Amino acid dipepetide frequency for Erwinia sp. OLSSP12

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.082AlaAla: 11.082 ± 0.135	1.149AlaCys: 1.149 ± 0.034	5.354AlaAsp: 5.354 ± 0.076	5.628AlaGlu: 5.628 ± 0.076	3.462AlaPhe: 3.462 ± 0.057	8.563AlaGly: 8.563 ± 0.101	1.89AlaHis: 1.89 ± 0.041	5.9AlaIle: 5.9 ± 0.088	3.278AlaLys: 3.278 ± 0.066	12.633AlaLeu: 12.633 ± 0.151	2.923AlaMet: 2.923 ± 0.056	2.92AlaAsn: 2.92 ± 0.058	3.72AlaPro: 3.72 ± 0.064	4.664AlaGln: 4.664 ± 0.083	6.381AlaArg: 6.381 ± 0.086	6.323AlaSer: 6.323 ± 0.101	4.857AlaThr: 4.857 ± 0.081	6.665AlaVal: 6.665 ± 0.087	1.567AlaTrp: 1.567 ± 0.046	2.033AlaTyr: 2.033 ± 0.041	0.0AlaXaa: 0.0 ± 0.0
Cys	1.02CysAla: 1.02 ± 0.03	0.207CysCys: 0.207 ± 0.013	0.618CysAsp: 0.618 ± 0.026	0.529CysGlu: 0.529 ± 0.025	0.453CysPhe: 0.453 ± 0.021	1.101CysGly: 1.101 ± 0.034	0.359CysHis: 0.359 ± 0.018	0.542CysIle: 0.542 ± 0.024	0.307CysLys: 0.307 ± 0.018	1.086CysLeu: 1.086 ± 0.036	0.209CysMet: 0.209 ± 0.012	0.303CysAsn: 0.303 ± 0.017	0.521CysPro: 0.521 ± 0.024	0.623CysGln: 0.623 ± 0.027	0.692CysArg: 0.692 ± 0.03	0.695CysSer: 0.695 ± 0.027	0.456CysThr: 0.456 ± 0.023	0.713CysVal: 0.713 ± 0.027	0.235CysTrp: 0.235 ± 0.015	0.347CysTyr: 0.347 ± 0.023	0.0CysXaa: 0.0 ± 0.0
Asp	5.133AspAla: 5.133 ± 0.074	0.498AspCys: 0.498 ± 0.021	3.063AspAsp: 3.063 ± 0.054	3.219AspGlu: 3.219 ± 0.064	2.16AspPhe: 2.16 ± 0.044	3.758AspGly: 3.758 ± 0.073	1.005AspHis: 1.005 ± 0.031	3.435AspIle: 3.435 ± 0.059	2.372AspLys: 2.372 ± 0.056	4.574AspLeu: 4.574 ± 0.068	1.291AspMet: 1.291 ± 0.038	2.402AspAsn: 2.402 ± 0.055	2.214AspPro: 2.214 ± 0.046	1.741AspGln: 1.741 ± 0.045	3.015AspArg: 3.015 ± 0.054	3.148AspSer: 3.148 ± 0.055	2.311AspThr: 2.311 ± 0.05	3.505AspVal: 3.505 ± 0.059	0.846AspTrp: 0.846 ± 0.031	1.954AspTyr: 1.954 ± 0.045	0.0AspXaa: 0.0 ± 0.0
Glu	4.977GluAla: 4.977 ± 0.078	0.426GluCys: 0.426 ± 0.02	2.111GluAsp: 2.111 ± 0.049	2.918GluGlu: 2.918 ± 0.072	1.673GluPhe: 1.673 ± 0.039	3.133GluGly: 3.133 ± 0.062	1.255GluHis: 1.255 ± 0.033	3.169GluIle: 3.169 ± 0.065	3.089GluLys: 3.089 ± 0.062	5.233GluLeu: 5.233 ± 0.081	1.626GluMet: 1.626 ± 0.043	2.238GluAsn: 2.238 ± 0.046	1.777GluPro: 1.777 ± 0.043	3.281GluGln: 3.281 ± 0.061	3.482GluArg: 3.482 ± 0.066	2.677GluSer: 2.677 ± 0.053	2.806GluThr: 2.806 ± 0.053	3.5GluVal: 3.5 ± 0.064	0.672GluTrp: 0.672 ± 0.024	1.282GluTyr: 1.282 ± 0.034	0.0GluXaa: 0.0 ± 0.0
Phe	3.604PheAla: 3.604 ± 0.063	0.569PheCys: 0.569 ± 0.027	2.227PheAsp: 2.227 ± 0.05	1.617PheGlu: 1.617 ± 0.041	1.635PhePhe: 1.635 ± 0.048	2.839PheGly: 2.839 ± 0.062	0.865PheHis: 0.865 ± 0.032	2.474PheIle: 2.474 ± 0.05	1.164PheLys: 1.164 ± 0.034	3.278PheLeu: 3.278 ± 0.058	0.893PheMet: 0.893 ± 0.032	1.748PheAsn: 1.748 ± 0.041	1.532PhePro: 1.532 ± 0.04	1.236PheGln: 1.236 ± 0.032	1.966PheArg: 1.966 ± 0.041	3.37PheSer: 3.37 ± 0.059	2.169PheThr: 2.169 ± 0.045	2.293PheVal: 2.293 ± 0.045	0.598PheTrp: 0.598 ± 0.027	1.192PheTyr: 1.192 ± 0.036	0.0PheXaa: 0.0 ± 0.0
Gly	6.295GlyAla: 6.295 ± 0.086	1.029GlyCys: 1.029 ± 0.038	3.721GlyAsp: 3.721 ± 0.066	4.329GlyGlu: 4.329 ± 0.062	3.187GlyPhe: 3.187 ± 0.055	5.291GlyGly: 5.291 ± 0.087	1.721GlyHis: 1.721 ± 0.042	4.855GlyIle: 4.855 ± 0.067	3.737GlyLys: 3.737 ± 0.063	7.383GlyLeu: 7.383 ± 0.089	2.223GlyMet: 2.223 ± 0.048	2.738GlyAsn: 2.738 ± 0.065	2.11GlyPro: 2.11 ± 0.049	3.264GlyGln: 3.264 ± 0.064	4.162GlyArg: 4.162 ± 0.074	4.343GlySer: 4.343 ± 0.072	3.466GlyThr: 3.466 ± 0.067	5.47GlyVal: 5.47 ± 0.079	1.342GlyTrp: 1.342 ± 0.038	2.537GlyTyr: 2.537 ± 0.052	0.0GlyXaa: 0.0 ± 0.0
His	2.081HisAla: 2.081 ± 0.045	0.368HisCys: 0.368 ± 0.02	1.196HisAsp: 1.196 ± 0.035	0.973HisGlu: 0.973 ± 0.035	1.131HisPhe: 1.131 ± 0.034	1.73HisGly: 1.73 ± 0.048	0.86HisHis: 0.86 ± 0.032	1.36HisIle: 1.36 ± 0.036	0.749HisLys: 0.749 ± 0.027	2.356HisLeu: 2.356 ± 0.046	0.524HisMet: 0.524 ± 0.023	0.896HisAsn: 0.896 ± 0.03	1.478HisPro: 1.478 ± 0.04	1.488HisGln: 1.488 ± 0.039	1.37HisArg: 1.37 ± 0.035	1.444HisSer: 1.444 ± 0.035	1.03HisThr: 1.03 ± 0.03	1.198HisVal: 1.198 ± 0.033	0.475HisTrp: 0.475 ± 0.024	0.936HisTyr: 0.936 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	6.497IleAla: 6.497 ± 0.094	0.686IleCys: 0.686 ± 0.028	3.532IleAsp: 3.532 ± 0.053	3.174IleGlu: 3.174 ± 0.058	1.956IlePhe: 1.956 ± 0.048	4.411IleGly: 4.411 ± 0.073	1.244IleHis: 1.244 ± 0.034	3.462IleIle: 3.462 ± 0.073	2.293IleLys: 2.293 ± 0.058	4.846IleLeu: 4.846 ± 0.081	1.276IleMet: 1.276 ± 0.038	2.594IleAsn: 2.594 ± 0.055	2.633IlePro: 2.633 ± 0.051	1.935IleGln: 1.935 ± 0.046	3.194IleArg: 3.194 ± 0.05	4.096IleSer: 4.096 ± 0.055	3.401IleThr: 3.401 ± 0.054	3.592IleVal: 3.592 ± 0.063	0.693IleTrp: 0.693 ± 0.029	1.505IleTyr: 1.505 ± 0.038	0.0IleXaa: 0.0 ± 0.0
Lys	3.956LysAla: 3.956 ± 0.072	0.244LysCys: 0.244 ± 0.016	1.802LysAsp: 1.802 ± 0.051	2.068LysGlu: 2.068 ± 0.051	0.999LysPhe: 0.999 ± 0.033	2.736LysGly: 2.736 ± 0.054	0.788LysHis: 0.788 ± 0.027	2.267LysIle: 2.267 ± 0.051	2.301LysLys: 2.301 ± 0.06	3.906LysLeu: 3.906 ± 0.069	1.15LysMet: 1.15 ± 0.034	1.843LysAsn: 1.843 ± 0.049	1.996LysPro: 1.996 ± 0.049	1.982LysGln: 1.982 ± 0.045	2.411LysArg: 2.411 ± 0.055	2.274LysSer: 2.274 ± 0.057	2.423LysThr: 2.423 ± 0.047	2.63LysVal: 2.63 ± 0.052	0.389LysTrp: 0.389 ± 0.019	1.049LysTyr: 1.049 ± 0.036	0.0LysXaa: 0.0 ± 0.0
Leu	12.225LeuAla: 12.225 ± 0.124	1.321LeuCys: 1.321 ± 0.038	5.33LeuAsp: 5.33 ± 0.082	5.037LeuGlu: 5.037 ± 0.072	4.243LeuPhe: 4.243 ± 0.08	6.872LeuGly: 6.872 ± 0.086	2.481LeuHis: 2.481 ± 0.052	6.05LeuIle: 6.05 ± 0.091	4.352LeuLys: 4.352 ± 0.072	12.718LeuLeu: 12.718 ± 0.18	3.009LeuMet: 3.009 ± 0.064	4.376LeuAsn: 4.376 ± 0.063	5.97LeuPro: 5.97 ± 0.098	4.918LeuGln: 4.918 ± 0.079	6.672LeuArg: 6.672 ± 0.075	7.887LeuSer: 7.887 ± 0.098	6.634LeuThr: 6.634 ± 0.084	6.942LeuVal: 6.942 ± 0.102	1.441LeuTrp: 1.441 ± 0.041	2.66LeuTyr: 2.66 ± 0.054	0.0LeuXaa: 0.0 ± 0.0
Met	2.846MetAla: 2.846 ± 0.058	0.167MetCys: 0.167 ± 0.011	1.092MetAsp: 1.092 ± 0.032	1.126MetGlu: 1.126 ± 0.036	0.807MetPhe: 0.807 ± 0.029	1.667MetGly: 1.667 ± 0.044	0.524MetHis: 0.524 ± 0.022	1.401MetIle: 1.401 ± 0.035	1.371MetLys: 1.371 ± 0.041	3.237MetLeu: 3.237 ± 0.055	0.867MetMet: 0.867 ± 0.034	0.992MetAsn: 0.992 ± 0.033	1.347MetPro: 1.347 ± 0.037	1.284MetGln: 1.284 ± 0.033	1.574MetArg: 1.574 ± 0.034	1.783MetSer: 1.783 ± 0.041	1.742MetThr: 1.742 ± 0.047	1.827MetVal: 1.827 ± 0.046	0.204MetTrp: 0.204 ± 0.013	0.453MetTyr: 0.453 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	3.615AsnAla: 3.615 ± 0.063	0.324AsnCys: 0.324 ± 0.017	2.008AsnAsp: 2.008 ± 0.046	1.692AsnGlu: 1.692 ± 0.043	1.223AsnPhe: 1.223 ± 0.036	3.002AsnGly: 3.002 ± 0.058	0.909AsnHis: 0.909 ± 0.033	2.195AsnIle: 2.195 ± 0.052	1.536AsnLys: 1.536 ± 0.041	3.665AsnLeu: 3.665 ± 0.065	0.893AsnMet: 0.893 ± 0.031	1.645AsnAsn: 1.645 ± 0.051	2.1AsnPro: 2.1 ± 0.042	1.943AsnGln: 1.943 ± 0.045	2.151AsnArg: 2.151 ± 0.044	2.135AsnSer: 2.135 ± 0.048	1.87AsnThr: 1.87 ± 0.045	2.281AsnVal: 2.281 ± 0.049	0.56AsnTrp: 0.56 ± 0.025	1.096AsnTyr: 1.096 ± 0.034	0.0AsnXaa: 0.0 ± 0.0
Pro	5.395ProAla: 5.395 ± 0.084	0.445ProCys: 0.445 ± 0.022	3.013ProAsp: 3.013 ± 0.051	2.96ProGlu: 2.96 ± 0.058	1.801ProPhe: 1.801 ± 0.043	3.835ProGly: 3.835 ± 0.062	1.118ProHis: 1.118 ± 0.035	1.567ProIle: 1.567 ± 0.038	1.198ProLys: 1.198 ± 0.035	5.447ProLeu: 5.447 ± 0.084	0.99ProMet: 0.99 ± 0.031	1.032ProAsn: 1.032 ± 0.033	1.952ProPro: 1.952 ± 0.048	2.691ProGln: 2.691 ± 0.052	2.063ProArg: 2.063 ± 0.044	2.082ProSer: 2.082 ± 0.053	1.951ProThr: 1.951 ± 0.044	4.057ProVal: 4.057 ± 0.062	0.775ProTrp: 0.775 ± 0.027	1.196ProTyr: 1.196 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	5.44GlnAla: 5.44 ± 0.086	0.414GlnCys: 0.414 ± 0.02	1.961GlnAsp: 1.961 ± 0.047	1.905GlnGlu: 1.905 ± 0.043	1.545GlnPhe: 1.545 ± 0.043	3.429GlnGly: 3.429 ± 0.054	1.576GlnHis: 1.576 ± 0.04	2.496GlnIle: 2.496 ± 0.046	1.759GlnLys: 1.759 ± 0.044	6.046GlnLeu: 6.046 ± 0.093	1.277GlnMet: 1.277 ± 0.035	1.469GlnAsn: 1.469 ± 0.04	2.727GlnPro: 2.727 ± 0.053	4.703GlnGln: 4.703 ± 0.107	3.9GlnArg: 3.9 ± 0.072	2.548GlnSer: 2.548 ± 0.051	2.298GlnThr: 2.298 ± 0.048	3.226GlnVal: 3.226 ± 0.061	0.656GlnTrp: 0.656 ± 0.024	1.24GlnTyr: 1.24 ± 0.038	0.0GlnXaa: 0.0 ± 0.0
Arg	5.015ArgAla: 5.015 ± 0.069	0.696ArgCys: 0.696 ± 0.025	3.154ArgAsp: 3.154 ± 0.057	3.532ArgGlu: 3.532 ± 0.069	2.668ArgPhe: 2.668 ± 0.049	3.513ArgGly: 3.513 ± 0.066	1.768ArgHis: 1.768 ± 0.05	3.604ArgIle: 3.604 ± 0.056	2.255ArgLys: 2.255 ± 0.056	7.473ArgLeu: 7.473 ± 0.107	1.606ArgMet: 1.606 ± 0.037	2.031ArgAsn: 2.031 ± 0.042	2.478ArgPro: 2.478 ± 0.047	4.091ArgGln: 4.091 ± 0.078	4.127ArgArg: 4.127 ± 0.075	2.991ArgSer: 2.991 ± 0.048	2.599ArgThr: 2.599 ± 0.048	3.962ArgVal: 3.962 ± 0.063	1.172ArgTrp: 1.172 ± 0.036	2.298ArgTyr: 2.298 ± 0.048	0.0ArgXaa: 0.0 ± 0.0
Ser	6.384SerAla: 6.384 ± 0.088	0.615SerCys: 0.615 ± 0.025	3.341SerAsp: 3.341 ± 0.063	3.242SerGlu: 3.242 ± 0.059	2.252SerPhe: 2.252 ± 0.046	5.739SerGly: 5.739 ± 0.087	1.615SerHis: 1.615 ± 0.043	2.837SerIle: 2.837 ± 0.05	2.022SerLys: 2.022 ± 0.043	7.034SerLeu: 7.034 ± 0.099	1.438SerMet: 1.438 ± 0.036	1.939SerAsn: 1.939 ± 0.052	2.742SerPro: 2.742 ± 0.057	3.007SerGln: 3.007 ± 0.06	3.778SerArg: 3.778 ± 0.064	3.489SerSer: 3.489 ± 0.071	2.863SerThr: 2.863 ± 0.061	4.383SerVal: 4.383 ± 0.065	1.15SerTrp: 1.15 ± 0.036	1.663SerTyr: 1.663 ± 0.044	0.0SerXaa: 0.0 ± 0.0
Thr	5.019ThrAla: 5.019 ± 0.082	0.5ThrCys: 0.5 ± 0.023	2.445ThrAsp: 2.445 ± 0.052	2.294ThrGlu: 2.294 ± 0.045	1.974ThrPhe: 1.974 ± 0.05	4.341ThrGly: 4.341 ± 0.064	1.188ThrHis: 1.188 ± 0.037	2.802ThrIle: 2.802 ± 0.056	1.257ThrLys: 1.257 ± 0.039	7.657ThrLeu: 7.657 ± 0.098	1.06ThrMet: 1.06 ± 0.033	1.399ThrAsn: 1.399 ± 0.04	3.216ThrPro: 3.216 ± 0.057	2.145ThrGln: 2.145 ± 0.046	3.167ThrArg: 3.167 ± 0.053	3.005ThrSer: 3.005 ± 0.06	2.809ThrThr: 2.809 ± 0.055	3.649ThrVal: 3.649 ± 0.064	0.649ThrTrp: 0.649 ± 0.026	1.088ThrTyr: 1.088 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	7.053ValAla: 7.053 ± 0.084	0.743ValCys: 0.743 ± 0.027	3.498ValAsp: 3.498 ± 0.056	3.501ValGlu: 3.501 ± 0.065	2.383ValPhe: 2.383 ± 0.05	4.299ValGly: 4.299 ± 0.077	1.179ValHis: 1.179 ± 0.033	4.477ValIle: 4.477 ± 0.071	2.805ValLys: 2.805 ± 0.06	6.923ValLeu: 6.923 ± 0.096	2.124ValMet: 2.124 ± 0.042	2.778ValAsn: 2.778 ± 0.051	2.941ValPro: 2.941 ± 0.056	2.36ValGln: 2.36 ± 0.045	3.789ValArg: 3.789 ± 0.065	4.754ValSer: 4.754 ± 0.076	4.147ValThr: 4.147 ± 0.07	5.143ValVal: 5.143 ± 0.083	0.928ValTrp: 0.928 ± 0.03	1.646ValTyr: 1.646 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	0.912TrpAla: 0.912 ± 0.031	0.225TrpCys: 0.225 ± 0.016	0.625TrpAsp: 0.625 ± 0.031	0.484TrpGlu: 0.484 ± 0.02	0.634TrpPhe: 0.634 ± 0.026	0.845TrpGly: 0.845 ± 0.031	0.505TrpHis: 0.505 ± 0.024	0.722TrpIle: 0.722 ± 0.03	0.494TrpLys: 0.494 ± 0.021	2.515TrpLeu: 2.515 ± 0.059	0.388TrpMet: 0.388 ± 0.018	0.469TrpAsn: 0.469 ± 0.023	0.706TrpPro: 0.706 ± 0.03	1.464TrpGln: 1.464 ± 0.043	1.189TrpArg: 1.189 ± 0.04	0.802TrpSer: 0.802 ± 0.03	0.506TrpThr: 0.506 ± 0.018	0.839TrpVal: 0.839 ± 0.027	0.22TrpTrp: 0.22 ± 0.017	0.464TrpTyr: 0.464 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.442TyrAla: 2.442 ± 0.046	0.393TyrCys: 0.393 ± 0.015	1.552TyrAsp: 1.552 ± 0.044	1.096TyrGlu: 1.096 ± 0.033	1.081TyrPhe: 1.081 ± 0.035	2.1TyrGly: 2.1 ± 0.051	0.794TyrHis: 0.794 ± 0.029	1.405TyrIle: 1.405 ± 0.037	0.875TyrLys: 0.875 ± 0.03	3.128TyrLeu: 3.128 ± 0.057	0.542TyrMet: 0.542 ± 0.026	1.029TyrAsn: 1.029 ± 0.032	1.407TyrPro: 1.407 ± 0.033	1.794TyrGln: 1.794 ± 0.041	1.95TyrArg: 1.95 ± 0.045	1.686TyrSer: 1.686 ± 0.041	1.329TyrThr: 1.329 ± 0.039	1.597TyrVal: 1.597 ± 0.039	0.437TyrTrp: 0.437 ± 0.021	0.862TyrTyr: 0.862 ± 0.033	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3383 proteins (1038597 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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