Amino acid dipepetide frequency for Acinetobacter sp. CIP 102637

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.625AlaAla: 7.625 ± 0.149
0.937AlaCys: 0.937 ± 0.04
4.523AlaAsp: 4.523 ± 0.086
5.784AlaGlu: 5.784 ± 0.12
3.293AlaPhe: 3.293 ± 0.073
5.716AlaGly: 5.716 ± 0.107
1.814AlaHis: 1.814 ± 0.054
6.092AlaIle: 6.092 ± 0.114
5.31AlaLys: 5.31 ± 0.099
9.615AlaLeu: 9.615 ± 0.11
2.504AlaMet: 2.504 ± 0.058
3.473AlaAsn: 3.473 ± 0.071
2.768AlaPro: 2.768 ± 0.06
4.763AlaGln: 4.763 ± 0.092
3.623AlaArg: 3.623 ± 0.071
4.78AlaSer: 4.78 ± 0.099
4.644AlaThr: 4.644 ± 0.091
5.786AlaVal: 5.786 ± 0.113
1.061AlaTrp: 1.061 ± 0.036
2.649AlaTyr: 2.649 ± 0.065
0.0AlaXaa: 0.0 ± 0.0
Cys
0.743CysAla: 0.743 ± 0.035
0.136CysCys: 0.136 ± 0.014
0.495CysAsp: 0.495 ± 0.029
0.534CysGlu: 0.534 ± 0.024
0.446CysPhe: 0.446 ± 0.023
0.785CysGly: 0.785 ± 0.037
0.279CysHis: 0.279 ± 0.019
0.657CysIle: 0.657 ± 0.031
0.421CysLys: 0.421 ± 0.023
1.009CysLeu: 1.009 ± 0.037
0.229CysMet: 0.229 ± 0.017
0.348CysAsn: 0.348 ± 0.021
0.428CysPro: 0.428 ± 0.025
0.483CysGln: 0.483 ± 0.029
0.449CysArg: 0.449 ± 0.028
0.651CysSer: 0.651 ± 0.035
0.44CysThr: 0.44 ± 0.024
0.656CysVal: 0.656 ± 0.026
0.116CysTrp: 0.116 ± 0.013
0.285CysTyr: 0.285 ± 0.022
0.0CysXaa: 0.0 ± 0.0
Asp
4.661AspAla: 4.661 ± 0.085
0.471AspCys: 0.471 ± 0.024
2.681AspAsp: 2.681 ± 0.07
3.615AspGlu: 3.615 ± 0.079
2.431AspPhe: 2.431 ± 0.054
3.244AspGly: 3.244 ± 0.076
1.353AspHis: 1.353 ± 0.036
3.64AspIle: 3.64 ± 0.068
2.483AspLys: 2.483 ± 0.057
5.746AspLeu: 5.746 ± 0.085
1.206AspMet: 1.206 ± 0.04
1.88AspAsn: 1.88 ± 0.057
2.033AspPro: 2.033 ± 0.051
3.116AspGln: 3.116 ± 0.069
2.463AspArg: 2.463 ± 0.06
2.649AspSer: 2.649 ± 0.067
2.476AspThr: 2.476 ± 0.056
3.724AspVal: 3.724 ± 0.071
0.831AspTrp: 0.831 ± 0.036
1.997AspTyr: 1.997 ± 0.059
0.0AspXaa: 0.0 ± 0.0
Glu
4.983GluAla: 4.983 ± 0.09
0.43GluCys: 0.43 ± 0.026
2.651GluAsp: 2.651 ± 0.064
3.16GluGlu: 3.16 ± 0.092
2.268GluPhe: 2.268 ± 0.061
2.885GluGly: 2.885 ± 0.066
1.635GluHis: 1.635 ± 0.048
4.345GluIle: 4.345 ± 0.076
4.087GluLys: 4.087 ± 0.072
6.249GluLeu: 6.249 ± 0.111
1.547GluMet: 1.547 ± 0.05
2.991GluAsn: 2.991 ± 0.059
1.807GluPro: 1.807 ± 0.055
4.786GluGln: 4.786 ± 0.094
3.171GluArg: 3.171 ± 0.065
3.02GluSer: 3.02 ± 0.069
3.0GluThr: 3.0 ± 0.068
3.796GluVal: 3.796 ± 0.076
0.78GluTrp: 0.78 ± 0.034
1.821GluTyr: 1.821 ± 0.053
0.0GluXaa: 0.0 ± 0.0
Phe
3.648PheAla: 3.648 ± 0.069
0.523PheCys: 0.523 ± 0.028
2.684PheAsp: 2.684 ± 0.06
2.612PheGlu: 2.612 ± 0.054
1.798PhePhe: 1.798 ± 0.055
2.951PheGly: 2.951 ± 0.068
0.862PheHis: 0.862 ± 0.035
2.965PheIle: 2.965 ± 0.067
2.522PheLys: 2.522 ± 0.057
3.825PheLeu: 3.825 ± 0.092
1.057PheMet: 1.057 ± 0.043
2.047PheAsn: 2.047 ± 0.057
1.454PhePro: 1.454 ± 0.051
1.611PheGln: 1.611 ± 0.044
1.485PheArg: 1.485 ± 0.04
2.974PheSer: 2.974 ± 0.063
2.031PheThr: 2.031 ± 0.054
2.542PheVal: 2.542 ± 0.063
0.543PheTrp: 0.543 ± 0.03
1.495PheTyr: 1.495 ± 0.05
0.0PheXaa: 0.0 ± 0.0
Gly
4.965GlyAla: 4.965 ± 0.098
0.809GlyCys: 0.809 ± 0.031
3.045GlyAsp: 3.045 ± 0.07
3.73GlyGlu: 3.73 ± 0.077
3.238GlyPhe: 3.238 ± 0.072
4.487GlyGly: 4.487 ± 0.114
1.595GlyHis: 1.595 ± 0.05
4.559GlyIle: 4.559 ± 0.089
3.776GlyLys: 3.776 ± 0.07
6.95GlyLeu: 6.95 ± 0.104
1.765GlyMet: 1.765 ± 0.05
2.41GlyAsn: 2.41 ± 0.076
1.233GlyPro: 1.233 ± 0.043
3.3GlyGln: 3.3 ± 0.073
2.921GlyArg: 2.921 ± 0.069
3.684GlySer: 3.684 ± 0.08
3.421GlyThr: 3.421 ± 0.078
4.695GlyVal: 4.695 ± 0.083
0.901GlyTrp: 0.901 ± 0.034
2.312GlyTyr: 2.312 ± 0.056
0.0GlyXaa: 0.0 ± 0.0
His
2.001HisAla: 2.001 ± 0.056
0.262HisCys: 0.262 ± 0.02
1.275HisAsp: 1.275 ± 0.046
1.216HisGlu: 1.216 ± 0.043
1.243HisPhe: 1.243 ± 0.044
1.616HisGly: 1.616 ± 0.047
0.809HisHis: 0.809 ± 0.038
1.607HisIle: 1.607 ± 0.051
1.005HisLys: 1.005 ± 0.037
2.757HisLeu: 2.757 ± 0.068
0.488HisMet: 0.488 ± 0.026
0.827HisAsn: 0.827 ± 0.033
1.353HisPro: 1.353 ± 0.044
1.505HisGln: 1.505 ± 0.05
1.133HisArg: 1.133 ± 0.041
1.395HisSer: 1.395 ± 0.045
1.083HisThr: 1.083 ± 0.042
1.412HisVal: 1.412 ± 0.041
0.359HisTrp: 0.359 ± 0.025
0.978HisTyr: 0.978 ± 0.043
0.0HisXaa: 0.0 ± 0.0
Ile
6.575IleAla: 6.575 ± 0.098
0.71IleCys: 0.71 ± 0.027
4.131IleAsp: 4.131 ± 0.074
4.761IleGlu: 4.761 ± 0.088
2.635IlePhe: 2.635 ± 0.064
4.616IleGly: 4.616 ± 0.094
1.486IleHis: 1.486 ± 0.051
3.908IleIle: 3.908 ± 0.078
3.397IleLys: 3.397 ± 0.078
6.429IleLeu: 6.429 ± 0.111
1.395IleMet: 1.395 ± 0.043
2.71IleAsn: 2.71 ± 0.062
2.825IlePro: 2.825 ± 0.06
3.919IleGln: 3.919 ± 0.076
3.138IleArg: 3.138 ± 0.073
4.142IleSer: 4.142 ± 0.075
3.415IleThr: 3.415 ± 0.063
4.263IleVal: 4.263 ± 0.088
0.756IleTrp: 0.756 ± 0.038
2.054IleTyr: 2.054 ± 0.051
0.0IleXaa: 0.0 ± 0.0
Lys
5.107LysAla: 5.107 ± 0.114
0.35LysCys: 0.35 ± 0.023
3.098LysAsp: 3.098 ± 0.067
3.043LysGlu: 3.043 ± 0.075
1.903LysPhe: 1.903 ± 0.046
3.199LysGly: 3.199 ± 0.072
1.279LysHis: 1.279 ± 0.043
3.862LysIle: 3.862 ± 0.074
3.546LysLys: 3.546 ± 0.085
5.461LysLeu: 5.461 ± 0.093
1.471LysMet: 1.471 ± 0.045
2.846LysAsn: 2.846 ± 0.065
2.358LysPro: 2.358 ± 0.052
3.588LysGln: 3.588 ± 0.077
2.694LysArg: 2.694 ± 0.065
3.082LysSer: 3.082 ± 0.061
3.461LysThr: 3.461 ± 0.073
3.819LysVal: 3.819 ± 0.074
0.595LysTrp: 0.595 ± 0.032
1.696LysTyr: 1.696 ± 0.054
0.0LysXaa: 0.0 ± 0.0
Leu
9.561LeuAla: 9.561 ± 0.124
1.024LeuCys: 1.024 ± 0.038
5.997LeuAsp: 5.997 ± 0.081
6.025LeuGlu: 6.025 ± 0.104
4.149LeuPhe: 4.149 ± 0.094
7.09LeuGly: 7.09 ± 0.122
2.284LeuHis: 2.284 ± 0.062
6.707LeuIle: 6.707 ± 0.105
6.703LeuLys: 6.703 ± 0.101
9.969LeuLeu: 9.969 ± 0.177
2.683LeuMet: 2.683 ± 0.063
5.34LeuAsn: 5.34 ± 0.099
4.587LeuPro: 4.587 ± 0.078
4.946LeuGln: 4.946 ± 0.097
4.459LeuArg: 4.459 ± 0.085
7.276LeuSer: 7.276 ± 0.097
5.642LeuThr: 5.642 ± 0.091
6.391LeuVal: 6.391 ± 0.083
1.239LeuTrp: 1.239 ± 0.039
2.785LeuTyr: 2.785 ± 0.064
0.0LeuXaa: 0.0 ± 0.0
Met
2.265MetAla: 2.265 ± 0.055
0.179MetCys: 0.179 ± 0.015
1.073MetAsp: 1.073 ± 0.037
0.999MetGlu: 0.999 ± 0.036
0.848MetPhe: 0.848 ± 0.038
1.697MetGly: 1.697 ± 0.05
0.545MetHis: 0.545 ± 0.027
1.61MetIle: 1.61 ± 0.045
1.413MetLys: 1.413 ± 0.046
2.612MetLeu: 2.612 ± 0.053
0.729MetMet: 0.729 ± 0.036
1.329MetAsn: 1.329 ± 0.043
1.13MetPro: 1.13 ± 0.04
1.586MetGln: 1.586 ± 0.048
1.182MetArg: 1.182 ± 0.041
1.83MetSer: 1.83 ± 0.044
1.537MetThr: 1.537 ± 0.046
1.592MetVal: 1.592 ± 0.054
0.216MetTrp: 0.216 ± 0.017
0.575MetTyr: 0.575 ± 0.026
0.0MetXaa: 0.0 ± 0.0
Asn
3.767AsnAla: 3.767 ± 0.086
0.343AsnCys: 0.343 ± 0.02
2.18AsnAsp: 2.18 ± 0.059
2.336AsnGlu: 2.336 ± 0.063
1.807AsnPhe: 1.807 ± 0.05
2.797AsnGly: 2.797 ± 0.087
1.097AsnHis: 1.097 ± 0.038
3.218AsnIle: 3.218 ± 0.061
2.308AsnLys: 2.308 ± 0.06
4.309AsnLeu: 4.309 ± 0.077
1.059AsnMet: 1.059 ± 0.036
1.917AsnAsn: 1.917 ± 0.076
2.352AsnPro: 2.352 ± 0.05
2.606AsnGln: 2.606 ± 0.075
1.914AsnArg: 1.914 ± 0.043
2.417AsnSer: 2.417 ± 0.063
2.483AsnThr: 2.483 ± 0.075
2.687AsnVal: 2.687 ± 0.071
0.517AsnTrp: 0.517 ± 0.03
1.463AsnTyr: 1.463 ± 0.045
0.0AsnXaa: 0.0 ± 0.0
Pro
3.101ProAla: 3.101 ± 0.07
0.29ProCys: 0.29 ± 0.019
2.139ProAsp: 2.139 ± 0.052
3.323ProGlu: 3.323 ± 0.065
1.67ProPhe: 1.67 ± 0.049
1.426ProGly: 1.426 ± 0.048
0.924ProHis: 0.924 ± 0.038
2.61ProIle: 2.61 ± 0.054
2.479ProLys: 2.479 ± 0.055
3.83ProLeu: 3.83 ± 0.077
0.994ProMet: 0.994 ± 0.037
2.029ProAsn: 2.029 ± 0.056
1.142ProPro: 1.142 ± 0.044
2.057ProGln: 2.057 ± 0.052
1.497ProArg: 1.497 ± 0.048
2.309ProSer: 2.309 ± 0.049
2.303ProThr: 2.303 ± 0.069
2.964ProVal: 2.964 ± 0.057
0.432ProTrp: 0.432 ± 0.027
1.386ProTyr: 1.386 ± 0.04
0.0ProXaa: 0.0 ± 0.0
Gln
5.413GlnAla: 5.413 ± 0.084
0.449GlnCys: 0.449 ± 0.026
2.574GlnAsp: 2.574 ± 0.067
2.667GlnGlu: 2.667 ± 0.061
2.28GlnPhe: 2.28 ± 0.05
3.288GlnGly: 3.288 ± 0.074
1.913GlnHis: 1.913 ± 0.064
3.679GlnIle: 3.679 ± 0.074
3.212GlnLys: 3.212 ± 0.066
6.289GlnLeu: 6.289 ± 0.122
1.304GlnMet: 1.304 ± 0.041
2.437GlnAsn: 2.437 ± 0.062
2.382GlnPro: 2.382 ± 0.065
5.087GlnGln: 5.087 ± 0.144
2.849GlnArg: 2.849 ± 0.081
3.028GlnSer: 3.028 ± 0.064
2.928GlnThr: 2.928 ± 0.071
3.612GlnVal: 3.612 ± 0.084
0.722GlnTrp: 0.722 ± 0.028
1.914GlnTyr: 1.914 ± 0.05
0.0GlnXaa: 0.0 ± 0.0
Arg
3.371ArgAla: 3.371 ± 0.07
0.386ArgCys: 0.386 ± 0.024
2.381ArgAsp: 2.381 ± 0.059
2.804ArgGlu: 2.804 ± 0.068
2.18ArgPhe: 2.18 ± 0.062
2.461ArgGly: 2.461 ± 0.059
1.206ArgHis: 1.206 ± 0.04
3.193ArgIle: 3.193 ± 0.074
2.485ArgLys: 2.485 ± 0.06
5.286ArgLeu: 5.286 ± 0.09
1.189ArgMet: 1.189 ± 0.038
1.872ArgAsn: 1.872 ± 0.044
1.795ArgPro: 1.795 ± 0.06
2.684ArgGln: 2.684 ± 0.063
2.267ArgArg: 2.267 ± 0.06
2.316ArgSer: 2.316 ± 0.055
2.064ArgThr: 2.064 ± 0.054
2.913ArgVal: 2.913 ± 0.073
0.574ArgTrp: 0.574 ± 0.027
1.811ArgTyr: 1.811 ± 0.052
0.0ArgXaa: 0.0 ± 0.0
Ser
4.72SerAla: 4.72 ± 0.103
0.601SerCys: 0.601 ± 0.03
2.818SerAsp: 2.818 ± 0.064
3.218SerGlu: 3.218 ± 0.061
2.713SerPhe: 2.713 ± 0.06
4.179SerGly: 4.179 ± 0.093
1.454SerHis: 1.454 ± 0.042
4.013SerIle: 4.013 ± 0.067
3.144SerLys: 3.144 ± 0.061
6.317SerLeu: 6.317 ± 0.089
1.485SerMet: 1.485 ± 0.047
2.641SerAsn: 2.641 ± 0.061
2.266SerPro: 2.266 ± 0.044
2.983SerGln: 2.983 ± 0.069
2.658SerArg: 2.658 ± 0.059
4.001SerSer: 4.001 ± 0.095
3.296SerThr: 3.296 ± 0.082
3.809SerVal: 3.809 ± 0.078
0.667SerTrp: 0.667 ± 0.029
1.946SerTyr: 1.946 ± 0.047
0.0SerXaa: 0.0 ± 0.0
Thr
4.833ThrAla: 4.833 ± 0.102
0.468ThrCys: 0.468 ± 0.028
2.86ThrAsp: 2.86 ± 0.066
3.167ThrGlu: 3.167 ± 0.066
1.936ThrPhe: 1.936 ± 0.057
4.14ThrGly: 4.14 ± 0.081
1.289ThrHis: 1.289 ± 0.044
3.345ThrIle: 3.345 ± 0.067
2.348ThrLys: 2.348 ± 0.065
6.023ThrLeu: 6.023 ± 0.092
1.04ThrMet: 1.04 ± 0.038
1.894ThrAsn: 1.894 ± 0.059
2.763ThrPro: 2.763 ± 0.079
2.873ThrGln: 2.873 ± 0.076
2.231ThrArg: 2.231 ± 0.062
2.904ThrSer: 2.904 ± 0.075
3.249ThrThr: 3.249 ± 0.106
3.793ThrVal: 3.793 ± 0.111
0.633ThrTrp: 0.633 ± 0.028
1.482ThrTyr: 1.482 ± 0.05
0.0ThrXaa: 0.0 ± 0.0
Val
5.801ValAla: 5.801 ± 0.094
0.721ValCys: 0.721 ± 0.033
3.842ValAsp: 3.842 ± 0.081
4.325ValGlu: 4.325 ± 0.076
2.661ValPhe: 2.661 ± 0.062
4.368ValGly: 4.368 ± 0.086
1.335ValHis: 1.335 ± 0.047
4.539ValIle: 4.539 ± 0.079
3.64ValLys: 3.64 ± 0.082
6.868ValLeu: 6.868 ± 0.092
1.829ValMet: 1.829 ± 0.049
2.793ValAsn: 2.793 ± 0.084
2.527ValPro: 2.527 ± 0.057
3.041ValGln: 3.041 ± 0.063
2.797ValArg: 2.797 ± 0.058
3.901ValSer: 3.901 ± 0.081
3.646ValThr: 3.646 ± 0.085
4.796ValVal: 4.796 ± 0.084
0.811ValTrp: 0.811 ± 0.031
1.8ValTyr: 1.8 ± 0.05
0.0ValXaa: 0.0 ± 0.0
Trp
0.855TrpAla: 0.855 ± 0.038
0.153TrpCys: 0.153 ± 0.014
0.542TrpAsp: 0.542 ± 0.025
0.464TrpGlu: 0.464 ± 0.023
0.643TrpPhe: 0.643 ± 0.032
0.705TrpGly: 0.705 ± 0.029
0.355TrpHis: 0.355 ± 0.024
0.868TrpIle: 0.868 ± 0.035
0.61TrpLys: 0.61 ± 0.025
1.684TrpLeu: 1.684 ± 0.051
0.387TrpMet: 0.387 ± 0.022
0.537TrpAsn: 0.537 ± 0.029
0.272TrpPro: 0.272 ± 0.019
0.978TrpGln: 0.978 ± 0.039
0.614TrpArg: 0.614 ± 0.031
0.751TrpSer: 0.751 ± 0.03
0.568TrpThr: 0.568 ± 0.025
0.844TrpVal: 0.844 ± 0.033
0.16TrpTrp: 0.16 ± 0.012
0.386TrpTyr: 0.386 ± 0.026
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.765TyrAla: 2.765 ± 0.063
0.348TyrCys: 0.348 ± 0.021
1.71TyrAsp: 1.71 ± 0.048
1.628TyrGlu: 1.628 ± 0.042
1.487TyrPhe: 1.487 ± 0.052
2.144TyrGly: 2.144 ± 0.056
0.812TyrHis: 0.812 ± 0.035
1.848TyrIle: 1.848 ± 0.056
1.57TyrLys: 1.57 ± 0.044
3.629TyrLeu: 3.629 ± 0.075
0.584TyrMet: 0.584 ± 0.027
1.256TyrAsn: 1.256 ± 0.04
1.432TyrPro: 1.432 ± 0.051
2.114TyrGln: 2.114 ± 0.059
1.694TyrArg: 1.694 ± 0.048
1.821TyrSer: 1.821 ± 0.052
1.586TyrThr: 1.586 ± 0.049
1.946TyrVal: 1.946 ± 0.045
0.463TyrTrp: 0.463 ± 0.025
1.061TyrTyr: 1.061 ± 0.045
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2615 proteins (782047 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski