Amino acid dipepetide frequency for Effusibacillus lacus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.37AlaAla: 8.37 ± 0.114	0.769AlaCys: 0.769 ± 0.026	4.208AlaAsp: 4.208 ± 0.066	5.632AlaGlu: 5.632 ± 0.087	3.216AlaPhe: 3.216 ± 0.064	7.237AlaGly: 7.237 ± 0.094	1.479AlaHis: 1.479 ± 0.039	5.673AlaIle: 5.673 ± 0.087	4.86AlaLys: 4.86 ± 0.081	8.238AlaLeu: 8.238 ± 0.087	2.444AlaMet: 2.444 ± 0.049	2.839AlaAsn: 2.839 ± 0.051	2.602AlaPro: 2.602 ± 0.049	2.694AlaGln: 2.694 ± 0.051	4.191AlaArg: 4.191 ± 0.069	4.273AlaSer: 4.273 ± 0.068	3.803AlaThr: 3.803 ± 0.064	6.963AlaVal: 6.963 ± 0.085	0.811AlaTrp: 0.811 ± 0.03	2.373AlaTyr: 2.373 ± 0.046	0.0AlaXaa: 0.0 ± 0.0
Cys	0.547CysAla: 0.547 ± 0.023	0.108CysCys: 0.108 ± 0.01	0.429CysAsp: 0.429 ± 0.02	0.476CysGlu: 0.476 ± 0.02	0.298CysPhe: 0.298 ± 0.015	0.845CysGly: 0.845 ± 0.032	0.237CysHis: 0.237 ± 0.02	0.483CysIle: 0.483 ± 0.022	0.408CysLys: 0.408 ± 0.019	0.728CysLeu: 0.728 ± 0.027	0.214CysMet: 0.214 ± 0.013	0.297CysAsn: 0.297 ± 0.017	0.475CysPro: 0.475 ± 0.024	0.25CysGln: 0.25 ± 0.016	0.53CysArg: 0.53 ± 0.023	0.524CysSer: 0.524 ± 0.022	0.43CysThr: 0.43 ± 0.023	0.512CysVal: 0.512 ± 0.025	0.082CysTrp: 0.082 ± 0.01	0.248CysTyr: 0.248 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	3.577AspAla: 3.577 ± 0.054	0.44AspCys: 0.44 ± 0.022	2.091AspAsp: 2.091 ± 0.054	3.442AspGlu: 3.442 ± 0.061	2.042AspPhe: 2.042 ± 0.041	3.489AspGly: 3.489 ± 0.067	1.043AspHis: 1.043 ± 0.032	3.451AspIle: 3.451 ± 0.063	2.847AspLys: 2.847 ± 0.063	5.483AspLeu: 5.483 ± 0.075	1.356AspMet: 1.356 ± 0.04	1.464AspAsn: 1.464 ± 0.04	2.663AspPro: 2.663 ± 0.052	1.745AspGln: 1.745 ± 0.042	3.173AspArg: 3.173 ± 0.058	2.573AspSer: 2.573 ± 0.049	2.356AspThr: 2.356 ± 0.05	3.75AspVal: 3.75 ± 0.063	0.784AspTrp: 0.784 ± 0.029	1.638AspTyr: 1.638 ± 0.041	0.0AspXaa: 0.0 ± 0.0
Glu	5.82GluAla: 5.82 ± 0.085	0.417GluCys: 0.417 ± 0.02	3.255GluAsp: 3.255 ± 0.061	5.732GluGlu: 5.732 ± 0.089	2.46GluPhe: 2.46 ± 0.047	4.499GluGly: 4.499 ± 0.069	1.461GluHis: 1.461 ± 0.031	5.012GluIle: 5.012 ± 0.074	4.715GluLys: 4.715 ± 0.086	6.986GluLeu: 6.986 ± 0.092	2.127GluMet: 2.127 ± 0.047	2.466GluAsn: 2.466 ± 0.051	2.341GluPro: 2.341 ± 0.048	3.478GluGln: 3.478 ± 0.065	4.272GluArg: 4.272 ± 0.075	3.204GluSer: 3.204 ± 0.056	3.719GluThr: 3.719 ± 0.061	5.13GluVal: 5.13 ± 0.077	0.917GluTrp: 0.917 ± 0.033	2.029GluTyr: 2.029 ± 0.045	0.0GluXaa: 0.0 ± 0.0
Phe	3.453PheAla: 3.453 ± 0.07	0.375PheCys: 0.375 ± 0.019	2.145PheAsp: 2.145 ± 0.047	2.489PheGlu: 2.489 ± 0.052	1.742PhePhe: 1.742 ± 0.047	3.352PheGly: 3.352 ± 0.07	0.942PheHis: 0.942 ± 0.029	2.253PheIle: 2.253 ± 0.054	1.689PheLys: 1.689 ± 0.043	4.318PheLeu: 4.318 ± 0.086	0.938PheMet: 0.938 ± 0.034	1.298PheAsn: 1.298 ± 0.035	1.792PhePro: 1.792 ± 0.043	1.423PheGln: 1.423 ± 0.035	2.063PheArg: 2.063 ± 0.042	2.453PheSer: 2.453 ± 0.053	2.11PheThr: 2.11 ± 0.044	3.132PheVal: 3.132 ± 0.069	0.464PheTrp: 0.464 ± 0.021	1.357PheTyr: 1.357 ± 0.039	0.0PheXaa: 0.0 ± 0.0
Gly	5.792GlyAla: 5.792 ± 0.081	0.792GlyCys: 0.792 ± 0.032	3.578GlyAsp: 3.578 ± 0.066	4.757GlyGlu: 4.757 ± 0.065	3.337GlyPhe: 3.337 ± 0.057	5.726GlyGly: 5.726 ± 0.081	1.649GlyHis: 1.649 ± 0.043	6.394GlyIle: 6.394 ± 0.081	5.028GlyLys: 5.028 ± 0.085	7.5GlyLeu: 7.5 ± 0.1	2.43GlyMet: 2.43 ± 0.048	2.697GlyAsn: 2.697 ± 0.058	2.262GlyPro: 2.262 ± 0.046	2.816GlyGln: 2.816 ± 0.054	3.934GlyArg: 3.934 ± 0.064	4.427GlySer: 4.427 ± 0.066	4.65GlyThr: 4.65 ± 0.074	5.97GlyVal: 5.97 ± 0.078	1.008GlyTrp: 1.008 ± 0.034	2.778GlyTyr: 2.778 ± 0.055	0.0GlyXaa: 0.0 ± 0.0
His	1.542HisAla: 1.542 ± 0.039	0.203HisCys: 0.203 ± 0.014	0.918HisAsp: 0.918 ± 0.029	1.277HisGlu: 1.277 ± 0.034	0.977HisPhe: 0.977 ± 0.033	1.648HisGly: 1.648 ± 0.04	0.578HisHis: 0.578 ± 0.032	1.253HisIle: 1.253 ± 0.031	0.993HisLys: 0.993 ± 0.032	2.156HisLeu: 2.156 ± 0.047	0.533HisMet: 0.533 ± 0.021	0.674HisAsn: 0.674 ± 0.029	1.41HisPro: 1.41 ± 0.034	0.715HisGln: 0.715 ± 0.026	1.133HisArg: 1.133 ± 0.029	1.192HisSer: 1.192 ± 0.032	1.082HisThr: 1.082 ± 0.031	1.538HisVal: 1.538 ± 0.038	0.271HisTrp: 0.271 ± 0.018	0.749HisTyr: 0.749 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	5.907IleAla: 5.907 ± 0.083	0.59IleCys: 0.59 ± 0.024	3.543IleAsp: 3.543 ± 0.062	4.535IleGlu: 4.535 ± 0.062	2.336IlePhe: 2.336 ± 0.051	5.753IleGly: 5.753 ± 0.084	1.568IleHis: 1.568 ± 0.042	3.512IleIle: 3.512 ± 0.073	3.199IleLys: 3.199 ± 0.058	6.682IleLeu: 6.682 ± 0.091	1.454IleMet: 1.454 ± 0.043	2.127IleAsn: 2.127 ± 0.053	3.533IlePro: 3.533 ± 0.065	2.585IleGln: 2.585 ± 0.051	4.361IleArg: 4.361 ± 0.071	3.864IleSer: 3.864 ± 0.065	3.585IleThr: 3.585 ± 0.058	5.304IleVal: 5.304 ± 0.069	0.682IleTrp: 0.682 ± 0.026	1.81IleTyr: 1.81 ± 0.04	0.0IleXaa: 0.0 ± 0.0
Lys	4.483LysAla: 4.483 ± 0.066	0.32LysCys: 0.32 ± 0.019	2.884LysAsp: 2.884 ± 0.056	4.873LysGlu: 4.873 ± 0.071	1.697LysPhe: 1.697 ± 0.036	4.084LysGly: 4.084 ± 0.057	1.056LysHis: 1.056 ± 0.033	3.642LysIle: 3.642 ± 0.068	3.742LysLys: 3.742 ± 0.075	5.068LysLeu: 5.068 ± 0.073	1.761LysMet: 1.761 ± 0.038	2.192LysAsn: 2.192 ± 0.044	2.425LysPro: 2.425 ± 0.048	2.599LysGln: 2.599 ± 0.049	3.122LysArg: 3.122 ± 0.054	2.605LysSer: 2.605 ± 0.058	2.873LysThr: 2.873 ± 0.055	4.207LysVal: 4.207 ± 0.065	0.713LysTrp: 0.713 ± 0.025	1.715LysTyr: 1.715 ± 0.037	0.0LysXaa: 0.0 ± 0.0
Leu	9.529LeuAla: 9.529 ± 0.099	0.727LeuCys: 0.727 ± 0.028	4.91LeuAsp: 4.91 ± 0.069	6.853LeuGlu: 6.853 ± 0.097	4.209LeuPhe: 4.209 ± 0.084	7.531LeuGly: 7.531 ± 0.101	2.063LeuHis: 2.063 ± 0.041	6.278LeuIle: 6.278 ± 0.082	5.307LeuLys: 5.307 ± 0.069	10.718LeuLeu: 10.718 ± 0.142	2.523LeuMet: 2.523 ± 0.044	3.443LeuAsn: 3.443 ± 0.053	4.54LeuPro: 4.54 ± 0.071	4.209LeuGln: 4.209 ± 0.074	5.249LeuArg: 5.249 ± 0.079	6.175LeuSer: 6.175 ± 0.073	5.557LeuThr: 5.557 ± 0.071	7.431LeuVal: 7.431 ± 0.084	0.979LeuTrp: 0.979 ± 0.032	2.858LeuTyr: 2.858 ± 0.049	0.0LeuXaa: 0.0 ± 0.0
Met	2.531MetAla: 2.531 ± 0.045	0.165MetCys: 0.165 ± 0.012	1.357MetAsp: 1.357 ± 0.037	2.094MetGlu: 2.094 ± 0.049	0.929MetPhe: 0.929 ± 0.033	2.132MetGly: 2.132 ± 0.05	0.488MetHis: 0.488 ± 0.023	1.842MetIle: 1.842 ± 0.042	1.819MetLys: 1.819 ± 0.041	2.529MetLeu: 2.529 ± 0.056	0.804MetMet: 0.804 ± 0.026	1.26MetAsn: 1.26 ± 0.038	1.092MetPro: 1.092 ± 0.035	1.072MetGln: 1.072 ± 0.03	1.331MetArg: 1.331 ± 0.035	1.595MetSer: 1.595 ± 0.036	1.612MetThr: 1.612 ± 0.038	1.932MetVal: 1.932 ± 0.044	0.255MetTrp: 0.255 ± 0.017	0.695MetTyr: 0.695 ± 0.027	0.0MetXaa: 0.0 ± 0.0
Asn	2.578AsnAla: 2.578 ± 0.058	0.348AsnCys: 0.348 ± 0.019	1.579AsnAsp: 1.579 ± 0.041	2.135AsnGlu: 2.135 ± 0.047	1.165AsnPhe: 1.165 ± 0.034	3.084AsnGly: 3.084 ± 0.056	0.738AsnHis: 0.738 ± 0.025	2.095AsnIle: 2.095 ± 0.044	1.823AsnLys: 1.823 ± 0.043	3.728AsnLeu: 3.728 ± 0.062	0.926AsnMet: 0.926 ± 0.027	1.184AsnAsn: 1.184 ± 0.035	2.326AsnPro: 2.326 ± 0.055	1.542AsnGln: 1.542 ± 0.042	2.394AsnArg: 2.394 ± 0.048	1.882AsnSer: 1.882 ± 0.045	1.686AsnThr: 1.686 ± 0.043	2.575AsnVal: 2.575 ± 0.051	0.529AsnTrp: 0.529 ± 0.023	1.055AsnTyr: 1.055 ± 0.034	0.0AsnXaa: 0.0 ± 0.0
Pro	3.298ProAla: 3.298 ± 0.064	0.312ProCys: 0.312 ± 0.017	2.785ProAsp: 2.785 ± 0.053	3.678ProGlu: 3.678 ± 0.054	1.902ProPhe: 1.902 ± 0.047	3.578ProGly: 3.578 ± 0.058	0.965ProHis: 0.965 ± 0.028	2.638ProIle: 2.638 ± 0.049	2.178ProLys: 2.178 ± 0.047	3.923ProLeu: 3.923 ± 0.057	1.003ProMet: 1.003 ± 0.031	1.608ProAsn: 1.608 ± 0.04	1.483ProPro: 1.483 ± 0.036	1.439ProGln: 1.439 ± 0.038	1.764ProArg: 1.764 ± 0.046	2.243ProSer: 2.243 ± 0.042	2.093ProThr: 2.093 ± 0.047	4.079ProVal: 4.079 ± 0.07	0.501ProTrp: 0.501 ± 0.022	1.498ProTyr: 1.498 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	3.48GlnAla: 3.48 ± 0.063	0.23GlnCys: 0.23 ± 0.015	1.686GlnAsp: 1.686 ± 0.043	2.911GlnGlu: 2.911 ± 0.062	1.445GlnPhe: 1.445 ± 0.04	2.594GlnGly: 2.594 ± 0.046	0.721GlnHis: 0.721 ± 0.025	2.806GlnIle: 2.806 ± 0.058	2.193GlnLys: 2.193 ± 0.053	3.851GlnLeu: 3.851 ± 0.066	1.225GlnMet: 1.225 ± 0.037	1.423GlnAsn: 1.423 ± 0.03	1.559GlnPro: 1.559 ± 0.043	1.872GlnGln: 1.872 ± 0.048	1.912GlnArg: 1.912 ± 0.044	2.103GlnSer: 2.103 ± 0.054	2.236GlnThr: 2.236 ± 0.045	3.035GlnVal: 3.035 ± 0.06	0.414GlnTrp: 0.414 ± 0.018	1.215GlnTyr: 1.215 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	3.457ArgAla: 3.457 ± 0.061	0.395ArgCys: 0.395 ± 0.024	2.665ArgAsp: 2.665 ± 0.042	4.491ArgGlu: 4.491 ± 0.06	2.433ArgPhe: 2.433 ± 0.052	3.29ArgGly: 3.29 ± 0.06	1.123ArgHis: 1.123 ± 0.03	4.388ArgIle: 4.388 ± 0.074	3.556ArgLys: 3.556 ± 0.063	5.546ArgLeu: 5.546 ± 0.078	1.734ArgMet: 1.734 ± 0.04	2.242ArgAsn: 2.242 ± 0.046	2.075ArgPro: 2.075 ± 0.046	2.35ArgGln: 2.35 ± 0.05	2.961ArgArg: 2.961 ± 0.049	2.89ArgSer: 2.89 ± 0.055	2.744ArgThr: 2.744 ± 0.052	3.92ArgVal: 3.92 ± 0.056	0.677ArgTrp: 0.677 ± 0.024	1.868ArgTyr: 1.868 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	4.101SerAla: 4.101 ± 0.072	0.448SerCys: 0.448 ± 0.024	2.651SerAsp: 2.651 ± 0.053	3.345SerGlu: 3.345 ± 0.061	2.637SerPhe: 2.637 ± 0.05	4.864SerGly: 4.864 ± 0.077	1.205SerHis: 1.205 ± 0.033	3.753SerIle: 3.753 ± 0.069	2.757SerLys: 2.757 ± 0.056	5.956SerLeu: 5.956 ± 0.088	1.534SerMet: 1.534 ± 0.041	1.862SerAsn: 1.862 ± 0.041	2.341SerPro: 2.341 ± 0.049	1.949SerGln: 1.949 ± 0.046	3.046SerArg: 3.046 ± 0.058	3.112SerSer: 3.112 ± 0.059	2.763SerThr: 2.763 ± 0.056	4.332SerVal: 4.332 ± 0.07	0.626SerTrp: 0.626 ± 0.032	1.69SerTyr: 1.69 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	4.584ThrAla: 4.584 ± 0.078	0.4ThrCys: 0.4 ± 0.022	2.616ThrAsp: 2.616 ± 0.05	3.25ThrGlu: 3.25 ± 0.058	2.152ThrPhe: 2.152 ± 0.044	5.147ThrGly: 5.147 ± 0.061	1.048ThrHis: 1.048 ± 0.031	3.62ThrIle: 3.62 ± 0.063	2.42ThrLys: 2.42 ± 0.051	5.125ThrLeu: 5.125 ± 0.074	1.311ThrMet: 1.311 ± 0.037	1.787ThrAsn: 1.787 ± 0.044	2.518ThrPro: 2.518 ± 0.051	1.518ThrGln: 1.518 ± 0.042	2.56ThrArg: 2.56 ± 0.049	2.865ThrSer: 2.865 ± 0.058	2.687ThrThr: 2.687 ± 0.051	4.81ThrVal: 4.81 ± 0.067	0.568ThrTrp: 0.568 ± 0.027	1.599ThrTyr: 1.599 ± 0.038	0.0ThrXaa: 0.0 ± 0.0
Val	6.586ValAla: 6.586 ± 0.092	0.703ValCys: 0.703 ± 0.029	3.913ValAsp: 3.913 ± 0.061	5.246ValGlu: 5.246 ± 0.071	3.054ValPhe: 3.054 ± 0.059	5.251ValGly: 5.251 ± 0.08	1.534ValHis: 1.534 ± 0.04	5.202ValIle: 5.202 ± 0.074	4.256ValLys: 4.256 ± 0.063	7.957ValLeu: 7.957 ± 0.09	2.11ValMet: 2.11 ± 0.044	2.844ValAsn: 2.844 ± 0.057	3.653ValPro: 3.653 ± 0.057	2.88ValGln: 2.88 ± 0.054	4.228ValArg: 4.228 ± 0.062	4.613ValSer: 4.613 ± 0.068	4.496ValThr: 4.496 ± 0.067	6.2ValVal: 6.2 ± 0.086	0.855ValTrp: 0.855 ± 0.031	2.231ValTyr: 2.231 ± 0.049	0.0ValXaa: 0.0 ± 0.0
Trp	0.836TrpAla: 0.836 ± 0.026	0.084TrpCys: 0.084 ± 0.008	0.567TrpAsp: 0.567 ± 0.024	0.768TrpGlu: 0.768 ± 0.026	0.497TrpPhe: 0.497 ± 0.022	0.805TrpGly: 0.805 ± 0.026	0.201TrpHis: 0.201 ± 0.014	0.869TrpIle: 0.869 ± 0.031	0.742TrpLys: 0.742 ± 0.027	1.306TrpLeu: 1.306 ± 0.04	0.395TrpMet: 0.395 ± 0.024	0.583TrpAsn: 0.583 ± 0.022	0.405TrpPro: 0.405 ± 0.021	0.494TrpGln: 0.494 ± 0.022	0.625TrpArg: 0.625 ± 0.025	0.623TrpSer: 0.623 ± 0.027	0.599TrpThr: 0.599 ± 0.026	0.785TrpVal: 0.785 ± 0.029	0.181TrpTrp: 0.181 ± 0.012	0.351TrpTyr: 0.351 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.204TyrAla: 2.204 ± 0.048	0.297TyrCys: 0.297 ± 0.019	1.627TyrAsp: 1.627 ± 0.044	2.057TyrGlu: 2.057 ± 0.046	1.259TyrPhe: 1.259 ± 0.038	2.617TyrGly: 2.617 ± 0.052	0.742TyrHis: 0.742 ± 0.026	1.766TyrIle: 1.766 ± 0.042	1.532TyrLys: 1.532 ± 0.034	3.291TyrLeu: 3.291 ± 0.055	0.711TyrMet: 0.711 ± 0.026	1.079TyrAsn: 1.079 ± 0.029	1.475TyrPro: 1.475 ± 0.039	1.282TyrGln: 1.282 ± 0.036	1.956TyrArg: 1.956 ± 0.044	1.755TyrSer: 1.755 ± 0.035	1.505TyrThr: 1.505 ± 0.038	2.207TyrVal: 2.207 ± 0.044	0.397TyrTrp: 0.397 ± 0.019	1.084TyrTyr: 1.084 ± 0.032	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3692 proteins (1079243 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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