Amino acid dipepetide frequency for Pseudoxanthomonas composti

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.069AlaAla: 18.069 ± 0.2	1.184AlaCys: 1.184 ± 0.033	6.726AlaAsp: 6.726 ± 0.075	6.908AlaGlu: 6.908 ± 0.077	4.014AlaPhe: 4.014 ± 0.062	11.501AlaGly: 11.501 ± 0.147	2.65AlaHis: 2.65 ± 0.055	5.049AlaIle: 5.049 ± 0.078	3.187AlaLys: 3.187 ± 0.069	16.249AlaLeu: 16.249 ± 0.182	3.352AlaMet: 3.352 ± 0.057	2.872AlaAsn: 2.872 ± 0.065	6.935AlaPro: 6.935 ± 0.102	6.754AlaGln: 6.754 ± 0.081	9.959AlaArg: 9.959 ± 0.103	7.271AlaSer: 7.271 ± 0.098	6.249AlaThr: 6.249 ± 0.099	8.752AlaVal: 8.752 ± 0.103	2.105AlaTrp: 2.105 ± 0.044	2.581AlaTyr: 2.581 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	1.044CysAla: 1.044 ± 0.034	0.109CysCys: 0.109 ± 0.01	0.441CysAsp: 0.441 ± 0.019	0.411CysGlu: 0.411 ± 0.021	0.246CysPhe: 0.246 ± 0.014	0.809CysGly: 0.809 ± 0.029	0.187CysHis: 0.187 ± 0.012	0.288CysIle: 0.288 ± 0.014	0.182CysLys: 0.182 ± 0.011	0.834CysLeu: 0.834 ± 0.03	0.145CysMet: 0.145 ± 0.011	0.194CysAsn: 0.194 ± 0.011	0.359CysPro: 0.359 ± 0.018	0.285CysGln: 0.285 ± 0.016	0.53CysArg: 0.53 ± 0.022	0.422CysSer: 0.422 ± 0.02	0.417CysThr: 0.417 ± 0.018	0.629CysVal: 0.629 ± 0.021	0.115CysTrp: 0.115 ± 0.01	0.19CysTyr: 0.19 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	8.289AspAla: 8.289 ± 0.08	0.365AspCys: 0.365 ± 0.017	2.843AspAsp: 2.843 ± 0.057	2.892AspGlu: 2.892 ± 0.052	1.995AspPhe: 1.995 ± 0.043	5.605AspGly: 5.605 ± 0.101	1.146AspHis: 1.146 ± 0.033	2.187AspIle: 2.187 ± 0.043	1.574AspLys: 1.574 ± 0.045	5.778AspLeu: 5.778 ± 0.071	1.085AspMet: 1.085 ± 0.033	1.337AspAsn: 1.337 ± 0.041	3.379AspPro: 3.379 ± 0.052	2.015AspGln: 2.015 ± 0.046	3.648AspArg: 3.648 ± 0.053	2.467AspSer: 2.467 ± 0.051	2.888AspThr: 2.888 ± 0.052	3.848AspVal: 3.848 ± 0.058	1.093AspTrp: 1.093 ± 0.035	1.71AspTyr: 1.71 ± 0.04	0.0AspXaa: 0.0 ± 0.0
Glu	6.937GluAla: 6.937 ± 0.092	0.299GluCys: 0.299 ± 0.016	2.692GluAsp: 2.692 ± 0.052	2.547GluGlu: 2.547 ± 0.056	1.581GluPhe: 1.581 ± 0.036	4.125GluGly: 4.125 ± 0.068	1.43GluHis: 1.43 ± 0.037	2.244GluIle: 2.244 ± 0.05	1.36GluLys: 1.36 ± 0.035	5.913GluLeu: 5.913 ± 0.094	1.018GluMet: 1.018 ± 0.032	1.069GluAsn: 1.069 ± 0.029	2.307GluPro: 2.307 ± 0.053	2.751GluGln: 2.751 ± 0.051	4.893GluArg: 4.893 ± 0.078	2.319GluSer: 2.319 ± 0.046	2.478GluThr: 2.478 ± 0.047	3.817GluVal: 3.817 ± 0.06	0.612GluTrp: 0.612 ± 0.021	1.081GluTyr: 1.081 ± 0.033	0.0GluXaa: 0.0 ± 0.0
Phe	3.988PheAla: 3.988 ± 0.062	0.293PheCys: 0.293 ± 0.015	2.557PheAsp: 2.557 ± 0.055	1.819PheGlu: 1.819 ± 0.037	1.189PhePhe: 1.189 ± 0.037	3.318PheGly: 3.318 ± 0.049	0.735PheHis: 0.735 ± 0.025	1.275PheIle: 1.275 ± 0.035	0.925PheLys: 0.925 ± 0.03	2.937PheLeu: 2.937 ± 0.06	0.641PheMet: 0.641 ± 0.023	1.085PheAsn: 1.085 ± 0.03	1.41PhePro: 1.41 ± 0.03	1.11PheGln: 1.11 ± 0.032	1.99PheArg: 1.99 ± 0.043	2.098PheSer: 2.098 ± 0.048	1.756PheThr: 1.756 ± 0.038	2.41PheVal: 2.41 ± 0.048	0.503PheTrp: 0.503 ± 0.022	0.828PheTyr: 0.828 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	9.554GlyAla: 9.554 ± 0.11	0.731GlyCys: 0.731 ± 0.025	4.533GlyAsp: 4.533 ± 0.085	4.58GlyGlu: 4.58 ± 0.074	3.305GlyPhe: 3.305 ± 0.055	7.331GlyGly: 7.331 ± 0.132	1.976GlyHis: 1.976 ± 0.041	3.736GlyIle: 3.736 ± 0.055	3.053GlyLys: 3.053 ± 0.063	9.308GlyLeu: 9.308 ± 0.114	2.252GlyMet: 2.252 ± 0.046	2.467GlyAsn: 2.467 ± 0.087	3.241GlyPro: 3.241 ± 0.06	4.278GlyGln: 4.278 ± 0.065	6.111GlyArg: 6.111 ± 0.077	4.783GlySer: 4.783 ± 0.09	4.637GlyThr: 4.637 ± 0.086	6.501GlyVal: 6.501 ± 0.084	1.656GlyTrp: 1.656 ± 0.038	2.474GlyTyr: 2.474 ± 0.051	0.0GlyXaa: 0.0 ± 0.0
His	3.176HisAla: 3.176 ± 0.055	0.218HisCys: 0.218 ± 0.013	1.264HisAsp: 1.264 ± 0.033	1.019HisGlu: 1.019 ± 0.027	0.769HisPhe: 0.769 ± 0.023	2.232HisGly: 2.232 ± 0.047	0.605HisHis: 0.605 ± 0.026	0.704HisIle: 0.704 ± 0.025	0.458HisLys: 0.458 ± 0.019	2.172HisLeu: 2.172 ± 0.046	0.405HisMet: 0.405 ± 0.02	0.46HisAsn: 0.46 ± 0.019	1.375HisPro: 1.375 ± 0.038	0.707HisGln: 0.707 ± 0.023	1.684HisArg: 1.684 ± 0.037	0.948HisSer: 0.948 ± 0.034	0.965HisThr: 0.965 ± 0.028	1.521HisVal: 1.521 ± 0.034	0.443HisTrp: 0.443 ± 0.021	0.613HisTyr: 0.613 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	6.251IleAla: 6.251 ± 0.08	0.338IleCys: 0.338 ± 0.023	2.987IleAsp: 2.987 ± 0.051	2.676IleGlu: 2.676 ± 0.053	1.05IlePhe: 1.05 ± 0.031	4.24IleGly: 4.24 ± 0.056	0.755IleHis: 0.755 ± 0.027	1.239IleIle: 1.239 ± 0.04	1.104IleLys: 1.104 ± 0.034	2.952IleLeu: 2.952 ± 0.049	0.483IleMet: 0.483 ± 0.021	1.184IleAsn: 1.184 ± 0.033	1.934IlePro: 1.934 ± 0.043	1.26IleGln: 1.26 ± 0.035	2.335IleArg: 2.335 ± 0.046	2.184IleSer: 2.184 ± 0.043	2.143IleThr: 2.143 ± 0.046	3.022IleVal: 3.022 ± 0.048	0.399IleTrp: 0.399 ± 0.021	0.8IleTyr: 0.8 ± 0.025	0.0IleXaa: 0.0 ± 0.0
Lys	3.544LysAla: 3.544 ± 0.076	0.107LysCys: 0.107 ± 0.011	1.481LysAsp: 1.481 ± 0.044	1.089LysGlu: 1.089 ± 0.039	0.747LysPhe: 0.747 ± 0.027	1.96LysGly: 1.96 ± 0.044	0.511LysHis: 0.511 ± 0.024	1.105LysIle: 1.105 ± 0.035	0.91LysLys: 0.91 ± 0.047	2.975LysLeu: 2.975 ± 0.059	0.546LysMet: 0.546 ± 0.024	0.582LysAsn: 0.582 ± 0.022	1.912LysPro: 1.912 ± 0.049	1.201LysGln: 1.201 ± 0.033	2.094LysArg: 2.094 ± 0.048	1.328LysSer: 1.328 ± 0.039	1.498LysThr: 1.498 ± 0.038	2.091LysVal: 2.091 ± 0.047	0.297LysTrp: 0.297 ± 0.018	0.588LysTyr: 0.588 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	15.25LeuAla: 15.25 ± 0.171	1.003LeuCys: 1.003 ± 0.032	6.666LeuAsp: 6.666 ± 0.088	5.678LeuGlu: 5.678 ± 0.087	3.3LeuPhe: 3.3 ± 0.06	9.035LeuGly: 9.035 ± 0.099	2.35LeuHis: 2.35 ± 0.045	4.02LeuIle: 4.02 ± 0.06	3.081LeuLys: 3.081 ± 0.056	12.14LeuLeu: 12.14 ± 0.173	2.311LeuMet: 2.311 ± 0.044	2.331LeuAsn: 2.331 ± 0.045	6.683LeuPro: 6.683 ± 0.084	4.622LeuGln: 4.622 ± 0.069	8.688LeuArg: 8.688 ± 0.109	6.532LeuSer: 6.532 ± 0.085	5.179LeuThr: 5.179 ± 0.072	7.83LeuVal: 7.83 ± 0.099	1.469LeuTrp: 1.469 ± 0.043	2.251LeuTyr: 2.251 ± 0.049	0.0LeuXaa: 0.0 ± 0.0
Met	2.759MetAla: 2.759 ± 0.048	0.134MetCys: 0.134 ± 0.01	1.085MetAsp: 1.085 ± 0.031	0.947MetGlu: 0.947 ± 0.027	0.603MetPhe: 0.603 ± 0.022	1.589MetGly: 1.589 ± 0.04	0.45MetHis: 0.45 ± 0.02	0.821MetIle: 0.821 ± 0.025	0.703MetLys: 0.703 ± 0.023	2.385MetLeu: 2.385 ± 0.049	0.414MetMet: 0.414 ± 0.02	0.568MetAsn: 0.568 ± 0.021	1.436MetPro: 1.436 ± 0.035	0.972MetGln: 0.972 ± 0.028	1.745MetArg: 1.745 ± 0.038	1.593MetSer: 1.593 ± 0.033	1.381MetThr: 1.381 ± 0.033	1.457MetVal: 1.457 ± 0.037	0.219MetTrp: 0.219 ± 0.015	0.339MetTyr: 0.339 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.377AsnAla: 3.377 ± 0.068	0.201AsnCys: 0.201 ± 0.023	1.399AsnAsp: 1.399 ± 0.055	1.079AsnGlu: 1.079 ± 0.03	0.907AsnPhe: 0.907 ± 0.033	2.285AsnGly: 2.285 ± 0.061	0.429AsnHis: 0.429 ± 0.017	0.994AsnIle: 0.994 ± 0.03	0.584AsnLys: 0.584 ± 0.022	2.478AsnLeu: 2.478 ± 0.056	0.383AsnMet: 0.383 ± 0.02	0.658AsnAsn: 0.658 ± 0.028	1.661AsnPro: 1.661 ± 0.042	0.872AsnGln: 0.872 ± 0.027	1.562AsnArg: 1.562 ± 0.036	1.146AsnSer: 1.146 ± 0.038	1.305AsnThr: 1.305 ± 0.04	1.802AsnVal: 1.802 ± 0.053	0.379AsnTrp: 0.379 ± 0.016	0.697AsnTyr: 0.697 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	7.671ProAla: 7.671 ± 0.114	0.312ProCys: 0.312 ± 0.015	3.362ProAsp: 3.362 ± 0.063	3.285ProGlu: 3.285 ± 0.055	1.63ProPhe: 1.63 ± 0.038	4.9ProGly: 4.9 ± 0.071	1.091ProHis: 1.091 ± 0.03	1.815ProIle: 1.815 ± 0.04	1.379ProLys: 1.379 ± 0.036	5.501ProLeu: 5.501 ± 0.08	1.322ProMet: 1.322 ± 0.031	1.19ProAsn: 1.19 ± 0.029	2.851ProPro: 2.851 ± 0.066	2.527ProGln: 2.527 ± 0.053	3.493ProArg: 3.493 ± 0.062	2.821ProSer: 2.821 ± 0.044	2.564ProThr: 2.564 ± 0.055	4.228ProVal: 4.228 ± 0.06	0.854ProTrp: 0.854 ± 0.031	1.194ProTyr: 1.194 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	7.359GlnAla: 7.359 ± 0.101	0.254GlnCys: 0.254 ± 0.016	2.152GlnAsp: 2.152 ± 0.043	1.589GlnGlu: 1.589 ± 0.039	1.237GlnPhe: 1.237 ± 0.031	3.515GlnGly: 3.515 ± 0.053	0.95GlnHis: 0.95 ± 0.03	1.741GlnIle: 1.741 ± 0.039	0.829GlnLys: 0.829 ± 0.025	4.841GlnLeu: 4.841 ± 0.061	0.856GlnMet: 0.856 ± 0.029	0.75GlnAsn: 0.75 ± 0.027	2.475GlnPro: 2.475 ± 0.052	2.233GlnGln: 2.233 ± 0.051	4.077GlnArg: 4.077 ± 0.067	1.953GlnSer: 1.953 ± 0.035	1.969GlnThr: 1.969 ± 0.04	3.717GlnVal: 3.717 ± 0.055	0.715GlnTrp: 0.715 ± 0.023	0.848GlnTyr: 0.848 ± 0.023	0.0GlnXaa: 0.0 ± 0.0
Arg	8.684ArgAla: 8.684 ± 0.098	0.563ArgCys: 0.563 ± 0.025	4.065ArgAsp: 4.065 ± 0.063	4.266ArgGlu: 4.266 ± 0.076	2.824ArgPhe: 2.824 ± 0.049	5.368ArgGly: 5.368 ± 0.073	1.943ArgHis: 1.943 ± 0.043	3.515ArgIle: 3.515 ± 0.05	1.973ArgLys: 1.973 ± 0.041	8.487ArgLeu: 8.487 ± 0.106	1.916ArgMet: 1.916 ± 0.041	1.888ArgAsn: 1.888 ± 0.04	3.496ArgPro: 3.496 ± 0.052	3.618ArgGln: 3.618 ± 0.064	5.731ArgArg: 5.731 ± 0.08	3.761ArgSer: 3.761 ± 0.056	3.434ArgThr: 3.434 ± 0.049	5.202ArgVal: 5.202 ± 0.064	1.471ArgTrp: 1.471 ± 0.039	2.273ArgTyr: 2.273 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	6.856SerAla: 6.856 ± 0.094	0.378SerCys: 0.378 ± 0.018	2.854SerAsp: 2.854 ± 0.056	2.579SerGlu: 2.579 ± 0.047	2.016SerPhe: 2.016 ± 0.043	5.238SerGly: 5.238 ± 0.087	1.099SerHis: 1.099 ± 0.032	2.172SerIle: 2.172 ± 0.048	1.392SerLys: 1.392 ± 0.035	5.788SerLeu: 5.788 ± 0.079	1.147SerMet: 1.147 ± 0.032	1.408SerAsn: 1.408 ± 0.041	2.992SerPro: 2.992 ± 0.053	2.119SerGln: 2.119 ± 0.04	3.707SerArg: 3.707 ± 0.057	3.03SerSer: 3.03 ± 0.061	2.839SerThr: 2.839 ± 0.052	3.853SerVal: 3.853 ± 0.06	0.802SerTrp: 0.802 ± 0.027	1.408SerTyr: 1.408 ± 0.043	0.0SerXaa: 0.0 ± 0.0
Thr	6.12ThrAla: 6.12 ± 0.093	0.347ThrCys: 0.347 ± 0.017	2.549ThrAsp: 2.549 ± 0.051	2.222ThrGlu: 2.222 ± 0.046	1.558ThrPhe: 1.558 ± 0.036	4.562ThrGly: 4.562 ± 0.073	1.078ThrHis: 1.078 ± 0.029	1.783ThrIle: 1.783 ± 0.044	0.969ThrLys: 0.969 ± 0.035	6.573ThrLeu: 6.573 ± 0.082	0.861ThrMet: 0.861 ± 0.025	1.116ThrAsn: 1.116 ± 0.037	3.748ThrPro: 3.748 ± 0.062	1.98ThrGln: 1.98 ± 0.043	3.603ThrArg: 3.603 ± 0.055	2.57ThrSer: 2.57 ± 0.056	2.63ThrThr: 2.63 ± 0.058	3.98ThrVal: 3.98 ± 0.072	0.753ThrTrp: 0.753 ± 0.023	1.19ThrTyr: 1.19 ± 0.039	0.0ThrXaa: 0.0 ± 0.0
Val	9.1ValAla: 9.1 ± 0.1	0.636ValCys: 0.636 ± 0.027	4.313ValAsp: 4.313 ± 0.064	4.173ValGlu: 4.173 ± 0.06	2.444ValPhe: 2.444 ± 0.051	5.661ValGly: 5.661 ± 0.089	1.535ValHis: 1.535 ± 0.04	3.205ValIle: 3.205 ± 0.047	1.836ValLys: 1.836 ± 0.048	8.447ValLeu: 8.447 ± 0.104	1.616ValMet: 1.616 ± 0.037	1.861ValAsn: 1.861 ± 0.044	3.929ValPro: 3.929 ± 0.052	2.95ValGln: 2.95 ± 0.051	5.199ValArg: 5.199 ± 0.064	4.233ValSer: 4.233 ± 0.068	3.767ValThr: 3.767 ± 0.067	6.068ValVal: 6.068 ± 0.085	0.903ValTrp: 0.903 ± 0.031	1.547ValTyr: 1.547 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	1.367TrpAla: 1.367 ± 0.037	0.155TrpCys: 0.155 ± 0.013	0.721TrpAsp: 0.721 ± 0.022	0.583TrpGlu: 0.583 ± 0.022	0.573TrpPhe: 0.573 ± 0.026	1.012TrpGly: 1.012 ± 0.033	0.353TrpHis: 0.353 ± 0.016	0.693TrpIle: 0.693 ± 0.023	0.514TrpLys: 0.514 ± 0.021	2.168TrpLeu: 2.168 ± 0.052	0.468TrpMet: 0.468 ± 0.018	0.506TrpAsn: 0.506 ± 0.021	0.768TrpPro: 0.768 ± 0.026	0.821TrpGln: 0.821 ± 0.027	1.395TrpArg: 1.395 ± 0.035	0.945TrpSer: 0.945 ± 0.03	0.767TrpThr: 0.767 ± 0.026	1.01TrpVal: 1.01 ± 0.028	0.309TrpTrp: 0.309 ± 0.016	0.363TrpTyr: 0.363 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.975TyrAla: 2.975 ± 0.054	0.208TyrCys: 0.208 ± 0.012	1.454TyrAsp: 1.454 ± 0.044	1.133TyrGlu: 1.133 ± 0.029	0.88TyrPhe: 0.88 ± 0.029	2.221TyrGly: 2.221 ± 0.05	0.463TyrHis: 0.463 ± 0.019	0.751TyrIle: 0.751 ± 0.024	0.554TyrLys: 0.554 ± 0.021	2.496TyrLeu: 2.496 ± 0.048	0.38TyrMet: 0.38 ± 0.019	0.674TyrAsn: 0.674 ± 0.027	1.097TyrPro: 1.097 ± 0.031	0.983TyrGln: 0.983 ± 0.03	2.031TyrArg: 2.031 ± 0.047	1.271TyrSer: 1.271 ± 0.039	1.329TyrThr: 1.329 ± 0.038	1.683TyrVal: 1.683 ± 0.041	0.392TyrTrp: 0.392 ± 0.015	0.677TyrTyr: 0.677 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3624 proteins (1257634 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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