Amino acid dipepetide frequency for Candidatus Methanoplasma termitum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.668AlaAla: 7.668 ± 0.186
0.943AlaCys: 0.943 ± 0.046
4.881AlaAsp: 4.881 ± 0.124
5.467AlaGlu: 5.467 ± 0.153
3.084AlaPhe: 3.084 ± 0.099
6.675AlaGly: 6.675 ± 0.245
1.098AlaHis: 1.098 ± 0.062
5.552AlaIle: 5.552 ± 0.132
5.027AlaLys: 5.027 ± 0.128
6.579AlaLeu: 6.579 ± 0.138
2.471AlaMet: 2.471 ± 0.09
2.868AlaAsn: 2.868 ± 0.116
2.466AlaPro: 2.466 ± 0.093
1.703AlaGln: 1.703 ± 0.073
2.841AlaArg: 2.841 ± 0.094
4.604AlaSer: 4.604 ± 0.119
4.045AlaThr: 4.045 ± 0.171
6.922AlaVal: 6.922 ± 0.146
0.584AlaTrp: 0.584 ± 0.045
2.26AlaTyr: 2.26 ± 0.071
0.0AlaXaa: 0.0 ± 0.0
Cys
1.002CysAla: 1.002 ± 0.054
0.281CysCys: 0.281 ± 0.033
0.802CysAsp: 0.802 ± 0.044
0.849CysGlu: 0.849 ± 0.046
0.467CysPhe: 0.467 ± 0.033
1.575CysGly: 1.575 ± 0.069
0.263CysHis: 0.263 ± 0.025
0.975CysIle: 0.975 ± 0.049
0.898CysLys: 0.898 ± 0.054
0.923CysLeu: 0.923 ± 0.052
0.332CysMet: 0.332 ± 0.027
0.496CysAsn: 0.496 ± 0.037
0.797CysPro: 0.797 ± 0.055
0.276CysGln: 0.276 ± 0.025
0.69CysArg: 0.69 ± 0.045
0.941CysSer: 0.941 ± 0.053
0.761CysThr: 0.761 ± 0.045
0.871CysVal: 0.871 ± 0.052
0.101CysTrp: 0.101 ± 0.015
0.469CysTyr: 0.469 ± 0.045
0.0CysXaa: 0.0 ± 0.0
Asp
4.575AspAla: 4.575 ± 0.1
0.784AspCys: 0.784 ± 0.046
3.194AspAsp: 3.194 ± 0.094
4.279AspGlu: 4.279 ± 0.119
2.28AspPhe: 2.28 ± 0.072
4.89AspGly: 4.89 ± 0.153
1.121AspHis: 1.121 ± 0.056
5.462AspIle: 5.462 ± 0.133
3.475AspLys: 3.475 ± 0.118
5.245AspLeu: 5.245 ± 0.122
2.037AspMet: 2.037 ± 0.075
2.327AspAsn: 2.327 ± 0.082
2.987AspPro: 2.987 ± 0.095
1.152AspGln: 1.152 ± 0.051
2.823AspArg: 2.823 ± 0.098
3.504AspSer: 3.504 ± 0.102
2.996AspThr: 2.996 ± 0.103
4.872AspVal: 4.872 ± 0.109
0.615AspTrp: 0.615 ± 0.047
1.995AspTyr: 1.995 ± 0.071
0.0AspXaa: 0.0 ± 0.0
Glu
4.706GluAla: 4.706 ± 0.137
0.851GluCys: 0.851 ± 0.046
3.659GluAsp: 3.659 ± 0.12
5.013GluGlu: 5.013 ± 0.167
2.406GluPhe: 2.406 ± 0.081
4.317GluGly: 4.317 ± 0.099
1.206GluHis: 1.206 ± 0.052
5.301GluIle: 5.301 ± 0.133
5.359GluLys: 5.359 ± 0.151
5.507GluLeu: 5.507 ± 0.142
2.637GluMet: 2.637 ± 0.096
2.906GluAsn: 2.906 ± 0.089
2.123GluPro: 2.123 ± 0.086
1.525GluGln: 1.525 ± 0.065
3.65GluArg: 3.65 ± 0.129
3.538GluSer: 3.538 ± 0.106
3.178GluThr: 3.178 ± 0.094
4.263GluVal: 4.263 ± 0.108
0.692GluTrp: 0.692 ± 0.035
2.513GluTyr: 2.513 ± 0.081
0.0GluXaa: 0.0 ± 0.0
Phe
2.776PheAla: 2.776 ± 0.108
0.579PheCys: 0.579 ± 0.04
2.783PheAsp: 2.783 ± 0.08
2.468PheGlu: 2.468 ± 0.071
1.646PhePhe: 1.646 ± 0.073
3.259PheGly: 3.259 ± 0.12
0.562PheHis: 0.562 ± 0.034
2.884PheIle: 2.884 ± 0.099
2.199PheLys: 2.199 ± 0.085
3.003PheLeu: 3.003 ± 0.093
1.195PheMet: 1.195 ± 0.071
1.581PheAsn: 1.581 ± 0.07
1.411PhePro: 1.411 ± 0.059
0.748PheGln: 0.748 ± 0.047
1.732PheArg: 1.732 ± 0.065
2.749PheSer: 2.749 ± 0.081
2.394PheThr: 2.394 ± 0.107
3.059PheVal: 3.059 ± 0.094
0.371PheTrp: 0.371 ± 0.037
1.22PheTyr: 1.22 ± 0.061
0.0PheXaa: 0.0 ± 0.0
Gly
6.087GlyAla: 6.087 ± 0.206
1.224GlyCys: 1.224 ± 0.062
4.476GlyAsp: 4.476 ± 0.123
4.292GlyGlu: 4.292 ± 0.112
2.967GlyPhe: 2.967 ± 0.087
7.221GlyGly: 7.221 ± 0.461
1.309GlyHis: 1.309 ± 0.058
6.599GlyIle: 6.599 ± 0.185
6.109GlyLys: 6.109 ± 0.13
5.909GlyLeu: 5.909 ± 0.121
2.814GlyMet: 2.814 ± 0.093
3.78GlyAsn: 3.78 ± 0.203
2.336GlyPro: 2.336 ± 0.087
1.557GlyGln: 1.557 ± 0.072
3.731GlyArg: 3.731 ± 0.114
5.813GlySer: 5.813 ± 0.207
5.876GlyThr: 5.876 ± 0.357
5.687GlyVal: 5.687 ± 0.135
0.995GlyTrp: 0.995 ± 0.067
3.109GlyTyr: 3.109 ± 0.12
0.0GlyXaa: 0.0 ± 0.0
His
1.065HisAla: 1.065 ± 0.052
0.292HisCys: 0.292 ± 0.028
0.948HisAsp: 0.948 ± 0.05
0.795HisGlu: 0.795 ± 0.043
0.609HisPhe: 0.609 ± 0.036
1.211HisGly: 1.211 ± 0.056
0.362HisHis: 0.362 ± 0.04
1.195HisIle: 1.195 ± 0.057
0.885HisLys: 0.885 ± 0.047
1.289HisLeu: 1.289 ± 0.056
0.564HisMet: 0.564 ± 0.04
0.613HisAsn: 0.613 ± 0.035
0.869HisPro: 0.869 ± 0.051
0.312HisGln: 0.312 ± 0.028
0.791HisArg: 0.791 ± 0.044
0.968HisSer: 0.968 ± 0.048
0.973HisThr: 0.973 ± 0.061
1.107HisVal: 1.107 ± 0.054
0.15HisTrp: 0.15 ± 0.02
0.494HisTyr: 0.494 ± 0.036
0.0HisXaa: 0.0 ± 0.0
Ile
6.134IleAla: 6.134 ± 0.122
1.089IleCys: 1.089 ± 0.054
5.013IleAsp: 5.013 ± 0.114
5.09IleGlu: 5.09 ± 0.117
2.774IlePhe: 2.774 ± 0.098
6.343IleGly: 6.343 ± 0.171
1.166IleHis: 1.166 ± 0.05
5.716IleIle: 5.716 ± 0.165
4.512IleLys: 4.512 ± 0.124
6.161IleLeu: 6.161 ± 0.152
2.361IleMet: 2.361 ± 0.081
3.008IleAsn: 3.008 ± 0.109
3.538IlePro: 3.538 ± 0.091
1.604IleGln: 1.604 ± 0.06
3.686IleArg: 3.686 ± 0.108
5.795IleSer: 5.795 ± 0.126
4.883IleThr: 4.883 ± 0.175
5.656IleVal: 5.656 ± 0.134
0.591IleTrp: 0.591 ± 0.035
2.385IleTyr: 2.385 ± 0.084
0.002IleXaa: 0.002 ± 0.002
Lys
5.249LysAla: 5.249 ± 0.134
0.941LysCys: 0.941 ± 0.055
4.607LysAsp: 4.607 ± 0.12
6.161LysGlu: 6.161 ± 0.173
2.037LysPhe: 2.037 ± 0.08
5.168LysGly: 5.168 ± 0.119
1.002LysHis: 1.002 ± 0.048
5.377LysIle: 5.377 ± 0.136
6.197LysLys: 6.197 ± 0.164
4.508LysLeu: 4.508 ± 0.132
2.52LysMet: 2.52 ± 0.086
3.259LysAsn: 3.259 ± 0.097
1.806LysPro: 1.806 ± 0.072
1.5LysGln: 1.5 ± 0.063
3.279LysArg: 3.279 ± 0.102
3.106LysSer: 3.106 ± 0.086
3.484LysThr: 3.484 ± 0.092
4.629LysVal: 4.629 ± 0.113
0.656LysTrp: 0.656 ± 0.048
2.293LysTyr: 2.293 ± 0.079
0.0LysXaa: 0.0 ± 0.0
Leu
5.835LeuAla: 5.835 ± 0.14
1.168LeuCys: 1.168 ± 0.063
4.874LeuAsp: 4.874 ± 0.104
4.719LeuGlu: 4.719 ± 0.141
3.255LeuPhe: 3.255 ± 0.106
5.833LeuGly: 5.833 ± 0.142
1.137LeuHis: 1.137 ± 0.054
5.99LeuIle: 5.99 ± 0.156
5.611LeuLys: 5.611 ± 0.14
6.374LeuLeu: 6.374 ± 0.146
2.702LeuMet: 2.702 ± 0.096
3.513LeuAsn: 3.513 ± 0.093
3.039LeuPro: 3.039 ± 0.084
1.572LeuGln: 1.572 ± 0.062
3.744LeuArg: 3.744 ± 0.122
6.255LeuSer: 6.255 ± 0.126
4.861LeuThr: 4.861 ± 0.128
5.233LeuVal: 5.233 ± 0.139
0.663LeuTrp: 0.663 ± 0.037
2.403LeuTyr: 2.403 ± 0.083
0.0LeuXaa: 0.0 ± 0.0
Met
2.543MetAla: 2.543 ± 0.079
0.442MetCys: 0.442 ± 0.038
2.136MetAsp: 2.136 ± 0.074
2.107MetGlu: 2.107 ± 0.087
1.206MetPhe: 1.206 ± 0.067
2.473MetGly: 2.473 ± 0.09
0.505MetHis: 0.505 ± 0.035
2.733MetIle: 2.733 ± 0.094
2.468MetLys: 2.468 ± 0.086
2.48MetLeu: 2.48 ± 0.099
1.256MetMet: 1.256 ± 0.062
1.388MetAsn: 1.388 ± 0.057
1.343MetPro: 1.343 ± 0.051
0.681MetGln: 0.681 ± 0.045
1.592MetArg: 1.592 ± 0.077
2.206MetSer: 2.206 ± 0.063
1.952MetThr: 1.952 ± 0.074
2.273MetVal: 2.273 ± 0.076
0.238MetTrp: 0.238 ± 0.024
0.925MetTyr: 0.925 ± 0.051
0.0MetXaa: 0.0 ± 0.0
Asn
3.221AsnAla: 3.221 ± 0.103
0.557AsnCys: 0.557 ± 0.04
2.495AsnAsp: 2.495 ± 0.078
2.455AsnGlu: 2.455 ± 0.069
1.415AsnPhe: 1.415 ± 0.064
4.528AsnGly: 4.528 ± 0.235
0.519AsnHis: 0.519 ± 0.031
3.76AsnIle: 3.76 ± 0.11
2.5AsnLys: 2.5 ± 0.085
2.915AsnLeu: 2.915 ± 0.088
1.289AsnMet: 1.289 ± 0.054
1.927AsnAsn: 1.927 ± 0.085
1.956AsnPro: 1.956 ± 0.074
0.723AsnGln: 0.723 ± 0.038
1.716AsnArg: 1.716 ± 0.067
2.704AsnSer: 2.704 ± 0.119
2.392AsnThr: 2.392 ± 0.13
3.461AsnVal: 3.461 ± 0.12
0.341AsnTrp: 0.341 ± 0.027
1.395AsnTyr: 1.395 ± 0.083
0.0AsnXaa: 0.0 ± 0.0
Pro
3.012ProAla: 3.012 ± 0.107
0.456ProCys: 0.456 ± 0.035
2.59ProAsp: 2.59 ± 0.09
3.12ProGlu: 3.12 ± 0.102
1.747ProPhe: 1.747 ± 0.069
3.113ProGly: 3.113 ± 0.095
0.588ProHis: 0.588 ± 0.045
2.742ProIle: 2.742 ± 0.081
2.511ProLys: 2.511 ± 0.092
3.037ProLeu: 3.037 ± 0.095
1.11ProMet: 1.11 ± 0.052
1.608ProAsn: 1.608 ± 0.071
1.323ProPro: 1.323 ± 0.062
0.912ProGln: 0.912 ± 0.052
1.404ProArg: 1.404 ± 0.062
2.527ProSer: 2.527 ± 0.083
2.154ProThr: 2.154 ± 0.101
2.787ProVal: 2.787 ± 0.08
0.314ProTrp: 0.314 ± 0.032
1.283ProTyr: 1.283 ± 0.061
0.0ProXaa: 0.0 ± 0.0
Gln
1.649GlnAla: 1.649 ± 0.083
0.292GlnCys: 0.292 ± 0.024
1.08GlnAsp: 1.08 ± 0.057
1.204GlnGlu: 1.204 ± 0.054
0.813GlnPhe: 0.813 ± 0.043
1.352GlnGly: 1.352 ± 0.071
0.35GlnHis: 0.35 ± 0.028
1.716GlnIle: 1.716 ± 0.065
1.572GlnLys: 1.572 ± 0.072
1.682GlnLeu: 1.682 ± 0.064
0.905GlnMet: 0.905 ± 0.046
0.986GlnAsn: 0.986 ± 0.049
0.719GlnPro: 0.719 ± 0.046
0.633GlnGln: 0.633 ± 0.047
1.134GlnArg: 1.134 ± 0.057
1.35GlnSer: 1.35 ± 0.064
1.307GlnThr: 1.307 ± 0.071
1.312GlnVal: 1.312 ± 0.053
0.229GlnTrp: 0.229 ± 0.022
0.892GlnTyr: 0.892 ± 0.047
0.0GlnXaa: 0.0 ± 0.0
Arg
3.115ArgAla: 3.115 ± 0.088
0.676ArgCys: 0.676 ± 0.05
2.635ArgAsp: 2.635 ± 0.093
3.212ArgGlu: 3.212 ± 0.117
1.884ArgPhe: 1.884 ± 0.067
3.059ArgGly: 3.059 ± 0.094
0.699ArgHis: 0.699 ± 0.041
3.508ArgIle: 3.508 ± 0.102
3.295ArgLys: 3.295 ± 0.127
3.533ArgLeu: 3.533 ± 0.109
1.752ArgMet: 1.752 ± 0.076
2.066ArgAsn: 2.066 ± 0.088
1.732ArgPro: 1.732 ± 0.065
1.022ArgGln: 1.022 ± 0.049
2.309ArgArg: 2.309 ± 0.075
3.196ArgSer: 3.196 ± 0.095
2.738ArgThr: 2.738 ± 0.094
2.909ArgVal: 2.909 ± 0.098
0.391ArgTrp: 0.391 ± 0.032
1.698ArgTyr: 1.698 ± 0.068
0.0ArgXaa: 0.0 ± 0.0
Ser
5.182SerAla: 5.182 ± 0.134
0.791SerCys: 0.791 ± 0.047
3.996SerAsp: 3.996 ± 0.097
4.209SerGlu: 4.209 ± 0.116
2.805SerPhe: 2.805 ± 0.084
6.509SerGly: 6.509 ± 0.209
0.961SerHis: 0.961 ± 0.047
4.82SerIle: 4.82 ± 0.109
4.461SerLys: 4.461 ± 0.122
4.982SerLeu: 4.982 ± 0.1
2.004SerMet: 2.004 ± 0.078
2.675SerAsn: 2.675 ± 0.119
2.603SerPro: 2.603 ± 0.098
1.487SerGln: 1.487 ± 0.058
2.754SerArg: 2.754 ± 0.09
4.827SerSer: 4.827 ± 0.129
3.668SerThr: 3.668 ± 0.17
5.406SerVal: 5.406 ± 0.15
0.555SerTrp: 0.555 ± 0.038
1.983SerTyr: 1.983 ± 0.065
0.0SerXaa: 0.0 ± 0.0
Thr
5.179ThrAla: 5.179 ± 0.224
0.615ThrCys: 0.615 ± 0.041
3.403ThrAsp: 3.403 ± 0.105
3.232ThrGlu: 3.232 ± 0.103
2.34ThrPhe: 2.34 ± 0.108
5.635ThrGly: 5.635 ± 0.267
0.871ThrHis: 0.871 ± 0.055
4.784ThrIle: 4.784 ± 0.211
3.201ThrLys: 3.201 ± 0.093
4.874ThrLeu: 4.874 ± 0.167
1.568ThrMet: 1.568 ± 0.062
2.163ThrAsn: 2.163 ± 0.128
2.527ThrPro: 2.527 ± 0.106
1.206ThrGln: 1.206 ± 0.064
1.875ThrArg: 1.875 ± 0.067
3.926ThrSer: 3.926 ± 0.142
3.365ThrThr: 3.365 ± 0.154
5.676ThrVal: 5.676 ± 0.25
0.463ThrTrp: 0.463 ± 0.041
1.977ThrTyr: 1.977 ± 0.125
0.0ThrXaa: 0.0 ± 0.0
Val
5.606ValAla: 5.606 ± 0.153
1.101ValCys: 1.101 ± 0.06
4.216ValAsp: 4.216 ± 0.098
4.207ValGlu: 4.207 ± 0.106
3.118ValPhe: 3.118 ± 0.1
5.263ValGly: 5.263 ± 0.143
1.116ValHis: 1.116 ± 0.049
5.577ValIle: 5.577 ± 0.139
4.975ValLys: 4.975 ± 0.115
6.404ValLeu: 6.404 ± 0.143
2.291ValMet: 2.291 ± 0.075
2.999ValAsn: 2.999 ± 0.104
3.297ValPro: 3.297 ± 0.101
1.57ValGln: 1.57 ± 0.055
3.614ValArg: 3.614 ± 0.117
5.438ValSer: 5.438 ± 0.149
5.229ValThr: 5.229 ± 0.249
5.496ValVal: 5.496 ± 0.123
0.649ValTrp: 0.649 ± 0.043
2.3ValTyr: 2.3 ± 0.081
0.0ValXaa: 0.0 ± 0.0
Trp
0.622TrpAla: 0.622 ± 0.04
0.13TrpCys: 0.13 ± 0.018
0.521TrpAsp: 0.521 ± 0.033
0.615TrpGlu: 0.615 ± 0.043
0.42TrpPhe: 0.42 ± 0.036
0.586TrpGly: 0.586 ± 0.048
0.121TrpHis: 0.121 ± 0.016
0.651TrpIle: 0.651 ± 0.039
0.746TrpLys: 0.746 ± 0.049
0.678TrpLeu: 0.678 ± 0.039
0.33TrpMet: 0.33 ± 0.025
0.526TrpAsn: 0.526 ± 0.035
0.225TrpPro: 0.225 ± 0.023
0.22TrpGln: 0.22 ± 0.022
0.4TrpArg: 0.4 ± 0.033
0.586TrpSer: 0.586 ± 0.048
0.535TrpThr: 0.535 ± 0.064
0.649TrpVal: 0.649 ± 0.044
0.101TrpTrp: 0.101 ± 0.015
0.359TrpTyr: 0.359 ± 0.028
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.513TyrAla: 2.513 ± 0.096
0.557TyrCys: 0.557 ± 0.042
2.304TyrAsp: 2.304 ± 0.069
1.855TyrGlu: 1.855 ± 0.068
1.345TyrPhe: 1.345 ± 0.061
2.877TyrGly: 2.877 ± 0.095
0.535TyrHis: 0.535 ± 0.034
2.161TyrIle: 2.161 ± 0.077
1.779TyrLys: 1.779 ± 0.057
2.698TyrLeu: 2.698 ± 0.085
0.811TyrMet: 0.811 ± 0.054
1.581TyrAsn: 1.581 ± 0.077
1.242TyrPro: 1.242 ± 0.056
0.775TyrGln: 0.775 ± 0.047
1.667TyrArg: 1.667 ± 0.072
2.644TyrSer: 2.644 ± 0.093
2.091TyrThr: 2.091 ± 0.127
2.194TyrVal: 2.194 ± 0.074
0.323TyrTrp: 0.323 ± 0.028
1.285TyrTyr: 1.285 ± 0.06
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.002XaaGly: 0.002 ± 0.002
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1393 proteins (445219 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski