Amino acid dipepetide frequency for Pseudomonas phage vB_PaeP_C2-10_Ab09

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.86AlaAla: 8.86 ± 0.98
1.053AlaCys: 1.053 ± 0.262
4.913AlaAsp: 4.913 ± 0.466
6.843AlaGlu: 6.843 ± 0.591
2.983AlaPhe: 2.983 ± 0.29
6.492AlaGly: 6.492 ± 0.629
1.097AlaHis: 1.097 ± 0.178
3.509AlaIle: 3.509 ± 0.446
5.878AlaLys: 5.878 ± 0.753
8.071AlaLeu: 8.071 ± 0.818
2.763AlaMet: 2.763 ± 0.275
3.728AlaAsn: 3.728 ± 0.413
2.456AlaPro: 2.456 ± 0.388
4.474AlaGln: 4.474 ± 0.537
5.088AlaArg: 5.088 ± 0.438
5.351AlaSer: 5.351 ± 0.46
5.264AlaThr: 5.264 ± 0.601
7.545AlaVal: 7.545 ± 0.647
0.965AlaTrp: 0.965 ± 0.227
2.983AlaTyr: 2.983 ± 0.375
0.0AlaXaa: 0.0 ± 0.0
Cys
0.439CysAla: 0.439 ± 0.129
0.219CysCys: 0.219 ± 0.098
0.439CysAsp: 0.439 ± 0.145
0.746CysGlu: 0.746 ± 0.257
0.307CysPhe: 0.307 ± 0.124
0.833CysGly: 0.833 ± 0.212
0.351CysHis: 0.351 ± 0.147
0.482CysIle: 0.482 ± 0.149
0.482CysLys: 0.482 ± 0.136
1.053CysLeu: 1.053 ± 0.287
0.175CysMet: 0.175 ± 0.078
0.439CysAsn: 0.439 ± 0.177
0.351CysPro: 0.351 ± 0.136
0.351CysGln: 0.351 ± 0.133
0.658CysArg: 0.658 ± 0.208
0.482CysSer: 0.482 ± 0.163
0.526CysThr: 0.526 ± 0.179
0.658CysVal: 0.658 ± 0.185
0.175CysTrp: 0.175 ± 0.09
0.351CysTyr: 0.351 ± 0.132
0.0CysXaa: 0.0 ± 0.0
Asp
6.097AspAla: 6.097 ± 0.533
0.439AspCys: 0.439 ± 0.11
3.158AspAsp: 3.158 ± 0.481
4.255AspGlu: 4.255 ± 0.513
2.676AspPhe: 2.676 ± 0.354
4.255AspGly: 4.255 ± 0.495
1.053AspHis: 1.053 ± 0.286
3.377AspIle: 3.377 ± 0.309
2.851AspLys: 2.851 ± 0.324
5.439AspLeu: 5.439 ± 0.463
1.755AspMet: 1.755 ± 0.299
2.325AspAsn: 2.325 ± 0.338
3.465AspPro: 3.465 ± 0.384
2.807AspGln: 2.807 ± 0.36
3.334AspArg: 3.334 ± 0.427
4.123AspSer: 4.123 ± 0.399
3.29AspThr: 3.29 ± 0.274
2.983AspVal: 2.983 ± 0.356
0.833AspTrp: 0.833 ± 0.207
1.798AspTyr: 1.798 ± 0.318
0.0AspXaa: 0.0 ± 0.0
Glu
7.413GluAla: 7.413 ± 0.921
0.57GluCys: 0.57 ± 0.183
3.948GluAsp: 3.948 ± 0.362
5.132GluGlu: 5.132 ± 1.008
2.149GluPhe: 2.149 ± 0.3
4.079GluGly: 4.079 ± 0.507
1.535GluHis: 1.535 ± 0.286
3.685GluIle: 3.685 ± 0.469
3.86GluLys: 3.86 ± 0.477
6.36GluLeu: 6.36 ± 0.496
2.588GluMet: 2.588 ± 0.333
2.412GluAsn: 2.412 ± 0.283
2.851GluPro: 2.851 ± 0.495
3.772GluGln: 3.772 ± 0.632
3.158GluArg: 3.158 ± 0.399
3.904GluSer: 3.904 ± 0.494
2.588GluThr: 2.588 ± 0.304
5.088GluVal: 5.088 ± 0.463
0.965GluTrp: 0.965 ± 0.213
2.105GluTyr: 2.105 ± 0.306
0.0GluXaa: 0.0 ± 0.0
Phe
2.369PheAla: 2.369 ± 0.288
0.395PheCys: 0.395 ± 0.144
2.983PheAsp: 2.983 ± 0.333
1.491PheGlu: 1.491 ± 0.328
1.579PhePhe: 1.579 ± 0.263
2.325PheGly: 2.325 ± 0.294
0.658PheHis: 0.658 ± 0.211
2.588PheIle: 2.588 ± 0.368
2.018PheLys: 2.018 ± 0.252
2.939PheLeu: 2.939 ± 0.427
1.272PheMet: 1.272 ± 0.219
1.93PheAsn: 1.93 ± 0.222
1.097PhePro: 1.097 ± 0.249
1.974PheGln: 1.974 ± 0.261
2.325PheArg: 2.325 ± 0.319
2.588PheSer: 2.588 ± 0.317
2.325PheThr: 2.325 ± 0.38
2.369PheVal: 2.369 ± 0.287
0.263PheTrp: 0.263 ± 0.105
1.228PheTyr: 1.228 ± 0.21
0.0PheXaa: 0.0 ± 0.0
Gly
5.658GlyAla: 5.658 ± 0.47
0.614GlyCys: 0.614 ± 0.204
3.29GlyAsp: 3.29 ± 0.376
4.825GlyGlu: 4.825 ± 0.49
3.509GlyPhe: 3.509 ± 0.425
4.43GlyGly: 4.43 ± 0.51
1.14GlyHis: 1.14 ± 0.244
3.421GlyIle: 3.421 ± 0.392
4.167GlyLys: 4.167 ± 0.473
5.834GlyLeu: 5.834 ± 0.571
2.456GlyMet: 2.456 ± 0.315
3.114GlyAsn: 3.114 ± 0.4
1.93GlyPro: 1.93 ± 0.248
3.202GlyGln: 3.202 ± 0.439
3.29GlyArg: 3.29 ± 0.355
4.255GlySer: 4.255 ± 0.399
4.123GlyThr: 4.123 ± 0.459
5.571GlyVal: 5.571 ± 0.53
1.097GlyTrp: 1.097 ± 0.197
2.281GlyTyr: 2.281 ± 0.279
0.0GlyXaa: 0.0 ± 0.0
His
1.623HisAla: 1.623 ± 0.235
0.175HisCys: 0.175 ± 0.099
1.009HisAsp: 1.009 ± 0.211
0.965HisGlu: 0.965 ± 0.152
0.833HisPhe: 0.833 ± 0.209
1.404HisGly: 1.404 ± 0.281
0.614HisHis: 0.614 ± 0.165
1.053HisIle: 1.053 ± 0.23
0.965HisLys: 0.965 ± 0.227
1.886HisLeu: 1.886 ± 0.392
0.658HisMet: 0.658 ± 0.153
1.097HisAsn: 1.097 ± 0.231
0.877HisPro: 0.877 ± 0.22
0.526HisGln: 0.526 ± 0.151
1.097HisArg: 1.097 ± 0.242
1.184HisSer: 1.184 ± 0.347
0.57HisThr: 0.57 ± 0.155
1.404HisVal: 1.404 ± 0.274
0.439HisTrp: 0.439 ± 0.18
0.658HisTyr: 0.658 ± 0.137
0.0HisXaa: 0.0 ± 0.0
Ile
4.65IleAla: 4.65 ± 0.424
0.439IleCys: 0.439 ± 0.137
2.939IleAsp: 2.939 ± 0.447
3.202IleGlu: 3.202 ± 0.366
1.579IlePhe: 1.579 ± 0.222
3.641IleGly: 3.641 ± 0.471
1.447IleHis: 1.447 ± 0.301
1.842IleIle: 1.842 ± 0.308
3.027IleLys: 3.027 ± 0.329
3.421IleLeu: 3.421 ± 0.372
1.228IleMet: 1.228 ± 0.239
2.632IleAsn: 2.632 ± 0.311
2.018IlePro: 2.018 ± 0.369
2.676IleGln: 2.676 ± 0.394
3.772IleArg: 3.772 ± 0.339
2.325IleSer: 2.325 ± 0.295
3.114IleThr: 3.114 ± 0.291
3.07IleVal: 3.07 ± 0.331
0.307IleTrp: 0.307 ± 0.127
1.36IleTyr: 1.36 ± 0.314
0.0IleXaa: 0.0 ± 0.0
Lys
6.229LysAla: 6.229 ± 0.637
0.526LysCys: 0.526 ± 0.162
4.211LysAsp: 4.211 ± 0.447
3.772LysGlu: 3.772 ± 0.595
1.623LysPhe: 1.623 ± 0.255
3.465LysGly: 3.465 ± 0.437
1.009LysHis: 1.009 ± 0.203
2.5LysIle: 2.5 ± 0.359
3.553LysLys: 3.553 ± 0.652
5.264LysLeu: 5.264 ± 0.54
1.711LysMet: 1.711 ± 0.266
1.755LysAsn: 1.755 ± 0.257
2.588LysPro: 2.588 ± 0.316
2.325LysGln: 2.325 ± 0.311
2.939LysArg: 2.939 ± 0.425
3.377LysSer: 3.377 ± 0.343
3.685LysThr: 3.685 ± 0.348
4.737LysVal: 4.737 ± 0.551
0.57LysTrp: 0.57 ± 0.134
2.281LysTyr: 2.281 ± 0.325
0.0LysXaa: 0.0 ± 0.0
Leu
7.369LeuAla: 7.369 ± 0.589
1.009LeuCys: 1.009 ± 0.265
6.272LeuAsp: 6.272 ± 0.596
5.527LeuGlu: 5.527 ± 0.459
3.07LeuPhe: 3.07 ± 0.367
5.044LeuGly: 5.044 ± 0.477
1.93LeuHis: 1.93 ± 0.295
4.167LeuIle: 4.167 ± 0.536
5.571LeuLys: 5.571 ± 0.491
7.939LeuLeu: 7.939 ± 0.719
2.895LeuMet: 2.895 ± 0.356
4.211LeuAsn: 4.211 ± 0.46
4.693LeuPro: 4.693 ± 0.509
3.202LeuGln: 3.202 ± 0.34
5.044LeuArg: 5.044 ± 0.583
5.395LeuSer: 5.395 ± 0.473
5.527LeuThr: 5.527 ± 0.53
6.272LeuVal: 6.272 ± 0.593
0.833LeuTrp: 0.833 ± 0.169
2.807LeuTyr: 2.807 ± 0.307
0.0LeuXaa: 0.0 ± 0.0
Met
3.246MetAla: 3.246 ± 0.413
0.263MetCys: 0.263 ± 0.121
2.281MetAsp: 2.281 ± 0.307
2.193MetGlu: 2.193 ± 0.243
1.097MetPhe: 1.097 ± 0.195
2.237MetGly: 2.237 ± 0.299
0.877MetHis: 0.877 ± 0.203
1.316MetIle: 1.316 ± 0.262
1.228MetLys: 1.228 ± 0.263
2.939MetLeu: 2.939 ± 0.282
1.097MetMet: 1.097 ± 0.29
1.184MetAsn: 1.184 ± 0.201
1.798MetPro: 1.798 ± 0.248
1.579MetGln: 1.579 ± 0.255
1.711MetArg: 1.711 ± 0.268
2.105MetSer: 2.105 ± 0.388
2.369MetThr: 2.369 ± 0.28
1.623MetVal: 1.623 ± 0.32
0.307MetTrp: 0.307 ± 0.146
0.702MetTyr: 0.702 ± 0.193
0.0MetXaa: 0.0 ± 0.0
Asn
3.948AsnAla: 3.948 ± 0.535
0.395AsnCys: 0.395 ± 0.143
2.062AsnAsp: 2.062 ± 0.388
3.07AsnGlu: 3.07 ± 0.371
1.711AsnPhe: 1.711 ± 0.325
3.904AsnGly: 3.904 ± 0.662
0.921AsnHis: 0.921 ± 0.251
2.369AsnIle: 2.369 ± 0.285
2.763AsnLys: 2.763 ± 0.354
4.386AsnLeu: 4.386 ± 0.491
1.667AsnMet: 1.667 ± 0.315
2.237AsnAsn: 2.237 ± 0.381
2.676AsnPro: 2.676 ± 0.257
1.404AsnGln: 1.404 ± 0.267
2.149AsnArg: 2.149 ± 0.262
2.325AsnSer: 2.325 ± 0.289
2.939AsnThr: 2.939 ± 0.345
2.237AsnVal: 2.237 ± 0.303
0.57AsnTrp: 0.57 ± 0.184
1.097AsnTyr: 1.097 ± 0.168
0.0AsnXaa: 0.0 ± 0.0
Pro
3.597ProAla: 3.597 ± 0.543
0.395ProCys: 0.395 ± 0.137
2.369ProAsp: 2.369 ± 0.37
3.246ProGlu: 3.246 ± 0.515
2.149ProPhe: 2.149 ± 0.355
3.114ProGly: 3.114 ± 0.352
0.614ProHis: 0.614 ± 0.197
1.842ProIle: 1.842 ± 0.219
1.886ProLys: 1.886 ± 0.277
3.334ProLeu: 3.334 ± 0.306
1.228ProMet: 1.228 ± 0.178
1.974ProAsn: 1.974 ± 0.254
1.272ProPro: 1.272 ± 0.305
2.105ProGln: 2.105 ± 0.265
1.667ProArg: 1.667 ± 0.277
2.588ProSer: 2.588 ± 0.296
2.939ProThr: 2.939 ± 0.508
4.123ProVal: 4.123 ± 0.387
0.395ProTrp: 0.395 ± 0.146
1.272ProTyr: 1.272 ± 0.217
0.0ProXaa: 0.0 ± 0.0
Gln
4.693GlnAla: 4.693 ± 0.609
0.219GlnCys: 0.219 ± 0.102
2.193GlnAsp: 2.193 ± 0.352
4.211GlnGlu: 4.211 ± 0.557
1.491GlnPhe: 1.491 ± 0.263
2.325GlnGly: 2.325 ± 0.424
0.614GlnHis: 0.614 ± 0.178
2.237GlnIle: 2.237 ± 0.328
2.369GlnLys: 2.369 ± 0.294
4.65GlnLeu: 4.65 ± 0.444
1.272GlnMet: 1.272 ± 0.247
1.667GlnAsn: 1.667 ± 0.321
1.447GlnPro: 1.447 ± 0.225
2.149GlnGln: 2.149 ± 0.348
2.5GlnArg: 2.5 ± 0.398
2.149GlnSer: 2.149 ± 0.292
2.456GlnThr: 2.456 ± 0.412
4.211GlnVal: 4.211 ± 0.552
0.351GlnTrp: 0.351 ± 0.118
1.404GlnTyr: 1.404 ± 0.242
0.0GlnXaa: 0.0 ± 0.0
Arg
5.22ArgAla: 5.22 ± 0.55
0.658ArgCys: 0.658 ± 0.181
3.641ArgAsp: 3.641 ± 0.39
3.816ArgGlu: 3.816 ± 0.609
2.062ArgPhe: 2.062 ± 0.337
3.377ArgGly: 3.377 ± 0.435
0.965ArgHis: 0.965 ± 0.222
2.544ArgIle: 2.544 ± 0.296
2.895ArgLys: 2.895 ± 0.448
5.176ArgLeu: 5.176 ± 0.513
1.667ArgMet: 1.667 ± 0.226
2.763ArgAsn: 2.763 ± 0.339
2.018ArgPro: 2.018 ± 0.318
2.763ArgGln: 2.763 ± 0.424
3.465ArgArg: 3.465 ± 0.528
3.553ArgSer: 3.553 ± 0.36
2.895ArgThr: 2.895 ± 0.339
3.904ArgVal: 3.904 ± 0.383
0.79ArgTrp: 0.79 ± 0.187
1.447ArgTyr: 1.447 ± 0.239
0.0ArgXaa: 0.0 ± 0.0
Ser
4.474SerAla: 4.474 ± 0.418
0.351SerCys: 0.351 ± 0.123
3.948SerAsp: 3.948 ± 0.427
3.86SerGlu: 3.86 ± 0.422
1.886SerPhe: 1.886 ± 0.338
4.781SerGly: 4.781 ± 0.492
0.79SerHis: 0.79 ± 0.189
2.676SerIle: 2.676 ± 0.258
4.167SerLys: 4.167 ± 0.472
4.913SerLeu: 4.913 ± 0.442
2.062SerMet: 2.062 ± 0.26
2.632SerAsn: 2.632 ± 0.293
2.456SerPro: 2.456 ± 0.245
2.149SerGln: 2.149 ± 0.266
3.07SerArg: 3.07 ± 0.312
2.983SerSer: 2.983 ± 0.354
4.123SerThr: 4.123 ± 0.345
3.334SerVal: 3.334 ± 0.366
0.79SerTrp: 0.79 ± 0.166
2.237SerTyr: 2.237 ± 0.28
0.0SerXaa: 0.0 ± 0.0
Thr
4.913ThrAla: 4.913 ± 0.496
0.439ThrCys: 0.439 ± 0.152
3.334ThrAsp: 3.334 ± 0.337
4.035ThrGlu: 4.035 ± 0.444
1.886ThrPhe: 1.886 ± 0.299
4.474ThrGly: 4.474 ± 0.454
1.316ThrHis: 1.316 ± 0.264
3.465ThrIle: 3.465 ± 0.382
3.86ThrLys: 3.86 ± 0.448
4.167ThrLeu: 4.167 ± 0.38
2.018ThrMet: 2.018 ± 0.285
3.334ThrAsn: 3.334 ± 0.365
3.07ThrPro: 3.07 ± 0.332
2.369ThrGln: 2.369 ± 0.323
3.29ThrArg: 3.29 ± 0.381
2.5ThrSer: 2.5 ± 0.383
4.123ThrThr: 4.123 ± 0.513
4.562ThrVal: 4.562 ± 0.491
1.272ThrTrp: 1.272 ± 0.231
1.535ThrTyr: 1.535 ± 0.428
0.0ThrXaa: 0.0 ± 0.0
Val
6.448ValAla: 6.448 ± 0.666
0.833ValCys: 0.833 ± 0.212
4.518ValAsp: 4.518 ± 0.439
4.562ValGlu: 4.562 ± 0.443
2.369ValPhe: 2.369 ± 0.439
4.869ValGly: 4.869 ± 0.409
1.14ValHis: 1.14 ± 0.206
3.334ValIle: 3.334 ± 0.41
4.211ValLys: 4.211 ± 0.376
7.018ValLeu: 7.018 ± 0.553
2.369ValMet: 2.369 ± 0.306
3.465ValAsn: 3.465 ± 0.392
3.246ValPro: 3.246 ± 0.457
3.158ValGln: 3.158 ± 0.413
4.342ValArg: 4.342 ± 0.547
3.992ValSer: 3.992 ± 0.523
4.167ValThr: 4.167 ± 0.42
4.299ValVal: 4.299 ± 0.587
0.965ValTrp: 0.965 ± 0.213
1.93ValTyr: 1.93 ± 0.276
0.0ValXaa: 0.0 ± 0.0
Trp
0.921TrpAla: 0.921 ± 0.188
0.175TrpCys: 0.175 ± 0.093
0.57TrpAsp: 0.57 ± 0.181
0.833TrpGlu: 0.833 ± 0.156
0.526TrpPhe: 0.526 ± 0.156
0.79TrpGly: 0.79 ± 0.177
0.219TrpHis: 0.219 ± 0.103
0.614TrpIle: 0.614 ± 0.155
0.746TrpLys: 0.746 ± 0.196
1.184TrpLeu: 1.184 ± 0.286
0.351TrpMet: 0.351 ± 0.125
0.439TrpAsn: 0.439 ± 0.148
0.482TrpPro: 0.482 ± 0.159
0.57TrpGln: 0.57 ± 0.196
0.746TrpArg: 0.746 ± 0.147
0.833TrpSer: 0.833 ± 0.193
0.746TrpThr: 0.746 ± 0.179
1.316TrpVal: 1.316 ± 0.252
0.307TrpTrp: 0.307 ± 0.178
0.439TrpTyr: 0.439 ± 0.125
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.149TyrAla: 2.149 ± 0.299
0.351TyrCys: 0.351 ± 0.16
2.281TyrAsp: 2.281 ± 0.296
1.579TyrGlu: 1.579 ± 0.209
1.228TyrPhe: 1.228 ± 0.194
2.369TyrGly: 2.369 ± 0.401
0.746TyrHis: 0.746 ± 0.169
1.667TyrIle: 1.667 ± 0.36
1.623TyrLys: 1.623 ± 0.297
2.807TyrLeu: 2.807 ± 0.363
0.877TyrMet: 0.877 ± 0.196
1.491TyrAsn: 1.491 ± 0.26
1.316TyrPro: 1.316 ± 0.294
1.053TyrGln: 1.053 ± 0.207
1.974TyrArg: 1.974 ± 0.264
1.667TyrSer: 1.667 ± 0.205
2.193TyrThr: 2.193 ± 0.317
1.93TyrVal: 1.93 ± 0.351
0.614TyrTrp: 0.614 ± 0.212
1.228TyrTyr: 1.228 ± 0.271
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 83 proteins (22799 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski