Amino acid dipepetide frequency for Desulfacinum hydrothermale DSM 13146

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.624AlaAla: 10.624 ± 0.134	1.425AlaCys: 1.425 ± 0.043	4.538AlaAsp: 4.538 ± 0.066	5.356AlaGlu: 5.356 ± 0.073	3.903AlaPhe: 3.903 ± 0.069	7.702AlaGly: 7.702 ± 0.102	2.325AlaHis: 2.325 ± 0.054	4.124AlaIle: 4.124 ± 0.073	3.438AlaLys: 3.438 ± 0.058	11.523AlaLeu: 11.523 ± 0.12	2.691AlaMet: 2.691 ± 0.052	1.875AlaAsn: 1.875 ± 0.04	4.067AlaPro: 4.067 ± 0.072	3.965AlaGln: 3.965 ± 0.066	7.436AlaArg: 7.436 ± 0.098	4.802AlaSer: 4.802 ± 0.071	3.851AlaThr: 3.851 ± 0.067	8.594AlaVal: 8.594 ± 0.104	1.285AlaTrp: 1.285 ± 0.041	2.548AlaTyr: 2.548 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	1.228CysAla: 1.228 ± 0.036	0.273CysCys: 0.273 ± 0.018	0.629CysAsp: 0.629 ± 0.028	0.613CysGlu: 0.613 ± 0.025	0.47CysPhe: 0.47 ± 0.02	1.435CysGly: 1.435 ± 0.046	0.447CysHis: 0.447 ± 0.03	0.523CysIle: 0.523 ± 0.019	0.316CysLys: 0.316 ± 0.018	1.409CysLeu: 1.409 ± 0.037	0.267CysMet: 0.267 ± 0.015	0.283CysAsn: 0.283 ± 0.016	0.986CysPro: 0.986 ± 0.034	0.455CysGln: 0.455 ± 0.023	1.333CysArg: 1.333 ± 0.035	0.745CysSer: 0.745 ± 0.032	0.599CysThr: 0.599 ± 0.025	0.936CysVal: 0.936 ± 0.032	0.179CysTrp: 0.179 ± 0.014	0.344CysTyr: 0.344 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	4.659AspAla: 4.659 ± 0.062	0.587AspCys: 0.587 ± 0.025	2.333AspAsp: 2.333 ± 0.058	3.325AspGlu: 3.325 ± 0.051	2.298AspPhe: 2.298 ± 0.047	4.006AspGly: 4.006 ± 0.064	1.302AspHis: 1.302 ± 0.033	2.419AspIle: 2.419 ± 0.045	1.774AspLys: 1.774 ± 0.044	6.635AspLeu: 6.635 ± 0.091	1.234AspMet: 1.234 ± 0.03	0.982AspAsn: 0.982 ± 0.036	4.064AspPro: 4.064 ± 0.068	1.833AspGln: 1.833 ± 0.044	4.436AspArg: 4.436 ± 0.071	1.95AspSer: 1.95 ± 0.046	2.159AspThr: 2.159 ± 0.044	4.009AspVal: 4.009 ± 0.06	0.79AspTrp: 0.79 ± 0.027	1.599AspTyr: 1.599 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	7.594GluAla: 7.594 ± 0.096	0.631GluCys: 0.631 ± 0.023	3.602GluAsp: 3.602 ± 0.062	5.548GluGlu: 5.548 ± 0.095	1.577GluPhe: 1.577 ± 0.038	4.885GluGly: 4.885 ± 0.073	1.348GluHis: 1.348 ± 0.035	3.61GluIle: 3.61 ± 0.065	4.083GluLys: 4.083 ± 0.078	6.205GluLeu: 6.205 ± 0.092	1.772GluMet: 1.772 ± 0.038	1.795GluAsn: 1.795 ± 0.045	2.94GluPro: 2.94 ± 0.057	2.169GluGln: 2.169 ± 0.046	5.868GluArg: 5.868 ± 0.088	3.153GluSer: 3.153 ± 0.063	3.477GluThr: 3.477 ± 0.057	4.712GluVal: 4.712 ± 0.07	0.701GluTrp: 0.701 ± 0.026	1.32GluTyr: 1.32 ± 0.04	0.0GluXaa: 0.0 ± 0.0
Phe	3.076PheAla: 3.076 ± 0.056	0.589PheCys: 0.589 ± 0.024	2.027PheAsp: 2.027 ± 0.042	1.902PheGlu: 1.902 ± 0.041	1.995PhePhe: 1.995 ± 0.055	2.912PheGly: 2.912 ± 0.053	1.098PheHis: 1.098 ± 0.036	1.58PheIle: 1.58 ± 0.038	1.146PheLys: 1.146 ± 0.031	4.449PheLeu: 4.449 ± 0.081	0.844PheMet: 0.844 ± 0.028	0.895PheAsn: 0.895 ± 0.029	2.005PhePro: 2.005 ± 0.047	1.78PheGln: 1.78 ± 0.041	2.878PheArg: 2.878 ± 0.059	2.414PheSer: 2.414 ± 0.055	1.764PheThr: 1.764 ± 0.041	2.878PheVal: 2.878 ± 0.063	0.634PheTrp: 0.634 ± 0.029	1.183PheTyr: 1.183 ± 0.036	0.0PheXaa: 0.0 ± 0.0
Gly	7.077GlyAla: 7.077 ± 0.108	1.271GlyCys: 1.271 ± 0.041	3.725GlyAsp: 3.725 ± 0.062	4.351GlyGlu: 4.351 ± 0.071	3.147GlyPhe: 3.147 ± 0.062	5.854GlyGly: 5.854 ± 0.08	1.85GlyHis: 1.85 ± 0.044	4.597GlyIle: 4.597 ± 0.077	3.685GlyLys: 3.685 ± 0.066	8.462GlyLeu: 8.462 ± 0.079	2.131GlyMet: 2.131 ± 0.046	1.869GlyAsn: 1.869 ± 0.048	3.597GlyPro: 3.597 ± 0.068	2.488GlyGln: 2.488 ± 0.05	6.397GlyArg: 6.397 ± 0.091	4.233GlySer: 4.233 ± 0.073	4.382GlyThr: 4.382 ± 0.066	6.043GlyVal: 6.043 ± 0.09	1.229GlyTrp: 1.229 ± 0.039	2.396GlyTyr: 2.396 ± 0.045	0.0GlyXaa: 0.0 ± 0.0
His	1.951HisAla: 1.951 ± 0.047	0.366HisCys: 0.366 ± 0.018	1.001HisAsp: 1.001 ± 0.029	1.323HisGlu: 1.323 ± 0.032	1.067HisPhe: 1.067 ± 0.032	2.041HisGly: 2.041 ± 0.044	0.691HisHis: 0.691 ± 0.027	1.152HisIle: 1.152 ± 0.038	0.853HisLys: 0.853 ± 0.03	2.876HisLeu: 2.876 ± 0.056	0.562HisMet: 0.562 ± 0.026	0.588HisAsn: 0.588 ± 0.023	1.747HisPro: 1.747 ± 0.041	0.898HisGln: 0.898 ± 0.029	2.005HisArg: 2.005 ± 0.046	1.03HisSer: 1.03 ± 0.031	1.033HisThr: 1.033 ± 0.03	1.926HisVal: 1.926 ± 0.044	0.371HisTrp: 0.371 ± 0.018	0.759HisTyr: 0.759 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	4.266IleAla: 4.266 ± 0.064	0.65IleCys: 0.65 ± 0.025	2.246IleAsp: 2.246 ± 0.044	2.655IleGlu: 2.655 ± 0.058	2.024IlePhe: 2.024 ± 0.044	3.447IleGly: 3.447 ± 0.063	1.449IleHis: 1.449 ± 0.039	2.075IleIle: 2.075 ± 0.058	1.713IleLys: 1.713 ± 0.043	5.886IleLeu: 5.886 ± 0.09	0.982IleMet: 0.982 ± 0.034	1.348IleAsn: 1.348 ± 0.041	2.947IlePro: 2.947 ± 0.046	2.178IleGln: 2.178 ± 0.046	4.13IleArg: 4.13 ± 0.066	2.46IleSer: 2.46 ± 0.057	2.409IleThr: 2.409 ± 0.051	3.629IleVal: 3.629 ± 0.061	0.493IleTrp: 0.493 ± 0.022	1.399IleTyr: 1.399 ± 0.034	0.0IleXaa: 0.0 ± 0.0
Lys	4.492LysAla: 4.492 ± 0.067	0.372LysCys: 0.372 ± 0.022	2.468LysAsp: 2.468 ± 0.055	3.566LysGlu: 3.566 ± 0.07	0.896LysPhe: 0.896 ± 0.03	3.238LysGly: 3.238 ± 0.056	0.751LysHis: 0.751 ± 0.029	2.379LysIle: 2.379 ± 0.048	2.572LysLys: 2.572 ± 0.058	3.225LysLeu: 3.225 ± 0.054	1.038LysMet: 1.038 ± 0.034	1.129LysAsn: 1.129 ± 0.034	1.949LysPro: 1.949 ± 0.041	1.101LysGln: 1.101 ± 0.034	3.102LysArg: 3.102 ± 0.06	1.786LysSer: 1.786 ± 0.045	2.358LysThr: 2.358 ± 0.051	3.26LysVal: 3.26 ± 0.061	0.434LysTrp: 0.434 ± 0.021	0.897LysTyr: 0.897 ± 0.033	0.0LysXaa: 0.0 ± 0.0
Leu	10.98LeuAla: 10.98 ± 0.114	1.511LeuCys: 1.511 ± 0.04	6.525LeuAsp: 6.525 ± 0.071	8.769LeuGlu: 8.769 ± 0.09	4.105LeuPhe: 4.105 ± 0.084	8.734LeuGly: 8.734 ± 0.096	2.429LeuHis: 2.429 ± 0.041	4.507LeuIle: 4.507 ± 0.073	4.688LeuLys: 4.688 ± 0.074	11.024LeuLeu: 11.024 ± 0.128	2.375LeuMet: 2.375 ± 0.052	2.657LeuAsn: 2.657 ± 0.05	5.39LeuPro: 5.39 ± 0.069	4.011LeuGln: 4.011 ± 0.062	7.544LeuArg: 7.544 ± 0.084	6.237LeuSer: 6.237 ± 0.079	4.829LeuThr: 4.829 ± 0.069	8.367LeuVal: 8.367 ± 0.096	1.366LeuTrp: 1.366 ± 0.043	2.574LeuTyr: 2.574 ± 0.052	0.0LeuXaa: 0.0 ± 0.0
Met	2.966MetAla: 2.966 ± 0.055	0.194MetCys: 0.194 ± 0.012	1.667MetAsp: 1.667 ± 0.039	2.143MetGlu: 2.143 ± 0.048	0.53MetPhe: 0.53 ± 0.021	2.229MetGly: 2.229 ± 0.048	0.394MetHis: 0.394 ± 0.018	1.152MetIle: 1.152 ± 0.04	1.254MetLys: 1.254 ± 0.029	1.939MetLeu: 1.939 ± 0.042	0.556MetMet: 0.556 ± 0.024	0.764MetAsn: 0.764 ± 0.025	1.107MetPro: 1.107 ± 0.031	0.693MetGln: 0.693 ± 0.027	1.508MetArg: 1.508 ± 0.038	1.163MetSer: 1.163 ± 0.034	1.271MetThr: 1.271 ± 0.035	1.927MetVal: 1.927 ± 0.042	0.182MetTrp: 0.182 ± 0.014	0.311MetTyr: 0.311 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	2.184AsnAla: 2.184 ± 0.047	0.303AsnCys: 0.303 ± 0.017	1.044AsnAsp: 1.044 ± 0.03	1.24AsnGlu: 1.24 ± 0.036	0.868AsnPhe: 0.868 ± 0.03	1.928AsnGly: 1.928 ± 0.044	0.537AsnHis: 0.537 ± 0.024	1.273AsnIle: 1.273 ± 0.043	0.828AsnLys: 0.828 ± 0.032	2.869AsnLeu: 2.869 ± 0.054	0.551AsnMet: 0.551 ± 0.024	0.592AsnAsn: 0.592 ± 0.025	1.941AsnPro: 1.941 ± 0.039	0.771AsnGln: 0.771 ± 0.024	1.951AsnArg: 1.951 ± 0.046	0.893AsnSer: 0.893 ± 0.032	1.142AsnThr: 1.142 ± 0.037	1.982AsnVal: 1.982 ± 0.049	0.312AsnTrp: 0.312 ± 0.017	0.658AsnTyr: 0.658 ± 0.026	0.0AsnXaa: 0.0 ± 0.0
Pro	4.594ProAla: 4.594 ± 0.081	0.641ProCys: 0.641 ± 0.025	3.269ProAsp: 3.269 ± 0.061	4.45ProGlu: 4.45 ± 0.066	2.151ProPhe: 2.151 ± 0.047	4.341ProGly: 4.341 ± 0.066	1.499ProHis: 1.499 ± 0.039	2.168ProIle: 2.168 ± 0.046	2.026ProLys: 2.026 ± 0.046	5.153ProLeu: 5.153 ± 0.074	1.265ProMet: 1.265 ± 0.036	1.236ProAsn: 1.236 ± 0.037	2.844ProPro: 2.844 ± 0.067	2.045ProGln: 2.045 ± 0.042	3.22ProArg: 3.22 ± 0.056	2.864ProSer: 2.864 ± 0.059	2.37ProThr: 2.37 ± 0.055	4.537ProVal: 4.537 ± 0.074	0.875ProTrp: 0.875 ± 0.03	1.401ProTyr: 1.401 ± 0.043	0.0ProXaa: 0.0 ± 0.0
Gln	4.278GlnAla: 4.278 ± 0.067	0.47GlnCys: 0.47 ± 0.022	1.998GlnAsp: 1.998 ± 0.044	3.048GlnGlu: 3.048 ± 0.056	0.906GlnPhe: 0.906 ± 0.028	3.025GlnGly: 3.025 ± 0.058	0.626GlnHis: 0.626 ± 0.025	1.836GlnIle: 1.836 ± 0.044	1.874GlnLys: 1.874 ± 0.044	3.005GlnLeu: 3.005 ± 0.054	0.918GlnMet: 0.918 ± 0.03	0.879GlnAsn: 0.879 ± 0.034	1.479GlnPro: 1.479 ± 0.039	1.238GlnGln: 1.238 ± 0.038	2.831GlnArg: 2.831 ± 0.057	1.631GlnSer: 1.631 ± 0.04	1.536GlnThr: 1.536 ± 0.037	3.374GlnVal: 3.374 ± 0.063	0.649GlnTrp: 0.649 ± 0.026	0.676GlnTyr: 0.676 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	6.341ArgAla: 6.341 ± 0.086	1.114ArgCys: 1.114 ± 0.039	3.934ArgAsp: 3.934 ± 0.065	5.255ArgGlu: 5.255 ± 0.086	3.311ArgPhe: 3.311 ± 0.059	4.581ArgGly: 4.581 ± 0.069	2.041ArgHis: 2.041 ± 0.048	4.549ArgIle: 4.549 ± 0.069	3.465ArgLys: 3.465 ± 0.066	9.369ArgLeu: 9.369 ± 0.107	1.88ArgMet: 1.88 ± 0.044	1.91ArgAsn: 1.91 ± 0.046	3.858ArgPro: 3.858 ± 0.07	2.85ArgGln: 2.85 ± 0.065	6.952ArgArg: 6.952 ± 0.114	3.944ArgSer: 3.944 ± 0.06	3.444ArgThr: 3.444 ± 0.063	5.815ArgVal: 5.815 ± 0.079	1.286ArgTrp: 1.286 ± 0.042	2.206ArgTyr: 2.206 ± 0.05	0.0ArgXaa: 0.0 ± 0.0
Ser	4.447SerAla: 4.447 ± 0.066	0.653SerCys: 0.653 ± 0.026	2.382SerAsp: 2.382 ± 0.049	2.773SerGlu: 2.773 ± 0.051	2.204SerPhe: 2.204 ± 0.047	4.603SerGly: 4.603 ± 0.084	1.341SerHis: 1.341 ± 0.037	2.385SerIle: 2.385 ± 0.051	1.663SerLys: 1.663 ± 0.035	5.956SerLeu: 5.956 ± 0.075	1.33SerMet: 1.33 ± 0.037	1.062SerAsn: 1.062 ± 0.037	3.046SerPro: 3.046 ± 0.061	1.872SerGln: 1.872 ± 0.046	3.965SerArg: 3.965 ± 0.07	2.649SerSer: 2.649 ± 0.056	2.221SerThr: 2.221 ± 0.044	3.778SerVal: 3.778 ± 0.059	0.778SerTrp: 0.778 ± 0.028	1.271SerTyr: 1.271 ± 0.041	0.0SerXaa: 0.0 ± 0.0
Thr	4.638ThrAla: 4.638 ± 0.07	0.66ThrCys: 0.66 ± 0.029	2.332ThrAsp: 2.332 ± 0.049	2.522ThrGlu: 2.522 ± 0.051	1.894ThrPhe: 1.894 ± 0.038	4.407ThrGly: 4.407 ± 0.06	1.16ThrHis: 1.16 ± 0.028	2.384ThrIle: 2.384 ± 0.054	1.45ThrLys: 1.45 ± 0.038	5.262ThrLeu: 5.262 ± 0.081	0.991ThrMet: 0.991 ± 0.036	1.059ThrAsn: 1.059 ± 0.034	2.768ThrPro: 2.768 ± 0.053	1.522ThrGln: 1.522 ± 0.04	3.085ThrArg: 3.085 ± 0.049	2.229ThrSer: 2.229 ± 0.052	2.351ThrThr: 2.351 ± 0.051	4.061ThrVal: 4.061 ± 0.06	0.611ThrTrp: 0.611 ± 0.025	1.311ThrTyr: 1.311 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	7.338ValAla: 7.338 ± 0.098	1.19ValCys: 1.19 ± 0.034	4.512ValAsp: 4.512 ± 0.065	5.636ValGlu: 5.636 ± 0.08	3.1ValPhe: 3.1 ± 0.053	6.065ValGly: 6.065 ± 0.088	1.939ValHis: 1.939 ± 0.048	3.831ValIle: 3.831 ± 0.057	2.653ValLys: 2.653 ± 0.056	9.11ValLeu: 9.11 ± 0.106	1.666ValMet: 1.666 ± 0.041	1.802ValAsn: 1.802 ± 0.041	4.208ValPro: 4.208 ± 0.065	2.93ValGln: 2.93 ± 0.053	6.045ValArg: 6.045 ± 0.075	4.404ValSer: 4.404 ± 0.063	3.771ValThr: 3.771 ± 0.058	7.377ValVal: 7.377 ± 0.117	0.921ValTrp: 0.921 ± 0.03	1.773ValTyr: 1.773 ± 0.049	0.0ValXaa: 0.0 ± 0.0
Trp	1.215TrpAla: 1.215 ± 0.038	0.178TrpCys: 0.178 ± 0.014	0.743TrpAsp: 0.743 ± 0.025	0.927TrpGlu: 0.927 ± 0.031	0.47TrpPhe: 0.47 ± 0.021	1.02TrpGly: 1.02 ± 0.038	0.309TrpHis: 0.309 ± 0.016	0.865TrpIle: 0.865 ± 0.032	0.717TrpLys: 0.717 ± 0.03	1.361TrpLeu: 1.361 ± 0.042	0.382TrpMet: 0.382 ± 0.019	0.475TrpAsn: 0.475 ± 0.022	0.596TrpPro: 0.596 ± 0.026	0.496TrpGln: 0.496 ± 0.025	1.01TrpArg: 1.01 ± 0.034	0.634TrpSer: 0.634 ± 0.028	0.655TrpThr: 0.655 ± 0.022	1.12TrpVal: 1.12 ± 0.035	0.216TrpTrp: 0.216 ± 0.014	0.303TrpTyr: 0.303 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.123TyrAla: 2.123 ± 0.044	0.399TyrCys: 0.399 ± 0.02	1.419TyrAsp: 1.419 ± 0.043	1.59TyrGlu: 1.59 ± 0.045	1.131TyrPhe: 1.131 ± 0.035	2.331TyrGly: 2.331 ± 0.049	0.704TyrHis: 0.704 ± 0.028	0.978TyrIle: 0.978 ± 0.035	0.816TyrLys: 0.816 ± 0.03	2.904TyrLeu: 2.904 ± 0.063	0.514TyrMet: 0.514 ± 0.02	0.667TyrAsn: 0.667 ± 0.029	1.409TyrPro: 1.409 ± 0.04	0.98TyrGln: 0.98 ± 0.03	2.407TyrArg: 2.407 ± 0.049	1.155TyrSer: 1.155 ± 0.038	1.078TyrThr: 1.078 ± 0.036	1.945TyrVal: 1.945 ± 0.043	0.38TyrTrp: 0.38 ± 0.02	0.857TyrTyr: 0.857 ± 0.033	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3262 proteins (1058542 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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