Amino acid dipepetide frequency for Gluconobacter sp. DsW_058

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.118AlaAla: 13.118 ± 0.172	1.285AlaCys: 1.285 ± 0.044	5.808AlaAsp: 5.808 ± 0.086	6.189AlaGlu: 6.189 ± 0.109	3.826AlaPhe: 3.826 ± 0.076	9.479AlaGly: 9.479 ± 0.131	2.472AlaHis: 2.472 ± 0.062	5.433AlaIle: 5.433 ± 0.11	3.432AlaLys: 3.432 ± 0.073	13.085AlaLeu: 13.085 ± 0.185	2.935AlaMet: 2.935 ± 0.065	2.725AlaAsn: 2.725 ± 0.059	5.691AlaPro: 5.691 ± 0.096	4.167AlaGln: 4.167 ± 0.082	7.323AlaArg: 7.323 ± 0.108	6.867AlaSer: 6.867 ± 0.095	5.753AlaThr: 5.753 ± 0.089	7.469AlaVal: 7.469 ± 0.107	1.363AlaTrp: 1.363 ± 0.037	2.391AlaTyr: 2.391 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	1.102CysAla: 1.102 ± 0.039	0.134CysCys: 0.134 ± 0.013	0.513CysAsp: 0.513 ± 0.025	0.442CysGlu: 0.442 ± 0.025	0.356CysPhe: 0.356 ± 0.023	0.986CysGly: 0.986 ± 0.038	0.286CysHis: 0.286 ± 0.017	0.474CysIle: 0.474 ± 0.025	0.18CysLys: 0.18 ± 0.014	1.009CysLeu: 1.009 ± 0.037	0.189CysMet: 0.189 ± 0.016	0.23CysAsn: 0.23 ± 0.019	0.49CysPro: 0.49 ± 0.028	0.293CysGln: 0.293 ± 0.02	0.628CysArg: 0.628 ± 0.031	0.584CysSer: 0.584 ± 0.026	0.514CysThr: 0.514 ± 0.024	0.728CysVal: 0.728 ± 0.03	0.133CysTrp: 0.133 ± 0.013	0.187CysTyr: 0.187 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	6.455AspAla: 6.455 ± 0.103	0.467AspCys: 0.467 ± 0.02	2.825AspAsp: 2.825 ± 0.077	2.946AspGlu: 2.946 ± 0.071	2.037AspPhe: 2.037 ± 0.048	4.98AspGly: 4.98 ± 0.087	1.454AspHis: 1.454 ± 0.045	3.068AspIle: 3.068 ± 0.063	1.33AspLys: 1.33 ± 0.042	6.024AspLeu: 6.024 ± 0.096	1.451AspMet: 1.451 ± 0.049	1.353AspAsn: 1.353 ± 0.042	3.274AspPro: 3.274 ± 0.067	1.897AspGln: 1.897 ± 0.051	3.944AspArg: 3.944 ± 0.086	2.431AspSer: 2.431 ± 0.067	2.784AspThr: 2.784 ± 0.059	4.45AspVal: 4.45 ± 0.083	0.973AspTrp: 0.973 ± 0.043	1.434AspTyr: 1.434 ± 0.043	0.0AspXaa: 0.0 ± 0.0
Glu	6.511GluAla: 6.511 ± 0.116	0.343GluCys: 0.343 ± 0.02	3.017GluAsp: 3.017 ± 0.07	3.012GluGlu: 3.012 ± 0.079	1.423GluPhe: 1.423 ± 0.039	4.103GluGly: 4.103 ± 0.077	1.301GluHis: 1.301 ± 0.038	2.971GluIle: 2.971 ± 0.067	2.328GluLys: 2.328 ± 0.059	4.615GluLeu: 4.615 ± 0.089	1.342GluMet: 1.342 ± 0.04	1.913GluAsn: 1.913 ± 0.048	2.081GluPro: 2.081 ± 0.059	2.243GluGln: 2.243 ± 0.064	4.231GluArg: 4.231 ± 0.087	2.415GluSer: 2.415 ± 0.052	3.684GluThr: 3.684 ± 0.072	3.126GluVal: 3.126 ± 0.069	0.742GluTrp: 0.742 ± 0.032	0.934GluTyr: 0.934 ± 0.034	0.0GluXaa: 0.0 ± 0.0
Phe	3.697PheAla: 3.697 ± 0.074	0.49PheCys: 0.49 ± 0.027	2.327PheAsp: 2.327 ± 0.058	1.806PheGlu: 1.806 ± 0.049	1.366PhePhe: 1.366 ± 0.048	3.398PheGly: 3.398 ± 0.055	0.888PheHis: 0.888 ± 0.032	1.522PheIle: 1.522 ± 0.046	0.86PheLys: 0.86 ± 0.035	3.562PheLeu: 3.562 ± 0.068	0.884PheMet: 0.884 ± 0.037	1.116PheAsn: 1.116 ± 0.042	1.641PhePro: 1.641 ± 0.044	1.213PheGln: 1.213 ± 0.041	2.22PheArg: 2.22 ± 0.059	2.698PheSer: 2.698 ± 0.057	1.979PheThr: 1.979 ± 0.047	2.533PheVal: 2.533 ± 0.063	0.551PheTrp: 0.551 ± 0.027	0.91PheTyr: 0.91 ± 0.036	0.0PheXaa: 0.0 ± 0.0
Gly	8.131GlyAla: 8.131 ± 0.099	0.855GlyCys: 0.855 ± 0.033	3.838GlyAsp: 3.838 ± 0.08	3.949GlyGlu: 3.949 ± 0.086	3.459GlyPhe: 3.459 ± 0.078	7.181GlyGly: 7.181 ± 0.15	2.263GlyHis: 2.263 ± 0.05	4.517GlyIle: 4.517 ± 0.084	3.182GlyLys: 3.182 ± 0.071	9.076GlyLeu: 9.076 ± 0.136	2.32GlyMet: 2.32 ± 0.056	2.462GlyAsn: 2.462 ± 0.069	3.378GlyPro: 3.378 ± 0.068	3.381GlyGln: 3.381 ± 0.06	5.688GlyArg: 5.688 ± 0.091	4.986GlySer: 4.986 ± 0.074	5.21GlyThr: 5.21 ± 0.092	6.02GlyVal: 6.02 ± 0.089	1.444GlyTrp: 1.444 ± 0.049	2.323GlyTyr: 2.323 ± 0.055	0.0GlyXaa: 0.0 ± 0.0
His	2.646HisAla: 2.646 ± 0.068	0.248HisCys: 0.248 ± 0.017	1.5HisAsp: 1.5 ± 0.043	1.168HisGlu: 1.168 ± 0.041	0.944HisPhe: 0.944 ± 0.034	2.164HisGly: 2.164 ± 0.051	0.845HisHis: 0.845 ± 0.037	1.198HisIle: 1.198 ± 0.037	0.623HisLys: 0.623 ± 0.026	2.536HisLeu: 2.536 ± 0.056	0.576HisMet: 0.576 ± 0.027	0.673HisAsn: 0.673 ± 0.029	1.558HisPro: 1.558 ± 0.049	0.849HisGln: 0.849 ± 0.038	1.557HisArg: 1.557 ± 0.043	1.266HisSer: 1.266 ± 0.04	1.171HisThr: 1.171 ± 0.041	1.876HisVal: 1.876 ± 0.048	0.396HisTrp: 0.396 ± 0.021	0.734HisTyr: 0.734 ± 0.033	0.0HisXaa: 0.0 ± 0.0
Ile	5.968IleAla: 5.968 ± 0.102	0.564IleCys: 0.564 ± 0.028	2.991IleAsp: 2.991 ± 0.067	3.089IleGlu: 3.089 ± 0.065	1.548IlePhe: 1.548 ± 0.043	4.547IleGly: 4.547 ± 0.086	1.105IleHis: 1.105 ± 0.032	2.21IleIle: 2.21 ± 0.064	1.27IleLys: 1.27 ± 0.044	4.864IleLeu: 4.864 ± 0.092	1.099IleMet: 1.099 ± 0.042	1.475IleAsn: 1.475 ± 0.049	2.704IlePro: 2.704 ± 0.057	1.583IleGln: 1.583 ± 0.047	3.419IleArg: 3.419 ± 0.057	3.373IleSer: 3.373 ± 0.07	3.012IleThr: 3.012 ± 0.061	3.761IleVal: 3.761 ± 0.075	0.597IleTrp: 0.597 ± 0.026	0.99IleTyr: 0.99 ± 0.036	0.0IleXaa: 0.0 ± 0.0
Lys	4.071LysAla: 4.071 ± 0.079	0.148LysCys: 0.148 ± 0.013	1.795LysAsp: 1.795 ± 0.056	1.553LysGlu: 1.553 ± 0.051	0.781LysPhe: 0.781 ± 0.034	2.563LysGly: 2.563 ± 0.06	0.73LysHis: 0.73 ± 0.023	1.844LysIle: 1.844 ± 0.047	1.259LysLys: 1.259 ± 0.048	3.104LysLeu: 3.104 ± 0.068	0.713LysMet: 0.713 ± 0.028	1.06LysAsn: 1.06 ± 0.039	1.916LysPro: 1.916 ± 0.051	1.117LysGln: 1.117 ± 0.038	2.171LysArg: 2.171 ± 0.061	1.926LysSer: 1.926 ± 0.047	2.148LysThr: 2.148 ± 0.054	2.054LysVal: 2.054 ± 0.059	0.341LysTrp: 0.341 ± 0.02	0.595LysTyr: 0.595 ± 0.029	0.0LysXaa: 0.0 ± 0.0
Leu	11.702LeuAla: 11.702 ± 0.161	1.124LeuCys: 1.124 ± 0.04	5.788LeuAsp: 5.788 ± 0.093	5.387LeuGlu: 5.387 ± 0.107	3.633LeuPhe: 3.633 ± 0.079	8.183LeuGly: 8.183 ± 0.114	2.513LeuHis: 2.513 ± 0.065	4.723LeuIle: 4.723 ± 0.082	3.854LeuLys: 3.854 ± 0.057	10.245LeuLeu: 10.245 ± 0.165	2.463LeuMet: 2.463 ± 0.053	3.145LeuAsn: 3.145 ± 0.07	6.462LeuPro: 6.462 ± 0.102	3.428LeuGln: 3.428 ± 0.072	7.122LeuArg: 7.122 ± 0.107	7.84LeuSer: 7.84 ± 0.116	6.651LeuThr: 6.651 ± 0.092	6.693LeuVal: 6.693 ± 0.094	1.268LeuTrp: 1.268 ± 0.041	2.214LeuTyr: 2.214 ± 0.049	0.0LeuXaa: 0.0 ± 0.0
Met	2.822MetAla: 2.822 ± 0.071	0.151MetCys: 0.151 ± 0.013	1.211MetAsp: 1.211 ± 0.04	1.081MetGlu: 1.081 ± 0.034	0.756MetPhe: 0.756 ± 0.031	1.933MetGly: 1.933 ± 0.047	0.505MetHis: 0.505 ± 0.025	1.35MetIle: 1.35 ± 0.042	0.972MetLys: 0.972 ± 0.035	2.426MetLeu: 2.426 ± 0.058	0.7MetMet: 0.7 ± 0.03	0.769MetAsn: 0.769 ± 0.029	1.583MetPro: 1.583 ± 0.042	0.921MetGln: 0.921 ± 0.039	1.675MetArg: 1.675 ± 0.047	1.865MetSer: 1.865 ± 0.047	2.096MetThr: 2.096 ± 0.054	1.602MetVal: 1.602 ± 0.046	0.191MetTrp: 0.191 ± 0.016	0.313MetTyr: 0.313 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	3.402AsnAla: 3.402 ± 0.066	0.278AsnCys: 0.278 ± 0.018	1.499AsnAsp: 1.499 ± 0.046	1.227AsnGlu: 1.227 ± 0.036	1.034AsnPhe: 1.034 ± 0.038	2.921AsnGly: 2.921 ± 0.073	0.617AsnHis: 0.617 ± 0.031	1.6AsnIle: 1.6 ± 0.049	0.678AsnLys: 0.678 ± 0.031	2.753AsnLeu: 2.753 ± 0.059	0.786AsnMet: 0.786 ± 0.035	0.918AsnAsn: 0.918 ± 0.045	1.912AsnPro: 1.912 ± 0.048	0.92AsnGln: 0.92 ± 0.038	1.936AsnArg: 1.936 ± 0.049	1.589AsnSer: 1.589 ± 0.051	1.713AsnThr: 1.713 ± 0.052	2.231AsnVal: 2.231 ± 0.06	0.477AsnTrp: 0.477 ± 0.023	0.786AsnTyr: 0.786 ± 0.038	0.0AsnXaa: 0.0 ± 0.0
Pro	5.952ProAla: 5.952 ± 0.077	0.385ProCys: 0.385 ± 0.025	4.035ProAsp: 4.035 ± 0.077	3.897ProGlu: 3.897 ± 0.064	2.026ProPhe: 2.026 ± 0.055	4.368ProGly: 4.368 ± 0.09	1.325ProHis: 1.325 ± 0.036	2.229ProIle: 2.229 ± 0.054	1.672ProLys: 1.672 ± 0.047	5.044ProLeu: 5.044 ± 0.083	1.197ProMet: 1.197 ± 0.04	1.489ProAsn: 1.489 ± 0.044	2.653ProPro: 2.653 ± 0.085	2.062ProGln: 2.062 ± 0.051	2.564ProArg: 2.564 ± 0.064	3.563ProSer: 3.563 ± 0.07	2.901ProThr: 2.901 ± 0.064	4.564ProVal: 4.564 ± 0.073	0.785ProTrp: 0.785 ± 0.029	1.332ProTyr: 1.332 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	4.447GlnAla: 4.447 ± 0.081	0.211GlnCys: 0.211 ± 0.016	2.242GlnAsp: 2.242 ± 0.058	1.729GlnGlu: 1.729 ± 0.048	1.204GlnPhe: 1.204 ± 0.039	2.668GlnGly: 2.668 ± 0.063	0.858GlnHis: 0.858 ± 0.031	2.15GlnIle: 2.15 ± 0.047	1.485GlnLys: 1.485 ± 0.045	2.937GlnLeu: 2.937 ± 0.061	0.942GlnMet: 0.942 ± 0.038	1.312GlnAsn: 1.312 ± 0.045	2.009GlnPro: 2.009 ± 0.052	1.564GlnGln: 1.564 ± 0.061	2.207GlnArg: 2.207 ± 0.06	2.427GlnSer: 2.427 ± 0.059	2.496GlnThr: 2.496 ± 0.06	2.471GlnVal: 2.471 ± 0.052	0.446GlnTrp: 0.446 ± 0.022	0.843GlnTyr: 0.843 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	6.578ArgAla: 6.578 ± 0.11	0.497ArgCys: 0.497 ± 0.027	3.663ArgAsp: 3.663 ± 0.075	3.582ArgGlu: 3.582 ± 0.067	2.699ArgPhe: 2.699 ± 0.059	4.261ArgGly: 4.261 ± 0.078	1.89ArgHis: 1.89 ± 0.05	3.659ArgIle: 3.659 ± 0.076	2.381ArgLys: 2.381 ± 0.053	7.855ArgLeu: 7.855 ± 0.122	1.705ArgMet: 1.705 ± 0.047	1.974ArgAsn: 1.974 ± 0.051	3.459ArgPro: 3.459 ± 0.069	2.767ArgGln: 2.767 ± 0.053	4.917ArgArg: 4.917 ± 0.099	3.928ArgSer: 3.928 ± 0.074	3.504ArgThr: 3.504 ± 0.061	4.365ArgVal: 4.365 ± 0.076	0.924ArgTrp: 0.924 ± 0.036	1.769ArgTyr: 1.769 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	6.703SerAla: 6.703 ± 0.093	0.579SerCys: 0.579 ± 0.031	3.311SerAsp: 3.311 ± 0.066	3.052SerGlu: 3.052 ± 0.065	2.566SerPhe: 2.566 ± 0.052	6.0SerGly: 6.0 ± 0.095	1.481SerHis: 1.481 ± 0.041	2.998SerIle: 2.998 ± 0.061	1.635SerLys: 1.635 ± 0.046	6.663SerLeu: 6.663 ± 0.102	1.587SerMet: 1.587 ± 0.045	1.707SerAsn: 1.707 ± 0.053	3.459SerPro: 3.459 ± 0.068	2.189SerGln: 2.189 ± 0.054	4.143SerArg: 4.143 ± 0.074	4.116SerSer: 4.116 ± 0.092	3.413SerThr: 3.413 ± 0.076	4.784SerVal: 4.784 ± 0.076	0.906SerTrp: 0.906 ± 0.032	1.558SerTyr: 1.558 ± 0.06	0.0SerXaa: 0.0 ± 0.0
Thr	6.218ThrAla: 6.218 ± 0.089	0.525ThrCys: 0.525 ± 0.028	3.32ThrAsp: 3.32 ± 0.06	2.661ThrGlu: 2.661 ± 0.063	2.06ThrPhe: 2.06 ± 0.055	5.308ThrGly: 5.308 ± 0.088	1.366ThrHis: 1.366 ± 0.038	3.078ThrIle: 3.078 ± 0.064	1.582ThrLys: 1.582 ± 0.052	6.939ThrLeu: 6.939 ± 0.1	1.256ThrMet: 1.256 ± 0.044	1.634ThrAsn: 1.634 ± 0.052	3.973ThrPro: 3.973 ± 0.082	2.032ThrGln: 2.032 ± 0.052	3.324ThrArg: 3.324 ± 0.071	3.609ThrSer: 3.609 ± 0.076	3.387ThrThr: 3.387 ± 0.086	4.586ThrVal: 4.586 ± 0.066	0.718ThrTrp: 0.718 ± 0.03	1.506ThrTyr: 1.506 ± 0.049	0.0ThrXaa: 0.0 ± 0.0
Val	7.648ValAla: 7.648 ± 0.111	0.795ValCys: 0.795 ± 0.034	3.62ValAsp: 3.62 ± 0.072	3.829ValGlu: 3.829 ± 0.076	2.563ValPhe: 2.563 ± 0.054	5.26ValGly: 5.26 ± 0.086	1.628ValHis: 1.628 ± 0.044	3.524ValIle: 3.524 ± 0.067	1.998ValLys: 1.998 ± 0.055	7.843ValLeu: 7.843 ± 0.117	1.936ValMet: 1.936 ± 0.053	1.958ValAsn: 1.958 ± 0.052	3.936ValPro: 3.936 ± 0.072	2.524ValGln: 2.524 ± 0.064	4.491ValArg: 4.491 ± 0.075	5.146ValSer: 5.146 ± 0.08	4.696ValThr: 4.696 ± 0.08	5.427ValVal: 5.427 ± 0.089	1.032ValTrp: 1.032 ± 0.037	1.364ValTyr: 1.364 ± 0.042	0.0ValXaa: 0.0 ± 0.0
Trp	1.204TrpAla: 1.204 ± 0.042	0.156TrpCys: 0.156 ± 0.014	0.693TrpAsp: 0.693 ± 0.03	0.581TrpGlu: 0.581 ± 0.027	0.526TrpPhe: 0.526 ± 0.027	0.957TrpGly: 0.957 ± 0.045	0.44TrpHis: 0.44 ± 0.023	0.715TrpIle: 0.715 ± 0.034	0.584TrpLys: 0.584 ± 0.026	1.701TrpLeu: 1.701 ± 0.055	0.384TrpMet: 0.384 ± 0.024	0.551TrpAsn: 0.551 ± 0.026	0.68TrpPro: 0.68 ± 0.031	0.628TrpGln: 0.628 ± 0.031	1.12TrpArg: 1.12 ± 0.034	0.913TrpSer: 0.913 ± 0.035	0.734TrpThr: 0.734 ± 0.028	0.776TrpVal: 0.776 ± 0.033	0.209TrpTrp: 0.209 ± 0.019	0.325TrpTyr: 0.325 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.437TyrAla: 2.437 ± 0.055	0.223TyrCys: 0.223 ± 0.016	1.583TyrAsp: 1.583 ± 0.048	1.153TyrGlu: 1.153 ± 0.045	0.854TyrPhe: 0.854 ± 0.035	2.402TyrGly: 2.402 ± 0.06	0.564TyrHis: 0.564 ± 0.028	0.906TyrIle: 0.906 ± 0.033	0.584TyrLys: 0.584 ± 0.029	2.154TyrLeu: 2.154 ± 0.052	0.456TyrMet: 0.456 ± 0.024	0.812TyrAsn: 0.812 ± 0.04	1.183TyrPro: 1.183 ± 0.04	0.87TyrGln: 0.87 ± 0.036	1.698TyrArg: 1.698 ± 0.047	1.309TyrSer: 1.309 ± 0.046	1.237TyrThr: 1.237 ± 0.044	1.701TyrVal: 1.701 ± 0.043	0.381TyrTrp: 0.381 ± 0.023	0.675TyrTyr: 0.675 ± 0.036	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2448 proteins (805449 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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