Amino acid dipepetide frequency for Saccharothrix syringae (Nocardiopsis syringae)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	21.609AlaAla: 21.609 ± 0.135	1.089AlaCys: 1.089 ± 0.017	8.868AlaAsp: 8.868 ± 0.059	8.931AlaGlu: 8.931 ± 0.069	3.633AlaPhe: 3.633 ± 0.036	13.744AlaGly: 13.744 ± 0.08	3.249AlaHis: 3.249 ± 0.037	3.085AlaIle: 3.085 ± 0.036	2.078AlaLys: 2.078 ± 0.035	15.625AlaLeu: 15.625 ± 0.111	2.089AlaMet: 2.089 ± 0.027	2.214AlaAsn: 2.214 ± 0.037	7.035AlaPro: 7.035 ± 0.071	3.139AlaGln: 3.139 ± 0.035	11.443AlaArg: 11.443 ± 0.078	5.294AlaSer: 5.294 ± 0.046	7.107AlaThr: 7.107 ± 0.061	14.253AlaVal: 14.253 ± 0.101	2.047AlaTrp: 2.047 ± 0.027	2.305AlaTyr: 2.305 ± 0.031	0.0AlaXaa: 0.0 ± 0.0
Cys	1.178CysAla: 1.178 ± 0.024	0.097CysCys: 0.097 ± 0.006	0.473CysAsp: 0.473 ± 0.014	0.365CysGlu: 0.365 ± 0.011	0.213CysPhe: 0.213 ± 0.01	0.915CysGly: 0.915 ± 0.019	0.2CysHis: 0.2 ± 0.008	0.109CysIle: 0.109 ± 0.005	0.097CysLys: 0.097 ± 0.005	0.772CysLeu: 0.772 ± 0.018	0.1CysMet: 0.1 ± 0.006	0.134CysAsn: 0.134 ± 0.007	0.482CysPro: 0.482 ± 0.015	0.153CysGln: 0.153 ± 0.007	0.7CysArg: 0.7 ± 0.015	0.441CysSer: 0.441 ± 0.013	0.484CysThr: 0.484 ± 0.013	0.617CysVal: 0.617 ± 0.015	0.125CysTrp: 0.125 ± 0.007	0.172CysTyr: 0.172 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	7.726AspAla: 7.726 ± 0.058	0.399AspCys: 0.399 ± 0.011	3.974AspAsp: 3.974 ± 0.04	4.027AspGlu: 4.027 ± 0.037	1.637AspPhe: 1.637 ± 0.024	6.447AspGly: 6.447 ± 0.056	1.735AspHis: 1.735 ± 0.023	1.284AspIle: 1.284 ± 0.025	0.799AspLys: 0.799 ± 0.018	7.235AspLeu: 7.235 ± 0.06	0.603AspMet: 0.603 ± 0.013	1.01AspAsn: 1.01 ± 0.023	4.919AspPro: 4.919 ± 0.045	1.603AspGln: 1.603 ± 0.026	6.12AspArg: 6.12 ± 0.048	2.19AspSer: 2.19 ± 0.033	2.824AspThr: 2.824 ± 0.037	5.832AspVal: 5.832 ± 0.049	1.012AspTrp: 1.012 ± 0.018	1.216AspTyr: 1.216 ± 0.022	0.0AspXaa: 0.0 ± 0.0
Glu	6.996GluAla: 6.996 ± 0.06	0.354GluCys: 0.354 ± 0.012	2.651GluAsp: 2.651 ± 0.029	2.87GluGlu: 2.87 ± 0.036	1.623GluPhe: 1.623 ± 0.02	3.716GluGly: 3.716 ± 0.036	1.813GluHis: 1.813 ± 0.027	1.512GluIle: 1.512 ± 0.021	0.85GluLys: 0.85 ± 0.019	7.212GluLeu: 7.212 ± 0.063	0.667GluMet: 0.667 ± 0.018	0.793GluAsn: 0.793 ± 0.019	3.571GluPro: 3.571 ± 0.038	2.159GluGln: 2.159 ± 0.028	5.519GluArg: 5.519 ± 0.054	1.986GluSer: 1.986 ± 0.025	2.12GluThr: 2.12 ± 0.029	6.065GluVal: 6.065 ± 0.055	0.783GluTrp: 0.783 ± 0.019	0.931GluTyr: 0.931 ± 0.018	0.0GluXaa: 0.0 ± 0.0
Phe	3.956PheAla: 3.956 ± 0.039	0.24PheCys: 0.24 ± 0.009	2.244PheAsp: 2.244 ± 0.03	1.405PheGlu: 1.405 ± 0.025	0.801PhePhe: 0.801 ± 0.016	3.023PheGly: 3.023 ± 0.036	0.676PheHis: 0.676 ± 0.016	0.562PheIle: 0.562 ± 0.015	0.378PheLys: 0.378 ± 0.012	2.5PheLeu: 2.5 ± 0.032	0.303PheMet: 0.303 ± 0.011	0.547PheAsn: 0.547 ± 0.016	1.439PhePro: 1.439 ± 0.025	0.613PheGln: 0.613 ± 0.014	2.061PheArg: 2.061 ± 0.027	1.379PheSer: 1.379 ± 0.022	2.166PheThr: 2.166 ± 0.029	2.298PheVal: 2.298 ± 0.027	0.385PheTrp: 0.385 ± 0.012	0.563PheTyr: 0.563 ± 0.013	0.0PheXaa: 0.0 ± 0.0
Gly	11.452GlyAla: 11.452 ± 0.069	0.818GlyCys: 0.818 ± 0.018	5.487GlyAsp: 5.487 ± 0.046	5.098GlyGlu: 5.098 ± 0.044	3.001GlyPhe: 3.001 ± 0.028	9.128GlyGly: 9.128 ± 0.09	2.412GlyHis: 2.412 ± 0.027	2.73GlyIle: 2.73 ± 0.03	1.75GlyLys: 1.75 ± 0.023	9.537GlyLeu: 9.537 ± 0.067	1.785GlyMet: 1.785 ± 0.027	1.772GlyAsn: 1.772 ± 0.036	5.244GlyPro: 5.244 ± 0.056	2.503GlyGln: 2.503 ± 0.035	8.448GlyArg: 8.448 ± 0.056	4.808GlySer: 4.808 ± 0.046	6.184GlyThr: 6.184 ± 0.06	9.106GlyVal: 9.106 ± 0.068	1.781GlyTrp: 1.781 ± 0.028	2.231GlyTyr: 2.231 ± 0.032	0.0GlyXaa: 0.0 ± 0.0
His	2.9HisAla: 2.9 ± 0.035	0.213HisCys: 0.213 ± 0.008	1.621HisAsp: 1.621 ± 0.025	1.275HisGlu: 1.275 ± 0.018	0.605HisPhe: 0.605 ± 0.015	2.388HisGly: 2.388 ± 0.03	0.849HisHis: 0.849 ± 0.02	0.427HisIle: 0.427 ± 0.012	0.251HisLys: 0.251 ± 0.009	2.77HisLeu: 2.77 ± 0.034	0.238HisMet: 0.238 ± 0.009	0.399HisAsn: 0.399 ± 0.012	1.996HisPro: 1.996 ± 0.028	0.651HisGln: 0.651 ± 0.017	2.667HisArg: 2.667 ± 0.037	0.934HisSer: 0.934 ± 0.018	1.162HisThr: 1.162 ± 0.02	2.179HisVal: 2.179 ± 0.031	0.379HisTrp: 0.379 ± 0.011	0.506HisTyr: 0.506 ± 0.014	0.0HisXaa: 0.0 ± 0.0
Ile	4.003IleAla: 4.003 ± 0.041	0.194IleCys: 0.194 ± 0.008	1.655IleAsp: 1.655 ± 0.027	1.319IleGlu: 1.319 ± 0.022	0.483IlePhe: 0.483 ± 0.014	2.941IleGly: 2.941 ± 0.037	0.441IleHis: 0.441 ± 0.013	0.545IleIle: 0.545 ± 0.017	0.476IleLys: 0.476 ± 0.013	1.434IleLeu: 1.434 ± 0.023	0.289IleMet: 0.289 ± 0.01	0.528IleAsn: 0.528 ± 0.014	1.373IlePro: 1.373 ± 0.023	0.48IleGln: 0.48 ± 0.014	1.857IleArg: 1.857 ± 0.025	1.362IleSer: 1.362 ± 0.022	2.008IleThr: 2.008 ± 0.025	1.896IleVal: 1.896 ± 0.029	0.272IleTrp: 0.272 ± 0.011	0.381IleTyr: 0.381 ± 0.011	0.0IleXaa: 0.0 ± 0.0
Lys	1.984LysAla: 1.984 ± 0.036	0.098LysCys: 0.098 ± 0.006	0.766LysAsp: 0.766 ± 0.018	0.657LysGlu: 0.657 ± 0.018	0.375LysPhe: 0.375 ± 0.01	1.163LysGly: 1.163 ± 0.024	0.347LysHis: 0.347 ± 0.011	0.519LysIle: 0.519 ± 0.014	0.361LysLys: 0.361 ± 0.014	1.605LysLeu: 1.605 ± 0.027	0.242LysMet: 0.242 ± 0.01	0.283LysAsn: 0.283 ± 0.012	1.026LysPro: 1.026 ± 0.018	0.495LysGln: 0.495 ± 0.015	1.206LysArg: 1.206 ± 0.024	0.8LysSer: 0.8 ± 0.017	0.908LysThr: 0.908 ± 0.017	1.551LysVal: 1.551 ± 0.03	0.243LysTrp: 0.243 ± 0.01	0.319LysTyr: 0.319 ± 0.011	0.0LysXaa: 0.0 ± 0.0
Leu	16.368LeuAla: 16.368 ± 0.121	0.804LeuCys: 0.804 ± 0.015	7.452LeuAsp: 7.452 ± 0.057	4.607LeuGlu: 4.607 ± 0.052	2.673LeuPhe: 2.673 ± 0.036	9.746LeuGly: 9.746 ± 0.073	2.529LeuHis: 2.529 ± 0.03	2.285LeuIle: 2.285 ± 0.033	1.431LeuLys: 1.431 ± 0.024	11.459LeuLeu: 11.459 ± 0.087	1.232LeuMet: 1.232 ± 0.019	1.638LeuAsn: 1.638 ± 0.022	6.734LeuPro: 6.734 ± 0.05	1.731LeuGln: 1.731 ± 0.022	9.724LeuArg: 9.724 ± 0.073	4.856LeuSer: 4.856 ± 0.043	6.268LeuThr: 6.268 ± 0.053	11.56LeuVal: 11.56 ± 0.081	1.375LeuTrp: 1.375 ± 0.024	1.608LeuTyr: 1.608 ± 0.026	0.0LeuXaa: 0.0 ± 0.0
Met	1.9MetAla: 1.9 ± 0.028	0.108MetCys: 0.108 ± 0.005	0.664MetAsp: 0.664 ± 0.017	0.466MetGlu: 0.466 ± 0.013	0.358MetPhe: 0.358 ± 0.011	1.082MetGly: 1.082 ± 0.02	0.29MetHis: 0.29 ± 0.009	0.477MetIle: 0.477 ± 0.012	0.272MetLys: 0.272 ± 0.01	1.342MetLeu: 1.342 ± 0.023	0.194MetMet: 0.194 ± 0.009	0.294MetAsn: 0.294 ± 0.01	0.874MetPro: 0.874 ± 0.016	0.297MetGln: 0.297 ± 0.01	1.316MetArg: 1.316 ± 0.021	1.073MetSer: 1.073 ± 0.018	1.285MetThr: 1.285 ± 0.022	1.185MetVal: 1.185 ± 0.021	0.164MetTrp: 0.164 ± 0.008	0.215MetTyr: 0.215 ± 0.009	0.0MetXaa: 0.0 ± 0.0
Asn	2.327AsnAla: 2.327 ± 0.034	0.167AsnCys: 0.167 ± 0.008	0.915AsnAsp: 0.915 ± 0.019	0.712AsnGlu: 0.712 ± 0.016	0.48AsnPhe: 0.48 ± 0.014	1.948AsnGly: 1.948 ± 0.037	0.418AsnHis: 0.418 ± 0.011	0.461AsnIle: 0.461 ± 0.014	0.28AsnLys: 0.28 ± 0.011	1.697AsnLeu: 1.697 ± 0.026	0.221AsnMet: 0.221 ± 0.009	0.445AsnAsn: 0.445 ± 0.015	1.437AsnPro: 1.437 ± 0.023	0.536AsnGln: 0.536 ± 0.015	1.438AsnArg: 1.438 ± 0.023	0.86AsnSer: 0.86 ± 0.02	1.099AsnThr: 1.099 ± 0.026	1.305AsnVal: 1.305 ± 0.024	0.291AsnTrp: 0.291 ± 0.009	0.432AsnTyr: 0.432 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	8.898ProAla: 8.898 ± 0.068	0.364ProCys: 0.364 ± 0.012	5.061ProAsp: 5.061 ± 0.052	4.04ProGlu: 4.04 ± 0.04	1.554ProPhe: 1.554 ± 0.022	7.123ProGly: 7.123 ± 0.049	1.408ProHis: 1.408 ± 0.026	1.22ProIle: 1.22 ± 0.022	0.844ProLys: 0.844 ± 0.019	5.416ProLeu: 5.416 ± 0.047	0.862ProMet: 0.862 ± 0.017	1.072ProAsn: 1.072 ± 0.021	4.038ProPro: 4.038 ± 0.061	1.322ProGln: 1.322 ± 0.022	4.505ProArg: 4.505 ± 0.041	2.684ProSer: 2.684 ± 0.036	3.601ProThr: 3.601 ± 0.042	6.557ProVal: 6.557 ± 0.057	0.984ProTrp: 0.984 ± 0.02	0.983ProTyr: 0.983 ± 0.019	0.0ProXaa: 0.0 ± 0.0
Gln	3.509GlnAla: 3.509 ± 0.04	0.17GlnCys: 0.17 ± 0.007	1.185GlnAsp: 1.185 ± 0.02	1.109GlnGlu: 1.109 ± 0.02	0.642GlnPhe: 0.642 ± 0.015	1.882GlnGly: 1.882 ± 0.028	0.571GlnHis: 0.571 ± 0.015	0.592GlnIle: 0.592 ± 0.014	0.363GlnLys: 0.363 ± 0.013	2.652GlnLeu: 2.652 ± 0.035	0.296GlnMet: 0.296 ± 0.01	0.42GlnAsn: 0.42 ± 0.013	1.605GlnPro: 1.605 ± 0.025	1.005GlnGln: 1.005 ± 0.02	2.432GlnArg: 2.432 ± 0.027	0.932GlnSer: 0.932 ± 0.019	1.014GlnThr: 1.014 ± 0.019	2.788GlnVal: 2.788 ± 0.03	0.458GlnTrp: 0.458 ± 0.013	0.49GlnTyr: 0.49 ± 0.014	0.0GlnXaa: 0.0 ± 0.0
Arg	11.509ArgAla: 11.509 ± 0.08	0.727ArgCys: 0.727 ± 0.016	4.928ArgAsp: 4.928 ± 0.044	5.108ArgGlu: 5.108 ± 0.049	2.742ArgPhe: 2.742 ± 0.031	6.866ArgGly: 6.866 ± 0.051	2.413ArgHis: 2.413 ± 0.035	2.526ArgIle: 2.526 ± 0.032	1.336ArgLys: 1.336 ± 0.025	9.77ArgLeu: 9.77 ± 0.077	1.667ArgMet: 1.667 ± 0.027	1.457ArgAsn: 1.457 ± 0.023	5.419ArgPro: 5.419 ± 0.052	2.303ArgGln: 2.303 ± 0.026	8.81ArgArg: 8.81 ± 0.073	4.05ArgSer: 4.05 ± 0.038	5.086ArgThr: 5.086 ± 0.041	8.144ArgVal: 8.144 ± 0.057	1.688ArgTrp: 1.688 ± 0.025	1.935ArgTyr: 1.935 ± 0.026	0.0ArgXaa: 0.0 ± 0.0
Ser	6.167SerAla: 6.167 ± 0.052	0.421SerCys: 0.421 ± 0.013	2.239SerAsp: 2.239 ± 0.028	1.761SerGlu: 1.761 ± 0.026	1.451SerPhe: 1.451 ± 0.024	5.348SerGly: 5.348 ± 0.054	0.87SerHis: 0.87 ± 0.018	1.207SerIle: 1.207 ± 0.021	0.655SerLys: 0.655 ± 0.018	4.457SerLeu: 4.457 ± 0.044	0.785SerMet: 0.785 ± 0.014	0.803SerAsn: 0.803 ± 0.017	3.105SerPro: 3.105 ± 0.031	0.984SerGln: 0.984 ± 0.019	3.647SerArg: 3.647 ± 0.038	2.478SerSer: 2.478 ± 0.038	3.122SerThr: 3.122 ± 0.04	4.036SerVal: 4.036 ± 0.037	0.926SerTrp: 0.926 ± 0.018	1.031SerTyr: 1.031 ± 0.021	0.0SerXaa: 0.0 ± 0.0
Thr	9.046ThrAla: 9.046 ± 0.071	0.501ThrCys: 0.501 ± 0.015	3.399ThrAsp: 3.399 ± 0.039	2.724ThrGlu: 2.724 ± 0.033	1.525ThrPhe: 1.525 ± 0.026	6.987ThrGly: 6.987 ± 0.055	1.073ThrHis: 1.073 ± 0.02	1.439ThrIle: 1.439 ± 0.027	0.822ThrLys: 0.822 ± 0.017	4.833ThrLeu: 4.833 ± 0.046	0.746ThrMet: 0.746 ± 0.016	1.035ThrAsn: 1.035 ± 0.021	4.134ThrPro: 4.134 ± 0.045	1.02ThrGln: 1.02 ± 0.02	4.36ThrArg: 4.36 ± 0.042	3.17ThrSer: 3.17 ± 0.037	4.629ThrThr: 4.629 ± 0.072	5.224ThrVal: 5.224 ± 0.049	1.057ThrTrp: 1.057 ± 0.024	1.219ThrTyr: 1.219 ± 0.027	0.0ThrXaa: 0.0 ± 0.0
Val	13.095ValAla: 13.095 ± 0.086	0.721ValCys: 0.721 ± 0.017	6.87ValAsp: 6.87 ± 0.058	6.022ValGlu: 6.022 ± 0.048	2.631ValPhe: 2.631 ± 0.033	7.941ValGly: 7.941 ± 0.054	2.265ValHis: 2.265 ± 0.024	2.271ValIle: 2.271 ± 0.031	1.407ValLys: 1.407 ± 0.027	11.715ValLeu: 11.715 ± 0.09	1.141ValMet: 1.141 ± 0.019	1.842ValAsn: 1.842 ± 0.029	6.202ValPro: 6.202 ± 0.052	1.988ValGln: 1.988 ± 0.027	8.558ValArg: 8.558 ± 0.064	4.233ValSer: 4.233 ± 0.036	5.802ValThr: 5.802 ± 0.051	11.477ValVal: 11.477 ± 0.089	1.163ValTrp: 1.163 ± 0.021	1.481ValTyr: 1.481 ± 0.023	0.0ValXaa: 0.0 ± 0.0
Trp	1.792TrpAla: 1.792 ± 0.027	0.165TrpCys: 0.165 ± 0.008	0.871TrpAsp: 0.871 ± 0.02	0.722TrpGlu: 0.722 ± 0.016	0.531TrpPhe: 0.531 ± 0.014	1.114TrpGly: 1.114 ± 0.019	0.427TrpHis: 0.427 ± 0.011	0.38TrpIle: 0.38 ± 0.011	0.238TrpLys: 0.238 ± 0.009	1.906TrpLeu: 1.906 ± 0.027	0.233TrpMet: 0.233 ± 0.01	0.392TrpAsn: 0.392 ± 0.014	0.863TrpPro: 0.863 ± 0.017	0.561TrpGln: 0.561 ± 0.013	1.64TrpArg: 1.64 ± 0.027	1.044TrpSer: 1.044 ± 0.019	1.034TrpThr: 1.034 ± 0.021	1.233TrpVal: 1.233 ± 0.021	0.37TrpTrp: 0.37 ± 0.011	0.33TrpTyr: 0.33 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.421TyrAla: 2.421 ± 0.03	0.178TyrCys: 0.178 ± 0.007	1.271TyrAsp: 1.271 ± 0.028	0.974TyrGlu: 0.974 ± 0.017	0.582TyrPhe: 0.582 ± 0.014	1.773TyrGly: 1.773 ± 0.023	0.421TyrHis: 0.421 ± 0.012	0.307TyrIle: 0.307 ± 0.013	0.261TyrLys: 0.261 ± 0.009	2.143TyrLeu: 2.143 ± 0.031	0.161TyrMet: 0.161 ± 0.008	0.39TyrAsn: 0.39 ± 0.013	1.042TyrPro: 1.042 ± 0.019	0.573TyrGln: 0.573 ± 0.015	2.031TyrArg: 2.031 ± 0.032	0.92TyrSer: 0.92 ± 0.018	1.041TyrThr: 1.041 ± 0.02	1.516TyrVal: 1.516 ± 0.026	0.343TyrTrp: 0.343 ± 0.012	0.449TyrTyr: 0.449 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 8856 proteins (3125302 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---