Amino acid dipepetide frequency for Cottontail rabbit papillomavirus (strain Kansas) (CRPV) (Papillomavirus sylvilagi)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.873AlaAla: 4.873 ± 1.71
0.75AlaCys: 0.75 ± 0.506
6.372AlaAsp: 6.372 ± 2.089
5.247AlaGlu: 5.247 ± 1.484
3.748AlaPhe: 3.748 ± 1.011
4.123AlaGly: 4.123 ± 1.167
1.124AlaHis: 1.124 ± 0.478
1.499AlaIle: 1.499 ± 0.881
2.624AlaLys: 2.624 ± 0.585
6.372AlaLeu: 6.372 ± 2.254
1.124AlaMet: 1.124 ± 0.548
2.249AlaAsn: 2.249 ± 0.808
4.873AlaPro: 4.873 ± 1.008
2.624AlaGln: 2.624 ± 1.226
2.249AlaArg: 2.249 ± 0.536
3.748AlaSer: 3.748 ± 0.876
2.624AlaThr: 2.624 ± 0.877
2.249AlaVal: 2.249 ± 0.553
0.375AlaTrp: 0.375 ± 0.291
1.499AlaTyr: 1.499 ± 0.698
0.0AlaXaa: 0.0 ± 0.0
Cys
1.874CysAla: 1.874 ± 0.577
1.499CysCys: 1.499 ± 0.817
1.124CysAsp: 1.124 ± 0.599
0.75CysGlu: 0.75 ± 0.451
1.124CysPhe: 1.124 ± 0.781
2.249CysGly: 2.249 ± 1.442
0.375CysHis: 0.375 ± 0.366
2.624CysIle: 2.624 ± 1.433
1.874CysLys: 1.874 ± 0.537
1.874CysLeu: 1.874 ± 0.632
0.75CysMet: 0.75 ± 0.581
1.499CysAsn: 1.499 ± 0.886
2.249CysPro: 2.249 ± 0.679
0.0CysGln: 0.0 ± 0.0
1.874CysArg: 1.874 ± 0.675
0.75CysSer: 0.75 ± 0.592
1.874CysThr: 1.874 ± 1.828
1.874CysVal: 1.874 ± 0.685
0.75CysTrp: 0.75 ± 0.349
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
2.249AspAla: 2.249 ± 1.036
2.624AspCys: 2.624 ± 0.994
3.748AspAsp: 3.748 ± 1.83
5.622AspGlu: 5.622 ± 1.153
1.124AspPhe: 1.124 ± 0.384
5.247AspGly: 5.247 ± 1.358
0.75AspHis: 0.75 ± 0.508
2.999AspIle: 2.999 ± 1.12
2.999AspLys: 2.999 ± 0.674
5.247AspLeu: 5.247 ± 2.39
0.75AspMet: 0.75 ± 0.522
2.999AspAsn: 2.999 ± 1.168
4.498AspPro: 4.498 ± 1.271
2.999AspGln: 2.999 ± 1.478
2.624AspArg: 2.624 ± 0.572
3.748AspSer: 3.748 ± 1.412
4.873AspThr: 4.873 ± 1.293
4.123AspVal: 4.123 ± 1.355
0.75AspTrp: 0.75 ± 0.581
1.124AspTyr: 1.124 ± 0.668
0.0AspXaa: 0.0 ± 0.0
Glu
5.997GluAla: 5.997 ± 1.523
1.499GluCys: 1.499 ± 0.831
4.498GluAsp: 4.498 ± 1.171
4.873GluGlu: 4.873 ± 1.667
0.75GluPhe: 0.75 ± 0.418
4.498GluGly: 4.498 ± 1.441
1.124GluHis: 1.124 ± 0.461
1.499GluIle: 1.499 ± 0.623
2.999GluLys: 2.999 ± 1.038
6.747GluLeu: 6.747 ± 0.639
1.499GluMet: 1.499 ± 0.569
5.622GluAsn: 5.622 ± 1.535
2.624GluPro: 2.624 ± 0.744
2.624GluGln: 2.624 ± 1.083
1.124GluArg: 1.124 ± 0.515
4.873GluSer: 4.873 ± 1.606
3.748GluThr: 3.748 ± 1.551
2.624GluVal: 2.624 ± 1.046
1.124GluTrp: 1.124 ± 0.484
1.124GluTyr: 1.124 ± 0.668
0.0GluXaa: 0.0 ± 0.0
Phe
2.624PheAla: 2.624 ± 0.514
2.249PheCys: 2.249 ± 1.176
2.249PheAsp: 2.249 ± 0.482
2.999PheGlu: 2.999 ± 1.932
2.249PhePhe: 2.249 ± 0.612
3.373PheGly: 3.373 ± 0.87
0.0PheHis: 0.0 ± 0.0
2.624PheIle: 2.624 ± 0.874
1.874PheLys: 1.874 ± 0.692
3.748PheLeu: 3.748 ± 1.111
0.75PheMet: 0.75 ± 0.418
1.124PheAsn: 1.124 ± 0.619
0.375PhePro: 0.375 ± 0.463
2.249PheGln: 2.249 ± 0.752
1.499PheArg: 1.499 ± 0.358
4.123PheSer: 4.123 ± 0.898
1.499PheThr: 1.499 ± 0.72
2.249PheVal: 2.249 ± 1.141
1.499PheTrp: 1.499 ± 0.805
2.249PheTyr: 2.249 ± 0.808
0.0PheXaa: 0.0 ± 0.0
Gly
1.874GlyAla: 1.874 ± 0.643
1.499GlyCys: 1.499 ± 0.771
5.622GlyAsp: 5.622 ± 0.991
2.999GlyGlu: 2.999 ± 0.895
2.249GlyPhe: 2.249 ± 1.019
7.496GlyGly: 7.496 ± 2.676
2.999GlyHis: 2.999 ± 0.93
2.999GlyIle: 2.999 ± 0.744
1.874GlyLys: 1.874 ± 0.55
3.373GlyLeu: 3.373 ± 1.022
0.75GlyMet: 0.75 ± 0.349
3.373GlyAsn: 3.373 ± 1.105
4.873GlyPro: 4.873 ± 1.753
2.249GlyGln: 2.249 ± 0.641
5.997GlyArg: 5.997 ± 1.898
4.873GlySer: 4.873 ± 1.537
6.747GlyThr: 6.747 ± 1.266
4.123GlyVal: 4.123 ± 0.561
0.375GlyTrp: 0.375 ± 0.366
1.124GlyTyr: 1.124 ± 0.528
0.0GlyXaa: 0.0 ± 0.0
His
0.75HisAla: 0.75 ± 0.55
1.874HisCys: 1.874 ± 0.926
0.0HisAsp: 0.0 ± 0.0
1.124HisGlu: 1.124 ± 0.478
2.249HisPhe: 2.249 ± 0.501
1.874HisGly: 1.874 ± 0.638
0.75HisHis: 0.75 ± 0.506
0.375HisIle: 0.375 ± 0.328
1.499HisLys: 1.499 ± 0.564
2.249HisLeu: 2.249 ± 1.063
0.0HisMet: 0.0 ± 0.0
0.375HisAsn: 0.375 ± 0.32
1.124HisPro: 1.124 ± 0.689
1.499HisGln: 1.499 ± 0.872
0.0HisArg: 0.0 ± 0.0
1.874HisSer: 1.874 ± 0.299
0.75HisThr: 0.75 ± 0.506
1.499HisVal: 1.499 ± 0.56
1.124HisTrp: 1.124 ± 0.443
0.375HisTyr: 0.375 ± 0.32
0.0HisXaa: 0.0 ± 0.0
Ile
3.373IleAla: 3.373 ± 1.119
0.75IleCys: 0.75 ± 0.39
1.874IleAsp: 1.874 ± 0.614
4.123IleGlu: 4.123 ± 0.564
2.249IlePhe: 2.249 ± 0.796
2.249IleGly: 2.249 ± 0.809
0.375IleHis: 0.375 ± 0.291
0.75IleIle: 0.75 ± 0.403
2.249IleLys: 2.249 ± 0.933
2.249IleLeu: 2.249 ± 0.53
0.75IleMet: 0.75 ± 0.706
2.999IleAsn: 2.999 ± 1.238
2.624IlePro: 2.624 ± 0.791
1.124IleGln: 1.124 ± 0.573
2.249IleArg: 2.249 ± 0.77
3.373IleSer: 3.373 ± 0.898
2.249IleThr: 2.249 ± 0.498
1.499IleVal: 1.499 ± 0.505
0.0IleTrp: 0.0 ± 0.0
0.75IleTyr: 0.75 ± 0.421
0.0IleXaa: 0.0 ± 0.0
Lys
2.999LysAla: 2.999 ± 1.265
1.874LysCys: 1.874 ± 0.53
0.75LysAsp: 0.75 ± 0.423
2.624LysGlu: 2.624 ± 1.283
3.373LysPhe: 3.373 ± 1.596
1.874LysGly: 1.874 ± 0.768
1.874LysHis: 1.874 ± 0.701
1.499LysIle: 1.499 ± 0.703
2.999LysLys: 2.999 ± 0.911
3.748LysLeu: 3.748 ± 1.239
0.375LysMet: 0.375 ± 0.335
1.124LysAsn: 1.124 ± 0.37
0.75LysPro: 0.75 ± 0.465
3.373LysGln: 3.373 ± 1.225
5.997LysArg: 5.997 ± 1.897
4.498LysSer: 4.498 ± 1.174
5.247LysThr: 5.247 ± 1.368
2.249LysVal: 2.249 ± 0.847
0.0LysTrp: 0.0 ± 0.0
2.249LysTyr: 2.249 ± 0.742
0.0LysXaa: 0.0 ± 0.0
Leu
4.123LeuAla: 4.123 ± 1.51
1.124LeuCys: 1.124 ± 0.749
4.498LeuAsp: 4.498 ± 1.271
6.747LeuGlu: 6.747 ± 1.404
3.373LeuPhe: 3.373 ± 1.324
7.496LeuGly: 7.496 ± 1.281
2.624LeuHis: 2.624 ± 0.954
2.249LeuIle: 2.249 ± 0.768
5.247LeuLys: 5.247 ± 1.951
12.744LeuLeu: 12.744 ± 4.248
2.249LeuMet: 2.249 ± 0.983
2.624LeuAsn: 2.624 ± 0.854
3.748LeuPro: 3.748 ± 0.72
7.871LeuGln: 7.871 ± 1.577
7.871LeuArg: 7.871 ± 1.597
10.87LeuSer: 10.87 ± 1.991
4.498LeuThr: 4.498 ± 1.212
5.622LeuVal: 5.622 ± 1.448
0.375LeuTrp: 0.375 ± 0.32
2.249LeuTyr: 2.249 ± 0.841
0.0LeuXaa: 0.0 ± 0.0
Met
1.499MetAla: 1.499 ± 0.711
0.75MetCys: 0.75 ± 0.442
0.75MetAsp: 0.75 ± 0.442
0.75MetGlu: 0.75 ± 0.483
0.375MetPhe: 0.375 ± 0.335
0.75MetGly: 0.75 ± 0.659
0.375MetHis: 0.375 ± 0.335
0.375MetIle: 0.375 ± 0.445
0.0MetLys: 0.0 ± 0.0
1.874MetLeu: 1.874 ± 0.644
0.375MetMet: 0.375 ± 0.353
1.124MetAsn: 1.124 ± 0.461
0.375MetPro: 0.375 ± 0.291
1.124MetGln: 1.124 ± 0.689
1.124MetArg: 1.124 ± 0.489
1.499MetSer: 1.499 ± 0.952
1.124MetThr: 1.124 ± 0.449
3.373MetVal: 3.373 ± 1.28
0.75MetTrp: 0.75 ± 0.706
0.375MetTyr: 0.375 ± 0.335
0.0MetXaa: 0.0 ± 0.0
Asn
3.373AsnAla: 3.373 ± 1.13
1.874AsnCys: 1.874 ± 1.048
0.75AsnAsp: 0.75 ± 0.581
1.124AsnGlu: 1.124 ± 0.709
1.499AsnPhe: 1.499 ± 0.643
1.124AsnGly: 1.124 ± 0.37
1.124AsnHis: 1.124 ± 0.548
0.75AsnIle: 0.75 ± 0.423
1.874AsnLys: 1.874 ± 1.093
2.624AsnLeu: 2.624 ± 0.954
0.75AsnMet: 0.75 ± 0.563
1.874AsnAsn: 1.874 ± 0.78
3.373AsnPro: 3.373 ± 1.088
2.624AsnGln: 2.624 ± 1.058
2.249AsnArg: 2.249 ± 0.66
1.874AsnSer: 1.874 ± 1.453
2.624AsnThr: 2.624 ± 0.904
2.249AsnVal: 2.249 ± 0.663
0.75AsnTrp: 0.75 ± 0.349
1.499AsnTyr: 1.499 ± 0.588
0.0AsnXaa: 0.0 ± 0.0
Pro
6.747ProAla: 6.747 ± 1.971
0.375ProCys: 0.375 ± 0.445
3.748ProAsp: 3.748 ± 0.944
5.997ProGlu: 5.997 ± 0.944
1.874ProPhe: 1.874 ± 0.921
4.123ProGly: 4.123 ± 1.668
0.0ProHis: 0.0 ± 0.0
3.373ProIle: 3.373 ± 0.802
3.373ProLys: 3.373 ± 1.028
5.622ProLeu: 5.622 ± 1.098
0.75ProMet: 0.75 ± 0.337
1.499ProAsn: 1.499 ± 0.623
7.496ProPro: 7.496 ± 1.464
1.874ProGln: 1.874 ± 0.78
2.249ProArg: 2.249 ± 0.823
4.123ProSer: 4.123 ± 1.166
2.249ProThr: 2.249 ± 0.935
4.873ProVal: 4.873 ± 0.851
0.375ProTrp: 0.375 ± 0.32
2.249ProTyr: 2.249 ± 0.661
0.0ProXaa: 0.0 ± 0.0
Gln
2.624GlnAla: 2.624 ± 0.867
1.124GlnCys: 1.124 ± 0.511
3.373GlnAsp: 3.373 ± 1.077
2.624GlnGlu: 2.624 ± 0.756
1.124GlnPhe: 1.124 ± 0.689
3.373GlnGly: 3.373 ± 1.08
1.124GlnHis: 1.124 ± 0.562
2.249GlnIle: 2.249 ± 0.945
2.624GlnLys: 2.624 ± 0.783
5.622GlnLeu: 5.622 ± 1.398
1.499GlnMet: 1.499 ± 0.698
1.124GlnAsn: 1.124 ± 0.443
2.624GlnPro: 2.624 ± 0.86
2.624GlnGln: 2.624 ± 0.585
2.999GlnArg: 2.999 ± 1.233
3.373GlnSer: 3.373 ± 0.803
2.249GlnThr: 2.249 ± 0.711
3.373GlnVal: 3.373 ± 0.632
0.75GlnTrp: 0.75 ± 0.418
2.249GlnTyr: 2.249 ± 0.841
0.0GlnXaa: 0.0 ± 0.0
Arg
3.373ArgAla: 3.373 ± 0.791
1.124ArgCys: 1.124 ± 0.799
2.249ArgAsp: 2.249 ± 0.552
1.874ArgGlu: 1.874 ± 0.796
2.249ArgPhe: 2.249 ± 0.926
3.373ArgGly: 3.373 ± 0.829
1.874ArgHis: 1.874 ± 0.58
2.249ArgIle: 2.249 ± 1.021
4.123ArgLys: 4.123 ± 0.93
7.871ArgLeu: 7.871 ± 1.375
0.75ArgMet: 0.75 ± 0.45
1.499ArgAsn: 1.499 ± 0.643
3.373ArgPro: 3.373 ± 1.025
2.249ArgGln: 2.249 ± 1.156
4.498ArgArg: 4.498 ± 1.516
4.498ArgSer: 4.498 ± 1.491
5.247ArgThr: 5.247 ± 1.191
3.373ArgVal: 3.373 ± 0.745
0.75ArgTrp: 0.75 ± 0.465
1.499ArgTyr: 1.499 ± 0.303
0.0ArgXaa: 0.0 ± 0.0
Ser
4.123SerAla: 4.123 ± 0.958
0.75SerCys: 0.75 ± 0.731
6.372SerAsp: 6.372 ± 0.338
3.373SerGlu: 3.373 ± 0.883
3.373SerPhe: 3.373 ± 1.26
6.372SerGly: 6.372 ± 0.923
1.499SerHis: 1.499 ± 0.619
3.748SerIle: 3.748 ± 1.115
2.999SerLys: 2.999 ± 1.025
10.87SerLeu: 10.87 ± 2.21
1.499SerMet: 1.499 ± 1.072
0.75SerAsn: 0.75 ± 0.465
4.123SerPro: 4.123 ± 1.051
4.123SerGln: 4.123 ± 1.262
5.622SerArg: 5.622 ± 1.457
6.372SerSer: 6.372 ± 1.143
4.873SerThr: 4.873 ± 1.818
5.622SerVal: 5.622 ± 1.582
1.499SerTrp: 1.499 ± 0.636
1.874SerTyr: 1.874 ± 0.669
0.0SerXaa: 0.0 ± 0.0
Thr
1.124ThrAla: 1.124 ± 0.599
1.499ThrCys: 1.499 ± 0.534
4.873ThrAsp: 4.873 ± 1.031
3.373ThrGlu: 3.373 ± 0.811
1.499ThrPhe: 1.499 ± 0.506
3.373ThrGly: 3.373 ± 0.911
1.499ThrHis: 1.499 ± 0.506
2.999ThrIle: 2.999 ± 1.01
2.624ThrLys: 2.624 ± 1.704
6.372ThrLeu: 6.372 ± 1.166
3.373ThrMet: 3.373 ± 1.384
1.874ThrAsn: 1.874 ± 0.692
5.247ThrPro: 5.247 ± 0.699
3.373ThrGln: 3.373 ± 0.962
2.624ThrArg: 2.624 ± 0.463
7.121ThrSer: 7.121 ± 2.348
3.748ThrThr: 3.748 ± 1.786
4.498ThrVal: 4.498 ± 1.01
0.75ThrTrp: 0.75 ± 0.422
1.499ThrTyr: 1.499 ± 0.54
0.0ThrXaa: 0.0 ± 0.0
Val
2.624ValAla: 2.624 ± 1.497
2.249ValCys: 2.249 ± 1.379
5.247ValAsp: 5.247 ± 1.134
2.999ValGlu: 2.999 ± 0.654
5.997ValPhe: 5.997 ± 0.971
2.249ValGly: 2.249 ± 0.54
1.499ValHis: 1.499 ± 0.396
1.499ValIle: 1.499 ± 0.667
3.373ValLys: 3.373 ± 1.331
3.748ValLeu: 3.748 ± 1.002
0.375ValMet: 0.375 ± 0.291
1.874ValAsn: 1.874 ± 0.597
5.622ValPro: 5.622 ± 1.472
3.373ValGln: 3.373 ± 0.838
1.874ValArg: 1.874 ± 0.913
6.747ValSer: 6.747 ± 1.358
4.123ValThr: 4.123 ± 1.389
2.624ValVal: 2.624 ± 0.482
1.124ValTrp: 1.124 ± 0.705
2.999ValTyr: 2.999 ± 0.799
0.0ValXaa: 0.0 ± 0.0
Trp
1.124TrpAla: 1.124 ± 0.461
0.75TrpCys: 0.75 ± 0.442
1.124TrpAsp: 1.124 ± 0.548
0.375TrpGlu: 0.375 ± 0.335
0.375TrpPhe: 0.375 ± 0.366
0.375TrpGly: 0.375 ± 0.32
0.375TrpHis: 0.375 ± 0.366
0.75TrpIle: 0.75 ± 0.581
0.75TrpLys: 0.75 ± 0.581
1.499TrpLeu: 1.499 ± 0.711
0.0TrpMet: 0.0 ± 0.0
0.375TrpAsn: 0.375 ± 0.32
0.375TrpPro: 0.375 ± 0.366
0.375TrpGln: 0.375 ± 0.335
0.75TrpArg: 0.75 ± 0.418
1.124TrpSer: 1.124 ± 0.484
1.499TrpThr: 1.499 ± 1.038
1.124TrpVal: 1.124 ± 0.652
0.0TrpTrp: 0.0 ± 0.0
0.375TrpTyr: 0.375 ± 0.291
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.999TyrAla: 2.999 ± 0.984
0.75TyrCys: 0.75 ± 0.451
1.874TyrAsp: 1.874 ± 0.683
1.874TyrGlu: 1.874 ± 0.51
0.75TyrPhe: 0.75 ± 0.418
1.874TyrGly: 1.874 ± 0.549
0.0TyrHis: 0.0 ± 0.0
0.75TyrIle: 0.75 ± 0.403
1.499TyrLys: 1.499 ± 0.698
3.748TyrLeu: 3.748 ± 1.416
0.0TyrMet: 0.0 ± 0.0
0.375TyrAsn: 0.375 ± 0.335
2.624TyrPro: 2.624 ± 1.468
0.375TyrGln: 0.375 ± 0.328
2.624TyrArg: 2.624 ± 0.989
0.375TyrSer: 0.375 ± 0.32
1.499TyrThr: 1.499 ± 0.841
2.999TyrVal: 2.999 ± 0.911
0.375TyrTrp: 0.375 ± 0.335
3.373TyrTyr: 3.373 ± 1.328
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 8 proteins (2669 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski