Amino acid dipepetide frequency for Dongia mobilis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
20.324AlaAla: 20.324 ± 0.205
1.167AlaCys: 1.167 ± 0.029
7.443AlaAsp: 7.443 ± 0.092
8.52AlaGlu: 8.52 ± 0.11
4.435AlaPhe: 4.435 ± 0.065
11.997AlaGly: 11.997 ± 0.121
2.356AlaHis: 2.356 ± 0.05
7.101AlaIle: 7.101 ± 0.072
4.001AlaLys: 4.001 ± 0.072
13.954AlaLeu: 13.954 ± 0.141
3.607AlaMet: 3.607 ± 0.06
2.978AlaAsn: 2.978 ± 0.049
5.868AlaPro: 5.868 ± 0.088
4.341AlaGln: 4.341 ± 0.073
9.491AlaArg: 9.491 ± 0.104
5.493AlaSer: 5.493 ± 0.07
6.179AlaThr: 6.179 ± 0.076
8.487AlaVal: 8.487 ± 0.085
1.588AlaTrp: 1.588 ± 0.038
2.668AlaTyr: 2.668 ± 0.054
0.0AlaXaa: 0.0 ± 0.0
Cys
0.997CysAla: 0.997 ± 0.023
0.114CysCys: 0.114 ± 0.01
0.606CysAsp: 0.606 ± 0.024
0.379CysGlu: 0.379 ± 0.019
0.369CysPhe: 0.369 ± 0.018
1.012CysGly: 1.012 ± 0.03
0.265CysHis: 0.265 ± 0.014
0.409CysIle: 0.409 ± 0.018
0.182CysLys: 0.182 ± 0.012
0.924CysLeu: 0.924 ± 0.03
0.146CysMet: 0.146 ± 0.011
0.232CysAsn: 0.232 ± 0.012
0.443CysPro: 0.443 ± 0.023
0.267CysGln: 0.267 ± 0.014
0.744CysArg: 0.744 ± 0.025
0.447CysSer: 0.447 ± 0.019
0.388CysThr: 0.388 ± 0.019
0.575CysVal: 0.575 ± 0.02
0.129CysTrp: 0.129 ± 0.011
0.236CysTyr: 0.236 ± 0.012
0.0CysXaa: 0.0 ± 0.0
Asp
6.673AspAla: 6.673 ± 0.085
0.517AspCys: 0.517 ± 0.019
2.906AspAsp: 2.906 ± 0.075
3.114AspGlu: 3.114 ± 0.057
2.419AspPhe: 2.419 ± 0.047
5.248AspGly: 5.248 ± 0.105
1.205AspHis: 1.205 ± 0.036
3.208AspIle: 3.208 ± 0.051
1.62AspLys: 1.62 ± 0.042
6.712AspLeu: 6.712 ± 0.088
1.329AspMet: 1.329 ± 0.032
1.338AspAsn: 1.338 ± 0.036
3.566AspPro: 3.566 ± 0.055
1.9AspGln: 1.9 ± 0.043
4.213AspArg: 4.213 ± 0.069
2.448AspSer: 2.448 ± 0.055
2.206AspThr: 2.206 ± 0.074
3.716AspVal: 3.716 ± 0.055
1.082AspTrp: 1.082 ± 0.029
1.411AspTyr: 1.411 ± 0.037
0.0AspXaa: 0.0 ± 0.0
Glu
7.451GluAla: 7.451 ± 0.092
0.363GluCys: 0.363 ± 0.017
2.382GluAsp: 2.382 ± 0.048
2.951GluGlu: 2.951 ± 0.068
1.811GluPhe: 1.811 ± 0.036
3.986GluGly: 3.986 ± 0.067
1.027GluHis: 1.027 ± 0.03
4.092GluIle: 4.092 ± 0.063
2.236GluLys: 2.236 ± 0.053
5.681GluLeu: 5.681 ± 0.081
1.741GluMet: 1.741 ± 0.038
1.555GluAsn: 1.555 ± 0.038
2.577GluPro: 2.577 ± 0.053
1.996GluGln: 1.996 ± 0.046
4.615GluArg: 4.615 ± 0.066
2.498GluSer: 2.498 ± 0.048
3.016GluThr: 3.016 ± 0.053
3.866GluVal: 3.866 ± 0.062
0.63GluTrp: 0.63 ± 0.02
