Amino acid dipepetide frequency for Delftia acidovorans (strain DSM 14801 / SPH-1)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.851AlaAla: 18.851 ± 0.164	1.431AlaCys: 1.431 ± 0.027	6.55AlaAsp: 6.55 ± 0.056	6.516AlaGlu: 6.516 ± 0.066	3.75AlaPhe: 3.75 ± 0.047	11.486AlaGly: 11.486 ± 0.096	2.827AlaHis: 2.827 ± 0.045	4.987AlaIle: 4.987 ± 0.056	3.515AlaLys: 3.515 ± 0.061	15.738AlaLeu: 15.738 ± 0.108	3.793AlaMet: 3.793 ± 0.051	2.68AlaAsn: 2.68 ± 0.044	6.878AlaPro: 6.878 ± 0.086	7.186AlaGln: 7.186 ± 0.081	9.582AlaArg: 9.582 ± 0.092	7.419AlaSer: 7.419 ± 0.075	6.06AlaThr: 6.06 ± 0.075	9.015AlaVal: 9.015 ± 0.082	2.079AlaTrp: 2.079 ± 0.035	2.387AlaTyr: 2.387 ± 0.036	0.0AlaXaa: 0.0 ± 0.0
Cys	1.297CysAla: 1.297 ± 0.029	0.138CysCys: 0.138 ± 0.009	0.507CysAsp: 0.507 ± 0.017	0.51CysGlu: 0.51 ± 0.017	0.295CysPhe: 0.295 ± 0.012	0.961CysGly: 0.961 ± 0.026	0.25CysHis: 0.25 ± 0.012	0.418CysIle: 0.418 ± 0.016	0.223CysLys: 0.223 ± 0.01	0.953CysLeu: 0.953 ± 0.021	0.26CysMet: 0.26 ± 0.011	0.239CysAsn: 0.239 ± 0.012	0.482CysPro: 0.482 ± 0.016	0.272CysGln: 0.272 ± 0.013	0.63CysArg: 0.63 ± 0.017	0.565CysSer: 0.565 ± 0.02	0.578CysThr: 0.578 ± 0.029	0.717CysVal: 0.717 ± 0.019	0.143CysTrp: 0.143 ± 0.008	0.195CysTyr: 0.195 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	7.153AspAla: 7.153 ± 0.062	0.48AspCys: 0.48 ± 0.015	2.45AspAsp: 2.45 ± 0.04	2.871AspGlu: 2.871 ± 0.046	1.953AspPhe: 1.953 ± 0.032	4.702AspGly: 4.702 ± 0.058	1.081AspHis: 1.081 ± 0.029	2.312AspIle: 2.312 ± 0.037	1.582AspLys: 1.582 ± 0.032	5.214AspLeu: 5.214 ± 0.051	1.333AspMet: 1.333 ± 0.027	1.185AspAsn: 1.185 ± 0.025	2.709AspPro: 2.709 ± 0.044	1.732AspGln: 1.732 ± 0.034	3.189AspArg: 3.189 ± 0.041	2.481AspSer: 2.481 ± 0.034	2.434AspThr: 2.434 ± 0.033	3.641AspVal: 3.641 ± 0.041	0.963AspTrp: 0.963 ± 0.022	1.306AspTyr: 1.306 ± 0.024	0.0AspXaa: 0.0 ± 0.0
Glu	6.488GluAla: 6.488 ± 0.065	0.405GluCys: 0.405 ± 0.016	2.29GluAsp: 2.29 ± 0.035	2.414GluGlu: 2.414 ± 0.044	1.609GluPhe: 1.609 ± 0.032	3.826GluGly: 3.826 ± 0.052	1.373GluHis: 1.373 ± 0.028	2.451GluIle: 2.451 ± 0.036	1.652GluLys: 1.652 ± 0.035	5.702GluLeu: 5.702 ± 0.069	1.263GluMet: 1.263 ± 0.024	1.182GluAsn: 1.182 ± 0.025	2.484GluPro: 2.484 ± 0.04	3.018GluGln: 3.018 ± 0.046	4.515GluArg: 4.515 ± 0.059	2.527GluSer: 2.527 ± 0.037	2.268GluThr: 2.268 ± 0.037	3.72GluVal: 3.72 ± 0.045	0.699GluTrp: 0.699 ± 0.018	1.004GluTyr: 1.004 ± 0.025	0.0GluXaa: 0.0 ± 0.0
Phe	3.967PheAla: 3.967 ± 0.052	0.376PheCys: 0.376 ± 0.013	2.186PheAsp: 2.186 ± 0.033	1.845PheGlu: 1.845 ± 0.031	1.198PhePhe: 1.198 ± 0.026	3.141PheGly: 3.141 ± 0.048	0.68PheHis: 0.68 ± 0.018	1.411PheIle: 1.411 ± 0.025	1.043PheLys: 1.043 ± 0.023	2.718PheLeu: 2.718 ± 0.042	0.83PheMet: 0.83 ± 0.02	1.018PheAsn: 1.018 ± 0.026	1.414PhePro: 1.414 ± 0.03	1.046PheGln: 1.046 ± 0.026	1.7PheArg: 1.7 ± 0.029	2.049PheSer: 2.049 ± 0.037	1.791PheThr: 1.791 ± 0.042	2.525PheVal: 2.525 ± 0.037	0.484PheTrp: 0.484 ± 0.017	0.792PheTyr: 0.792 ± 0.022	0.0PheXaa: 0.0 ± 0.0
Gly	9.516GlyAla: 9.516 ± 0.083	0.924GlyCys: 0.924 ± 0.022	3.957GlyAsp: 3.957 ± 0.053	4.28GlyGlu: 4.28 ± 0.05	3.115GlyPhe: 3.115 ± 0.042	7.327GlyGly: 7.327 ± 0.119	2.028GlyHis: 2.028 ± 0.037	3.85GlyIle: 3.85 ± 0.041	3.066GlyLys: 3.066 ± 0.044	9.346GlyLeu: 9.346 ± 0.098	2.576GlyMet: 2.576 ± 0.034	2.182GlyAsn: 2.182 ± 0.039	3.248GlyPro: 3.248 ± 0.044	4.12GlyGln: 4.12 ± 0.051	5.747GlyArg: 5.747 ± 0.06	5.062GlySer: 5.062 ± 0.064	4.535GlyThr: 4.535 ± 0.069	6.347GlyVal: 6.347 ± 0.054	1.538GlyTrp: 1.538 ± 0.028	2.309GlyTyr: 2.309 ± 0.036	0.0GlyXaa: 0.0 ± 0.0
His	3.22HisAla: 3.22 ± 0.045	0.334HisCys: 0.334 ± 0.014	1.187HisAsp: 1.187 ± 0.027	1.147HisGlu: 1.147 ± 0.026	0.822HisPhe: 0.822 ± 0.019	2.197HisGly: 2.197 ± 0.037	0.627HisHis: 0.627 ± 0.021	0.931HisIle: 0.931 ± 0.022	0.533HisLys: 0.533 ± 0.017	2.327HisLeu: 2.327 ± 0.039	0.561HisMet: 0.561 ± 0.016	0.481HisAsn: 0.481 ± 0.016	1.519HisPro: 1.519 ± 0.032	0.844HisGln: 0.844 ± 0.019	1.523HisArg: 1.523 ± 0.026	1.173HisSer: 1.173 ± 0.023	1.067HisThr: 1.067 ± 0.022	1.607HisVal: 1.607 ± 0.026	0.477HisTrp: 0.477 ± 0.015	0.615HisTyr: 0.615 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	5.905IleAla: 5.905 ± 0.061	0.411IleCys: 0.411 ± 0.015	2.793IleAsp: 2.793 ± 0.037	2.782IleGlu: 2.782 ± 0.042	1.18IlePhe: 1.18 ± 0.027	3.761IleGly: 3.761 ± 0.045	0.89IleHis: 0.89 ± 0.02	1.445IleIle: 1.445 ± 0.036	1.328IleLys: 1.328 ± 0.027	2.97IleLeu: 2.97 ± 0.044	0.697IleMet: 0.697 ± 0.019	1.332IleAsn: 1.332 ± 0.029	1.962IlePro: 1.962 ± 0.035	1.302IleGln: 1.302 ± 0.029	2.464IleArg: 2.464 ± 0.032	2.392IleSer: 2.392 ± 0.043	2.555IleThr: 2.555 ± 0.045	3.252IleVal: 3.252 ± 0.041	0.497IleTrp: 0.497 ± 0.016	0.947IleTyr: 0.947 ± 0.024	0.0IleXaa: 0.0 ± 0.0
Lys	3.95LysAla: 3.95 ± 0.063	0.147LysCys: 0.147 ± 0.008	1.57LysAsp: 1.57 ± 0.035	1.43LysGlu: 1.43 ± 0.034	0.751LysPhe: 0.751 ± 0.025	2.331LysGly: 2.331 ± 0.035	0.543LysHis: 0.543 ± 0.018	1.271LysIle: 1.271 ± 0.03	1.177LysLys: 1.177 ± 0.034	2.991LysLeu: 2.991 ± 0.044	0.67LysMet: 0.67 ± 0.02	0.877LysAsn: 0.877 ± 0.025	1.832LysPro: 1.832 ± 0.036	1.151LysGln: 1.151 ± 0.029	1.77LysArg: 1.77 ± 0.029	1.613LysSer: 1.613 ± 0.031	1.69LysThr: 1.69 ± 0.031	2.134LysVal: 2.134 ± 0.042	0.311LysTrp: 0.311 ± 0.013	0.559LysTyr: 0.559 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	15.425LeuAla: 15.425 ± 0.106	1.098LeuCys: 1.098 ± 0.024	5.719LeuAsp: 5.719 ± 0.063	5.007LeuGlu: 5.007 ± 0.068	3.177LeuPhe: 3.177 ± 0.047	8.999LeuGly: 8.999 ± 0.096	2.514LeuHis: 2.514 ± 0.036	3.947LeuIle: 3.947 ± 0.042	3.062LeuLys: 3.062 ± 0.039	11.44LeuLeu: 11.44 ± 0.106	2.509LeuMet: 2.509 ± 0.038	2.551LeuAsn: 2.551 ± 0.033	6.605LeuPro: 6.605 ± 0.064	5.579LeuGln: 5.579 ± 0.071	8.264LeuArg: 8.264 ± 0.072	6.274LeuSer: 6.274 ± 0.065	4.955LeuThr: 4.955 ± 0.056	7.693LeuVal: 7.693 ± 0.073	1.431LeuTrp: 1.431 ± 0.031	1.98LeuTyr: 1.98 ± 0.034	0.0LeuXaa: 0.0 ± 0.0
Met	3.495MetAla: 3.495 ± 0.049	0.182MetCys: 0.182 ± 0.008	1.263MetAsp: 1.263 ± 0.024	1.181MetGlu: 1.181 ± 0.025	0.678MetPhe: 0.678 ± 0.022	2.053MetGly: 2.053 ± 0.039	0.611MetHis: 0.611 ± 0.017	0.795MetIle: 0.795 ± 0.021	0.862MetLys: 0.862 ± 0.023	2.717MetLeu: 2.717 ± 0.038	0.515MetMet: 0.515 ± 0.019	0.812MetAsn: 0.812 ± 0.021	1.666MetPro: 1.666 ± 0.029	1.375MetGln: 1.375 ± 0.027	1.822MetArg: 1.822 ± 0.032	1.539MetSer: 1.539 ± 0.029	1.454MetThr: 1.454 ± 0.03	1.748MetVal: 1.748 ± 0.033	0.22MetTrp: 0.22 ± 0.01	0.369MetTyr: 0.369 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	3.234AsnAla: 3.234 ± 0.049	0.252AsnCys: 0.252 ± 0.011	1.153AsnAsp: 1.153 ± 0.024	1.12AsnGlu: 1.12 ± 0.025	0.842AsnPhe: 0.842 ± 0.025	2.2AsnGly: 2.2 ± 0.042	0.532AsnHis: 0.532 ± 0.015	1.117AsnIle: 1.117 ± 0.027	0.717AsnLys: 0.717 ± 0.019	2.431AsnLeu: 2.431 ± 0.039	0.568AsnMet: 0.568 ± 0.016	0.707AsnAsn: 0.707 ± 0.021	1.777AsnPro: 1.777 ± 0.04	0.951AsnGln: 0.951 ± 0.022	1.567AsnArg: 1.567 ± 0.032	1.202AsnSer: 1.202 ± 0.03	1.351AsnThr: 1.351 ± 0.034	1.757AsnVal: 1.757 ± 0.033	0.403AsnTrp: 0.403 ± 0.017	0.641AsnTyr: 0.641 ± 0.02	0.0AsnXaa: 0.0 ± 0.0
Pro	8.075ProAla: 8.075 ± 0.092	0.419ProCys: 0.419 ± 0.015	3.013ProAsp: 3.013 ± 0.043	3.285ProGlu: 3.285 ± 0.044	1.649ProPhe: 1.649 ± 0.026	5.073ProGly: 5.073 ± 0.056	1.239ProHis: 1.239 ± 0.03	1.757ProIle: 1.757 ± 0.029	1.274ProLys: 1.274 ± 0.028	5.583ProLeu: 5.583 ± 0.06	1.397ProMet: 1.397 ± 0.027	1.086ProAsn: 1.086 ± 0.025	2.701ProPro: 2.701 ± 0.047	2.705ProGln: 2.705 ± 0.035	3.084ProArg: 3.084 ± 0.048	3.042ProSer: 3.042 ± 0.043	2.51ProThr: 2.51 ± 0.054	4.374ProVal: 4.374 ± 0.053	0.859ProTrp: 0.859 ± 0.022	1.132ProTyr: 1.132 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	7.529GlnAla: 7.529 ± 0.087	0.356GlnCys: 0.356 ± 0.015	1.973GlnAsp: 1.973 ± 0.032	2.042GlnGlu: 2.042 ± 0.036	1.245GlnPhe: 1.245 ± 0.025	3.906GlnGly: 3.906 ± 0.053	1.0GlnHis: 1.0 ± 0.021	1.898GlnIle: 1.898 ± 0.033	1.119GlnLys: 1.119 ± 0.031	5.122GlnLeu: 5.122 ± 0.069	1.126GlnMet: 1.126 ± 0.024	0.85GlnAsn: 0.85 ± 0.022	2.893GlnPro: 2.893 ± 0.045	2.651GlnGln: 2.651 ± 0.046	4.029GlnArg: 4.029 ± 0.057	2.381GlnSer: 2.381 ± 0.038	2.094GlnThr: 2.094 ± 0.032	3.296GlnVal: 3.296 ± 0.046	0.923GlnTrp: 0.923 ± 0.023	0.83GlnTyr: 0.83 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	7.794ArgAla: 7.794 ± 0.073	0.643ArgCys: 0.643 ± 0.018	3.431ArgAsp: 3.431 ± 0.05	4.057ArgGlu: 4.057 ± 0.05	2.613ArgPhe: 2.613 ± 0.044	4.55ArgGly: 4.55 ± 0.052	2.054ArgHis: 2.054 ± 0.033	3.463ArgIle: 3.463 ± 0.044	1.99ArgLys: 1.99 ± 0.031	8.225ArgLeu: 8.225 ± 0.081	2.078ArgMet: 2.078 ± 0.033	1.816ArgAsn: 1.816 ± 0.028	3.51ArgPro: 3.51 ± 0.044	3.576ArgGln: 3.576 ± 0.052	5.261ArgArg: 5.261 ± 0.06	4.032ArgSer: 4.032 ± 0.045	3.303ArgThr: 3.303 ± 0.039	4.637ArgVal: 4.637 ± 0.049	1.322ArgTrp: 1.322 ± 0.028	1.746ArgTyr: 1.746 ± 0.032	0.0ArgXaa: 0.0 ± 0.0
Ser	6.872SerAla: 6.872 ± 0.07	0.505SerCys: 0.505 ± 0.016	2.597SerAsp: 2.597 ± 0.042	2.569SerGlu: 2.569 ± 0.039	2.112SerPhe: 2.112 ± 0.035	5.386SerGly: 5.386 ± 0.058	1.346SerHis: 1.346 ± 0.024	2.429SerIle: 2.429 ± 0.037	1.44SerLys: 1.44 ± 0.03	6.059SerLeu: 6.059 ± 0.062	1.518SerMet: 1.518 ± 0.029	1.411SerAsn: 1.411 ± 0.032	3.071SerPro: 3.071 ± 0.04	2.284SerGln: 2.284 ± 0.031	3.677SerArg: 3.677 ± 0.046	3.392SerSer: 3.392 ± 0.054	3.116SerThr: 3.116 ± 0.05	4.098SerVal: 4.098 ± 0.057	0.835SerTrp: 0.835 ± 0.023	1.357SerTyr: 1.357 ± 0.032	0.0SerXaa: 0.0 ± 0.0
Thr	6.441ThrAla: 6.441 ± 0.09	0.416ThrCys: 0.416 ± 0.022	2.447ThrAsp: 2.447 ± 0.041	2.278ThrGlu: 2.278 ± 0.032	1.402ThrPhe: 1.402 ± 0.033	4.77ThrGly: 4.77 ± 0.058	1.104ThrHis: 1.104 ± 0.025	1.952ThrIle: 1.952 ± 0.045	1.064ThrLys: 1.064 ± 0.027	5.965ThrLeu: 5.965 ± 0.064	1.072ThrMet: 1.072 ± 0.023	1.174ThrAsn: 1.174 ± 0.04	3.618ThrPro: 3.618 ± 0.052	2.107ThrGln: 2.107 ± 0.036	3.13ThrArg: 3.13 ± 0.036	2.768ThrSer: 2.768 ± 0.046	2.76ThrThr: 2.76 ± 0.053	4.106ThrVal: 4.106 ± 0.069	0.638ThrTrp: 0.638 ± 0.019	0.993ThrTyr: 0.993 ± 0.028	0.0ThrXaa: 0.0 ± 0.0
Val	9.383ValAla: 9.383 ± 0.087	0.723ValCys: 0.723 ± 0.02	3.844ValAsp: 3.844 ± 0.039	3.813ValGlu: 3.813 ± 0.052	2.481ValPhe: 2.481 ± 0.041	5.348ValGly: 5.348 ± 0.057	1.664ValHis: 1.664 ± 0.029	3.068ValIle: 3.068 ± 0.045	2.016ValLys: 2.016 ± 0.04	8.233ValLeu: 8.233 ± 0.074	1.705ValMet: 1.705 ± 0.035	1.942ValAsn: 1.942 ± 0.033	4.059ValPro: 4.059 ± 0.053	3.602ValGln: 3.602 ± 0.046	5.205ValArg: 5.205 ± 0.063	4.039ValSer: 4.039 ± 0.05	3.778ValThr: 3.778 ± 0.057	5.882ValVal: 5.882 ± 0.071	0.91ValTrp: 0.91 ± 0.02	1.388ValTyr: 1.388 ± 0.029	0.0ValXaa: 0.0 ± 0.0
Trp	1.5TrpAla: 1.5 ± 0.028	0.174TrpCys: 0.174 ± 0.01	0.639TrpAsp: 0.639 ± 0.018	0.564TrpGlu: 0.564 ± 0.015	0.52TrpPhe: 0.52 ± 0.015	1.065TrpGly: 1.065 ± 0.028	0.397TrpHis: 0.397 ± 0.014	0.634TrpIle: 0.634 ± 0.02	0.467TrpLys: 0.467 ± 0.016	2.233TrpLeu: 2.233 ± 0.039	0.46TrpMet: 0.46 ± 0.016	0.447TrpAsn: 0.447 ± 0.017	0.776TrpPro: 0.776 ± 0.022	0.875TrpGln: 0.875 ± 0.024	1.307TrpArg: 1.307 ± 0.029	0.938TrpSer: 0.938 ± 0.022	0.765TrpThr: 0.765 ± 0.018	1.043TrpVal: 1.043 ± 0.025	0.296TrpTrp: 0.296 ± 0.012	0.287TrpTyr: 0.287 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.638TyrAla: 2.638 ± 0.04	0.221TyrCys: 0.221 ± 0.011	1.202TyrAsp: 1.202 ± 0.036	1.176TyrGlu: 1.176 ± 0.028	0.82TyrPhe: 0.82 ± 0.021	1.992TyrGly: 1.992 ± 0.036	0.432TyrHis: 0.432 ± 0.014	0.725TyrIle: 0.725 ± 0.019	0.638TyrLys: 0.638 ± 0.019	2.263TyrLeu: 2.263 ± 0.034	0.429TyrMet: 0.429 ± 0.016	0.548TyrAsn: 0.548 ± 0.019	1.051TyrPro: 1.051 ± 0.022	0.885TyrGln: 0.885 ± 0.022	1.634TyrArg: 1.634 ± 0.029	1.19TyrSer: 1.19 ± 0.024	1.144TyrThr: 1.144 ± 0.028	1.49TyrVal: 1.49 ± 0.027	0.359TyrTrp: 0.359 ± 0.012	0.557TyrTyr: 0.557 ± 0.019	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5968 proteins (2005225 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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