Amino acid dipepetide frequency for Lysobacter antibioticus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.096AlaAla: 19.096 ± 0.176	1.275AlaCys: 1.275 ± 0.038	7.247AlaAsp: 7.247 ± 0.071	6.958AlaGlu: 6.958 ± 0.094	4.064AlaPhe: 4.064 ± 0.048	11.276AlaGly: 11.276 ± 0.142	2.523AlaHis: 2.523 ± 0.044	5.547AlaIle: 5.547 ± 0.06	3.698AlaLys: 3.698 ± 0.064	14.614AlaLeu: 14.614 ± 0.146	3.144AlaMet: 3.144 ± 0.055	3.212AlaAsn: 3.212 ± 0.06	6.797AlaPro: 6.797 ± 0.08	5.503AlaGln: 5.503 ± 0.065	9.318AlaArg: 9.318 ± 0.106	7.306AlaSer: 7.306 ± 0.075	6.508AlaThr: 6.508 ± 0.081	8.726AlaVal: 8.726 ± 0.09	1.972AlaTrp: 1.972 ± 0.046	2.746AlaTyr: 2.746 ± 0.044	0.0AlaXaa: 0.0 ± 0.0
Cys	1.163CysAla: 1.163 ± 0.032	0.107CysCys: 0.107 ± 0.008	0.485CysAsp: 0.485 ± 0.018	0.49CysGlu: 0.49 ± 0.017	0.252CysPhe: 0.252 ± 0.014	0.948CysGly: 0.948 ± 0.03	0.199CysHis: 0.199 ± 0.012	0.319CysIle: 0.319 ± 0.015	0.197CysLys: 0.197 ± 0.011	0.778CysLeu: 0.778 ± 0.023	0.151CysMet: 0.151 ± 0.01	0.245CysAsn: 0.245 ± 0.013	0.441CysPro: 0.441 ± 0.02	0.21CysGln: 0.21 ± 0.011	0.615CysArg: 0.615 ± 0.021	0.521CysSer: 0.521 ± 0.017	0.471CysThr: 0.471 ± 0.028	0.616CysVal: 0.616 ± 0.024	0.113CysTrp: 0.113 ± 0.009	0.2CysTyr: 0.2 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	8.247AspAla: 8.247 ± 0.088	0.447AspCys: 0.447 ± 0.018	3.444AspAsp: 3.444 ± 0.063	3.431AspGlu: 3.431 ± 0.054	2.063AspPhe: 2.063 ± 0.038	6.248AspGly: 6.248 ± 0.084	1.136AspHis: 1.136 ± 0.028	2.171AspIle: 2.171 ± 0.035	1.553AspLys: 1.553 ± 0.038	5.587AspLeu: 5.587 ± 0.065	0.974AspMet: 0.974 ± 0.026	1.478AspAsn: 1.478 ± 0.036	3.573AspPro: 3.573 ± 0.057	1.699AspGln: 1.699 ± 0.03	4.371AspArg: 4.371 ± 0.056	3.05AspSer: 3.05 ± 0.049	2.873AspThr: 2.873 ± 0.058	3.77AspVal: 3.77 ± 0.055	1.106AspTrp: 1.106 ± 0.03	1.803AspTyr: 1.803 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	6.948GluAla: 6.948 ± 0.088	0.355GluCys: 0.355 ± 0.013	2.376GluAsp: 2.376 ± 0.043	2.13GluGlu: 2.13 ± 0.043	1.86GluPhe: 1.86 ± 0.036	3.689GluGly: 3.689 ± 0.049	1.428GluHis: 1.428 ± 0.035	2.46GluIle: 2.46 ± 0.038	1.326GluLys: 1.326 ± 0.034	6.132GluLeu: 6.132 ± 0.084	0.95GluMet: 0.95 ± 0.025	1.188GluAsn: 1.188 ± 0.029	2.644GluPro: 2.644 ± 0.054	2.519GluGln: 2.519 ± 0.047	5.667GluArg: 5.667 ± 0.076	2.703GluSer: 2.703 ± 0.042	2.654GluThr: 2.654 ± 0.047	3.731GluVal: 3.731 ± 0.053	0.751GluTrp: 0.751 ± 0.022	1.213GluTyr: 1.213 ± 0.031	0.0GluXaa: 0.0 ± 0.0
Phe	4.448PheAla: 4.448 ± 0.059	0.291PheCys: 0.291 ± 0.014	2.83PheAsp: 2.83 ± 0.046	2.08PheGlu: 2.08 ± 0.038	1.088PhePhe: 1.088 ± 0.029	3.354PheGly: 3.354 ± 0.058	0.671PheHis: 0.671 ± 0.022	1.166PheIle: 1.166 ± 0.024	0.877PheLys: 0.877 ± 0.028	2.731PheLeu: 2.731 ± 0.044	0.582PheMet: 0.582 ± 0.018	1.152PheAsn: 1.152 ± 0.029	1.342PhePro: 1.342 ± 0.029	0.937PheGln: 0.937 ± 0.028	2.016PheArg: 2.016 ± 0.042	2.022PheSer: 2.022 ± 0.043	1.618PheThr: 1.618 ± 0.04	2.686PheVal: 2.686 ± 0.046	0.502PheTrp: 0.502 ± 0.018	0.843PheTyr: 0.843 ± 0.024	0.0PheXaa: 0.0 ± 0.0
Gly	9.813GlyAla: 9.813 ± 0.141	0.822GlyCys: 0.822 ± 0.028	5.084GlyAsp: 5.084 ± 0.071	5.114GlyGlu: 5.114 ± 0.067	3.303GlyPhe: 3.303 ± 0.051	7.75GlyGly: 7.75 ± 0.17	1.964GlyHis: 1.964 ± 0.037	3.665GlyIle: 3.665 ± 0.05	3.014GlyLys: 3.014 ± 0.05	8.886GlyLeu: 8.886 ± 0.091	1.844GlyMet: 1.844 ± 0.032	2.789GlyAsn: 2.789 ± 0.081	3.327GlyPro: 3.327 ± 0.048	3.124GlyGln: 3.124 ± 0.05	6.423GlyArg: 6.423 ± 0.079	5.265GlySer: 5.265 ± 0.108	4.734GlyThr: 4.734 ± 0.15	6.095GlyVal: 6.095 ± 0.081	1.607GlyTrp: 1.607 ± 0.037	2.567GlyTyr: 2.567 ± 0.043	0.0GlyXaa: 0.0 ± 0.0
His	2.667HisAla: 2.667 ± 0.047	0.234HisCys: 0.234 ± 0.011	1.292HisAsp: 1.292 ± 0.031	1.149HisGlu: 1.149 ± 0.024	0.774HisPhe: 0.774 ± 0.025	2.242HisGly: 2.242 ± 0.036	0.591HisHis: 0.591 ± 0.023	0.691HisIle: 0.691 ± 0.022	0.435HisLys: 0.435 ± 0.017	2.015HisLeu: 2.015 ± 0.035	0.362HisMet: 0.362 ± 0.016	0.485HisAsn: 0.485 ± 0.017	1.373HisPro: 1.373 ± 0.03	0.599HisGln: 0.599 ± 0.022	1.835HisArg: 1.835 ± 0.04	1.113HisSer: 1.113 ± 0.027	0.94HisThr: 0.94 ± 0.023	1.351HisVal: 1.351 ± 0.028	0.443HisTrp: 0.443 ± 0.015	0.664HisTyr: 0.664 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	6.648IleAla: 6.648 ± 0.065	0.353IleCys: 0.353 ± 0.017	3.459IleAsp: 3.459 ± 0.051	3.307IleGlu: 3.307 ± 0.051	0.978IlePhe: 0.978 ± 0.028	4.459IleGly: 4.459 ± 0.06	0.792IleHis: 0.792 ± 0.025	1.043IleIle: 1.043 ± 0.029	1.196IleLys: 1.196 ± 0.033	2.779IleLeu: 2.779 ± 0.046	0.464IleMet: 0.464 ± 0.018	1.293IleAsn: 1.293 ± 0.035	1.842IlePro: 1.842 ± 0.034	1.093IleGln: 1.093 ± 0.026	2.555IleArg: 2.555 ± 0.04	2.194IleSer: 2.194 ± 0.043	1.972IleThr: 1.972 ± 0.045	3.404IleVal: 3.404 ± 0.048	0.468IleTrp: 0.468 ± 0.019	0.856IleTyr: 0.856 ± 0.025	0.0IleXaa: 0.0 ± 0.0
Lys	3.279LysAla: 3.279 ± 0.066	0.148LysCys: 0.148 ± 0.011	1.39LysAsp: 1.39 ± 0.031	1.128LysGlu: 1.128 ± 0.034	0.804LysPhe: 0.804 ± 0.021	1.936LysGly: 1.936 ± 0.037	0.629LysHis: 0.629 ± 0.022	1.265LysIle: 1.265 ± 0.041	1.012LysLys: 1.012 ± 0.043	3.095LysLeu: 3.095 ± 0.054	0.541LysMet: 0.541 ± 0.022	0.742LysAsn: 0.742 ± 0.026	2.019LysPro: 2.019 ± 0.044	1.263LysGln: 1.263 ± 0.032	2.28LysArg: 2.28 ± 0.05	1.549LysSer: 1.549 ± 0.036	1.659LysThr: 1.659 ± 0.04	1.943LysVal: 1.943 ± 0.042	0.294LysTrp: 0.294 ± 0.015	0.648LysTyr: 0.648 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	14.146LeuAla: 14.146 ± 0.13	0.907LeuCys: 0.907 ± 0.024	6.821LeuAsp: 6.821 ± 0.087	4.878LeuGlu: 4.878 ± 0.071	3.259LeuPhe: 3.259 ± 0.051	8.543LeuGly: 8.543 ± 0.084	2.206LeuHis: 2.206 ± 0.038	4.334LeuIle: 4.334 ± 0.062	2.914LeuLys: 2.914 ± 0.05	10.691LeuLeu: 10.691 ± 0.136	1.895LeuMet: 1.895 ± 0.042	2.66LeuAsn: 2.66 ± 0.076	6.179LeuPro: 6.179 ± 0.09	3.776LeuGln: 3.776 ± 0.053	8.827LeuArg: 8.827 ± 0.11	6.904LeuSer: 6.904 ± 0.083	4.902LeuThr: 4.902 ± 0.09	6.673LeuVal: 6.673 ± 0.068	1.399LeuTrp: 1.399 ± 0.038	2.243LeuTyr: 2.243 ± 0.046	0.0LeuXaa: 0.0 ± 0.0
Met	2.354MetAla: 2.354 ± 0.044	0.122MetCys: 0.122 ± 0.009	0.886MetAsp: 0.886 ± 0.023	0.735MetGlu: 0.735 ± 0.022	0.615MetPhe: 0.615 ± 0.023	1.248MetGly: 1.248 ± 0.029	0.427MetHis: 0.427 ± 0.017	0.852MetIle: 0.852 ± 0.024	0.709MetLys: 0.709 ± 0.022	2.115MetLeu: 2.115 ± 0.038	0.379MetMet: 0.379 ± 0.015	0.69MetAsn: 0.69 ± 0.021	1.278MetPro: 1.278 ± 0.03	0.824MetGln: 0.824 ± 0.024	1.727MetArg: 1.727 ± 0.039	1.5MetSer: 1.5 ± 0.03	1.28MetThr: 1.28 ± 0.028	1.183MetVal: 1.183 ± 0.028	0.182MetTrp: 0.182 ± 0.013	0.362MetTyr: 0.362 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.552AsnAla: 3.552 ± 0.049	0.231AsnCys: 0.231 ± 0.013	1.696AsnAsp: 1.696 ± 0.042	1.297AsnGlu: 1.297 ± 0.031	0.951AsnPhe: 0.951 ± 0.029	2.883AsnGly: 2.883 ± 0.074	0.493AsnHis: 0.493 ± 0.018	1.089AsnIle: 1.089 ± 0.033	0.646AsnLys: 0.646 ± 0.022	2.626AsnLeu: 2.626 ± 0.052	0.401AsnMet: 0.401 ± 0.016	0.874AsnAsn: 0.874 ± 0.039	1.802AsnPro: 1.802 ± 0.04	0.884AsnGln: 0.884 ± 0.028	1.9AsnArg: 1.9 ± 0.038	1.375AsnSer: 1.375 ± 0.039	1.576AsnThr: 1.576 ± 0.059	1.83AsnVal: 1.83 ± 0.05	0.42AsnTrp: 0.42 ± 0.017	0.782AsnTyr: 0.782 ± 0.025	0.0AsnXaa: 0.0 ± 0.0
Pro	7.484ProAla: 7.484 ± 0.101	0.368ProCys: 0.368 ± 0.016	3.364ProAsp: 3.364 ± 0.051	3.043ProGlu: 3.043 ± 0.047	1.544ProPhe: 1.544 ± 0.036	4.793ProGly: 4.793 ± 0.058	1.043ProHis: 1.043 ± 0.028	2.027ProIle: 2.027 ± 0.034	1.493ProLys: 1.493 ± 0.036	5.27ProLeu: 5.27 ± 0.076	1.211ProMet: 1.211 ± 0.029	1.441ProAsn: 1.441 ± 0.034	2.912ProPro: 2.912 ± 0.066	2.209ProGln: 2.209 ± 0.039	3.472ProArg: 3.472 ± 0.044	3.19ProSer: 3.19 ± 0.046	2.656ProThr: 2.656 ± 0.045	3.967ProVal: 3.967 ± 0.061	0.807ProTrp: 0.807 ± 0.022	1.191ProTyr: 1.191 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	5.415GlnAla: 5.415 ± 0.068	0.273GlnCys: 0.273 ± 0.014	1.654GlnAsp: 1.654 ± 0.03	1.316GlnGlu: 1.316 ± 0.034	1.125GlnPhe: 1.125 ± 0.027	2.79GlnGly: 2.79 ± 0.038	0.833GlnHis: 0.833 ± 0.022	1.582GlnIle: 1.582 ± 0.033	0.795GlnLys: 0.795 ± 0.027	3.859GlnLeu: 3.859 ± 0.061	0.677GlnMet: 0.677 ± 0.021	0.805GlnAsn: 0.805 ± 0.025	2.173GlnPro: 2.173 ± 0.043	1.714GlnGln: 1.714 ± 0.046	3.722GlnArg: 3.722 ± 0.064	1.974GlnSer: 1.974 ± 0.037	1.789GlnThr: 1.789 ± 0.036	2.814GlnVal: 2.814 ± 0.043	0.661GlnTrp: 0.661 ± 0.023	0.826GlnTyr: 0.826 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	8.496ArgAla: 8.496 ± 0.098	0.666ArgCys: 0.666 ± 0.021	4.669ArgAsp: 4.669 ± 0.063	4.684ArgGlu: 4.684 ± 0.059	2.956ArgPhe: 2.956 ± 0.05	5.631ArgGly: 5.631 ± 0.06	1.906ArgHis: 1.906 ± 0.039	3.997ArgIle: 3.997 ± 0.055	2.189ArgLys: 2.189 ± 0.04	8.707ArgLeu: 8.707 ± 0.119	1.795ArgMet: 1.795 ± 0.032	2.06ArgAsn: 2.06 ± 0.037	3.687ArgPro: 3.687 ± 0.055	2.771ArgGln: 2.771 ± 0.048	6.287ArgArg: 6.287 ± 0.084	4.375ArgSer: 4.375 ± 0.06	3.2ArgThr: 3.2 ± 0.045	5.305ArgVal: 5.305 ± 0.061	1.449ArgTrp: 1.449 ± 0.029	2.473ArgTyr: 2.473 ± 0.049	0.0ArgXaa: 0.0 ± 0.0
Ser	7.332SerAla: 7.332 ± 0.088	0.482SerCys: 0.482 ± 0.02	3.122SerAsp: 3.122 ± 0.047	2.834SerGlu: 2.834 ± 0.045	2.13SerPhe: 2.13 ± 0.044	5.963SerGly: 5.963 ± 0.116	1.167SerHis: 1.167 ± 0.026	2.446SerIle: 2.446 ± 0.042	1.624SerLys: 1.624 ± 0.038	6.067SerLeu: 6.067 ± 0.076	1.142SerMet: 1.142 ± 0.029	1.68SerAsn: 1.68 ± 0.039	3.044SerPro: 3.044 ± 0.045	2.053SerGln: 2.053 ± 0.034	3.841SerArg: 3.841 ± 0.06	3.325SerSer: 3.325 ± 0.061	2.974SerThr: 2.974 ± 0.053	4.032SerVal: 4.032 ± 0.054	0.859SerTrp: 0.859 ± 0.024	1.554SerTyr: 1.554 ± 0.034	0.0SerXaa: 0.0 ± 0.0
Thr	6.568ThrAla: 6.568 ± 0.1	0.415ThrCys: 0.415 ± 0.033	2.606ThrAsp: 2.606 ± 0.05	2.135ThrGlu: 2.135 ± 0.038	1.473ThrPhe: 1.473 ± 0.037	4.699ThrGly: 4.699 ± 0.098	1.018ThrHis: 1.018 ± 0.027	2.084ThrIle: 2.084 ± 0.046	1.022ThrLys: 1.022 ± 0.031	5.949ThrLeu: 5.949 ± 0.131	0.887ThrMet: 0.887 ± 0.023	1.221ThrAsn: 1.221 ± 0.045	3.461ThrPro: 3.461 ± 0.063	1.708ThrGln: 1.708 ± 0.035	3.431ThrArg: 3.431 ± 0.048	2.594ThrSer: 2.594 ± 0.049	2.829ThrThr: 2.829 ± 0.066	4.301ThrVal: 4.301 ± 0.105	0.708ThrTrp: 0.708 ± 0.024	1.32ThrTyr: 1.32 ± 0.048	0.0ThrXaa: 0.0 ± 0.0
Val	9.529ValAla: 9.529 ± 0.095	0.657ValCys: 0.657 ± 0.019	4.247ValAsp: 4.247 ± 0.054	4.242ValGlu: 4.242 ± 0.056	2.489ValPhe: 2.489 ± 0.045	5.465ValGly: 5.465 ± 0.066	1.43ValHis: 1.43 ± 0.032	2.979ValIle: 2.979 ± 0.049	1.806ValLys: 1.806 ± 0.039	7.57ValLeu: 7.57 ± 0.087	1.328ValMet: 1.328 ± 0.035	2.016ValAsn: 2.016 ± 0.05	3.558ValPro: 3.558 ± 0.05	2.316ValGln: 2.316 ± 0.046	5.103ValArg: 5.103 ± 0.057	4.25ValSer: 4.25 ± 0.065	3.592ValThr: 3.592 ± 0.083	5.61ValVal: 5.61 ± 0.085	0.951ValTrp: 0.951 ± 0.027	1.59ValTyr: 1.59 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	1.346TrpAla: 1.346 ± 0.03	0.14TrpCys: 0.14 ± 0.008	0.706TrpAsp: 0.706 ± 0.021	0.542TrpGlu: 0.542 ± 0.019	0.611TrpPhe: 0.611 ± 0.023	0.934TrpGly: 0.934 ± 0.023	0.338TrpHis: 0.338 ± 0.015	0.709TrpIle: 0.709 ± 0.023	0.482TrpLys: 0.482 ± 0.018	2.118TrpLeu: 2.118 ± 0.045	0.375TrpMet: 0.375 ± 0.013	0.551TrpAsn: 0.551 ± 0.02	0.799TrpPro: 0.799 ± 0.026	0.728TrpGln: 0.728 ± 0.023	1.516TrpArg: 1.516 ± 0.036	1.063TrpSer: 1.063 ± 0.024	0.84TrpThr: 0.84 ± 0.025	0.961TrpVal: 0.961 ± 0.027	0.316TrpTrp: 0.316 ± 0.018	0.355TrpTyr: 0.355 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.998TyrAla: 2.998 ± 0.045	0.226TyrCys: 0.226 ± 0.012	1.648TyrAsp: 1.648 ± 0.051	1.231TyrGlu: 1.231 ± 0.026	0.895TyrPhe: 0.895 ± 0.028	2.336TyrGly: 2.336 ± 0.038	0.459TyrHis: 0.459 ± 0.015	0.73TyrIle: 0.73 ± 0.023	0.638TyrLys: 0.638 ± 0.022	2.57TyrLeu: 2.57 ± 0.044	0.364TyrMet: 0.364 ± 0.016	0.723TyrAsn: 0.723 ± 0.03	1.233TyrPro: 1.233 ± 0.033	0.866TyrGln: 0.866 ± 0.027	2.399TyrArg: 2.399 ± 0.047	1.399TyrSer: 1.399 ± 0.038	1.364TyrThr: 1.364 ± 0.04	1.732TyrVal: 1.732 ± 0.033	0.424TyrTrp: 0.424 ± 0.019	0.718TyrTyr: 0.718 ± 0.024	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5139 proteins (1660852 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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