Amino acid dipepetide frequency for Nesiotobacter exalbescens

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.669AlaAla: 12.669 ± 0.159	1.028AlaCys: 1.028 ± 0.031	5.977AlaAsp: 5.977 ± 0.077	7.018AlaGlu: 7.018 ± 0.088	4.284AlaPhe: 4.284 ± 0.072	8.921AlaGly: 8.921 ± 0.088	2.175AlaHis: 2.175 ± 0.049	5.84AlaIle: 5.84 ± 0.073	3.972AlaLys: 3.972 ± 0.072	12.212AlaLeu: 12.212 ± 0.119	3.171AlaMet: 3.171 ± 0.054	3.121AlaAsn: 3.121 ± 0.058	4.578AlaPro: 4.578 ± 0.068	4.194AlaGln: 4.194 ± 0.063	6.565AlaArg: 6.565 ± 0.092	6.154AlaSer: 6.154 ± 0.093	5.473AlaThr: 5.473 ± 0.079	7.938AlaVal: 7.938 ± 0.096	1.1AlaTrp: 1.1 ± 0.028	2.655AlaTyr: 2.655 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	0.928CysAla: 0.928 ± 0.03	0.142CysCys: 0.142 ± 0.012	0.54CysAsp: 0.54 ± 0.023	0.561CysGlu: 0.561 ± 0.025	0.385CysPhe: 0.385 ± 0.018	0.931CysGly: 0.931 ± 0.032	0.253CysHis: 0.253 ± 0.015	0.46CysIle: 0.46 ± 0.019	0.264CysLys: 0.264 ± 0.016	0.923CysLeu: 0.923 ± 0.03	0.185CysMet: 0.185 ± 0.013	0.255CysAsn: 0.255 ± 0.015	0.439CysPro: 0.439 ± 0.022	0.292CysGln: 0.292 ± 0.016	0.524CysArg: 0.524 ± 0.023	0.543CysSer: 0.543 ± 0.024	0.507CysThr: 0.507 ± 0.021	0.706CysVal: 0.706 ± 0.028	0.116CysTrp: 0.116 ± 0.01	0.214CysTyr: 0.214 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	5.916AspAla: 5.916 ± 0.077	0.488AspCys: 0.488 ± 0.021	3.084AspAsp: 3.084 ± 0.075	3.81AspGlu: 3.81 ± 0.065	2.138AspPhe: 2.138 ± 0.046	4.747AspGly: 4.747 ± 0.099	1.321AspHis: 1.321 ± 0.038	3.11AspIle: 3.11 ± 0.059	2.036AspLys: 2.036 ± 0.049	6.309AspLeu: 6.309 ± 0.085	1.546AspMet: 1.546 ± 0.039	1.588AspAsn: 1.588 ± 0.039	3.182AspPro: 3.182 ± 0.057	2.115AspGln: 2.115 ± 0.042	3.683AspArg: 3.683 ± 0.06	2.218AspSer: 2.218 ± 0.043	2.957AspThr: 2.957 ± 0.069	4.264AspVal: 4.264 ± 0.064	0.852AspTrp: 0.852 ± 0.026	1.635AspTyr: 1.635 ± 0.038	0.0AspXaa: 0.0 ± 0.0
Glu	7.727GluAla: 7.727 ± 0.095	0.416GluCys: 0.416 ± 0.023	3.609GluAsp: 3.609 ± 0.066	4.434GluGlu: 4.434 ± 0.074	2.064GluPhe: 2.064 ± 0.041	4.682GluGly: 4.682 ± 0.068	1.272GluHis: 1.272 ± 0.033	3.73GluIle: 3.73 ± 0.058	2.922GluLys: 2.922 ± 0.058	6.044GluLeu: 6.044 ± 0.083	1.701GluMet: 1.701 ± 0.04	2.215GluAsn: 2.215 ± 0.043	2.705GluPro: 2.705 ± 0.055	2.7GluGln: 2.7 ± 0.048	4.489GluArg: 4.489 ± 0.073	2.516GluSer: 2.516 ± 0.048	3.943GluThr: 3.943 ± 0.054	4.544GluVal: 4.544 ± 0.071	0.668GluTrp: 0.668 ± 0.027	1.167GluTyr: 1.167 ± 0.034	0.0GluXaa: 0.0 ± 0.0
Phe	3.938PheAla: 3.938 ± 0.062	0.447PheCys: 0.447 ± 0.021	2.598PheAsp: 2.598 ± 0.057	2.53PheGlu: 2.53 ± 0.047	1.722PhePhe: 1.722 ± 0.043	3.556PheGly: 3.556 ± 0.066	0.739PheHis: 0.739 ± 0.026	2.116PheIle: 2.116 ± 0.049	1.446PheLys: 1.446 ± 0.037	3.764PheLeu: 3.764 ± 0.061	1.019PheMet: 1.019 ± 0.032	1.271PheAsn: 1.271 ± 0.037	1.482PhePro: 1.482 ± 0.036	1.17PheGln: 1.17 ± 0.03	1.992PheArg: 1.992 ± 0.041	2.679PheSer: 2.679 ± 0.055	2.136PheThr: 2.136 ± 0.045	2.899PheVal: 2.899 ± 0.061	0.579PheTrp: 0.579 ± 0.025	1.06PheTyr: 1.06 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	8.101GlyAla: 8.101 ± 0.081	0.849GlyCys: 0.849 ± 0.026	4.21GlyAsp: 4.21 ± 0.085	4.718GlyGlu: 4.718 ± 0.063	3.608GlyPhe: 3.608 ± 0.063	6.471GlyGly: 6.471 ± 0.114	1.771GlyHis: 1.771 ± 0.039	4.628GlyIle: 4.628 ± 0.085	3.228GlyLys: 3.228 ± 0.054	8.666GlyLeu: 8.666 ± 0.093	2.214GlyMet: 2.214 ± 0.048	2.334GlyAsn: 2.334 ± 0.062	2.973GlyPro: 2.973 ± 0.052	2.974GlyGln: 2.974 ± 0.048	4.822GlyArg: 4.822 ± 0.06	4.748GlySer: 4.748 ± 0.086	4.647GlyThr: 4.647 ± 0.085	6.15GlyVal: 6.15 ± 0.079	1.126GlyTrp: 1.126 ± 0.034	2.458GlyTyr: 2.458 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	1.928HisAla: 1.928 ± 0.046	0.235HisCys: 0.235 ± 0.015	1.205HisAsp: 1.205 ± 0.036	1.243HisGlu: 1.243 ± 0.034	0.878HisPhe: 0.878 ± 0.026	1.825HisGly: 1.825 ± 0.044	0.593HisHis: 0.593 ± 0.03	1.048HisIle: 1.048 ± 0.033	0.745HisLys: 0.745 ± 0.027	2.284HisLeu: 2.284 ± 0.053	0.56HisMet: 0.56 ± 0.023	0.535HisAsn: 0.535 ± 0.022	1.267HisPro: 1.267 ± 0.034	0.736HisGln: 0.736 ± 0.024	1.23HisArg: 1.23 ± 0.031	1.094HisSer: 1.094 ± 0.035	0.997HisThr: 0.997 ± 0.026	1.476HisVal: 1.476 ± 0.031	0.304HisTrp: 0.304 ± 0.018	0.608HisTyr: 0.608 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	6.601IleAla: 6.601 ± 0.07	0.617IleCys: 0.617 ± 0.024	3.371IleAsp: 3.371 ± 0.055	3.769IleGlu: 3.769 ± 0.058	1.856IlePhe: 1.856 ± 0.047	4.86IleGly: 4.86 ± 0.077	0.966IleHis: 0.966 ± 0.027	2.567IleIle: 2.567 ± 0.049	1.95IleLys: 1.95 ± 0.041	5.008IleLeu: 5.008 ± 0.079	1.253IleMet: 1.253 ± 0.033	1.773IleAsn: 1.773 ± 0.043	2.323IlePro: 2.323 ± 0.047	1.494IleGln: 1.494 ± 0.034	2.968IleArg: 2.968 ± 0.051	3.579IleSer: 3.579 ± 0.064	3.086IleThr: 3.086 ± 0.059	3.984IleVal: 3.984 ± 0.062	0.651IleTrp: 0.651 ± 0.024	1.337IleTyr: 1.337 ± 0.035	0.0IleXaa: 0.0 ± 0.0
Lys	4.626LysAla: 4.626 ± 0.077	0.236LysCys: 0.236 ± 0.013	2.214LysAsp: 2.214 ± 0.045	2.331LysGlu: 2.331 ± 0.043	1.02LysPhe: 1.02 ± 0.031	2.951LysGly: 2.951 ± 0.051	0.766LysHis: 0.766 ± 0.025	2.032LysIle: 2.032 ± 0.046	1.678LysLys: 1.678 ± 0.043	3.72LysLeu: 3.72 ± 0.053	0.925LysMet: 0.925 ± 0.024	1.199LysAsn: 1.199 ± 0.033	2.196LysPro: 2.196 ± 0.047	1.499LysGln: 1.499 ± 0.039	2.613LysArg: 2.613 ± 0.05	2.078LysSer: 2.078 ± 0.049	2.411LysThr: 2.411 ± 0.042	2.901LysVal: 2.901 ± 0.058	0.436LysTrp: 0.436 ± 0.018	0.73LysTyr: 0.73 ± 0.028	0.0LysXaa: 0.0 ± 0.0
Leu	11.568LeuAla: 11.568 ± 0.125	1.034LeuCys: 1.034 ± 0.031	5.938LeuAsp: 5.938 ± 0.069	6.379LeuGlu: 6.379 ± 0.089	3.849LeuPhe: 3.849 ± 0.067	7.828LeuGly: 7.828 ± 0.104	1.924LeuHis: 1.924 ± 0.045	5.298LeuIle: 5.298 ± 0.072	4.551LeuLys: 4.551 ± 0.066	9.163LeuLeu: 9.163 ± 0.106	2.696LeuMet: 2.696 ± 0.052	3.25LeuAsn: 3.25 ± 0.056	5.298LeuPro: 5.298 ± 0.074	3.406LeuGln: 3.406 ± 0.052	5.88LeuArg: 5.88 ± 0.081	7.251LeuSer: 7.251 ± 0.086	5.813LeuThr: 5.813 ± 0.084	7.487LeuVal: 7.487 ± 0.086	1.11LeuTrp: 1.11 ± 0.034	2.228LeuTyr: 2.228 ± 0.048	0.0LeuXaa: 0.0 ± 0.0
Met	3.092MetAla: 3.092 ± 0.057	0.185MetCys: 0.185 ± 0.012	1.41MetAsp: 1.41 ± 0.033	1.454MetGlu: 1.454 ± 0.036	0.781MetPhe: 0.781 ± 0.027	2.017MetGly: 2.017 ± 0.043	0.463MetHis: 0.463 ± 0.019	1.408MetIle: 1.408 ± 0.041	1.181MetLys: 1.181 ± 0.036	2.469MetLeu: 2.469 ± 0.046	0.764MetMet: 0.764 ± 0.029	0.903MetAsn: 0.903 ± 0.028	1.411MetPro: 1.411 ± 0.035	0.914MetGln: 0.914 ± 0.029	1.675MetArg: 1.675 ± 0.039	1.849MetSer: 1.849 ± 0.038	1.872MetThr: 1.872 ± 0.042	1.941MetVal: 1.941 ± 0.041	0.239MetTrp: 0.239 ± 0.015	0.393MetTyr: 0.393 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.491AsnAla: 3.491 ± 0.052	0.288AsnCys: 0.288 ± 0.016	1.669AsnAsp: 1.669 ± 0.047	1.712AsnGlu: 1.712 ± 0.041	1.067AsnPhe: 1.067 ± 0.035	2.728AsnGly: 2.728 ± 0.06	0.605AsnHis: 0.605 ± 0.023	1.564AsnIle: 1.564 ± 0.041	1.084AsnLys: 1.084 ± 0.029	3.003AsnLeu: 3.003 ± 0.05	0.77AsnMet: 0.77 ± 0.025	1.0AsnAsn: 1.0 ± 0.033	1.999AsnPro: 1.999 ± 0.04	1.067AsnGln: 1.067 ± 0.032	1.917AsnArg: 1.917 ± 0.038	1.595AsnSer: 1.595 ± 0.035	1.643AsnThr: 1.643 ± 0.035	2.126AsnVal: 2.126 ± 0.041	0.487AsnTrp: 0.487 ± 0.019	0.806AsnTyr: 0.806 ± 0.03	0.0AsnXaa: 0.0 ± 0.0
Pro	4.658ProAla: 4.658 ± 0.069	0.32ProCys: 0.32 ± 0.015	3.203ProAsp: 3.203 ± 0.057	4.029ProGlu: 4.029 ± 0.062	2.027ProPhe: 2.027 ± 0.042	3.515ProGly: 3.515 ± 0.062	1.038ProHis: 1.038 ± 0.03	2.365ProIle: 2.365 ± 0.047	1.853ProLys: 1.853 ± 0.039	4.535ProLeu: 4.535 ± 0.068	1.108ProMet: 1.108 ± 0.029	1.417ProAsn: 1.417 ± 0.037	1.801ProPro: 1.801 ± 0.041	1.831ProGln: 1.831 ± 0.039	2.37ProArg: 2.37 ± 0.046	2.804ProSer: 2.804 ± 0.059	2.477ProThr: 2.477 ± 0.048	4.061ProVal: 4.061 ± 0.056	0.558ProTrp: 0.558 ± 0.021	1.196ProTyr: 1.196 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	4.117GlnAla: 4.117 ± 0.063	0.252GlnCys: 0.252 ± 0.014	1.874GlnAsp: 1.874 ± 0.04	2.211GlnGlu: 2.211 ± 0.047	1.331GlnPhe: 1.331 ± 0.033	2.596GlnGly: 2.596 ± 0.047	0.818GlnHis: 0.818 ± 0.026	2.146GlnIle: 2.146 ± 0.037	1.425GlnLys: 1.425 ± 0.038	3.452GlnLeu: 3.452 ± 0.06	1.059GlnMet: 1.059 ± 0.029	1.19GlnAsn: 1.19 ± 0.033	1.702GlnPro: 1.702 ± 0.043	1.552GlnGln: 1.552 ± 0.046	2.47GlnArg: 2.47 ± 0.052	2.14GlnSer: 2.14 ± 0.047	2.139GlnThr: 2.139 ± 0.051	2.603GlnVal: 2.603 ± 0.047	0.424GlnTrp: 0.424 ± 0.017	0.712GlnTyr: 0.712 ± 0.025	0.0GlnXaa: 0.0 ± 0.0
Arg	6.047ArgAla: 6.047 ± 0.09	0.489ArgCys: 0.489 ± 0.021	3.358ArgAsp: 3.358 ± 0.06	3.744ArgGlu: 3.744 ± 0.06	2.746ArgPhe: 2.746 ± 0.05	3.933ArgGly: 3.933 ± 0.062	1.419ArgHis: 1.419 ± 0.042	3.546ArgIle: 3.546 ± 0.06	2.477ArgLys: 2.477 ± 0.047	6.714ArgLeu: 6.714 ± 0.095	1.662ArgMet: 1.662 ± 0.04	1.833ArgAsn: 1.833 ± 0.04	2.718ArgPro: 2.718 ± 0.051	2.45ArgGln: 2.45 ± 0.052	4.207ArgArg: 4.207 ± 0.078	3.352ArgSer: 3.352 ± 0.06	3.095ArgThr: 3.095 ± 0.049	4.313ArgVal: 4.313 ± 0.065	0.754ArgTrp: 0.754 ± 0.026	1.595ArgTyr: 1.595 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	6.175SerAla: 6.175 ± 0.089	0.475SerCys: 0.475 ± 0.02	3.265SerAsp: 3.265 ± 0.061	3.689SerGlu: 3.689 ± 0.062	2.598SerPhe: 2.598 ± 0.048	5.635SerGly: 5.635 ± 0.084	1.22SerHis: 1.22 ± 0.036	3.208SerIle: 3.208 ± 0.058	2.027SerLys: 2.027 ± 0.043	5.898SerLeu: 5.898 ± 0.077	1.539SerMet: 1.539 ± 0.031	1.66SerAsn: 1.66 ± 0.044	2.532SerPro: 2.532 ± 0.047	2.162SerGln: 2.162 ± 0.043	3.284SerArg: 3.284 ± 0.056	3.53SerSer: 3.53 ± 0.067	2.94SerThr: 2.94 ± 0.058	4.415SerVal: 4.415 ± 0.073	0.719SerTrp: 0.719 ± 0.031	1.497SerTyr: 1.497 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	5.967ThrAla: 5.967 ± 0.079	0.515ThrCys: 0.515 ± 0.02	2.935ThrAsp: 2.935 ± 0.056	3.062ThrGlu: 3.062 ± 0.062	2.148ThrPhe: 2.148 ± 0.045	4.91ThrGly: 4.91 ± 0.078	1.148ThrHis: 1.148 ± 0.032	3.035ThrIle: 3.035 ± 0.057	1.82ThrLys: 1.82 ± 0.039	6.095ThrLeu: 6.095 ± 0.076	1.294ThrMet: 1.294 ± 0.035	1.631ThrAsn: 1.631 ± 0.045	3.118ThrPro: 3.118 ± 0.059	1.916ThrGln: 1.916 ± 0.042	3.1ThrArg: 3.1 ± 0.052	3.335ThrSer: 3.335 ± 0.068	3.159ThrThr: 3.159 ± 0.072	4.293ThrVal: 4.293 ± 0.084	0.626ThrTrp: 0.626 ± 0.024	1.414ThrTyr: 1.414 ± 0.038	0.0ThrXaa: 0.0 ± 0.0
Val	7.996ValAla: 7.996 ± 0.082	0.76ValCys: 0.76 ± 0.028	4.398ValAsp: 4.398 ± 0.077	4.719ValGlu: 4.719 ± 0.062	3.095ValPhe: 3.095 ± 0.055	5.551ValGly: 5.551 ± 0.075	1.437ValHis: 1.437 ± 0.038	4.146ValIle: 4.146 ± 0.062	2.605ValLys: 2.605 ± 0.052	7.691ValLeu: 7.691 ± 0.099	2.021ValMet: 2.021 ± 0.044	2.262ValAsn: 2.262 ± 0.049	3.707ValPro: 3.707 ± 0.056	2.266ValGln: 2.266 ± 0.043	4.188ValArg: 4.188 ± 0.063	4.884ValSer: 4.884 ± 0.07	4.304ValThr: 4.304 ± 0.086	6.019ValVal: 6.019 ± 0.08	0.865ValTrp: 0.865 ± 0.027	1.716ValTyr: 1.716 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	1.116TrpAla: 1.116 ± 0.033	0.125TrpCys: 0.125 ± 0.01	0.624TrpAsp: 0.624 ± 0.027	0.588TrpGlu: 0.588 ± 0.021	0.537TrpPhe: 0.537 ± 0.02	0.88TrpGly: 0.88 ± 0.026	0.297TrpHis: 0.297 ± 0.014	0.628TrpIle: 0.628 ± 0.024	0.421TrpLys: 0.421 ± 0.019	1.407TrpLeu: 1.407 ± 0.04	0.356TrpMet: 0.356 ± 0.018	0.413TrpAsn: 0.413 ± 0.018	0.59TrpPro: 0.59 ± 0.024	0.62TrpGln: 0.62 ± 0.027	0.858TrpArg: 0.858 ± 0.027	0.744TrpSer: 0.744 ± 0.022	0.622TrpThr: 0.622 ± 0.022	0.86TrpVal: 0.86 ± 0.028	0.196TrpTrp: 0.196 ± 0.013	0.287TrpTyr: 0.287 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.386TyrAla: 2.386 ± 0.048	0.268TyrCys: 0.268 ± 0.015	1.517TyrAsp: 1.517 ± 0.041	1.546TyrGlu: 1.546 ± 0.036	1.01TyrPhe: 1.01 ± 0.034	2.16TyrGly: 2.16 ± 0.049	0.565TyrHis: 0.565 ± 0.022	1.138TyrIle: 1.138 ± 0.034	0.877TyrLys: 0.877 ± 0.029	2.595TyrLeu: 2.595 ± 0.048	0.578TyrMet: 0.578 ± 0.022	0.769TyrAsn: 0.769 ± 0.025	1.143TyrPro: 1.143 ± 0.029	0.856TyrGln: 0.856 ± 0.027	1.615TyrArg: 1.615 ± 0.033	1.374TyrSer: 1.374 ± 0.035	1.301TyrThr: 1.301 ± 0.033	1.653TyrVal: 1.653 ± 0.033	0.356TyrTrp: 0.356 ± 0.02	0.712TyrTyr: 0.712 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3634 proteins (1186005 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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