.751 ± 0.031	0.185CysHis: 0.185 ± 0.014	0.684CysIle: 0.684 ± 0.024	0.617CysLys: 0.617 ± 0.024	0.832CysLeu: 0.832 ± 0.03	0.194CysMet: 0.194 ± 0.012	0.393CysAsn: 0.393 ± 0.019	0.387CysPro: 0.387 ± 0.022	0.206CysGln: 0.206 ± 0.013	0.394CysArg: 0.394 ± 0.019	0.703CysSer: 0.703 ± 0.031	0.422CysThr: 0.422 ± 0.021	0.502CysVal: 0.502 ± 0.024	0.084CysTrp: 0.084 ± 0.008	0.323CysTyr: 0.323 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	2.451AspAla: 2.451 ± 0.058	0.43AspCys: 0.43 ± 0.019	1.772AspAsp: 1.772 ± 0.047	2.83AspGlu: 2.83 ± 0.062	3.204AspPhe: 3.204 ± 0.058	2.982AspGly: 2.982 ± 0.063	0.855AspHis: 0.855 ± 0.028	3.227AspIle: 3.227 ± 0.053	3.13AspLys: 3.13 ± 0.066	5.817AspLeu: 5.817 ± 0.078	0.928AspMet: 0.928 ± 0.028	1.562AspAsn: 1.562 ± 0.036	2.531AspPro: 2.531 ± 0.055	1.604AspGln: 1.604 ± 0.039	2.688AspArg: 2.688 ± 0.047	4.105AspSer: 4.105 ± 0.061	2.16AspThr: 2.16 ± 0.041	2.542AspVal: 2.542 ± 0.044	0.627AspTrp: 0.627 ± 0.025	1.85AspTyr: 1.85 ± 0.04	0.0AspXaa: 0.0 ± 0.0
Glu	3.726GluAla: 3.726 ± 0.064	0.474GluCys: 0.474 ± 0.02	3.282GluAsp: 3.282 ± 0.058	6.171GluGlu: 6.171 ± 0.093	3.748GluPhe: 3.748 ± 0.068	3.811GluGly: 3.811 ± 0.066	0.927GluHis: 0.927 ± 0.027	6.672GluIle: 6.672 ± 0.093	7.086GluLys: 7.086 ± 0.084	6.643GluLeu: 6.643 ± 0.093	1.589GluMet: 1.589 ± 0.035	4.181GluAsn: 4.181 ± 0.063	1.822GluPro: 1.822 ± 0.044	1.849GluGln: 1.849 ± 0.041	3.383GluArg: 3.383 ± 0.066	4.84GluSer: 4.84 ± 0.065	3.853GluThr: 3.853 ± 0.062	3.95GluVal: 3.95 ± 0.072	0.788GluTrp: 0.788 ± 0.027	2.392GluTyr: 2.392 ± 0.048	0.0GluXaa: 0.0 ± 0.0
Phe	2.96PheAla: 2.96 ± 0.047	0.757PheCys: 0.757 ± 0.029	2.438PheAsp: 2.438 ± 0.05	3.309PheGlu: 3.309 ± 0.055	3.835PhePhe: 3.835 ± 0.08	3.733PheGly: 3.733 ± 0.068	1.237PheHis: 1.237 ± 0.031	3.435PheIle: 3.435 ± 0.063	3.07PheLys: 3.07 ± 0.058	7.325PheLeu: 7.325 ± 0.114	1.12PheMet: 1.12 ± 0.034	2.04PheAsn: 2.04 ± 0.046	2.712PhePro: 2.712 ± 0.049	2.633PheGln: 2.633 ± 0.051	3.253PheArg: 3.253 ± 0.06	5.042PheSer: 5.042 ± 0.081	2.701PheThr: 2.701 ± 0.056	3.118PheVal: 3.118 ± 0.058	0.848PheTrp: 0.848 ± 0.029	2.385PheTyr: 2.385 ± 0.051	0.0PheXaa: 0.0 ± 0.0
Gly	3.821GlyAla: 3.821 ± 0.076	0.574GlyCys: 0.574 ± 0.027	2.943GlyAsp: 2.943 ± 0.05	4.192GlyGlu: 4.192 ± 0.066	3.953GlyPhe: 3.953 ± 0.057	4.455GlyGly: 4.455 ± 0.085	1.083GlyHis: 1.083 ± 0.033	6.38GlyIle: 6.38 ± 0.082	5.947GlyLys: 5.947 ± 0.077	5.955GlyLeu: 5.955 ± 0.083	1.653GlyMet: 1.653 ± 0.043	3.445GlyAsn: 3.445 ± 0.062	1.682GlyPro: 1.682 ± 0.036	1.695GlyGln: 1.695 ± 0.041	2.754GlyArg: 2.754 ± 0.051	4.574GlySer: 4.574 ± 0.079	3.626GlyThr: 3.626 ± 0.067	4.094GlyVal: 4.094 ± 0.06	0.724GlyTrp: 0.724 ± 0.029	2.483GlyTyr: 2.483 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	0.804HisAla: 0.804 ± 0.029	0.198HisCys: 0.198 ± 0.013	0.638HisAsp: 0.638 ± 0.023	0.884HisGlu: 0.884 ± 0.03	1.142HisPhe: 1.142 ± 0.027	1.06HisGly: 1.06 ± 0.036	0.406HisHis: 0.406 ± 0.02	1.15HisIle: 1.15 ± 0.03	1.13HisLys: 1.13 ± 0.035	1.846HisLeu: 1.846 ± 0.046	0.279HisMet: 0.279 ± 0.015	0.683HisAsn: 0.683 ± 0.027	1.065HisPro: 1.065 ± 0.031	0.464HisGln: 0.464 ± 0.02	0.903HisArg: 0.903 ± 0.03	1.559HisSer: 1.559 ± 0.038	0.876HisThr: 0.876 ± 0.029	0.825HisVal: 0.825 ± 0.023	0.248HisTrp: 0.248 ± 0.015	0.644HisTyr: 0.644 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	4.625IleAla: 4.625 ± 0.065	0.802IleCys: 0.802 ± 0.029	3.438IleAsp: 3.438 ± 0.054	4.84IleGlu: 4.84 ± 0.071	4.491IlePhe: 4.491 ± 0.073	5.046IleGly: 5.046 ± 0.075	1.68IleHis: 1.68 ± 0.037	3.934IleIle: 3.934 ± 0.073	3.968IleLys: 3.968 ± 0.07	10.502IleLeu: 10.502 ± 0.107	1.132IleMet: 1.132 ± 0.031	2.6IleAsn: 2.6 ± 0.051	4.069IlePro: 4.069 ± 0.049	3.498IleGln: 3.498 ± 0.055	4.775IleArg: 4.775 ± 0.066	6.424IleSer: 6.424 ± 0.09	3.603IleThr: 3.603 ± 0.063	4.592IleVal: 4.592 ± 0.067	0.774IleTrp: 0.774 ± 0.03	2.736IleTyr: 2.736 ± 0.05	0.0IleXaa: 0.0 ± 0.0
Lys	4.013LysAla: 4.013 ± 0.073	0.33LysCys: 0.33 ± 0.017	3.985LysAsp: 3.985 ± 0.066	7.111LysGlu: 7.111 ± 0.091	3.247LysPhe: 3.247 ± 0.056	4.185LysGly: 4.185 ± 0.064	1.065LysHis: 1.065 ± 0.031	7.127LysIle: 7.127 ± 0.09	7.374LysLys: 7.374 ± 0.1	6.33LysLeu: 6.33 ± 0.083	1.757LysMet: 1.757 ± 0.042	5.23LysAsn: 5.23 ± 0.07	2.509LysPro: 2.509 ± 0.048	2.176LysGln: 2.176 ± 0.041	3.727LysArg: 3.727 ± 0.066	5.097LysSer: 5.097 ± 0.067	4.524LysThr: 4.524 ± 0.065	4.125LysVal: 4.125 ± 0.067	0.573LysTrp: 0.573 ± 0.022	2.378LysTyr: 2.378 ± 0.052	0.0LysXaa: 0.0 ± 0.0
Leu	5.622LeuAla: 5.622 ± 0.078	0.938LeuCys: 0.938 ± 0.032	5.048LeuAsp: 5.048 ± 0.071	7.698LeuGlu: 7.698 ± 0.107	6.109LeuPhe: 6.109 ± 0.096	6.689LeuGly: 6.689 ± 0.087	1.615LeuHis: 1.615 ± 0.047	7.477LeuIle: 7.477 ± 0.097	8.888LeuLys: 8.888 ± 0.095	9.877LeuLeu: 9.877 ± 0.131	1.93LeuMet: 1.93 ± 0.044	5.217LeuAsn: 5.217 ± 0.075	4.165LeuPro: 4.165 ± 0.064	3.295LeuGln: 3.295 ± 0.056	4.788LeuArg: 4.788 ± 0.064	8.7LeuSer: 8.7 ± 0.1	4.841LeuThr: 4.841 ± 0.068	5.515LeuVal: 5.515 ± 0.08	0.971LeuTrp: 0.971 ± 0.03	3.402LeuTyr: 3.402 ± 0.06	0.0LeuXaa: 0.0 ± 0.0
Met	1.241MetAla: 1.241 ± 0.036	0.125MetCys: 0.125 ± 0.01	1.247MetAsp: 1.247 ± 0.037	1.7MetGlu: 1.7 ± 0.04	0.928MetPhe: 0.928 ± 0.029	1.439MetGly: 1.439 ± 0.039	0.259MetHis: 0.259 ± 0.015	1.846MetIle: 1.846 ± 0.037	1.984MetLys: 1.984 ± 0.042	1.576MetLeu: 1.576 ± 0.038	0.45MetMet: 0.45 ± 0.02	1.328MetAsn: 1.328 ± 0.035	0.674MetPro: 0.674 ± 0.024	0.609MetGln: 0.609 ± 0.02	0.952MetArg: 0.952 ± 0.034	1.414MetSer: 1.414 ± 0.037	1.012MetThr: 1.012 ± 0.035	1.119MetVal: 1.119 ± 0.037	0.113MetTrp: 0.113 ± 0.011	0.486MetTyr: 0.486 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	2.653AsnAla: 2.653 ± 0.058	0.506AsnCys: 0.506 ± 0.022	1.885AsnAsp: 1.885 ± 0.048	2.854AsnGlu: 2.854 ± 0.056	2.876AsnPhe: 2.876 ± 0.046	3.223AsnGly: 3.223 ± 0.067	0.98AsnHis: 0.98 ± 0.03	3.104AsnIle: 3.104 ± 0.054	2.554AsnLys: 2.554 ± 0.047	5.822AsnLeu: 5.822 ± 0.074	0.86AsnMet: 0.86 ± 0.028	1.703AsnAsn: 1.703 ± 0.049	2.811AsnPro: 2.811 ± 0.051	2.018AsnGln: 2.018 ± 0.044	2.876AsnArg: 2.876 ± 0.057	4.103AsnSer: 4.103 ± 0.075	2.254AsnThr: 2.254 ± 0.046	2.879AsnVal: 2.879 ± 0.057	0.601AsnTrp: 0.601 ± 0.024	1.774AsnTyr: 1.774 ± 0.043	0.0AsnXaa: 0.0 ± 0.0
Pro	2.043ProAla: 2.043 ± 0.048	0.239ProCys: 0.239 ± 0.016	2.389ProAsp: 2.389 ± 0.051	3.742ProGlu: 3.742 ± 0.061	2.335ProPhe: 2.335 ± 0.051	3.038ProGly: 3.038 ± 0.059	0.625ProHis: 0.625 ± 0.024	3.13ProIle: 3.13 ± 0.053	2.805ProLys: 2.805 ± 0.055	3.355ProLeu: 3.355 ± 0.057	0.837ProMet: 0.837 ± 0.027	2.039ProAsn: 2.039 ± 0.044	1.323ProPro: 1.323 ± 0.043	1.001ProGln: 1.001 ± 0.028	1.276ProArg: 1.276 ± 0.032	2.902ProSer: 2.902 ± 0.054	1.918ProThr: 1.918 ± 0.043	2.614ProVal: 2.614 ± 0.057	0.418ProTrp: 0.418 ± 0.019	1.3ProTyr: 1.3 ± 0.041	0.0ProXaa: 0.0 ± 0.0
Gln	1.807GlnAla: 1.807 ± 0.047	0.198GlnCys: 0.198 ± 0.015	1.608GlnAsp: 1.608 ± 0.041	2.563GlnGlu: 2.563 ± 0.048	1.554GlnPhe: 1.554 ± 0.04	1.954GlnGly: 1.954 ± 0.043	0.352GlnHis: 0.352 ± 0.02	2.941GlnIle: 2.941 ± 0.056	3.374GlnLys: 3.374 ± 0.057	2.389GlnLeu: 2.389 ± 0.046	0.675GlnMet: 0.675 ± 0.025	2.166GlnAsn: 2.166 ± 0.05	0.843GlnPro: 0.843 ± 0.027	0.702GlnGln: 0.702 ± 0.027	1.417GlnArg: 1.417 ± 0.039	2.179GlnSer: 2.179 ± 0.054	1.929GlnThr: 1.929 ± 0.051	1.826GlnVal: 1.826 ± 0.049	0.29GlnTrp: 0.29 ± 0.017	0.984GlnTyr: 0.984 ± 0.038	0.0GlnXaa: 0.0 ± 0.0
Arg	2.341ArgAla: 2.341 ± 0.042	0.353ArgCys: 0.353 ± 0.016	2.273ArgAsp: 2.273 ± 0.044	3.665ArgGlu: 3.665 ± 0.065	3.051ArgPhe: 3.051 ± 0.051	2.562ArgGly: 2.562 ± 0.054	0.683ArgHis: 0.683 ± 0.028	4.878ArgIle: 4.878 ± 0.068	4.751ArgLys: 4.751 ± 0.073	4.423ArgLeu: 4.423 ± 0.062	1.329ArgMet: 1.329 ± 0.038	2.877ArgAsn: 2.877 ± 0.056	1.502ArgPro: 1.502 ± 0.038	1.279ArgGln: 1.279 ± 0.031	2.127ArgArg: 2.127 ± 0.048	3.409ArgSer: 3.409 ± 0.056	2.439ArgThr: 2.439 ± 0.048	2.653ArgVal: 2.653 ± 0.044	0.531ArgTrp: 0.531 ± 0.021	1.832ArgTyr: 1.832 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	4.218SerAla: 4.218 ± 0.066	0.651SerCys: 0.651 ± 0.028	3.563SerAsp: 3.563 ± 0.055	5.47SerGlu: 5.47 ± 0.084	4.914SerPhe: 4.914 ± 0.079	6.036SerGly: 6.036 ± 0.08	1.189SerHis: 1.189 ± 0.029	5.872SerIle: 5.872 ± 0.081	5.668SerLys: 5.668 ± 0.071	8.143SerLeu: 8.143 ± 0.096	1.616SerMet: 1.616 ± 0.039	3.324SerAsn: 3.324 ± 0.064	3.04SerPro: 3.04 ± 0.065	2.346SerGln: 2.346 ± 0.055	3.552SerArg: 3.552 ± 0.061	6.222SerSer: 6.222 ± 0.105	3.335SerThr: 3.335 ± 0.06	4.769SerVal: 4.769 ± 0.068	0.874SerTrp: 0.874 ± 0.028	2.758SerTyr: 2.758 ± 0.05	0.0SerXaa: 0.0 ± 0.0
Thr	2.887ThrAla: 2.887 ± 0.066	0.396ThrCys: 0.396 ± 0.019	2.56ThrAsp: 2.56 ± 0.05	3.226ThrGlu: 3.226 ± 0.049	2.749ThrPhe: 2.749 ± 0.053	4.053ThrGly: 4.053 ± 0.068	0.891ThrHis: 0.891 ± 0.029	3.979ThrIle: 3.979 ± 0.062	3.207ThrLys: 3.207 ± 0.055	5.161ThrLeu: 5.161 ± 0.068	0.928ThrMet: 0.928 ± 0.031	2.328ThrAsn: 2.328 ± 0.05	2.231ThrPro: 2.231 ± 0.038	1.427ThrGln: 1.427 ± 0.04	2.175ThrArg: 2.175 ± 0.044	3.635ThrSer: 3.635 ± 0.073	2.532ThrThr: 2.532 ± 0.064	3.185ThrVal: 3.185 ± 0.06	0.551ThrTrp: 0.551 ± 0.024	1.594ThrTyr: 1.594 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	3.349ValAla: 3.349 ± 0.056	0.577ValCys: 0.577 ± 0.027	2.779ValAsp: 2.779 ± 0.059	3.686ValGlu: 3.686 ± 0.061	3.596ValPhe: 3.596 ± 0.065	3.756ValGly: 3.756 ± 0.071	1.035ValHis: 1.035 ± 0.034	4.109ValIle: 4.109 ± 0.07	3.715ValLys: 3.715 ± 0.072	6.41ValLeu: 6.41 ± 0.091	1.149ValMet: 1.149 ± 0.035	2.433ValAsn: 2.433 ± 0.051	2.409ValPro: 2.409 ± 0.048	1.833ValGln: 1.833 ± 0.036	3.045ValArg: 3.045 ± 0.058	4.957ValSer: 4.957 ± 0.069	2.833ValThr: 2.833 ± 0.056	3.694ValVal: 3.694 ± 0.062	0.645ValTrp: 0.645 ± 0.025	2.043ValTyr: 2.043 ± 0.053	0.0ValXaa: 0.0 ± 0.0
Trp	0.499TrpAla: 0.499 ± 0.022	0.081TrpCys: 0.081 ± 0.008	0.605TrpAsp: 0.605 ± 0.026	0.742TrpGlu: 0.742 ± 0.025	0.546TrpPhe: 0.546 ± 0.026	0.68TrpGly: 0.68 ± 0.026	0.156TrpHis: 0.156 ± 0.014	1.156TrpIle: 1.156 ± 0.037	1.278TrpLys: 1.278 ± 0.04	0.883TrpLeu: 0.883 ± 0.032	0.271TrpMet: 0.271 ± 0.014	0.794TrpAsn: 0.794 ± 0.027	0.278TrpPro: 0.278 ± 0.016	0.252TrpGln: 0.252 ± 0.016	0.422TrpArg: 0.422 ± 0.021	0.658TrpSer: 0.658 ± 0.024	0.497TrpThr: 0.497 ± 0.02	0.594TrpVal: 0.594 ± 0.021	0.117TrpTrp: 0.117 ± 0.01	0.3TrpTyr: 0.3 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.76TyrAla: 1.76 ± 0.044	0.352TyrCys: 0.352 ± 0.018	1.758TyrAsp: 1.758 ± 0.04	2.217TyrGlu: 2.217 ± 0.045	2.363TyrPhe: 2.363 ± 0.051	2.216TyrGly: 2.216 ± 0.047	0.73TyrHis: 0.73 ± 0.025	2.095TyrIle: 2.095 ± 0.046	2.37TyrLys: 2.37 ± 0.047	3.831TyrLeu: 3.831 ± 0.067	0.592TyrMet: 0.592 ± 0.022	1.532TyrAsn: 1.532 ± 0.042	1.531TyrPro: 1.531 ± 0.042	1.305TyrGln: 1.305 ± 0.037	1.932TyrArg: 1.932 ± 0.04	3.027TyrSer: 3.027 ± 0.051	1.694TyrThr: 1.694 ± 0.041	1.763TyrVal: 1.763 ± 0.037	0.427TyrTrp: 0.427 ± 0.02	1.571TyrTyr: 1.571 ± 0.042	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4773 proteins (1094403 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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