Amino acid dipepetide frequency for Candidatus Photodesmus blepharus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.632AlaAla: 4.632 ± 0.154
0.924AlaCys: 0.924 ± 0.06
2.988AlaAsp: 2.988 ± 0.1
3.818AlaGlu: 3.818 ± 0.128
2.591AlaPhe: 2.591 ± 0.1
3.929AlaGly: 3.929 ± 0.151
1.292AlaHis: 1.292 ± 0.073
5.888AlaIle: 5.888 ± 0.157
4.733AlaLys: 4.733 ± 0.117
7.555AlaLeu: 7.555 ± 0.154
1.865AlaMet: 1.865 ± 0.082
3.089AlaAsn: 3.089 ± 0.109
1.696AlaPro: 1.696 ± 0.067
2.445AlaGln: 2.445 ± 0.089
3.314AlaArg: 3.314 ± 0.116
4.316AlaSer: 4.316 ± 0.128
3.18AlaThr: 3.18 ± 0.103
4.437AlaVal: 4.437 ± 0.13
0.602AlaTrp: 0.602 ± 0.042
2.002AlaTyr: 2.002 ± 0.079
0.0AlaXaa: 0.0 ± 0.0
Cys
0.807CysAla: 0.807 ± 0.057
0.221CysCys: 0.221 ± 0.029
0.609CysAsp: 0.609 ± 0.046
0.592CysGlu: 0.592 ± 0.044
0.57CysPhe: 0.57 ± 0.048
0.859CysGly: 0.859 ± 0.054
0.339CysHis: 0.339 ± 0.035
0.872CysIle: 0.872 ± 0.052
0.664CysLys: 0.664 ± 0.058
1.162CysLeu: 1.162 ± 0.061
0.231CysMet: 0.231 ± 0.028
0.527CysAsn: 0.527 ± 0.044
0.4CysPro: 0.4 ± 0.04
0.478CysGln: 0.478 ± 0.035
0.573CysArg: 0.573 ± 0.043
0.872CysSer: 0.872 ± 0.05
0.586CysThr: 0.586 ± 0.044
0.749CysVal: 0.749 ± 0.05
0.156CysTrp: 0.156 ± 0.021
0.387CysTyr: 0.387 ± 0.034
0.0CysXaa: 0.0 ± 0.0
Asp
2.991AspAla: 2.991 ± 0.099
0.544AspCys: 0.544 ± 0.04
2.113AspAsp: 2.113 ± 0.082
3.157AspGlu: 3.157 ± 0.109
2.523AspPhe: 2.523 ± 0.095
2.923AspGly: 2.923 ± 0.103
0.82AspHis: 0.82 ± 0.052
4.622AspIle: 4.622 ± 0.137
3.32AspLys: 3.32 ± 0.109
4.918AspLeu: 4.918 ± 0.119
1.237AspMet: 1.237 ± 0.068
2.148AspAsn: 2.148 ± 0.09
1.67AspPro: 1.67 ± 0.073
1.569AspGln: 1.569 ± 0.06
2.516AspArg: 2.516 ± 0.093
3.18AspSer: 3.18 ± 0.105
2.269AspThr: 2.269 ± 0.088
3.698AspVal: 3.698 ± 0.1
0.635AspTrp: 0.635 ± 0.048
1.751AspTyr: 1.751 ± 0.096
0.0AspXaa: 0.0 ± 0.0
Glu
3.929GluAla: 3.929 ± 0.111
0.618GluCys: 0.618 ± 0.043
2.637GluAsp: 2.637 ± 0.108
4.036GluGlu: 4.036 ± 0.145
2.419GluPhe: 2.419 ± 0.089
3.372GluGly: 3.372 ± 0.109
1.266GluHis: 1.266 ± 0.066
5.521GluIle: 5.521 ± 0.143
5.189GluLys: 5.189 ± 0.132
6.608GluLeu: 6.608 ± 0.13
1.794GluMet: 1.794 ± 0.082
3.424GluAsn: 3.424 ± 0.116
1.422GluPro: 1.422 ± 0.079
2.715GluGln: 2.715 ± 0.095
3.564GluArg: 3.564 ± 0.118
3.519GluSer: 3.519 ± 0.104
2.604GluThr: 2.604 ± 0.106
4.385GluVal: 4.385 ± 0.129
0.615GluTrp: 0.615 ± 0.049
1.849GluTyr: 1.849 ± 0.079
0.0GluXaa: 0.0 ± 0.0
Phe
2.611PheAla: 2.611 ± 0.099
0.57PheCys: 0.57 ± 0.039
2.438PheAsp: 2.438 ± 0.087
2.454PheGlu: 2.454 ± 0.091
2.314PhePhe: 2.314 ± 0.098
3.073PheGly: 3.073 ± 0.105
0.944PheHis: 0.944 ± 0.059
3.756PheIle: 3.756 ± 0.111
2.474PheLys: 2.474 ± 0.094
4.222PheLeu: 4.222 ± 0.141
0.934PheMet: 0.934 ± 0.056
2.318PheAsn: 2.318 ± 0.082
1.527PhePro: 1.527 ± 0.07
1.523PheGln: 1.523 ± 0.073
1.849PheArg: 1.849 ± 0.073
4.241PheSer: 4.241 ± 0.128
2.126PheThr: 2.126 ± 0.084
2.695PheVal: 2.695 ± 0.11
0.527PheTrp: 0.527 ± 0.044
1.354PheTyr: 1.354 ± 0.073
0.0PheXaa: 0.0 ± 0.0
Gly
3.945GlyAla: 3.945 ± 0.146
0.898GlyCys: 0.898 ± 0.062
3.027GlyAsp: 3.027 ± 0.113
3.695GlyGlu: 3.695 ± 0.105
2.982GlyPhe: 2.982 ± 0.103
4.053GlyGly: 4.053 ± 0.162
1.458GlyHis: 1.458 ± 0.07
5.784GlyIle: 5.784 ± 0.143
4.743GlyLys: 4.743 ± 0.122
6.116GlyLeu: 6.116 ± 0.127
1.807GlyMet: 1.807 ± 0.094
2.793GlyAsn: 2.793 ± 0.109
1.501GlyPro: 1.501 ± 0.072
2.174GlyGln: 2.174 ± 0.083
3.164GlyArg: 3.164 ± 0.107
4.095GlySer: 4.095 ± 0.118
3.196GlyThr: 3.196 ± 0.103
4.586GlyVal: 4.586 ± 0.12
0.654GlyTrp: 0.654 ± 0.044
2.292GlyTyr: 2.292 ± 0.097
0.0GlyXaa: 0.0 ± 0.0
His
1.276HisAla: 1.276 ± 0.073
0.329HisCys: 0.329 ± 0.028
0.82HisAsp: 0.82 ± 0.051
0.931HisGlu: 0.931 ± 0.058
1.032HisPhe: 1.032 ± 0.057
1.4HisGly: 1.4 ± 0.068
0.527HisHis: 0.527 ± 0.041
1.8HisIle: 1.8 ± 0.073
1.253HisLys: 1.253 ± 0.066
2.168HisLeu: 2.168 ± 0.085
0.452HisMet: 0.452 ± 0.037
1.042HisAsn: 1.042 ± 0.06
0.98HisPro: 0.98 ± 0.052
0.846HisGln: 0.846 ± 0.053
1.084HisArg: 1.084 ± 0.059
1.481HisSer: 1.481 ± 0.067
1.077HisThr: 1.077 ± 0.065
1.227HisVal: 1.227 ± 0.066
0.267HisTrp: 0.267 ± 0.026
0.755HisTyr: 0.755 ± 0.043
0.0HisXaa: 0.0 ± 0.0
Ile
6.373IleAla: 6.373 ± 0.141
1.042IleCys: 1.042 ± 0.063
4.964IleAsp: 4.964 ± 0.121
5.931IleGlu: 5.931 ± 0.149
3.294IlePhe: 3.294 ± 0.127
5.7IleGly: 5.7 ± 0.147
1.728IleHis: 1.728 ± 0.062
6.159IleIle: 6.159 ± 0.17
5.68IleLys: 5.68 ± 0.146
7.991IleLeu: 7.991 ± 0.18
1.644IleMet: 1.644 ± 0.065
4.43IleAsn: 4.43 ± 0.123
3.359IlePro: 3.359 ± 0.107
3.239IleGln: 3.239 ± 0.101
4.212IleArg: 4.212 ± 0.119
6.569IleSer: 6.569 ± 0.124
4.525IleThr: 4.525 ± 0.125
5.449IleVal: 5.449 ± 0.122
0.762IleTrp: 0.762 ± 0.057
2.386IleTyr: 2.386 ± 0.101
0.0IleXaa: 0.0 ± 0.0
Lys
4.3LysAla: 4.3 ± 0.128
0.534LysCys: 0.534 ± 0.044
2.959LysAsp: 2.959 ± 0.088
4.756LysGlu: 4.756 ± 0.141
2.62LysPhe: 2.62 ± 0.094
3.76LysGly: 3.76 ± 0.114
1.462LysHis: 1.462 ± 0.074
6.439LysIle: 6.439 ± 0.171
6.513LysLys: 6.513 ± 0.175
7.096LysLeu: 7.096 ± 0.16
1.859LysMet: 1.859 ± 0.09
4.427LysAsn: 4.427 ± 0.124
2.142LysPro: 2.142 ± 0.082
3.141LysGln: 3.141 ± 0.118
3.691LysArg: 3.691 ± 0.106
4.284LysSer: 4.284 ± 0.114
3.376LysThr: 3.376 ± 0.103
4.544LysVal: 4.544 ± 0.125
0.618LysTrp: 0.618 ± 0.042
2.034LysTyr: 2.034 ± 0.09
0.003LysXaa: 0.003 ± 0.004
Leu
7.08LeuAla: 7.08 ± 0.152
1.113LeuCys: 1.113 ± 0.066
5.478LeuAsp: 5.478 ± 0.141
6.767LeuGlu: 6.767 ± 0.133
4.378LeuPhe: 4.378 ± 0.137
6.474LeuGly: 6.474 ± 0.16
2.109LeuHis: 2.109 ± 0.087
8.086LeuIle: 8.086 ± 0.178
7.106LeuLys: 7.106 ± 0.157
10.201LeuLeu: 10.201 ± 0.244
2.585LeuMet: 2.585 ± 0.089
5.527LeuAsn: 5.527 ± 0.144
3.994LeuPro: 3.994 ± 0.103
3.382LeuGln: 3.382 ± 0.108
4.876LeuArg: 4.876 ± 0.118
8.382LeuSer: 8.382 ± 0.181
5.13LeuThr: 5.13 ± 0.121
6.605LeuVal: 6.605 ± 0.189
0.905LeuTrp: 0.905 ± 0.048
2.731LeuTyr: 2.731 ± 0.11
0.0LeuXaa: 0.0 ± 0.0
Met
1.761MetAla: 1.761 ± 0.079
0.267MetCys: 0.267 ± 0.027
1.113MetAsp: 1.113 ± 0.057
1.39MetGlu: 1.39 ± 0.074
0.957MetPhe: 0.957 ± 0.063
1.618MetGly: 1.618 ± 0.078
0.511MetHis: 0.511 ± 0.037
2.09MetIle: 2.09 ± 0.099
1.745MetLys: 1.745 ± 0.076
2.715MetLeu: 2.715 ± 0.094
0.752MetMet: 0.752 ± 0.052
1.282MetAsn: 1.282 ± 0.067
0.99MetPro: 0.99 ± 0.066
0.97MetGln: 0.97 ± 0.061
1.312MetArg: 1.312 ± 0.058
1.842MetSer: 1.842 ± 0.08
1.221MetThr: 1.221 ± 0.057
1.741MetVal: 1.741 ± 0.083
0.176MetTrp: 0.176 ± 0.027
0.631MetTyr: 0.631 ± 0.044
0.0MetXaa: 0.0 ± 0.0
Asn
3.148AsnAla: 3.148 ± 0.092
0.661AsnCys: 0.661 ± 0.049
2.171AsnAsp: 2.171 ± 0.09
2.9AsnGlu: 2.9 ± 0.084
2.572AsnPhe: 2.572 ± 0.091
3.011AsnGly: 3.011 ± 0.103
1.048AsnHis: 1.048 ± 0.059
4.583AsnIle: 4.583 ± 0.125
3.675AsnLys: 3.675 ± 0.132
5.146AsnLeu: 5.146 ± 0.13
1.256AsnMet: 1.256 ± 0.08
2.939AsnAsn: 2.939 ± 0.096
2.116AsnPro: 2.116 ± 0.085
2.269AsnGln: 2.269 ± 0.086
2.578AsnArg: 2.578 ± 0.079
3.633AsnSer: 3.633 ± 0.107
2.516AsnThr: 2.516 ± 0.092
3.083AsnVal: 3.083 ± 0.089
0.612AsnTrp: 0.612 ± 0.049
1.82AsnTyr: 1.82 ± 0.08
0.0AsnXaa: 0.0 ± 0.0
Pro
1.761ProAla: 1.761 ± 0.073
0.361ProCys: 0.361 ± 0.032
1.709ProAsp: 1.709 ± 0.073
2.409ProGlu: 2.409 ± 0.081
1.579ProPhe: 1.579 ± 0.08
1.966ProGly: 1.966 ± 0.095
0.703ProHis: 0.703 ± 0.046
3.236ProIle: 3.236 ± 0.104
2.292ProLys: 2.292 ± 0.079
3.323ProLeu: 3.323 ± 0.101
0.833ProMet: 0.833 ± 0.051
1.833ProAsn: 1.833 ± 0.076
0.876ProPro: 0.876 ± 0.055
1.09ProGln: 1.09 ± 0.059
1.302ProArg: 1.302 ± 0.063
2.301ProSer: 2.301 ± 0.079
1.82ProThr: 1.82 ± 0.069
2.461ProVal: 2.461 ± 0.083
0.413ProTrp: 0.413 ± 0.037
1.133ProTyr: 1.133 ± 0.056
0.0ProXaa: 0.0 ± 0.0
Gln
2.812GlnAla: 2.812 ± 0.096
0.339GlnCys: 0.339 ± 0.031
1.715GlnAsp: 1.715 ± 0.083
2.282GlnGlu: 2.282 ± 0.08
1.575GlnPhe: 1.575 ± 0.068
2.327GlnGly: 2.327 ± 0.081
0.781GlnHis: 0.781 ± 0.057
3.252GlnIle: 3.252 ± 0.096
2.747GlnLys: 2.747 ± 0.11
4.235GlnLeu: 4.235 ± 0.135
0.911GlnMet: 0.911 ± 0.051
2.113GlnAsn: 2.113 ± 0.083
1.061GlnPro: 1.061 ± 0.057
1.449GlnGln: 1.449 ± 0.08
1.917GlnArg: 1.917 ± 0.075
2.321GlnSer: 2.321 ± 0.091
1.735GlnThr: 1.735 ± 0.079
2.601GlnVal: 2.601 ± 0.093
0.387GlnTrp: 0.387 ± 0.033
1.243GlnTyr: 1.243 ± 0.069
0.0GlnXaa: 0.0 ± 0.0
Arg
2.998ArgAla: 2.998 ± 0.101
0.518ArgCys: 0.518 ± 0.043
2.536ArgAsp: 2.536 ± 0.09
2.9ArgGlu: 2.9 ± 0.112
2.477ArgPhe: 2.477 ± 0.093
2.848ArgGly: 2.848 ± 0.103
0.967ArgHis: 0.967 ± 0.058
4.508ArgIle: 4.508 ± 0.13
3.522ArgLys: 3.522 ± 0.103
5.117ArgLeu: 5.117 ± 0.127
1.328ArgMet: 1.328 ± 0.066
2.767ArgAsn: 2.767 ± 0.088
1.592ArgPro: 1.592 ± 0.074
1.836ArgGln: 1.836 ± 0.079
2.809ArgArg: 2.809 ± 0.127
3.307ArgSer: 3.307 ± 0.104
2.217ArgThr: 2.217 ± 0.092
3.509ArgVal: 3.509 ± 0.097
0.531ArgTrp: 0.531 ± 0.044
1.735ArgTyr: 1.735 ± 0.076
0.0ArgXaa: 0.0 ± 0.0
Ser
4.531SerAla: 4.531 ± 0.11
0.807SerCys: 0.807 ± 0.06
3.512SerAsp: 3.512 ± 0.112
4.479SerGlu: 4.479 ± 0.115
3.05SerPhe: 3.05 ± 0.111
5.097SerGly: 5.097 ± 0.125
1.286SerHis: 1.286 ± 0.074
6.113SerIle: 6.113 ± 0.147
4.902SerLys: 4.902 ± 0.136
7.054SerLeu: 7.054 ± 0.173
1.781SerMet: 1.781 ± 0.079
3.594SerAsn: 3.594 ± 0.115
2.129SerPro: 2.129 ± 0.08
2.575SerGln: 2.575 ± 0.093
3.216SerArg: 3.216 ± 0.115
5.231SerSer: 5.231 ± 0.138
3.528SerThr: 3.528 ± 0.111
4.87SerVal: 4.87 ± 0.129
0.732SerTrp: 0.732 ± 0.047
2.334SerTyr: 2.334 ± 0.087
0.007SerXaa: 0.007 ± 0.004
Thr
3.076ThrAla: 3.076 ± 0.092
0.557ThrCys: 0.557 ± 0.046
2.217ThrAsp: 2.217 ± 0.097
2.754ThrGlu: 2.754 ± 0.104
2.113ThrPhe: 2.113 ± 0.076
3.369ThrGly: 3.369 ± 0.094
1.094ThrHis: 1.094 ± 0.063
4.101ThrIle: 4.101 ± 0.122
3.024ThrLys: 3.024 ± 0.105
5.739ThrLeu: 5.739 ± 0.141
1.074ThrMet: 1.074 ± 0.058
2.243ThrAsn: 2.243 ± 0.092
2.06ThrPro: 2.06 ± 0.075
1.92ThrGln: 1.92 ± 0.073
2.314ThrArg: 2.314 ± 0.086
3.245ThrSer: 3.245 ± 0.101
2.562ThrThr: 2.562 ± 0.099
3.294ThrVal: 3.294 ± 0.099
0.472ThrTrp: 0.472 ± 0.041
1.315ThrTyr: 1.315 ± 0.063
0.0ThrXaa: 0.0 ± 0.0
Val
4.827ValAla: 4.827 ± 0.134
0.771ValCys: 0.771 ± 0.049
3.672ValAsp: 3.672 ± 0.119
4.219ValGlu: 4.219 ± 0.13
2.985ValPhe: 2.985 ± 0.112
4.56ValGly: 4.56 ± 0.127
1.364ValHis: 1.364 ± 0.063
5.413ValIle: 5.413 ± 0.119
4.28ValLys: 4.28 ± 0.108
6.81ValLeu: 6.81 ± 0.159
1.754ValMet: 1.754 ± 0.088
3.265ValAsn: 3.265 ± 0.097
2.279ValPro: 2.279 ± 0.092
2.165ValGln: 2.165 ± 0.078
3.33ValArg: 3.33 ± 0.106
4.967ValSer: 4.967 ± 0.137
3.236ValThr: 3.236 ± 0.113
5.176ValVal: 5.176 ± 0.141
0.687ValTrp: 0.687 ± 0.053
1.807ValTyr: 1.807 ± 0.073
0.0ValXaa: 0.0 ± 0.0
Trp
0.482TrpAla: 0.482 ± 0.043
0.143TrpCys: 0.143 ± 0.021
0.381TrpAsp: 0.381 ± 0.038
0.449TrpGlu: 0.449 ± 0.042
0.482TrpPhe: 0.482 ± 0.044
0.573TrpGly: 0.573 ± 0.052
0.244TrpHis: 0.244 ± 0.03
0.934TrpIle: 0.934 ± 0.068
0.83TrpLys: 0.83 ± 0.053
1.396TrpLeu: 1.396 ± 0.071
0.306TrpMet: 0.306 ± 0.035
0.55TrpAsn: 0.55 ± 0.047
0.374TrpPro: 0.374 ± 0.033
0.446TrpGln: 0.446 ± 0.036
0.563TrpArg: 0.563 ± 0.045
0.612TrpSer: 0.612 ± 0.047
0.348TrpThr: 0.348 ± 0.035
0.573TrpVal: 0.573 ± 0.047
0.146TrpTrp: 0.146 ± 0.024
0.465TrpTyr: 0.465 ± 0.045
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.956TyrAla: 1.956 ± 0.075
0.439TyrCys: 0.439 ± 0.035
1.546TyrAsp: 1.546 ± 0.081
1.569TyrGlu: 1.569 ± 0.065
1.439TyrPhe: 1.439 ± 0.063
2.051TyrGly: 2.051 ± 0.098
0.804TyrHis: 0.804 ± 0.051
2.275TyrIle: 2.275 ± 0.093
1.865TyrLys: 1.865 ± 0.071
3.333TyrLeu: 3.333 ± 0.117
0.677TyrMet: 0.677 ± 0.051
1.426TyrAsn: 1.426 ± 0.071
1.23TyrPro: 1.23 ± 0.059
1.572TyrGln: 1.572 ± 0.079
1.836TyrArg: 1.836 ± 0.087
2.428TyrSer: 2.428 ± 0.087
1.292TyrThr: 1.292 ± 0.071
1.885TyrVal: 1.885 ± 0.081
0.4TyrTrp: 0.4 ± 0.046
1.081TyrTyr: 1.081 ± 0.06
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.003XaaIle: 0.003 ± 0.003
0.0XaaLys: 0.0 ± 0.0
0.003XaaLeu: 0.003 ± 0.003
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.003XaaPro: 0.003 ± 0.004
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 923 proteins (307214 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski