Amino acid dipepetide frequency for Heliothis zea nudivirus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.086AlaAla: 3.086 ± 0.304
0.781AlaCys: 0.781 ± 0.134
2.724AlaAsp: 2.724 ± 0.219
2.896AlaGlu: 2.896 ± 0.231
2.02AlaPhe: 2.02 ± 0.213
1.638AlaGly: 1.638 ± 0.2
1.048AlaHis: 1.048 ± 0.155
3.01AlaIle: 3.01 ± 0.219
3.906AlaLys: 3.906 ± 0.381
4.134AlaLeu: 4.134 ± 0.302
1.658AlaMet: 1.658 ± 0.183
3.963AlaAsn: 3.963 ± 0.373
2.115AlaPro: 2.115 ± 0.262
1.619AlaGln: 1.619 ± 0.188
2.496AlaArg: 2.496 ± 0.22
5.563AlaSer: 5.563 ± 0.438
3.925AlaThr: 3.925 ± 0.398
2.705AlaVal: 2.705 ± 0.254
0.305AlaTrp: 0.305 ± 0.077
1.924AlaTyr: 1.924 ± 0.202
0.0AlaXaa: 0.0 ± 0.0
Cys
0.686CysAla: 0.686 ± 0.093
0.457CysCys: 0.457 ± 0.095
1.238CysAsp: 1.238 ± 0.167
0.838CysGlu: 0.838 ± 0.118
0.743CysPhe: 0.743 ± 0.115
0.8CysGly: 0.8 ± 0.125
0.286CysHis: 0.286 ± 0.077
1.981CysIle: 1.981 ± 0.233
2.077CysLys: 2.077 ± 0.228
1.353CysLeu: 1.353 ± 0.155
0.857CysMet: 0.857 ± 0.133
1.791CysAsn: 1.791 ± 0.238
0.553CysPro: 0.553 ± 0.1
0.553CysGln: 0.553 ± 0.107
1.143CysArg: 1.143 ± 0.151
1.524CysSer: 1.524 ± 0.176
1.753CysThr: 1.753 ± 0.229
1.524CysVal: 1.524 ± 0.181
0.038CysTrp: 0.038 ± 0.024
0.838CysTyr: 0.838 ± 0.137
0.0CysXaa: 0.0 ± 0.0
Asp
4.649AspAla: 4.649 ± 0.323
1.353AspCys: 1.353 ± 0.175
5.982AspAsp: 5.982 ± 0.452
5.658AspGlu: 5.658 ± 0.519
2.42AspPhe: 2.42 ± 0.193
3.22AspGly: 3.22 ± 0.301
1.086AspHis: 1.086 ± 0.166
2.305AspIle: 2.305 ± 0.209
2.705AspLys: 2.705 ± 0.27
4.782AspLeu: 4.782 ± 0.371
1.296AspMet: 1.296 ± 0.136
2.61AspAsn: 2.61 ± 0.229
2.305AspPro: 2.305 ± 0.209
1.372AspGln: 1.372 ± 0.18
2.82AspArg: 2.82 ± 0.236
6.897AspSer: 6.897 ± 0.512
4.172AspThr: 4.172 ± 0.292
4.401AspVal: 4.401 ± 0.332
0.362AspTrp: 0.362 ± 0.076
2.991AspTyr: 2.991 ± 0.26
0.0AspXaa: 0.0 ± 0.0
Glu
3.029GluAla: 3.029 ± 0.281
2.039GluCys: 2.039 ± 0.228
4.344GluAsp: 4.344 ± 0.385
3.677GluGlu: 3.677 ± 0.299
2.763GluPhe: 2.763 ± 0.22
2.096GluGly: 2.096 ± 0.224
1.296GluHis: 1.296 ± 0.201
1.962GluIle: 1.962 ± 0.19
2.401GluLys: 2.401 ± 0.225
4.668GluLeu: 4.668 ± 0.371
1.467GluMet: 1.467 ± 0.203
2.972GluAsn: 2.972 ± 0.302
3.506GluPro: 3.506 ± 0.381
1.753GluGln: 1.753 ± 0.211
3.067GluArg: 3.067 ± 0.296
6.573GluSer: 6.573 ± 0.521
3.144GluThr: 3.144 ± 0.251
2.972GluVal: 2.972 ± 0.252
0.305GluTrp: 0.305 ± 0.072
3.125GluTyr: 3.125 ± 0.342
0.0GluXaa: 0.0 ± 0.0
Phe
1.962PheAla: 1.962 ± 0.236
0.457PheCys: 0.457 ± 0.105
3.144PheAsp: 3.144 ± 0.215
2.534PheGlu: 2.534 ± 0.219
0.972PhePhe: 0.972 ± 0.17
1.696PheGly: 1.696 ± 0.209
0.705PheHis: 0.705 ± 0.102
2.458PheIle: 2.458 ± 0.219
3.848PheLys: 3.848 ± 0.262
2.629PheLeu: 2.629 ± 0.263
1.257PheMet: 1.257 ± 0.155
3.41PheAsn: 3.41 ± 0.477
0.876PhePro: 0.876 ± 0.131
0.972PheGln: 0.972 ± 0.155
1.543PheArg: 1.543 ± 0.197
2.077PheSer: 2.077 ± 0.179
2.42PheThr: 2.42 ± 0.24
2.629PheVal: 2.629 ± 0.236
0.267PheTrp: 0.267 ± 0.073
1.562PheTyr: 1.562 ± 0.185
0.0PheXaa: 0.0 ± 0.0
Gly
2.153GlyAla: 2.153 ± 0.182
0.743GlyCys: 0.743 ± 0.153
2.724GlyAsp: 2.724 ± 0.232
1.696GlyGlu: 1.696 ± 0.159
1.81GlyPhe: 1.81 ± 0.257
3.639GlyGly: 3.639 ± 0.683
0.667GlyHis: 0.667 ± 0.126
2.191GlyIle: 2.191 ± 0.196
2.61GlyLys: 2.61 ± 0.269
2.782GlyLeu: 2.782 ± 0.272
0.972GlyMet: 0.972 ± 0.135
2.743GlyAsn: 2.743 ± 0.217
1.162GlyPro: 1.162 ± 0.151
0.934GlyGln: 0.934 ± 0.136
1.772GlyArg: 1.772 ± 0.177
5.239GlySer: 5.239 ± 0.43
3.182GlyThr: 3.182 ± 0.285
3.525GlyVal: 3.525 ± 0.319
0.267GlyTrp: 0.267 ± 0.07
1.6GlyTyr: 1.6 ± 0.199
0.0GlyXaa: 0.0 ± 0.0
His
1.276HisAla: 1.276 ± 0.146
0.457HisCys: 0.457 ± 0.097
1.105HisAsp: 1.105 ± 0.118
1.067HisGlu: 1.067 ± 0.159
1.067HisPhe: 1.067 ± 0.144
0.857HisGly: 0.857 ± 0.134
0.705HisHis: 0.705 ± 0.105
1.238HisIle: 1.238 ± 0.145
1.581HisLys: 1.581 ± 0.223
2.401HisLeu: 2.401 ± 0.232
0.553HisMet: 0.553 ± 0.106
1.219HisAsn: 1.219 ± 0.148
1.048HisPro: 1.048 ± 0.149
1.029HisGln: 1.029 ± 0.164
1.315HisArg: 1.315 ± 0.162
2.153HisSer: 2.153 ± 0.406
1.734HisThr: 1.734 ± 0.242
1.486HisVal: 1.486 ± 0.141
0.114HisTrp: 0.114 ± 0.044
1.105HisTyr: 1.105 ± 0.156
0.0HisXaa: 0.0 ± 0.0
Ile
3.029IleAla: 3.029 ± 0.28
0.876IleCys: 0.876 ± 0.143
4.268IleAsp: 4.268 ± 0.271
4.039IleGlu: 4.039 ± 0.271
1.543IlePhe: 1.543 ± 0.175
2.096IleGly: 2.096 ± 0.209
1.638IleHis: 1.638 ± 0.176
3.086IleIle: 3.086 ± 0.29
4.382IleLys: 4.382 ± 0.325
4.763IleLeu: 4.763 ± 0.38
1.619IleMet: 1.619 ± 0.17
4.477IleAsn: 4.477 ± 0.316
2.343IlePro: 2.343 ± 0.263
2.0IleGln: 2.0 ± 0.18
2.763IleArg: 2.763 ± 0.262
3.544IleSer: 3.544 ± 0.25
3.029IleThr: 3.029 ± 0.267
4.249IleVal: 4.249 ± 0.313
0.248IleTrp: 0.248 ± 0.071
1.467IleTyr: 1.467 ± 0.186
0.0IleXaa: 0.0 ± 0.0
Lys
3.086LysAla: 3.086 ± 0.433
1.829LysCys: 1.829 ± 0.241
3.296LysAsp: 3.296 ± 0.283
3.315LysGlu: 3.315 ± 0.332
2.191LysPhe: 2.191 ± 0.204
2.61LysGly: 2.61 ± 0.216
1.905LysHis: 1.905 ± 0.288
3.448LysIle: 3.448 ± 0.305
2.648LysLys: 2.648 ± 0.238
6.344LysLeu: 6.344 ± 0.447
1.658LysMet: 1.658 ± 0.228
3.639LysAsn: 3.639 ± 0.294
4.992LysPro: 4.992 ± 0.726
2.477LysGln: 2.477 ± 0.274
5.049LysArg: 5.049 ± 0.349
7.621LysSer: 7.621 ± 0.797
4.363LysThr: 4.363 ± 0.363
3.81LysVal: 3.81 ± 0.329
0.476LysTrp: 0.476 ± 0.116
2.381LysTyr: 2.381 ± 0.245
0.019LysXaa: 0.019 ± 0.02
Leu
4.077LeuAla: 4.077 ± 0.301
1.924LeuCys: 1.924 ± 0.211
4.992LeuAsp: 4.992 ± 0.357
4.725LeuGlu: 4.725 ± 0.338
3.353LeuPhe: 3.353 ± 0.269
3.22LeuGly: 3.22 ± 0.252
2.782LeuHis: 2.782 ± 0.252
4.268LeuIle: 4.268 ± 0.345
6.783LeuLys: 6.783 ± 0.573
7.526LeuLeu: 7.526 ± 0.59
2.991LeuMet: 2.991 ± 0.272
6.249LeuAsn: 6.249 ± 0.436
4.096LeuPro: 4.096 ± 0.323
2.991LeuGln: 2.991 ± 0.339
3.506LeuArg: 3.506 ± 0.299
5.049LeuSer: 5.049 ± 0.326
5.011LeuThr: 5.011 ± 0.349
5.011LeuVal: 5.011 ± 0.401
0.629LeuTrp: 0.629 ± 0.116
4.115LeuTyr: 4.115 ± 0.313
0.0LeuXaa: 0.0 ± 0.0
Met
1.581MetAla: 1.581 ± 0.24
0.781MetCys: 0.781 ± 0.145
1.962MetAsp: 1.962 ± 0.166
1.562MetGlu: 1.562 ± 0.211
1.257MetPhe: 1.257 ± 0.166
1.238MetGly: 1.238 ± 0.173
1.257MetHis: 1.257 ± 0.175
1.41MetIle: 1.41 ± 0.189
1.315MetLys: 1.315 ± 0.136
2.248MetLeu: 2.248 ± 0.25
0.895MetMet: 0.895 ± 0.123
1.734MetAsn: 1.734 ± 0.17
1.067MetPro: 1.067 ± 0.14
1.296MetGln: 1.296 ± 0.159
0.972MetArg: 0.972 ± 0.149
2.229MetSer: 2.229 ± 0.187
1.086MetThr: 1.086 ± 0.147
1.505MetVal: 1.505 ± 0.17
0.057MetTrp: 0.057 ± 0.035
1.6MetTyr: 1.6 ± 0.182
0.0MetXaa: 0.0 ± 0.0
Asn
4.172AsnAla: 4.172 ± 0.312
1.315AsnCys: 1.315 ± 0.166
3.544AsnAsp: 3.544 ± 0.291
3.353AsnGlu: 3.353 ± 0.367
2.477AsnPhe: 2.477 ± 0.192
3.658AsnGly: 3.658 ± 0.264
1.372AsnHis: 1.372 ± 0.225
3.829AsnIle: 3.829 ± 0.276
3.582AsnLys: 3.582 ± 0.325
5.563AsnLeu: 5.563 ± 0.356
1.276AsnMet: 1.276 ± 0.157
6.973AsnAsn: 6.973 ± 1.123
2.839AsnPro: 2.839 ± 0.293
2.21AsnGln: 2.21 ± 0.285
3.067AsnArg: 3.067 ± 0.312
6.325AsnSer: 6.325 ± 0.596
5.868AsnThr: 5.868 ± 0.647
5.43AsnVal: 5.43 ± 0.505
0.324AsnTrp: 0.324 ± 0.074
2.401AsnTyr: 2.401 ± 0.372
0.0AsnXaa: 0.0 ± 0.0
Pro
1.905ProAla: 1.905 ± 0.307
0.914ProCys: 0.914 ± 0.14
1.924ProAsp: 1.924 ± 0.207
2.782ProGlu: 2.782 ± 0.293
1.848ProPhe: 1.848 ± 0.262
1.2ProGly: 1.2 ± 0.16
0.724ProHis: 0.724 ± 0.11
2.896ProIle: 2.896 ± 0.231
3.829ProLys: 3.829 ± 0.452
3.41ProLeu: 3.41 ± 0.327
1.353ProMet: 1.353 ± 0.168
2.801ProAsn: 2.801 ± 0.348
2.934ProPro: 2.934 ± 0.623
1.219ProGln: 1.219 ± 0.191
1.486ProArg: 1.486 ± 0.2
4.42ProSer: 4.42 ± 0.418
5.277ProThr: 5.277 ± 0.84
2.572ProVal: 2.572 ± 0.237
0.267ProTrp: 0.267 ± 0.073
1.162ProTyr: 1.162 ± 0.166
0.019ProXaa: 0.019 ± 0.02
Gln
1.048GlnAla: 1.048 ± 0.139
0.914GlnCys: 0.914 ± 0.143
1.353GlnAsp: 1.353 ± 0.156
1.696GlnGlu: 1.696 ± 0.198
0.972GlnPhe: 0.972 ± 0.133
0.895GlnGly: 0.895 ± 0.133
1.086GlnHis: 1.086 ± 0.157
1.677GlnIle: 1.677 ± 0.156
1.772GlnLys: 1.772 ± 0.33
3.105GlnLeu: 3.105 ± 0.291
1.067GlnMet: 1.067 ± 0.14
1.638GlnAsn: 1.638 ± 0.202
1.981GlnPro: 1.981 ± 0.309
2.439GlnGln: 2.439 ± 0.367
1.562GlnArg: 1.562 ± 0.203
3.391GlnSer: 3.391 ± 0.391
2.591GlnThr: 2.591 ± 0.292
1.581GlnVal: 1.581 ± 0.163
0.21GlnTrp: 0.21 ± 0.069
1.429GlnTyr: 1.429 ± 0.166
0.0GlnXaa: 0.0 ± 0.0
Arg
2.096ArgAla: 2.096 ± 0.247
1.086ArgCys: 1.086 ± 0.149
2.534ArgAsp: 2.534 ± 0.235
1.886ArgGlu: 1.886 ± 0.191
2.096ArgPhe: 2.096 ± 0.221
2.02ArgGly: 2.02 ± 0.204
1.086ArgHis: 1.086 ± 0.146
3.353ArgIle: 3.353 ± 0.211
3.296ArgLys: 3.296 ± 0.292
5.468ArgLeu: 5.468 ± 0.443
1.429ArgMet: 1.429 ± 0.181
2.21ArgAsn: 2.21 ± 0.187
2.248ArgPro: 2.248 ± 0.227
1.505ArgGln: 1.505 ± 0.193
3.067ArgArg: 3.067 ± 0.334
4.153ArgSer: 4.153 ± 0.402
2.458ArgThr: 2.458 ± 0.247
3.906ArgVal: 3.906 ± 0.247
0.419ArgTrp: 0.419 ± 0.1
2.172ArgTyr: 2.172 ± 0.224
0.0ArgXaa: 0.0 ± 0.0
Ser
4.649SerAla: 4.649 ± 0.479
1.677SerCys: 1.677 ± 0.193
4.992SerAsp: 4.992 ± 0.428
5.201SerGlu: 5.201 ± 0.489
3.315SerPhe: 3.315 ± 0.288
4.134SerGly: 4.134 ± 0.447
1.181SerHis: 1.181 ± 0.133
6.078SerIle: 6.078 ± 0.406
7.602SerLys: 7.602 ± 1.028
6.287SerLeu: 6.287 ± 0.411
2.058SerMet: 2.058 ± 0.208
7.773SerAsn: 7.773 ± 0.654
2.191SerPro: 2.191 ± 0.276
2.02SerGln: 2.02 ± 0.22
3.925SerArg: 3.925 ± 0.477
9.64SerSer: 9.64 ± 0.958
7.964SerThr: 7.964 ± 0.655
6.592SerVal: 6.592 ± 0.293
0.381SerTrp: 0.381 ± 0.08
2.801SerTyr: 2.801 ± 0.254
0.019SerXaa: 0.019 ± 0.02
Thr
3.182ThrAla: 3.182 ± 0.295
1.2ThrCys: 1.2 ± 0.158
4.687ThrAsp: 4.687 ± 0.37
3.467ThrGlu: 3.467 ± 0.301
2.724ThrPhe: 2.724 ± 0.222
2.972ThrGly: 2.972 ± 0.299
1.41ThrHis: 1.41 ± 0.226
4.382ThrIle: 4.382 ± 0.491
4.553ThrLys: 4.553 ± 0.449
7.183ThrLeu: 7.183 ± 0.8
1.867ThrMet: 1.867 ± 0.234
5.03ThrAsn: 5.03 ± 0.572
4.344ThrPro: 4.344 ± 0.574
1.772ThrGln: 1.772 ± 0.212
3.048ThrArg: 3.048 ± 0.257
6.039ThrSer: 6.039 ± 0.614
7.468ThrThr: 7.468 ± 1.228
4.725ThrVal: 4.725 ± 0.403
0.438ThrTrp: 0.438 ± 0.088
2.267ThrTyr: 2.267 ± 0.249
0.019ThrXaa: 0.019 ± 0.02
Val
3.62ValAla: 3.62 ± 0.303
1.41ValCys: 1.41 ± 0.209
5.925ValAsp: 5.925 ± 0.447
4.553ValGlu: 4.553 ± 0.368
2.21ValPhe: 2.21 ± 0.206
2.839ValGly: 2.839 ± 0.239
2.077ValHis: 2.077 ± 0.224
3.01ValIle: 3.01 ± 0.206
4.477ValLys: 4.477 ± 0.377
5.049ValLeu: 5.049 ± 0.366
1.524ValMet: 1.524 ± 0.153
4.153ValAsn: 4.153 ± 0.296
2.743ValPro: 2.743 ± 0.253
2.896ValGln: 2.896 ± 0.312
2.934ValArg: 2.934 ± 0.272
4.534ValSer: 4.534 ± 0.336
3.506ValThr: 3.506 ± 0.321
4.63ValVal: 4.63 ± 0.336
0.4ValTrp: 0.4 ± 0.08
2.915ValTyr: 2.915 ± 0.264
0.019ValXaa: 0.019 ± 0.02
Trp
0.114TrpAla: 0.114 ± 0.048
0.171TrpCys: 0.171 ± 0.054
0.229TrpAsp: 0.229 ± 0.07
0.21TrpGlu: 0.21 ± 0.063
0.362TrpPhe: 0.362 ± 0.092
0.133TrpGly: 0.133 ± 0.059
0.229TrpHis: 0.229 ± 0.071
0.419TrpIle: 0.419 ± 0.089
0.324TrpLys: 0.324 ± 0.06
0.667TrpLeu: 0.667 ± 0.118
0.152TrpMet: 0.152 ± 0.047
0.324TrpAsn: 0.324 ± 0.086
0.133TrpPro: 0.133 ± 0.048
0.152TrpGln: 0.152 ± 0.054
0.457TrpArg: 0.457 ± 0.103
0.667TrpSer: 0.667 ± 0.088
0.324TrpThr: 0.324 ± 0.078
0.324TrpVal: 0.324 ± 0.072
0.076TrpTrp: 0.076 ± 0.039
0.362TrpTyr: 0.362 ± 0.078
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.115TyrAla: 2.115 ± 0.208
0.648TyrCys: 0.648 ± 0.127
2.42TyrAsp: 2.42 ± 0.276
2.0TyrGlu: 2.0 ± 0.168
1.276TyrPhe: 1.276 ± 0.181
1.448TyrGly: 1.448 ± 0.187
0.972TyrHis: 0.972 ± 0.126
2.439TyrIle: 2.439 ± 0.208
3.467TyrLys: 3.467 ± 0.332
2.934TyrLeu: 2.934 ± 0.261
1.086TyrMet: 1.086 ± 0.147
3.868TyrAsn: 3.868 ± 0.601
1.448TyrPro: 1.448 ± 0.21
1.2TyrGln: 1.2 ± 0.174
2.515TyrArg: 2.515 ± 0.243
2.82TyrSer: 2.82 ± 0.252
3.506TyrThr: 3.506 ± 0.301
1.81TyrVal: 1.81 ± 0.216
0.248TyrTrp: 0.248 ± 0.073
2.267TyrTyr: 2.267 ± 0.274
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.019XaaIle: 0.019 ± 0.02
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.019XaaPro: 0.019 ± 0.02
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.019XaaSer: 0.019 ± 0.02
0.0XaaThr: 0.0 ± 0.0
0.038XaaVal: 0.038 ± 0.04
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.095XaaXaa: 0.095 ± 0.1
Statistics based on 154 proteins (52489 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski