Amino acid dipepetide frequency for Lachnoclostridium sp. An118

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.606AlaAla: 8.606 ± 0.153	1.273AlaCys: 1.273 ± 0.035	4.911AlaAsp: 4.911 ± 0.074	5.553AlaGlu: 5.553 ± 0.099	3.188AlaPhe: 3.188 ± 0.069	7.694AlaGly: 7.694 ± 0.114	1.172AlaHis: 1.172 ± 0.039	4.384AlaIle: 4.384 ± 0.076	3.963AlaLys: 3.963 ± 0.079	7.604AlaLeu: 7.604 ± 0.115	2.48AlaMet: 2.48 ± 0.054	2.093AlaAsn: 2.093 ± 0.046	2.248AlaPro: 2.248 ± 0.052	2.458AlaGln: 2.458 ± 0.055	4.115AlaArg: 4.115 ± 0.073	4.098AlaSer: 4.098 ± 0.069	2.975AlaThr: 2.975 ± 0.065	7.047AlaVal: 7.047 ± 0.1	0.725AlaTrp: 0.725 ± 0.03	2.701AlaTyr: 2.701 ± 0.06	0.0AlaXaa: 0.0 ± 0.0
Cys	1.131CysAla: 1.131 ± 0.032	0.301CysCys: 0.301 ± 0.017	0.731CysAsp: 0.731 ± 0.031	0.849CysGlu: 0.849 ± 0.028	0.665CysPhe: 0.665 ± 0.028	1.649CysGly: 1.649 ± 0.041	0.37CysHis: 0.37 ± 0.02	1.078CysIle: 1.078 ± 0.032	0.611CysLys: 0.611 ± 0.027	1.35CysLeu: 1.35 ± 0.039	0.459CysMet: 0.459 ± 0.021	0.482CysAsn: 0.482 ± 0.021	0.737CysPro: 0.737 ± 0.031	0.515CysGln: 0.515 ± 0.025	0.998CysArg: 0.998 ± 0.028	0.887CysSer: 0.887 ± 0.029	0.785CysThr: 0.785 ± 0.027	1.134CysVal: 1.134 ± 0.041	0.12CysTrp: 0.12 ± 0.01	0.495CysTyr: 0.495 ± 0.024	0.0CysXaa: 0.0 ± 0.0
Asp	4.102AspAla: 4.102 ± 0.077	0.83AspCys: 0.83 ± 0.029	2.725AspAsp: 2.725 ± 0.065	4.611AspGlu: 4.611 ± 0.079	2.588AspPhe: 2.588 ± 0.05	4.505AspGly: 4.505 ± 0.093	1.069AspHis: 1.069 ± 0.036	4.475AspIle: 4.475 ± 0.078	2.9AspLys: 2.9 ± 0.062	4.729AspLeu: 4.729 ± 0.07	2.028AspMet: 2.028 ± 0.051	1.83AspAsn: 1.83 ± 0.044	2.155AspPro: 2.155 ± 0.048	1.692AspGln: 1.692 ± 0.044	3.435AspArg: 3.435 ± 0.069	2.922AspSer: 2.922 ± 0.06	3.155AspThr: 3.155 ± 0.066	3.867AspVal: 3.867 ± 0.07	0.611AspTrp: 0.611 ± 0.024	2.716AspTyr: 2.716 ± 0.058	0.0AspXaa: 0.0 ± 0.0
Glu	6.404GluAla: 6.404 ± 0.097	0.776GluCys: 0.776 ± 0.029	4.777GluAsp: 4.777 ± 0.079	8.89GluGlu: 8.89 ± 0.153	2.34GluPhe: 2.34 ± 0.054	5.52GluGly: 5.52 ± 0.085	1.373GluHis: 1.373 ± 0.035	5.123GluIle: 5.123 ± 0.089	6.731GluLys: 6.731 ± 0.085	7.358GluLeu: 7.358 ± 0.1	2.509GluMet: 2.509 ± 0.06	3.469GluAsn: 3.469 ± 0.063	2.235GluPro: 2.235 ± 0.054	3.007GluGln: 3.007 ± 0.061	4.505GluArg: 4.505 ± 0.085	3.375GluSer: 3.375 ± 0.058	3.924GluThr: 3.924 ± 0.08	4.517GluVal: 4.517 ± 0.081	0.64GluTrp: 0.64 ± 0.024	3.004GluTyr: 3.004 ± 0.053	0.0GluXaa: 0.0 ± 0.0
Phe	2.984PheAla: 2.984 ± 0.056	0.761PheCys: 0.761 ± 0.029	2.455PheAsp: 2.455 ± 0.052	2.551PheGlu: 2.551 ± 0.054	1.779PhePhe: 1.779 ± 0.044	2.998PheGly: 2.998 ± 0.061	0.866PheHis: 0.866 ± 0.031	2.549PheIle: 2.549 ± 0.052	1.604PheLys: 1.604 ± 0.044	4.082PheLeu: 4.082 ± 0.082	1.078PheMet: 1.078 ± 0.035	1.187PheAsn: 1.187 ± 0.034	1.477PhePro: 1.477 ± 0.04	1.381PheGln: 1.381 ± 0.036	2.139PheArg: 2.139 ± 0.048	2.69PheSer: 2.69 ± 0.045	2.332PheThr: 2.332 ± 0.051	2.669PheVal: 2.669 ± 0.064	0.404PheTrp: 0.404 ± 0.021	1.667PheTyr: 1.667 ± 0.035	0.0PheXaa: 0.0 ± 0.0
Gly	5.723GlyAla: 5.723 ± 0.093	1.358GlyCys: 1.358 ± 0.04	3.815GlyAsp: 3.815 ± 0.075	5.733GlyGlu: 5.733 ± 0.09	3.102GlyPhe: 3.102 ± 0.059	5.601GlyGly: 5.601 ± 0.103	1.36GlyHis: 1.36 ± 0.039	5.791GlyIle: 5.791 ± 0.079	5.229GlyLys: 5.229 ± 0.085	6.306GlyLeu: 6.306 ± 0.079	2.637GlyMet: 2.637 ± 0.054	2.801GlyAsn: 2.801 ± 0.064	1.542GlyPro: 1.542 ± 0.043	2.641GlyGln: 2.641 ± 0.06	4.362GlyArg: 4.362 ± 0.081	4.273GlySer: 4.273 ± 0.077	4.446GlyThr: 4.446 ± 0.087	5.279GlyVal: 5.279 ± 0.078	0.75GlyTrp: 0.75 ± 0.029	3.311GlyTyr: 3.311 ± 0.066	0.0GlyXaa: 0.0 ± 0.0
His	1.14HisAla: 1.14 ± 0.034	0.329HisCys: 0.329 ± 0.021	0.953HisAsp: 0.953 ± 0.029	0.997HisGlu: 0.997 ± 0.031	0.817HisPhe: 0.817 ± 0.027	1.261HisGly: 1.261 ± 0.041	0.424HisHis: 0.424 ± 0.027	1.465HisIle: 1.465 ± 0.043	0.713HisLys: 0.713 ± 0.029	1.624HisLeu: 1.624 ± 0.039	0.62HisMet: 0.62 ± 0.024	0.608HisAsn: 0.608 ± 0.027	0.972HisPro: 0.972 ± 0.035	0.57HisGln: 0.57 ± 0.021	1.063HisArg: 1.063 ± 0.03	0.983HisSer: 0.983 ± 0.037	1.032HisThr: 1.032 ± 0.039	1.202HisVal: 1.202 ± 0.036	0.139HisTrp: 0.139 ± 0.011	0.704HisTyr: 0.704 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	5.261IleAla: 5.261 ± 0.077	1.256IleCys: 1.256 ± 0.039	3.674IleAsp: 3.674 ± 0.073	4.244IleGlu: 4.244 ± 0.076	2.647IlePhe: 2.647 ± 0.058	4.733IleGly: 4.733 ± 0.078	1.32IleHis: 1.32 ± 0.039	4.158IleIle: 4.158 ± 0.091	3.006IleLys: 3.006 ± 0.06	6.79IleLeu: 6.79 ± 0.106	1.767IleMet: 1.767 ± 0.048	2.203IleAsn: 2.203 ± 0.059	3.106IlePro: 3.106 ± 0.057	2.268IleGln: 2.268 ± 0.051	4.296IleArg: 4.296 ± 0.075	4.315IleSer: 4.315 ± 0.07	3.666IleThr: 3.666 ± 0.064	4.501IleVal: 4.501 ± 0.077	0.624IleTrp: 0.624 ± 0.024	2.617IleTyr: 2.617 ± 0.049	0.0IleXaa: 0.0 ± 0.0
Lys	4.561LysAla: 4.561 ± 0.073	0.647LysCys: 0.647 ± 0.026	3.389LysAsp: 3.389 ± 0.062	6.037LysGlu: 6.037 ± 0.085	1.543LysPhe: 1.543 ± 0.042	3.864LysGly: 3.864 ± 0.066	0.837LysHis: 0.837 ± 0.033	3.863LysIle: 3.863 ± 0.07	5.227LysLys: 5.227 ± 0.089	4.612LysLeu: 4.612 ± 0.068	1.823LysMet: 1.823 ± 0.054	2.692LysAsn: 2.692 ± 0.057	1.646LysPro: 1.646 ± 0.043	1.83LysGln: 1.83 ± 0.054	3.197LysArg: 3.197 ± 0.058	2.853LysSer: 2.853 ± 0.057	3.061LysThr: 3.061 ± 0.064	3.818LysVal: 3.818 ± 0.067	0.521LysTrp: 0.521 ± 0.025	2.527LysTyr: 2.527 ± 0.05	0.0LysXaa: 0.0 ± 0.0
Leu	7.801LeuAla: 7.801 ± 0.11	1.59LeuCys: 1.59 ± 0.044	5.357LeuAsp: 5.357 ± 0.082	7.247LeuGlu: 7.247 ± 0.093	3.841LeuPhe: 3.841 ± 0.071	6.392LeuGly: 6.392 ± 0.098	1.662LeuHis: 1.662 ± 0.038	5.422LeuIle: 5.422 ± 0.081	5.364LeuLys: 5.364 ± 0.08	9.382LeuLeu: 9.382 ± 0.17	2.596LeuMet: 2.596 ± 0.056	3.089LeuAsn: 3.089 ± 0.067	3.832LeuPro: 3.832 ± 0.063	2.752LeuGln: 2.752 ± 0.055	4.669LeuArg: 4.669 ± 0.084	6.048LeuSer: 6.048 ± 0.085	5.296LeuThr: 5.296 ± 0.087	5.778LeuVal: 5.778 ± 0.092	0.822LeuTrp: 0.822 ± 0.032	3.439LeuTyr: 3.439 ± 0.062	0.0LeuXaa: 0.0 ± 0.0
Met	2.647MetAla: 2.647 ± 0.059	0.373MetCys: 0.373 ± 0.017	2.064MetAsp: 2.064 ± 0.049	2.949MetGlu: 2.949 ± 0.059	0.95MetPhe: 0.95 ± 0.035	2.158MetGly: 2.158 ± 0.051	0.46MetHis: 0.46 ± 0.024	1.822MetIle: 1.822 ± 0.048	2.313MetLys: 2.313 ± 0.047	2.692MetLeu: 2.692 ± 0.055	0.926MetMet: 0.926 ± 0.032	1.261MetAsn: 1.261 ± 0.032	1.158MetPro: 1.158 ± 0.038	1.025MetGln: 1.025 ± 0.03	1.583MetArg: 1.583 ± 0.045	1.75MetSer: 1.75 ± 0.041	1.769MetThr: 1.769 ± 0.044	1.829MetVal: 1.829 ± 0.045	0.246MetTrp: 0.246 ± 0.015	0.933MetTyr: 0.933 ± 0.03	0.0MetXaa: 0.0 ± 0.0
Asn	2.646AsnAla: 2.646 ± 0.054	0.562AsnCys: 0.562 ± 0.024	1.68AsnAsp: 1.68 ± 0.039	2.294AsnGlu: 2.294 ± 0.048	1.292AsnPhe: 1.292 ± 0.036	2.887AsnGly: 2.887 ± 0.057	0.641AsnHis: 0.641 ± 0.03	2.776AsnIle: 2.776 ± 0.06	1.73AsnLys: 1.73 ± 0.045	3.198AsnLeu: 3.198 ± 0.061	1.161AsnMet: 1.161 ± 0.037	1.335AsnAsn: 1.335 ± 0.044	1.648AsnPro: 1.648 ± 0.045	1.133AsnGln: 1.133 ± 0.036	1.898AsnArg: 1.898 ± 0.046	1.823AsnSer: 1.823 ± 0.042	1.992AsnThr: 1.992 ± 0.042	2.395AsnVal: 2.395 ± 0.053	0.309AsnTrp: 0.309 ± 0.018	1.547AsnTyr: 1.547 ± 0.039	0.0AsnXaa: 0.0 ± 0.0
Pro	3.006ProAla: 3.006 ± 0.065	0.543ProCys: 0.543 ± 0.025	2.556ProAsp: 2.556 ± 0.056	3.676ProGlu: 3.676 ± 0.062	1.601ProPhe: 1.601 ± 0.042	2.918ProGly: 2.918 ± 0.056	0.601ProHis: 0.601 ± 0.026	1.754ProIle: 1.754 ± 0.04	1.555ProLys: 1.555 ± 0.046	3.054ProLeu: 3.054 ± 0.06	0.896ProMet: 0.896 ± 0.03	0.997ProAsn: 0.997 ± 0.031	0.849ProPro: 0.849 ± 0.028	1.031ProGln: 1.031 ± 0.035	1.414ProArg: 1.414 ± 0.041	1.884ProSer: 1.884 ± 0.044	1.466ProThr: 1.466 ± 0.042	3.314ProVal: 3.314 ± 0.06	0.362ProTrp: 0.362 ± 0.022	1.443ProTyr: 1.443 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	2.723GlnAla: 2.723 ± 0.065	0.397GlnCys: 0.397 ± 0.022	1.669GlnAsp: 1.669 ± 0.043	3.095GlnGlu: 3.095 ± 0.055	1.136GlnPhe: 1.136 ± 0.031	2.219GlnGly: 2.219 ± 0.054	0.469GlnHis: 0.469 ± 0.024	2.544GlnIle: 2.544 ± 0.046	2.34GlnLys: 2.34 ± 0.052	2.791GlnLeu: 2.791 ± 0.056	1.269GlnMet: 1.269 ± 0.036	1.284GlnAsn: 1.284 ± 0.036	0.952GlnPro: 0.952 ± 0.03	1.258GlnGln: 1.258 ± 0.042	1.729GlnArg: 1.729 ± 0.048	1.678GlnSer: 1.678 ± 0.048	1.755GlnThr: 1.755 ± 0.045	2.341GlnVal: 2.341 ± 0.049	0.334GlnTrp: 0.334 ± 0.019	1.328GlnTyr: 1.328 ± 0.036	0.0GlnXaa: 0.0 ± 0.0
Arg	3.716ArgAla: 3.716 ± 0.071	0.717ArgCys: 0.717 ± 0.027	2.931ArgAsp: 2.931 ± 0.051	5.67ArgGlu: 5.67 ± 0.102	2.136ArgPhe: 2.136 ± 0.047	3.363ArgGly: 3.363 ± 0.065	0.993ArgHis: 0.993 ± 0.034	3.992ArgIle: 3.992 ± 0.061	3.89ArgLys: 3.89 ± 0.07	5.099ArgLeu: 5.099 ± 0.092	1.986ArgMet: 1.986 ± 0.043	1.887ArgAsn: 1.887 ± 0.047	1.77ArgPro: 1.77 ± 0.05	2.411ArgGln: 2.411 ± 0.056	3.961ArgArg: 3.961 ± 0.09	2.715ArgSer: 2.715 ± 0.058	2.831ArgThr: 2.831 ± 0.055	3.221ArgVal: 3.221 ± 0.07	0.496ArgTrp: 0.496 ± 0.021	2.133ArgTyr: 2.133 ± 0.054	0.0ArgXaa: 0.0 ± 0.0
Ser	4.178SerAla: 4.178 ± 0.069	0.938SerCys: 0.938 ± 0.032	3.057SerAsp: 3.057 ± 0.059	3.461SerGlu: 3.461 ± 0.064	2.73SerPhe: 2.73 ± 0.06	5.211SerGly: 5.211 ± 0.077	1.05SerHis: 1.05 ± 0.032	3.646SerIle: 3.646 ± 0.067	2.294SerLys: 2.294 ± 0.046	5.342SerLeu: 5.342 ± 0.073	1.747SerMet: 1.747 ± 0.041	1.647SerAsn: 1.647 ± 0.042	1.99SerPro: 1.99 ± 0.055	1.898SerGln: 1.898 ± 0.047	3.525SerArg: 3.525 ± 0.06	3.508SerSer: 3.508 ± 0.077	2.539SerThr: 2.539 ± 0.058	4.228SerVal: 4.228 ± 0.071	0.56SerTrp: 0.56 ± 0.027	2.378SerTyr: 2.378 ± 0.064	0.0SerXaa: 0.0 ± 0.0
Thr	4.789ThrAla: 4.789 ± 0.092	0.672ThrCys: 0.672 ± 0.025	3.376ThrAsp: 3.376 ± 0.068	3.878ThrGlu: 3.878 ± 0.067	2.082ThrPhe: 2.082 ± 0.061	5.03ThrGly: 5.03 ± 0.088	0.827ThrHis: 0.827 ± 0.029	3.323ThrIle: 3.323 ± 0.062	2.602ThrLys: 2.602 ± 0.052	4.684ThrLeu: 4.684 ± 0.075	1.376ThrMet: 1.376 ± 0.037	1.664ThrAsn: 1.664 ± 0.042	2.153ThrPro: 2.153 ± 0.053	1.379ThrGln: 1.379 ± 0.037	2.263ThrArg: 2.263 ± 0.051	2.814ThrSer: 2.814 ± 0.055	2.596ThrThr: 2.596 ± 0.063	4.649ThrVal: 4.649 ± 0.087	0.499ThrTrp: 0.499 ± 0.025	2.051ThrTyr: 2.051 ± 0.056	0.0ThrXaa: 0.0 ± 0.0
Val	4.59ValAla: 4.59 ± 0.07	1.281ValCys: 1.281 ± 0.037	3.798ValAsp: 3.798 ± 0.058	4.961ValGlu: 4.961 ± 0.08	3.081ValPhe: 3.081 ± 0.068	4.382ValGly: 4.382 ± 0.082	1.144ValHis: 1.144 ± 0.035	4.979ValIle: 4.979 ± 0.082	3.962ValLys: 3.962 ± 0.069	7.166ValLeu: 7.166 ± 0.098	2.065ValMet: 2.065 ± 0.044	2.483ValAsn: 2.483 ± 0.049	2.677ValPro: 2.677 ± 0.051	2.147ValGln: 2.147 ± 0.049	3.798ValArg: 3.798 ± 0.067	4.571ValSer: 4.571 ± 0.075	4.374ValThr: 4.374 ± 0.09	4.685ValVal: 4.685 ± 0.092	0.713ValTrp: 0.713 ± 0.026	2.689ValTyr: 2.689 ± 0.054	0.0ValXaa: 0.0 ± 0.0
Trp	0.603TrpAla: 0.603 ± 0.023	0.154TrpCys: 0.154 ± 0.012	0.58TrpAsp: 0.58 ± 0.024	0.685TrpGlu: 0.685 ± 0.026	0.403TrpPhe: 0.403 ± 0.021	0.633TrpGly: 0.633 ± 0.027	0.167TrpHis: 0.167 ± 0.011	0.639TrpIle: 0.639 ± 0.027	0.716TrpLys: 0.716 ± 0.028	0.884TrpLeu: 0.884 ± 0.03	0.338TrpMet: 0.338 ± 0.017	0.434TrpAsn: 0.434 ± 0.021	0.251TrpPro: 0.251 ± 0.017	0.417TrpGln: 0.417 ± 0.021	0.465TrpArg: 0.465 ± 0.021	0.467TrpSer: 0.467 ± 0.022	0.447TrpThr: 0.447 ± 0.023	0.522TrpVal: 0.522 ± 0.022	0.088TrpTrp: 0.088 ± 0.009	0.37TrpTyr: 0.37 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.679TyrAla: 2.679 ± 0.047	0.59TyrCys: 0.59 ± 0.025	2.446TyrAsp: 2.446 ± 0.055	3.099TyrGlu: 3.099 ± 0.057	1.731TyrPhe: 1.731 ± 0.045	3.041TyrGly: 3.041 ± 0.051	0.809TyrHis: 0.809 ± 0.029	2.671TyrIle: 2.671 ± 0.053	1.798TyrLys: 1.798 ± 0.046	3.634TyrLeu: 3.634 ± 0.065	1.146TyrMet: 1.146 ± 0.037	1.502TyrAsn: 1.502 ± 0.039	1.518TyrPro: 1.518 ± 0.038	1.498TyrGln: 1.498 ± 0.04	2.502TyrArg: 2.502 ± 0.052	2.272TyrSer: 2.272 ± 0.06	2.265TyrThr: 2.265 ± 0.056	2.551TyrVal: 2.551 ± 0.051	0.301TyrTrp: 0.301 ± 0.016	1.738TyrTyr: 1.738 ± 0.048	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3184 proteins (1015018 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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