0.908GluTyr: 0.908 ± 0.032
0.0GluXaa: 0.0 ± 0.0
Phe
4.671PheAla: 4.671 ± 0.065
0.453PheCys: 0.453 ± 0.019
2.637PheAsp: 2.637 ± 0.049
1.931PheGlu: 1.931 ± 0.043
1.315PhePhe: 1.315 ± 0.037
3.644PheGly: 3.644 ± 0.064
0.765PheHis: 0.765 ± 0.023
1.682PheIle: 1.682 ± 0.041
1.002PheLys: 1.002 ± 0.034
3.529PheLeu: 3.529 ± 0.061
0.772PheMet: 0.772 ± 0.025
1.018PheAsn: 1.018 ± 0.026
1.6PhePro: 1.6 ± 0.04
1.081PheGln: 1.081 ± 0.031
2.213PheArg: 2.213 ± 0.049
1.898PheSer: 1.898 ± 0.043
1.962PheThr: 1.962 ± 0.04
2.701PheVal: 2.701 ± 0.053
0.61PheTrp: 0.61 ± 0.024
0.912PheTyr: 0.912 ± 0.029
0.0PheXaa: 0.0 ± 0.0
Gly
9.756GlyAla: 9.756 ± 0.097
0.938GlyCys: 0.938 ± 0.03
4.833GlyAsp: 4.833 ± 0.094
4.91GlyGlu: 4.91 ± 0.072
3.626GlyPhe: 3.626 ± 0.055
7.956GlyGly: 7.956 ± 0.13
1.976GlyHis: 1.976 ± 0.036
5.483GlyIle: 5.483 ± 0.059
3.34GlyLys: 3.34 ± 0.063
9.15GlyLeu: 9.15 ± 0.101
2.347GlyMet: 2.347 ± 0.047
2.506GlyAsn: 2.506 ± 0.097
3.584GlyPro: 3.584 ± 0.057
3.067GlyGln: 3.067 ± 0.056
6.575GlyArg: 6.575 ± 0.087
4.659GlySer: 4.659 ± 0.07
4.354GlyThr: 4.354 ± 0.077
5.537GlyVal: 5.537 ± 0.072
1.335GlyTrp: 1.335 ± 0.032
2.306GlyTyr: 2.306 ± 0.05
0.0GlyXaa: 0.0 ± 0.0
His
2.249HisAla: 2.249 ± 0.045
0.275HisCys: 0.275 ± 0.016
1.225HisAsp: 1.225 ± 0.032
1.025HisGlu: 1.025 ± 0.03
0.964HisPhe: 0.964 ± 0.031
1.939HisGly: 1.939 ± 0.042
0.623HisHis: 0.623 ± 0.024
0.915HisIle: 0.915 ± 0.026
0.485HisLys: 0.485 ± 0.018
2.417HisLeu: 2.417 ± 0.051
0.47HisMet: 0.47 ± 0.019
0.492HisAsn: 0.492 ± 0.022
1.36HisPro: 1.36 ± 0.037
0.641HisGln: 0.641 ± 0.026
1.529HisArg: 1.529 ± 0.039
0.832HisSer: 0.832 ± 0.028
0.67HisThr: 0.67 ± 0.024
1.565HisVal: 1.565 ± 0.039
0.363HisTrp: 0.363 ± 0.017
0.568HisTyr: 0.568 ± 0.023
0.0HisXaa: 0.0 ± 0.0
Ile
7.856IleAla: 7.856 ± 0.087
0.603IleCys: 0.603 ± 0.021
3.896IleAsp: 3.896 ± 0.063
3.624IleGlu: 3.624 ± 0.066
1.73IlePhe: 1.73 ± 0.038
5.5IleGly: 5.5 ± 0.078
0.965IleHis: 0.965 ± 0.029
2.369IleIle: 2.369 ± 0.05
1.374IleLys: 1.374 ± 0.038
5.052IleLeu: 5.052 ± 0.071
1.026IleMet: 1.026 ± 0.031
1.471IleAsn: 1.471 ± 0.033
2.268IlePro: 2.268 ± 0.034
1.289IleGln: 1.289 ± 0.032
3.366IleArg: 3.366 ± 0.05
2.665IleSer: 2.665 ± 0.052
2.537IleThr: 2.537 ± 0.05
4.208IleVal: 4.208 ± 0.067
0.645IleTrp: 0.645 ± 0.025
1.164IleTyr: 1.164 ± 0.033
0.0IleXaa: 0.0 ± 0.0
Lys
4.22LysAla: 4.22 ± 0.064
0.18LysCys: 0.18 ± 0.012
1.656LysAsp: 1.656 ± 0.048
1.654LysGlu: 1.654 ± 0.044
0.931LysPhe: 0.931 ± 0.029
2.681LysGly: 2.681 ± 0.053
0.571LysHis: 0.571 ± 0.021
1.632LysIle: 1.632 ± 0.042
1.328LysLys: 1.328 ± 0.044
3.281LysLeu: 3.281 ± 0.073
0.732LysMet: 0.732 ± 0.027
0.805LysAsn: 0.805 ± 0.026
1.921LysPro: 1.921 ± 0.036
1.049LysGln: 1.049 ± 0.03
2.223LysArg: 2.223 ± 0.045
1.81LysSer: 1.81 ± 0.032
1.582LysThr: 1.582 ± 0.04
2.42LysVal: 2.42 ± 0.049
0.339LysTrp: 0.339 ± 0.015
0.586LysTyr: 0.586 ± 0.023
0.0LysXaa: 0.0 ± 0.0
Leu
15.928LeuAla: 15.928 ± 0.145
0.918LeuCys: 0.918 ± 0.03
6.281LeuAsp: 6.281 ± 0.077
5.145LeuGlu: 5.145 ± 0.071
3.532LeuPhe: 3.532 ± 0.066
9.415LeuGly: 9.415 ± 0.11
1.909LeuHis: 1.909 ± 0.041
5.003LeuIle: 5.003 ± 0.066
3.818LeuLys: 3.818 ± 0.069
10.767LeuLeu: 10.767 ± 0.142
2.511LeuMet: 2.511 ± 0.046
2.578LeuAsn: 2.578 ± 0.053
6.316LeuPro: 6.316 ± 0.077
3.076LeuGln: 3.076 ± 0.052
7.066LeuArg: 7.066 ± 0.092
5.667LeuSer: 5.667 ± 0.075
5.314LeuThr: 5.314 ± 0.06
7.875LeuVal: 7.875 ± 0.093
1.242LeuTrp: 1.242 ± 0.035
2.148LeuTyr: 2.148 ± 0.044
0.0LeuXaa: 0.0 ± 0.0
Met
3.472MetAla: 3.472 ± 0.059
0.152MetCys: 0.152 ± 0.011
1.059MetAsp: 1.059 ± 0.03
1.069MetGlu: 1.069 ± 0.029
0.707MetPhe: 0.707 ± 0.025
1.909MetGly: 1.909 ± 0.041
0.433MetHis: 0.433 ± 0.016
1.238MetIle: 1.238 ± 0.035
0.967MetLys: 0.967 ± 0.029
2.564MetLeu: 2.564 ± 0.046
0.63MetMet: 0.63 ± 0.028
0.718MetAsn: 0.718 ± 0.023
1.515MetPro: 1.515 ± 0.031
0.878MetGln: 0.878 ± 0.029
1.784MetArg: 1.784 ± 0.042
1.697MetSer: 1.697 ± 0.037
1.697MetThr: 1.697 ± 0.038
1.765MetVal: 1.765 ± 0.038
0.214MetTrp: 0.214 ± 0.014
0.315MetTyr: 0.315 ± 0.016
0.0MetXaa: 0.0 ± 0.0
Asn
3.17AsnAla: 3.17 ± 0.056
0.271AsnCys: 0.271 ± 0.016
1.492AsnAsp: 1.492 ± 0.071
1.242AsnGlu: 1.242 ± 0.033
0.938AsnPhe: 0.938 ± 0.028
2.163AsnGly: 2.163 ± 0.052
0.472AsnHis: 0.472 ± 0.02
1.365AsnIle: 1.365 ± 0.04
0.651AsnLys: 0.651 ± 0.024
2.904AsnLeu: 2.904 ± 0.041
0.648AsnMet: 0.648 ± 0.022
0.662AsnAsn: 0.662 ± 0.033
1.807AsnPro: 1.807 ± 0.046
0.881AsnGln: 0.881 ± 0.027
1.811AsnArg: 1.811 ± 0.04
1.146AsnSer: 1.146 ± 0.031
1.093AsnThr: 1.093 ± 0.033
1.924AsnVal: 1.924 ± 0.042
0.455AsnTrp: 0.455 ± 0.021
0.643AsnTyr: 0.643 ± 0.024
0.0AsnXaa: 0.0 ± 0.0
Pro
7.189ProAla: 7.189 ± 0.097
0.335ProCys: 0.335 ± 0.015
3.514ProAsp: 3.514 ± 0.053
3.545ProGlu: 3.545 ± 0.065
2.006ProPhe: 2.006 ± 0.039
4.887ProGly: 4.887 ± 0.066
1.131ProHis: 1.131 ± 0.032
2.281ProIle: 2.281 ± 0.044
1.676ProLys: 1.676 ± 0.042
5.226ProLeu: 5.226 ± 0.077
1.187ProMet: 1.187 ± 0.031
1.294ProAsn: 1.294 ± 0.035
2.525ProPro: 2.525 ± 0.061
1.766ProGln: 1.766 ± 0.039
3.036ProArg: 3.036 ± 0.054
2.206ProSer: 2.206 ± 0.046
2.31ProThr: 2.31 ± 0.045
4.139ProVal: 4.139 ± 0.064
0.733ProTrp: 0.733 ± 0.024
1.209ProTyr: 1.209 ± 0.034
0.0ProXaa: 0.0 ± 0.0
Gln
4.53GlnAla: 4.53 ± 0.069
0.236GlnCys: 0.236 ± 0.015
1.462GlnAsp: 1.462 ± 0.031
1.628GlnGlu: 1.628 ± 0.047
1.077GlnPhe: 1.077 ± 0.031
2.56GlnGly: 2.56 ± 0.052
0.766GlnHis: 0.766 ± 0.028
1.861GlnIle: 1.861 ± 0.041
1.118GlnLys: 1.118 ± 0.034
3.236GlnLeu: 3.236 ± 0.063
0.953GlnMet: 0.953 ± 0.029
0.818GlnAsn: 0.818 ± 0.026
2.067GlnPro: 2.067 ± 0.045
1.45GlnGln: 1.45 ± 0.042
2.736GlnArg: 2.736 ± 0.055
1.779GlnSer: 1.779 ± 0.044
1.411GlnThr: 1.411 ± 0.038
2.448GlnVal: 2.448 ± 0.044
0.394GlnTrp: 0.394 ± 0.018
0.601GlnTyr: 0.601 ± 0.021
0.0GlnXaa: 0.0 ± 0.0
Arg
8.436ArgAla: 8.436 ± 0.097
0.576ArgCys: 0.576 ± 0.02
4.148ArgAsp: 4.148 ± 0.068
3.903ArgGlu: 3.903 ± 0.063
2.764ArgPhe: 2.764 ± 0.049
4.791ArgGly: 4.791 ± 0.067
2.027ArgHis: 2.027 ± 0.042
4.127ArgIle: 4.127 ± 0.068
2.088ArgLys: 2.088 ± 0.044
8.607ArgLeu: 8.607 ± 0.112
1.766ArgMet: 1.766 ± 0.038
1.945ArgAsn: 1.945 ± 0.041
3.718ArgPro: 3.718 ± 0.063
3.137ArgGln: 3.137 ± 0.055
6.39ArgArg: 6.39 ± 0.095
3.146ArgSer: 3.146 ± 0.052
2.622ArgThr: 2.622 ± 0.045
4.657ArgVal: 4.657 ± 0.061
0.927ArgTrp: 0.927 ± 0.028
1.661ArgTyr: 1.661 ± 0.043
0.0ArgXaa: 0.0 ± 0.0
Ser
5.736SerAla: 5.736 ± 0.075
0.408SerCys: 0.408 ± 0.017
2.668SerAsp: 2.668 ± 0.049
2.396SerGlu: 2.396 ± 0.046
2.088SerPhe: 2.088 ± 0.048
5.32SerGly: 5.32 ± 0.075
1.052SerHis: 1.052 ± 0.03
2.547SerIle: 2.547 ± 0.046
1.227SerLys: 1.227 ± 0.032
5.489SerLeu: 5.489 ± 0.071
1.152SerMet: 1.152 ± 0.031
1.249SerAsn: 1.249 ± 0.038
2.621SerPro: 2.621 ± 0.044
1.484SerGln: 1.484 ± 0.037
3.135SerArg: 3.135 ± 0.053
2.287SerSer: 2.287 ± 0.047
2.162SerThr: 2.162 ± 0.041
3.508SerVal: 3.508 ± 0.059
0.711SerTrp: 0.711 ± 0.023
1.207SerTyr: 1.207 ± 0.032
0.0SerXaa: 0.0 ± 0.0
Thr
5.956ThrAla: 5.956 ± 0.065
0.427ThrCys: 0.427 ± 0.021
2.613ThrAsp: 2.613 ± 0.052
2.543ThrGlu: 2.543 ± 0.048
1.735ThrPhe: 1.735 ± 0.043
4.972ThrGly: 4.972 ± 0.078
0.941ThrHis: 0.941 ± 0.031
2.659ThrIle: 2.659 ± 0.053
1.15ThrLys: 1.15 ± 0.033
5.392ThrLeu: 5.392 ± 0.083
1.096ThrMet: 1.096 ± 0.027
1.125ThrAsn: 1.125 ± 0.03
2.952ThrPro: 2.952 ± 0.058
1.423ThrGln: 1.423 ± 0.037
3.158ThrArg: 3.158 ± 0.05
2.283ThrSer: 2.283 ± 0.047
2.431ThrThr: 2.431 ± 0.051
3.419ThrVal: 3.419 ± 0.071
0.62ThrTrp: 0.62 ± 0.022
1.18ThrTyr: 1.18 ± 0.032
0.0ThrXaa: 0.0 ± 0.0
Val
9.74ValAla: 9.74 ± 0.103
0.543ValCys: 0.543 ± 0.021
3.939ValAsp: 3.939 ± 0.049
4.122ValGlu: 4.122 ± 0.059
2.504ValPhe: 2.504 ± 0.053
5.378ValGly: 5.378 ± 0.063
1.206ValHis: 1.206 ± 0.031
4.104ValIle: 4.104 ± 0.064
2.391ValLys: 2.391 ± 0.045
7.366ValLeu: 7.366 ± 0.087
1.895ValMet: 1.895 ± 0.041
1.98ValAsn: 1.98 ± 0.041
3.633ValPro: 3.633 ± 0.058
1.878ValGln: 1.878 ± 0.038
4.102ValArg: 4.102 ± 0.061
3.652ValSer: 3.652 ± 0.062
4.581ValThr: 4.581 ± 0.069
5.506ValVal: 5.506 ± 0.077
0.779ValTrp: 0.779 ± 0.028
1.419ValTyr: 1.419 ± 0.032
0.0ValXaa: 0.0 ± 0.0
Trp
1.262TrpAla: 1.262 ± 0.034
0.132TrpCys: 0.132 ± 0.011
0.635TrpAsp: 0.635 ± 0.025
0.588TrpGlu: 0.588 ± 0.022
0.524TrpPhe: 0.524 ± 0.021
0.925TrpGly: 0.925 ± 0.028
0.353TrpHis: 0.353 ± 0.017
0.629TrpIle: 0.629 ± 0.022
0.39TrpLys: 0.39 ± 0.018
1.76TrpLeu: 1.76 ± 0.044
0.314TrpMet: 0.314 ± 0.015
0.402TrpAsn: 0.402 ± 0.017
0.74TrpPro: 0.74 ± 0.025
0.714TrpGln: 0.714 ± 0.024
1.292TrpArg: 1.292 ± 0.031
0.824TrpSer: 0.824 ± 0.027
0.574TrpThr: 0.574 ± 0.022
0.83TrpVal: 0.83 ± 0.025
0.233TrpTrp: 0.233 ± 0.012
0.308TrpTyr: 0.308 ± 0.018
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.385TyrAla: 2.385 ± 0.045
0.256TyrCys: 0.256 ± 0.015
1.438TyrAsp: 1.438 ± 0.034
1.093TyrGlu: 1.093 ± 0.033
0.92TyrPhe: 0.92 ± 0.028
1.956TyrGly: 1.956 ± 0.038
0.565TyrHis: 0.565 ± 0.023
0.901TyrIle: 0.901 ± 0.024
0.555TyrLys: 0.555 ± 0.023
2.499TyrLeu: 2.499 ± 0.044
0.462TyrMet: 0.462 ± 0.019
0.569TyrAsn: 0.569 ± 0.021
1.115TyrPro: 1.115 ± 0.033
0.812TyrGln: 0.812 ± 0.025
1.958TyrArg: 1.958 ± 0.044
1.009TyrSer: 1.009 ± 0.026
0.985TyrThr: 0.985 ± 0.042
1.571TyrVal: 1.571 ± 0.039
0.401TyrTrp: 0.401 ± 0.019
0.56TyrTyr: 0.56 ± 0.021
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3804 proteins (1260373 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski