Amino acid dipepetide frequency for Leuconostoc sp. DORA_2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.138AlaAla: 6.138 ± 0.253
0.145AlaCys: 0.145 ± 0.033
4.33AlaAsp: 4.33 ± 0.178
4.136AlaGlu: 4.136 ± 0.179
3.561AlaPhe: 3.561 ± 0.165
5.293AlaGly: 5.293 ± 0.219
1.746AlaHis: 1.746 ± 0.128
6.45AlaIle: 6.45 ± 0.229
5.154AlaLys: 5.154 ± 0.22
8.113AlaLeu: 8.113 ± 0.26
2.418AlaMet: 2.418 ± 0.138
4.067AlaAsn: 4.067 ± 0.146
2.196AlaPro: 2.196 ± 0.132
3.79AlaGln: 3.79 ± 0.181
2.626AlaArg: 2.626 ± 0.132
3.893AlaSer: 3.893 ± 0.18
4.946AlaThr: 4.946 ± 0.176
5.667AlaVal: 5.667 ± 0.256
0.727AlaTrp: 0.727 ± 0.075
2.64AlaTyr: 2.64 ± 0.129
0.0AlaXaa: 0.0 ± 0.0
Cys
0.201CysAla: 0.201 ± 0.036
0.048CysCys: 0.048 ± 0.021
0.125CysAsp: 0.125 ± 0.032
0.187CysGlu: 0.187 ± 0.044
0.201CysPhe: 0.201 ± 0.04
0.339CysGly: 0.339 ± 0.057
0.069CysHis: 0.069 ± 0.022
0.201CysIle: 0.201 ± 0.04
0.125CysLys: 0.125 ± 0.03
0.395CysLeu: 0.395 ± 0.058
0.097CysMet: 0.097 ± 0.028
0.187CysAsn: 0.187 ± 0.044
0.097CysPro: 0.097 ± 0.028
0.215CysGln: 0.215 ± 0.039
0.194CysArg: 0.194 ± 0.035
0.173CysSer: 0.173 ± 0.038
0.18CysThr: 0.18 ± 0.035
0.18CysVal: 0.18 ± 0.033
0.055CysTrp: 0.055 ± 0.019
0.201CysTyr: 0.201 ± 0.044
0.0CysXaa: 0.0 ± 0.0
Asp
4.164AspAla: 4.164 ± 0.205
0.201AspCys: 0.201 ± 0.042
3.436AspAsp: 3.436 ± 0.144
3.679AspGlu: 3.679 ± 0.181
3.021AspPhe: 3.021 ± 0.165
3.402AspGly: 3.402 ± 0.16
1.053AspHis: 1.053 ± 0.086
4.351AspIle: 4.351 ± 0.188
3.949AspLys: 3.949 ± 0.182
5.092AspLeu: 5.092 ± 0.202
1.573AspMet: 1.573 ± 0.099
3.367AspAsn: 3.367 ± 0.181
1.607AspPro: 1.607 ± 0.127
2.099AspGln: 2.099 ± 0.123
2.037AspArg: 2.037 ± 0.128
3.152AspSer: 3.152 ± 0.143
3.152AspThr: 3.152 ± 0.151
3.99AspVal: 3.99 ± 0.155
0.769AspTrp: 0.769 ± 0.081
2.633AspTyr: 2.633 ± 0.154
0.007AspXaa: 0.007 ± 0.006
Glu
3.921GluAla: 3.921 ± 0.167
0.118GluCys: 0.118 ± 0.031
2.619GluAsp: 2.619 ± 0.131
2.743GluGlu: 2.743 ± 0.173
2.217GluPhe: 2.217 ± 0.128
2.307GluGly: 2.307 ± 0.159
1.074GluHis: 1.074 ± 0.078
4.254GluIle: 4.254 ± 0.187
4.198GluLys: 4.198 ± 0.19
5.265GluLeu: 5.265 ± 0.199
1.392GluMet: 1.392 ± 0.097
3.09GluAsn: 3.09 ± 0.158
1.199GluPro: 1.199 ± 0.092
2.889GluGln: 2.889 ± 0.162
2.39GluArg: 2.39 ± 0.156
3.104GluSer: 3.104 ± 0.157
3.554GluThr: 3.554 ± 0.157
3.208GluVal: 3.208 ± 0.175
0.54GluTrp: 0.54 ± 0.064
1.739GluTyr: 1.739 ± 0.091
0.0GluXaa: 0.0 ± 0.0
Phe
3.36PheAla: 3.36 ± 0.18
0.139PheCys: 0.139 ± 0.031
3.027PheAsp: 3.027 ± 0.159
2.674PheGlu: 2.674 ± 0.138
2.349PhePhe: 2.349 ± 0.116
3.589PheGly: 3.589 ± 0.162
0.831PheHis: 0.831 ± 0.079
3.298PheIle: 3.298 ± 0.146
2.889PheLys: 2.889 ± 0.126
4.399PheLeu: 4.399 ± 0.189
1.129PheMet: 1.129 ± 0.083
2.972PheAsn: 2.972 ± 0.14
1.316PhePro: 1.316 ± 0.086
1.538PheGln: 1.538 ± 0.11
1.531PheArg: 1.531 ± 0.095
3.208PheSer: 3.208 ± 0.158
2.39PheThr: 2.39 ± 0.122
3.242PheVal: 3.242 ± 0.163
0.61PheTrp: 0.61 ± 0.061
1.843PheTyr: 1.843 ± 0.103
0.007PheXaa: 0.007 ± 0.007
Gly
4.247GlyAla: 4.247 ± 0.19
0.18GlyCys: 0.18 ± 0.037
3.014GlyAsp: 3.014 ± 0.159
3.152GlyGlu: 3.152 ± 0.146
3.346GlyPhe: 3.346 ± 0.15
3.429GlyGly: 3.429 ± 0.169
1.524GlyHis: 1.524 ± 0.108
5.321GlyIle: 5.321 ± 0.24
3.637GlyLys: 3.637 ± 0.168
6.325GlyLeu: 6.325 ± 0.254
1.822GlyMet: 1.822 ± 0.115
3.0GlyAsn: 3.0 ± 0.16
1.129GlyPro: 1.129 ± 0.093
3.478GlyGln: 3.478 ± 0.162
2.446GlyArg: 2.446 ± 0.138
3.395GlySer: 3.395 ± 0.168
3.602GlyThr: 3.602 ± 0.175
4.42GlyVal: 4.42 ± 0.164
0.7GlyTrp: 0.7 ± 0.079
2.813GlyTyr: 2.813 ± 0.141
0.007GlyXaa: 0.007 ± 0.007
His
1.559HisAla: 1.559 ± 0.095
0.09HisCys: 0.09 ± 0.03
1.434HisAsp: 1.434 ± 0.113
1.095HisGlu: 1.095 ± 0.083
1.143HisPhe: 1.143 ± 0.087
1.489HisGly: 1.489 ± 0.113
0.665HisHis: 0.665 ± 0.076
1.573HisIle: 1.573 ± 0.111
0.956HisLys: 0.956 ± 0.086
2.252HisLeu: 2.252 ± 0.125
0.513HisMet: 0.513 ± 0.057
1.088HisAsn: 1.088 ± 0.096
0.734HisPro: 0.734 ± 0.085
1.282HisGln: 1.282 ± 0.099
0.831HisArg: 0.831 ± 0.079
0.852HisSer: 0.852 ± 0.073
1.005HisThr: 1.005 ± 0.085
1.628HisVal: 1.628 ± 0.111
0.284HisTrp: 0.284 ± 0.042
1.046HisTyr: 1.046 ± 0.082
0.007HisXaa: 0.007 ± 0.007
Ile
7.115IleAla: 7.115 ± 0.24
0.284IleCys: 0.284 ± 0.048
4.392IleAsp: 4.392 ± 0.182
4.067IleGlu: 4.067 ± 0.196
3.478IlePhe: 3.478 ± 0.163
5.154IleGly: 5.154 ± 0.207
1.372IleHis: 1.372 ± 0.109
6.013IleIle: 6.013 ± 0.257
4.953IleLys: 4.953 ± 0.193
7.337IleLeu: 7.337 ± 0.284
1.981IleMet: 1.981 ± 0.113
4.067IleAsn: 4.067 ± 0.193
2.501IlePro: 2.501 ± 0.125
2.785IleGln: 2.785 ± 0.154
2.653IleArg: 2.653 ± 0.131
4.656IleSer: 4.656 ± 0.195
4.586IleThr: 4.586 ± 0.175
6.131IleVal: 6.131 ± 0.218
0.748IleTrp: 0.748 ± 0.071
2.383IleTyr: 2.383 ± 0.122
0.021IleXaa: 0.021 ± 0.013
Lys
4.51LysAla: 4.51 ± 0.174
0.201LysCys: 0.201 ± 0.034
3.111LysAsp: 3.111 ± 0.162
3.263LysGlu: 3.263 ± 0.196
2.141LysPhe: 2.141 ± 0.136
2.944LysGly: 2.944 ± 0.135
1.434LysHis: 1.434 ± 0.095
4.78LysIle: 4.78 ± 0.183
4.649LysLys: 4.649 ± 0.222
5.653LysLeu: 5.653 ± 0.224
1.663LysMet: 1.663 ± 0.118
3.748LysAsn: 3.748 ± 0.179
2.071LysPro: 2.071 ± 0.135
3.72LysGln: 3.72 ± 0.197
3.152LysArg: 3.152 ± 0.167
3.838LysSer: 3.838 ± 0.174
3.949LysThr: 3.949 ± 0.181
3.783LysVal: 3.783 ± 0.162
0.727LysTrp: 0.727 ± 0.065
2.605LysTyr: 2.605 ± 0.155
0.007LysXaa: 0.007 ± 0.007
Leu
9.082LeuAla: 9.082 ± 0.269
0.43LeuCys: 0.43 ± 0.062
5.584LeuAsp: 5.584 ± 0.249
4.704LeuGlu: 4.704 ± 0.233
4.281LeuPhe: 4.281 ± 0.171
5.909LeuGly: 5.909 ± 0.217
1.884LeuHis: 1.884 ± 0.102
7.572LeuIle: 7.572 ± 0.303
6.214LeuLys: 6.214 ± 0.222
9.872LeuLeu: 9.872 ± 0.299
2.64LeuMet: 2.64 ± 0.126
5.14LeuAsn: 5.14 ± 0.206
4.101LeuPro: 4.101 ± 0.175
3.935LeuGln: 3.935 ± 0.172
3.845LeuArg: 3.845 ± 0.154
7.399LeuSer: 7.399 ± 0.242
7.115LeuThr: 7.115 ± 0.226
6.72LeuVal: 6.72 ± 0.231
0.824LeuTrp: 0.824 ± 0.082
2.854LeuTyr: 2.854 ± 0.17
0.014LeuXaa: 0.014 ± 0.01
Met
2.508MetAla: 2.508 ± 0.125
0.069MetCys: 0.069 ± 0.024
1.143MetAsp: 1.143 ± 0.083
0.79MetGlu: 0.79 ± 0.08
1.011MetPhe: 1.011 ± 0.085
1.517MetGly: 1.517 ± 0.109
0.478MetHis: 0.478 ± 0.056
2.307MetIle: 2.307 ± 0.142
1.656MetLys: 1.656 ± 0.11
2.612MetLeu: 2.612 ± 0.145
0.956MetMet: 0.956 ± 0.098
1.316MetAsn: 1.316 ± 0.098
1.136MetPro: 1.136 ± 0.093
1.282MetGln: 1.282 ± 0.104
1.164MetArg: 1.164 ± 0.096
2.071MetSer: 2.071 ± 0.112
2.335MetThr: 2.335 ± 0.139
1.767MetVal: 1.767 ± 0.107
0.256MetTrp: 0.256 ± 0.043
0.624MetTyr: 0.624 ± 0.069
0.014MetXaa: 0.014 ± 0.01
Asn
3.547AsnAla: 3.547 ± 0.152
0.201AsnCys: 0.201 ± 0.039
3.27AsnAsp: 3.27 ± 0.154
2.792AsnGlu: 2.792 ± 0.146
2.155AsnPhe: 2.155 ± 0.098
3.575AsnGly: 3.575 ± 0.162
1.323AsnHis: 1.323 ± 0.08
4.184AsnIle: 4.184 ± 0.2
3.055AsnLys: 3.055 ± 0.174
4.967AsnLeu: 4.967 ± 0.197
1.538AsnMet: 1.538 ± 0.114
3.208AsnAsn: 3.208 ± 0.182
1.898AsnPro: 1.898 ± 0.105
3.152AsnGln: 3.152 ± 0.156
2.064AsnArg: 2.064 ± 0.128
2.806AsnSer: 2.806 ± 0.16
3.055AsnThr: 3.055 ± 0.163
3.589AsnVal: 3.589 ± 0.174
0.755AsnTrp: 0.755 ± 0.07
2.12AsnTyr: 2.12 ± 0.12
0.007AsnXaa: 0.007 ± 0.007
Pro
2.265ProAla: 2.265 ± 0.125
0.069ProCys: 0.069 ± 0.024
2.016ProAsp: 2.016 ± 0.124
2.397ProGlu: 2.397 ± 0.144
1.455ProPhe: 1.455 ± 0.092
1.566ProGly: 1.566 ± 0.111
0.707ProHis: 0.707 ± 0.073
2.314ProIle: 2.314 ± 0.135
2.362ProLys: 2.362 ± 0.127
2.799ProLeu: 2.799 ± 0.137
0.984ProMet: 0.984 ± 0.087
1.961ProAsn: 1.961 ± 0.116
0.485ProPro: 0.485 ± 0.064
1.233ProGln: 1.233 ± 0.072
0.921ProArg: 0.921 ± 0.078
1.877ProSer: 1.877 ± 0.108
2.175ProThr: 2.175 ± 0.141
2.376ProVal: 2.376 ± 0.145
0.381ProTrp: 0.381 ± 0.054
1.289ProTyr: 1.289 ± 0.098
0.0ProXaa: 0.0 ± 0.0
Gln
4.288GlnAla: 4.288 ± 0.197
0.18GlnCys: 0.18 ± 0.038
2.196GlnAsp: 2.196 ± 0.122
2.238GlnGlu: 2.238 ± 0.136
2.051GlnPhe: 2.051 ± 0.118
2.584GlnGly: 2.584 ± 0.126
1.476GlnHis: 1.476 ± 0.094
3.208GlnIle: 3.208 ± 0.155
3.208GlnLys: 3.208 ± 0.169
5.57GlnLeu: 5.57 ± 0.228
1.15GlnMet: 1.15 ± 0.086
2.418GlnAsn: 2.418 ± 0.122
1.427GlnPro: 1.427 ± 0.11
3.097GlnGln: 3.097 ± 0.184
2.092GlnArg: 2.092 ± 0.122
2.896GlnSer: 2.896 ± 0.178
3.166GlnThr: 3.166 ± 0.155
3.381GlnVal: 3.381 ± 0.148
0.554GlnTrp: 0.554 ± 0.059
1.704GlnTyr: 1.704 ± 0.118
0.021GlnXaa: 0.021 ± 0.012
Arg
2.612ArgAla: 2.612 ± 0.152
0.139ArgCys: 0.139 ± 0.032
2.508ArgAsp: 2.508 ± 0.149
2.501ArgGlu: 2.501 ± 0.139
2.009ArgPhe: 2.009 ± 0.112
2.203ArgGly: 2.203 ± 0.122
0.977ArgHis: 0.977 ± 0.089
2.82ArgIle: 2.82 ± 0.137
2.113ArgLys: 2.113 ± 0.132
4.074ArgLeu: 4.074 ± 0.174
1.192ArgMet: 1.192 ± 0.097
1.78ArgAsn: 1.78 ± 0.125
1.108ArgPro: 1.108 ± 0.096
2.646ArgGln: 2.646 ± 0.15
2.03ArgArg: 2.03 ± 0.121
1.843ArgSer: 1.843 ± 0.106
2.155ArgThr: 2.155 ± 0.111
2.667ArgVal: 2.667 ± 0.128
0.464ArgTrp: 0.464 ± 0.051
1.711ArgTyr: 1.711 ± 0.104
0.014ArgXaa: 0.014 ± 0.01
Ser
4.323SerAla: 4.323 ± 0.201
0.242SerCys: 0.242 ± 0.045
3.956SerAsp: 3.956 ± 0.179
3.533SerGlu: 3.533 ± 0.155
3.055SerPhe: 3.055 ± 0.15
4.365SerGly: 4.365 ± 0.189
1.323SerHis: 1.323 ± 0.112
4.011SerIle: 4.011 ± 0.17
3.263SerLys: 3.263 ± 0.148
6.221SerLeu: 6.221 ± 0.193
1.496SerMet: 1.496 ± 0.107
3.18SerAsn: 3.18 ± 0.152
1.746SerPro: 1.746 ± 0.115
3.208SerGln: 3.208 ± 0.164
2.383SerArg: 2.383 ± 0.132
3.796SerSer: 3.796 ± 0.299
3.312SerThr: 3.312 ± 0.157
4.067SerVal: 4.067 ± 0.195
0.644SerTrp: 0.644 ± 0.067
2.127SerTyr: 2.127 ± 0.13
0.0SerXaa: 0.0 ± 0.0
Thr
4.946ThrAla: 4.946 ± 0.192
0.187ThrCys: 0.187 ± 0.034
3.415ThrAsp: 3.415 ± 0.158
2.695ThrGlu: 2.695 ± 0.14
2.937ThrPhe: 2.937 ± 0.165
4.067ThrGly: 4.067 ± 0.186
1.178ThrHis: 1.178 ± 0.086
5.023ThrIle: 5.023 ± 0.148
3.395ThrLys: 3.395 ± 0.156
6.519ThrLeu: 6.519 ± 0.21
1.559ThrMet: 1.559 ± 0.1
3.014ThrAsn: 3.014 ± 0.173
2.536ThrPro: 2.536 ± 0.148
2.944ThrGln: 2.944 ± 0.162
2.335ThrArg: 2.335 ± 0.114
3.762ThrSer: 3.762 ± 0.184
4.565ThrThr: 4.565 ± 0.218
4.503ThrVal: 4.503 ± 0.196
0.589ThrTrp: 0.589 ± 0.066
2.175ThrTyr: 2.175 ± 0.135
0.0ThrXaa: 0.0 ± 0.0
Val
6.138ValAla: 6.138 ± 0.223
0.284ValCys: 0.284 ± 0.046
4.177ValAsp: 4.177 ± 0.18
2.972ValGlu: 2.972 ± 0.156
2.979ValPhe: 2.979 ± 0.137
4.489ValGly: 4.489 ± 0.195
1.178ValHis: 1.178 ± 0.08
5.702ValIle: 5.702 ± 0.181
4.108ValLys: 4.108 ± 0.16
7.136ValLeu: 7.136 ± 0.231
1.836ValMet: 1.836 ± 0.1
3.415ValAsn: 3.415 ± 0.154
2.709ValPro: 2.709 ± 0.146
2.39ValGln: 2.39 ± 0.14
2.501ValArg: 2.501 ± 0.14
4.94ValSer: 4.94 ± 0.199
4.753ValThr: 4.753 ± 0.196
5.799ValVal: 5.799 ± 0.251
0.658ValTrp: 0.658 ± 0.06
2.085ValTyr: 2.085 ± 0.129
0.007ValXaa: 0.007 ± 0.007
Trp
0.727TrpAla: 0.727 ± 0.066
0.062TrpCys: 0.062 ± 0.02
0.52TrpAsp: 0.52 ± 0.063
0.443TrpGlu: 0.443 ± 0.05
0.624TrpPhe: 0.624 ± 0.074
0.561TrpGly: 0.561 ± 0.065
0.402TrpHis: 0.402 ± 0.053
0.582TrpIle: 0.582 ± 0.059
0.284TrpLys: 0.284 ± 0.049
1.559TrpLeu: 1.559 ± 0.105
0.249TrpMet: 0.249 ± 0.046
0.506TrpAsn: 0.506 ± 0.073
0.326TrpPro: 0.326 ± 0.052
0.873TrpGln: 0.873 ± 0.075
0.61TrpArg: 0.61 ± 0.07
0.617TrpSer: 0.617 ± 0.061
0.554TrpThr: 0.554 ± 0.057
0.734TrpVal: 0.734 ± 0.073
0.194TrpTrp: 0.194 ± 0.04
0.436TrpTyr: 0.436 ± 0.051
0.014TrpXaa: 0.014 ± 0.013
Tyr
2.376TyrAla: 2.376 ± 0.14
0.201TyrCys: 0.201 ± 0.04
2.446TyrAsp: 2.446 ± 0.125
1.746TyrGlu: 1.746 ± 0.122
2.328TyrPhe: 2.328 ± 0.134
2.203TyrGly: 2.203 ± 0.131
0.831TyrHis: 0.831 ± 0.078
2.716TyrIle: 2.716 ± 0.153
1.78TyrLys: 1.78 ± 0.11
3.949TyrLeu: 3.949 ± 0.192
0.804TyrMet: 0.804 ± 0.077
1.739TyrAsn: 1.739 ± 0.111
1.309TyrPro: 1.309 ± 0.107
2.349TyrGln: 2.349 ± 0.152
1.746TyrArg: 1.746 ± 0.116
1.961TyrSer: 1.961 ± 0.117
1.774TyrThr: 1.774 ± 0.128
2.369TyrVal: 2.369 ± 0.136
0.402TyrTrp: 0.402 ± 0.061
1.67TyrTyr: 1.67 ± 0.132
0.007TyrXaa: 0.007 ± 0.006
Xaa
0.007XaaAla: 0.007 ± 0.007
0.0XaaCys: 0.0 ± 0.001
0.014XaaAsp: 0.014 ± 0.009
0.014XaaGlu: 0.014 ± 0.01
0.0XaaPhe: 0.0 ± 0.001
0.0XaaGly: 0.0 ± 0.001
0.0XaaHis: 0.0 ± 0.001
0.0XaaIle: 0.0 ± 0.001
0.0XaaLys: 0.0 ± 0.001
0.014XaaLeu: 0.014 ± 0.011
0.014XaaMet: 0.014 ± 0.008
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.001
0.0XaaGln: 0.0 ± 0.0
0.014XaaArg: 0.014 ± 0.011
0.014XaaSer: 0.014 ± 0.013
0.021XaaThr: 0.021 ± 0.013
0.035XaaVal: 0.035 ± 0.017
0.0XaaTrp: 0.0 ± 0.0
0.007XaaTyr: 0.007 ± 0.007
1.386XaaXaa: 1.386 ± 0.366
Statistics based on 844 proteins (144346 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski