Amino acid dipepetide frequency for Halovirus HGTV-1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.353AlaAla: 4.353 ± 0.509
0.515AlaCys: 0.515 ± 0.116
5.009AlaAsp: 5.009 ± 0.355
7.77AlaGlu: 7.77 ± 0.406
2.902AlaPhe: 2.902 ± 0.33
5.219AlaGly: 5.219 ± 0.444
1.381AlaHis: 1.381 ± 0.187
4.072AlaIle: 4.072 ± 0.446
3.23AlaLys: 3.23 ± 0.266
5.524AlaLeu: 5.524 ± 0.474
1.755AlaMet: 1.755 ± 0.253
2.902AlaAsn: 2.902 ± 0.261
2.13AlaPro: 2.13 ± 0.216
2.2AlaGln: 2.2 ± 0.221
4.33AlaArg: 4.33 ± 0.363
4.096AlaSer: 4.096 ± 0.337
3.558AlaThr: 3.558 ± 0.28
5.079AlaVal: 5.079 ± 0.367
1.077AlaTrp: 1.077 ± 0.157
2.434AlaTyr: 2.434 ± 0.232
0.0AlaXaa: 0.0 ± 0.0
Cys
0.562CysAla: 0.562 ± 0.124
0.047CysCys: 0.047 ± 0.032
1.03CysAsp: 1.03 ± 0.182
1.1CysGlu: 1.1 ± 0.199
0.211CysPhe: 0.211 ± 0.077
1.381CysGly: 1.381 ± 0.185
0.351CysHis: 0.351 ± 0.083
0.421CysIle: 0.421 ± 0.111
0.281CysLys: 0.281 ± 0.079
0.468CysLeu: 0.468 ± 0.098
0.14CysMet: 0.14 ± 0.056
0.492CysAsn: 0.492 ± 0.118
0.819CysPro: 0.819 ± 0.152
0.609CysGln: 0.609 ± 0.128
0.515CysArg: 0.515 ± 0.121
0.562CysSer: 0.562 ± 0.121
0.585CysThr: 0.585 ± 0.126
0.515CysVal: 0.515 ± 0.111
0.117CysTrp: 0.117 ± 0.047
0.187CysTyr: 0.187 ± 0.064
0.0CysXaa: 0.0 ± 0.0
Asp
5.968AspAla: 5.968 ± 0.425
0.983AspCys: 0.983 ± 0.163
7.068AspAsp: 7.068 ± 0.438
9.924AspGlu: 9.924 ± 0.634
3.675AspPhe: 3.675 ± 0.319
7.373AspGly: 7.373 ± 0.485
1.147AspHis: 1.147 ± 0.193
3.113AspIle: 3.113 ± 0.267
2.762AspLys: 2.762 ± 0.312
5.36AspLeu: 5.36 ± 0.322
2.06AspMet: 2.06 ± 0.236
3.206AspAsn: 3.206 ± 0.275
3.16AspPro: 3.16 ± 0.28
1.123AspGln: 1.123 ± 0.182
3.183AspArg: 3.183 ± 0.327
5.664AspSer: 5.664 ± 0.324
4.587AspThr: 4.587 ± 0.364
6.553AspVal: 6.553 ± 0.392
1.428AspTrp: 1.428 ± 0.177
3.768AspTyr: 3.768 ± 0.352
0.0AspXaa: 0.0 ± 0.0
Glu
7.349GluAla: 7.349 ± 0.397
1.428GluCys: 1.428 ± 0.209
7.724GluAsp: 7.724 ± 0.458
9.385GluGlu: 9.385 ± 0.808
3.066GluPhe: 3.066 ± 0.265
5.524GluGly: 5.524 ± 0.36
2.27GluHis: 2.27 ± 0.249
4.681GluIle: 4.681 ± 0.291
4.143GluLys: 4.143 ± 0.318
8.824GluLeu: 8.824 ± 0.6
3.698GluMet: 3.698 ± 0.326
4.283GluAsn: 4.283 ± 0.315
3.698GluPro: 3.698 ± 0.282
4.119GluGln: 4.119 ± 0.358
6.015GluArg: 6.015 ± 0.357
5.172GluSer: 5.172 ± 0.366
4.681GluThr: 4.681 ± 0.286
7.115GluVal: 7.115 ± 0.418
1.615GluTrp: 1.615 ± 0.199
4.658GluTyr: 4.658 ± 0.337
0.0GluXaa: 0.0 ± 0.0
Phe
2.598PheAla: 2.598 ± 0.33
0.281PheCys: 0.281 ± 0.088
3.698PheAsp: 3.698 ± 0.271
4.447PheGlu: 4.447 ± 0.328
1.264PhePhe: 1.264 ± 0.187
3.206PheGly: 3.206 ± 0.232
0.913PheHis: 0.913 ± 0.149
1.896PheIle: 1.896 ± 0.223
1.826PheLys: 1.826 ± 0.191
1.989PheLeu: 1.989 ± 0.234
0.843PheMet: 0.843 ± 0.135
1.521PheAsn: 1.521 ± 0.202
1.615PhePro: 1.615 ± 0.212
1.1PheGln: 1.1 ± 0.142
2.06PheArg: 2.06 ± 0.188
2.106PheSer: 2.106 ± 0.21
2.434PheThr: 2.434 ± 0.238
2.809PheVal: 2.809 ± 0.259
0.538PheTrp: 0.538 ± 0.113
1.1PheTyr: 1.1 ± 0.157
0.0PheXaa: 0.0 ± 0.0
Gly
4.938GlyAla: 4.938 ± 0.484
0.468GlyCys: 0.468 ± 0.106
5.57GlyAsp: 5.57 ± 0.415
6.67GlyGlu: 6.67 ± 0.496
3.347GlyPhe: 3.347 ± 0.29
4.868GlyGly: 4.868 ± 0.491
1.779GlyHis: 1.779 ± 0.2
3.464GlyIle: 3.464 ± 0.283
3.043GlyLys: 3.043 ± 0.261
4.681GlyLeu: 4.681 ± 0.378
2.06GlyMet: 2.06 ± 0.184
3.37GlyAsn: 3.37 ± 0.274
2.223GlyPro: 2.223 ± 0.217
2.294GlyGln: 2.294 ± 0.236
3.347GlyArg: 3.347 ± 0.297
4.985GlySer: 4.985 ± 0.349
4.353GlyThr: 4.353 ± 0.397
5.804GlyVal: 5.804 ± 0.342
1.451GlyTrp: 1.451 ± 0.189
3.113GlyTyr: 3.113 ± 0.276
0.0GlyXaa: 0.0 ± 0.0
His
1.381HisAla: 1.381 ± 0.192
0.211HisCys: 0.211 ± 0.083
1.802HisAsp: 1.802 ± 0.216
2.06HisGlu: 2.06 ± 0.231
0.796HisPhe: 0.796 ± 0.123
1.545HisGly: 1.545 ± 0.189
0.866HisHis: 0.866 ± 0.173
1.428HisIle: 1.428 ± 0.184
1.147HisLys: 1.147 ± 0.168
1.264HisLeu: 1.264 ± 0.177
0.609HisMet: 0.609 ± 0.12
0.936HisAsn: 0.936 ± 0.167
1.194HisPro: 1.194 ± 0.135
0.585HisGln: 0.585 ± 0.128
1.381HisArg: 1.381 ± 0.185
1.357HisSer: 1.357 ± 0.169
1.1HisThr: 1.1 ± 0.185
1.592HisVal: 1.592 ± 0.208
0.445HisTrp: 0.445 ± 0.101
0.936HisTyr: 0.936 ± 0.153
0.0HisXaa: 0.0 ± 0.0
Ile
3.721IleAla: 3.721 ± 0.3
0.702IleCys: 0.702 ± 0.137
4.026IleAsp: 4.026 ± 0.314
6.226IleGlu: 6.226 ± 0.369
1.334IlePhe: 1.334 ± 0.154
3.792IleGly: 3.792 ± 0.288
1.475IleHis: 1.475 ± 0.196
1.919IleIle: 1.919 ± 0.224
1.638IleLys: 1.638 ± 0.176
2.972IleLeu: 2.972 ± 0.302
0.913IleMet: 0.913 ± 0.147
1.919IleAsn: 1.919 ± 0.235
2.481IlePro: 2.481 ± 0.249
1.615IleGln: 1.615 ± 0.181
3.37IleArg: 3.37 ± 0.298
2.668IleSer: 2.668 ± 0.253
2.715IleThr: 2.715 ± 0.283
3.628IleVal: 3.628 ± 0.303
0.585IleTrp: 0.585 ± 0.113
1.381IleTyr: 1.381 ± 0.173
0.0IleXaa: 0.0 ± 0.0
Lys
2.972LysAla: 2.972 ± 0.238
0.538LysCys: 0.538 ± 0.163
3.089LysAsp: 3.089 ± 0.246
3.979LysGlu: 3.979 ± 0.353
1.638LysPhe: 1.638 ± 0.153
2.738LysGly: 2.738 ± 0.253
1.568LysHis: 1.568 ± 0.204
2.083LysIle: 2.083 ± 0.195
2.668LysLys: 2.668 ± 0.358
2.809LysLeu: 2.809 ± 0.225
1.755LysMet: 1.755 ± 0.198
1.826LysAsn: 1.826 ± 0.21
1.451LysPro: 1.451 ± 0.22
1.615LysGln: 1.615 ± 0.168
2.949LysArg: 2.949 ± 0.286
2.645LysSer: 2.645 ± 0.239
2.27LysThr: 2.27 ± 0.187
3.3LysVal: 3.3 ± 0.302
0.983LysTrp: 0.983 ± 0.142
2.294LysTyr: 2.294 ± 0.239
0.0LysXaa: 0.0 ± 0.0
Leu
5.594LeuAla: 5.594 ± 0.385
0.492LeuCys: 0.492 ± 0.125
5.968LeuAsp: 5.968 ± 0.365
5.828LeuGlu: 5.828 ± 0.512
2.458LeuPhe: 2.458 ± 0.253
4.751LeuGly: 4.751 ± 0.352
1.217LeuHis: 1.217 ± 0.159
2.949LeuIle: 2.949 ± 0.26
3.534LeuLys: 3.534 ± 0.323
5.009LeuLeu: 5.009 ± 0.458
1.849LeuMet: 1.849 ± 0.246
3.066LeuAsn: 3.066 ± 0.267
3.066LeuPro: 3.066 ± 0.267
2.645LeuGln: 2.645 ± 0.272
4.049LeuArg: 4.049 ± 0.38
5.172LeuSer: 5.172 ± 0.388
3.277LeuThr: 3.277 ± 0.307
5.032LeuVal: 5.032 ± 0.357
1.03LeuTrp: 1.03 ± 0.17
2.645LeuTyr: 2.645 ± 0.273
0.0LeuXaa: 0.0 ± 0.0
Met
2.902MetAla: 2.902 ± 0.295
0.164MetCys: 0.164 ± 0.066
1.521MetAsp: 1.521 ± 0.203
2.551MetGlu: 2.551 ± 0.25
0.632MetPhe: 0.632 ± 0.105
1.919MetGly: 1.919 ± 0.231
0.726MetHis: 0.726 ± 0.126
1.077MetIle: 1.077 ± 0.14
1.592MetLys: 1.592 ± 0.179
2.106MetLeu: 2.106 ± 0.216
0.866MetMet: 0.866 ± 0.13
1.334MetAsn: 1.334 ± 0.19
1.475MetPro: 1.475 ± 0.164
1.053MetGln: 1.053 ± 0.184
1.709MetArg: 1.709 ± 0.22
2.411MetSer: 2.411 ± 0.241
1.779MetThr: 1.779 ± 0.185
1.943MetVal: 1.943 ± 0.203
0.234MetTrp: 0.234 ± 0.078
0.819MetTyr: 0.819 ± 0.142
0.0MetXaa: 0.0 ± 0.0
Asn
3.136AsnAla: 3.136 ± 0.323
0.562AsnCys: 0.562 ± 0.135
2.575AsnAsp: 2.575 ± 0.241
4.002AsnGlu: 4.002 ± 0.328
1.685AsnPhe: 1.685 ± 0.186
3.745AsnGly: 3.745 ± 0.339
1.123AsnHis: 1.123 ± 0.185
1.896AsnIle: 1.896 ± 0.221
1.428AsnLys: 1.428 ± 0.228
3.675AsnLeu: 3.675 ± 0.288
1.123AsnMet: 1.123 ± 0.161
1.498AsnAsn: 1.498 ± 0.204
2.809AsnPro: 2.809 ± 0.313
1.077AsnGln: 1.077 ± 0.158
2.715AsnArg: 2.715 ± 0.233
2.645AsnSer: 2.645 ± 0.291
2.34AsnThr: 2.34 ± 0.227
2.879AsnVal: 2.879 ± 0.237
0.702AsnTrp: 0.702 ± 0.109
1.521AsnTyr: 1.521 ± 0.207
0.0AsnXaa: 0.0 ± 0.0
Pro
2.153ProAla: 2.153 ± 0.21
0.374ProCys: 0.374 ± 0.098
4.33ProAsp: 4.33 ± 0.298
4.189ProGlu: 4.189 ± 0.333
1.194ProPhe: 1.194 ± 0.162
1.872ProGly: 1.872 ± 0.209
0.843ProHis: 0.843 ± 0.144
2.083ProIle: 2.083 ± 0.246
1.428ProLys: 1.428 ± 0.177
2.294ProLeu: 2.294 ± 0.25
1.147ProMet: 1.147 ± 0.169
2.13ProAsn: 2.13 ± 0.223
0.96ProPro: 0.96 ± 0.158
1.311ProGln: 1.311 ± 0.19
1.521ProArg: 1.521 ± 0.207
3.066ProSer: 3.066 ± 0.273
2.504ProThr: 2.504 ± 0.218
2.621ProVal: 2.621 ± 0.25
0.562ProTrp: 0.562 ± 0.1
1.451ProTyr: 1.451 ± 0.195
0.0ProXaa: 0.0 ± 0.0
Gln
2.692GlnAla: 2.692 ± 0.243
0.257GlnCys: 0.257 ± 0.076
2.411GlnAsp: 2.411 ± 0.242
3.37GlnGlu: 3.37 ± 0.275
1.989GlnPhe: 1.989 ± 0.2
1.849GlnGly: 1.849 ± 0.172
0.585GlnHis: 0.585 ± 0.104
1.943GlnIle: 1.943 ± 0.237
1.779GlnLys: 1.779 ± 0.193
1.872GlnLeu: 1.872 ± 0.251
1.264GlnMet: 1.264 ± 0.157
1.404GlnAsn: 1.404 ± 0.195
0.726GlnPro: 0.726 ± 0.14
1.357GlnGln: 1.357 ± 0.207
1.381GlnArg: 1.381 ± 0.175
1.896GlnSer: 1.896 ± 0.215
1.919GlnThr: 1.919 ± 0.212
2.106GlnVal: 2.106 ± 0.255
0.609GlnTrp: 0.609 ± 0.125
1.287GlnTyr: 1.287 ± 0.168
0.0GlnXaa: 0.0 ± 0.0
Arg
3.253ArgAla: 3.253 ± 0.339
0.492ArgCys: 0.492 ± 0.111
4.494ArgAsp: 4.494 ± 0.326
5.126ArgGlu: 5.126 ± 0.336
1.896ArgPhe: 1.896 ± 0.2
3.581ArgGly: 3.581 ± 0.318
1.077ArgHis: 1.077 ± 0.154
3.277ArgIle: 3.277 ± 0.308
3.441ArgLys: 3.441 ± 0.336
4.283ArgLeu: 4.283 ± 0.351
1.989ArgMet: 1.989 ± 0.205
3.089ArgAsn: 3.089 ± 0.236
1.357ArgPro: 1.357 ± 0.177
2.27ArgGln: 2.27 ± 0.268
3.324ArgArg: 3.324 ± 0.32
3.3ArgSer: 3.3 ± 0.316
2.762ArgThr: 2.762 ± 0.259
3.885ArgVal: 3.885 ± 0.335
0.796ArgTrp: 0.796 ± 0.153
1.802ArgTyr: 1.802 ± 0.196
0.0ArgXaa: 0.0 ± 0.0
Ser
3.909SerAla: 3.909 ± 0.383
0.819SerCys: 0.819 ± 0.138
6.015SerAsp: 6.015 ± 0.422
5.687SerGlu: 5.687 ± 0.338
2.598SerPhe: 2.598 ± 0.234
5.945SerGly: 5.945 ± 0.451
1.404SerHis: 1.404 ± 0.173
2.926SerIle: 2.926 ± 0.208
2.949SerLys: 2.949 ± 0.243
4.494SerLeu: 4.494 ± 0.338
2.27SerMet: 2.27 ± 0.208
2.434SerAsn: 2.434 ± 0.262
2.13SerPro: 2.13 ± 0.25
1.872SerGln: 1.872 ± 0.18
3.441SerArg: 3.441 ± 0.315
4.143SerSer: 4.143 ± 0.347
3.324SerThr: 3.324 ± 0.3
4.47SerVal: 4.47 ± 0.349
0.983SerTrp: 0.983 ± 0.159
2.036SerTyr: 2.036 ± 0.243
0.0SerXaa: 0.0 ± 0.0
Thr
3.675ThrAla: 3.675 ± 0.337
0.538ThrCys: 0.538 ± 0.112
4.353ThrAsp: 4.353 ± 0.309
4.845ThrGlu: 4.845 ± 0.32
2.715ThrPhe: 2.715 ± 0.317
3.815ThrGly: 3.815 ± 0.332
1.217ThrHis: 1.217 ± 0.147
3.487ThrIle: 3.487 ± 0.304
2.223ThrLys: 2.223 ± 0.199
4.096ThrLeu: 4.096 ± 0.307
1.311ThrMet: 1.311 ± 0.165
2.364ThrAsn: 2.364 ± 0.22
2.223ThrPro: 2.223 ± 0.242
1.475ThrGln: 1.475 ± 0.187
2.879ThrArg: 2.879 ± 0.27
3.909ThrSer: 3.909 ± 0.339
3.675ThrThr: 3.675 ± 0.415
4.096ThrVal: 4.096 ± 0.324
0.421ThrTrp: 0.421 ± 0.098
2.153ThrTyr: 2.153 ± 0.229
0.0ThrXaa: 0.0 ± 0.0
Val
5.172ValAla: 5.172 ± 0.364
0.796ValCys: 0.796 ± 0.149
6.343ValAsp: 6.343 ± 0.377
6.694ValGlu: 6.694 ± 0.353
2.949ValPhe: 2.949 ± 0.275
4.775ValGly: 4.775 ± 0.307
1.404ValHis: 1.404 ± 0.169
3.628ValIle: 3.628 ± 0.269
3.581ValLys: 3.581 ± 0.301
4.33ValLeu: 4.33 ± 0.344
1.779ValMet: 1.779 ± 0.21
2.972ValAsn: 2.972 ± 0.289
2.551ValPro: 2.551 ± 0.279
2.387ValGln: 2.387 ± 0.253
4.119ValArg: 4.119 ± 0.397
4.821ValSer: 4.821 ± 0.318
4.915ValThr: 4.915 ± 0.406
4.4ValVal: 4.4 ± 0.287
0.819ValTrp: 0.819 ± 0.151
2.481ValTyr: 2.481 ± 0.244
0.0ValXaa: 0.0 ± 0.0
Trp
1.053TrpAla: 1.053 ± 0.177
0.211TrpCys: 0.211 ± 0.068
1.568TrpAsp: 1.568 ± 0.17
1.568TrpGlu: 1.568 ± 0.184
0.562TrpPhe: 0.562 ± 0.099
0.772TrpGly: 0.772 ± 0.12
0.421TrpHis: 0.421 ± 0.115
0.796TrpIle: 0.796 ± 0.142
1.03TrpLys: 1.03 ± 0.134
1.077TrpLeu: 1.077 ± 0.208
0.515TrpMet: 0.515 ± 0.111
0.726TrpAsn: 0.726 ± 0.12
0.328TrpPro: 0.328 ± 0.078
0.515TrpGln: 0.515 ± 0.122
1.077TrpArg: 1.077 ± 0.143
0.866TrpSer: 0.866 ± 0.134
0.679TrpThr: 0.679 ± 0.14
0.585TrpVal: 0.585 ± 0.12
0.164TrpTrp: 0.164 ± 0.059
0.819TrpTyr: 0.819 ± 0.123
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.177TyrAla: 2.177 ± 0.21
0.515TyrCys: 0.515 ± 0.117
3.511TyrAsp: 3.511 ± 0.326
4.026TyrGlu: 4.026 ± 0.296
1.334TyrPhe: 1.334 ± 0.175
3.16TyrGly: 3.16 ± 0.281
0.866TyrHis: 0.866 ± 0.134
1.943TyrIle: 1.943 ± 0.231
1.451TyrLys: 1.451 ± 0.173
2.504TyrLeu: 2.504 ± 0.235
0.843TyrMet: 0.843 ± 0.129
1.662TyrAsn: 1.662 ± 0.214
1.638TyrPro: 1.638 ± 0.221
1.475TyrGln: 1.475 ± 0.212
2.13TyrArg: 2.13 ± 0.211
2.364TyrSer: 2.364 ± 0.232
2.013TyrThr: 2.013 ± 0.208
2.504TyrVal: 2.504 ± 0.216
0.772TyrTrp: 0.772 ± 0.143
1.311TyrTyr: 1.311 ± 0.195
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 281 proteins (42727 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski