Amino acid dipepetide frequency for Chitinophaga sancti

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.068AlaAla: 8.068 ± 0.087
0.752AlaCys: 0.752 ± 0.019
4.503AlaAsp: 4.503 ± 0.046
4.013AlaGlu: 4.013 ± 0.041
3.493AlaPhe: 3.493 ± 0.043
6.434AlaGly: 6.434 ± 0.063
1.445AlaHis: 1.445 ± 0.029
5.372AlaIle: 5.372 ± 0.053
4.135AlaLys: 4.135 ± 0.049
7.177AlaLeu: 7.177 ± 0.062
1.965AlaMet: 1.965 ± 0.032
3.894AlaAsn: 3.894 ± 0.043
2.887AlaPro: 2.887 ± 0.046
3.069AlaGln: 3.069 ± 0.041
2.942AlaArg: 2.942 ± 0.035
4.636AlaSer: 4.636 ± 0.055
4.918AlaThr: 4.918 ± 0.072
5.254AlaVal: 5.254 ± 0.061
0.917AlaTrp: 0.917 ± 0.02
3.264AlaTyr: 3.264 ± 0.041
0.0AlaXaa: 0.0 ± 0.0
Cys
0.557CysAla: 0.557 ± 0.019
0.154CysCys: 0.154 ± 0.01
0.415CysAsp: 0.415 ± 0.017
0.403CysGlu: 0.403 ± 0.015
0.437CysPhe: 0.437 ± 0.015
0.643CysGly: 0.643 ± 0.022
0.205CysHis: 0.205 ± 0.009
0.619CysIle: 0.619 ± 0.016
0.492CysLys: 0.492 ± 0.016
0.866CysLeu: 0.866 ± 0.023
0.236CysMet: 0.236 ± 0.009
0.431CysAsn: 0.431 ± 0.013
0.361CysPro: 0.361 ± 0.013
0.276CysGln: 0.276 ± 0.011
0.403CysArg: 0.403 ± 0.013
0.571CysSer: 0.571 ± 0.023
0.526CysThr: 0.526 ± 0.018
0.479CysVal: 0.479 ± 0.018
0.121CysTrp: 0.121 ± 0.007
0.39CysTyr: 0.39 ± 0.013
0.0CysXaa: 0.0 ± 0.0
Asp
4.153AspAla: 4.153 ± 0.052
0.409AspCys: 0.409 ± 0.015
2.48AspAsp: 2.48 ± 0.034
3.019AspGlu: 3.019 ± 0.041
2.61AspPhe: 2.61 ± 0.039
3.841AspGly: 3.841 ± 0.052
1.079AspHis: 1.079 ± 0.019
3.686AspIle: 3.686 ± 0.041
3.492AspLys: 3.492 ± 0.04
4.834AspLeu: 4.834 ± 0.049
1.247AspMet: 1.247 ± 0.022
2.799AspAsn: 2.799 ± 0.035
2.221AspPro: 2.221 ± 0.028
1.83AspGln: 1.83 ± 0.024
2.096AspArg: 2.096 ± 0.034
3.181AspSer: 3.181 ± 0.049
3.056AspThr: 3.056 ± 0.044
3.456AspVal: 3.456 ± 0.037
0.765AspTrp: 0.765 ± 0.018
2.596AspTyr: 2.596 ± 0.039
0.0AspXaa: 0.0 ± 0.0
Glu
4.044GluAla: 4.044 ± 0.055
0.346GluCys: 0.346 ± 0.012
2.681GluAsp: 2.681 ± 0.04
3.546GluGlu: 3.546 ± 0.061
2.086GluPhe: 2.086 ± 0.027
3.37GluGly: 3.37 ± 0.046
1.172GluHis: 1.172 ± 0.027
3.852GluIle: 3.852 ± 0.046
4.484GluLys: 4.484 ± 0.051
5.42GluLeu: 5.42 ± 0.062
1.612GluMet: 1.612 ± 0.029
2.949GluAsn: 2.949 ± 0.039
1.51GluPro: 1.51 ± 0.028
2.494GluGln: 2.494 ± 0.038
2.463GluArg: 2.463 ± 0.036
2.573GluSer: 2.573 ± 0.036
2.733GluThr: 2.733 ± 0.039
3.521GluVal: 3.521 ± 0.044
0.736GluTrp: 0.736 ± 0.016
2.039GluTyr: 2.039 ± 0.028
0.0GluXaa: 0.0 ± 0.0
Phe
3.095PheAla: 3.095 ± 0.04
0.466PheCys: 0.466 ± 0.014
2.641PheAsp: 2.641 ± 0.034
2.391PheGlu: 2.391 ± 0.033
2.283PhePhe: 2.283 ± 0.04
3.025PheGly: 3.025 ± 0.038
0.905PheHis: 0.905 ± 0.021
3.115PheIle: 3.115 ± 0.043
2.611PheLys: 2.611 ± 0.038
4.026PheLeu: 4.026 ± 0.051
1.121PheMet: 1.121 ± 0.025
2.769PheAsn: 2.769 ± 0.039
1.838PhePro: 1.838 ± 0.033
1.45PheGln: 1.45 ± 0.023
2.151PheArg: 2.151 ± 0.032
3.558PheSer: 3.558 ± 0.045
3.112PheThr: 3.112 ± 0.046
2.654PheVal: 2.654 ± 0.034
0.566PheTrp: 0.566 ± 0.018
2.054PheTyr: 2.054 ± 0.03
0.0PheXaa: 0.0 ± 0.0
Gly
4.985GlyAla: 4.985 ± 0.056
0.679GlyCys: 0.679 ± 0.023
3.507GlyAsp: 3.507 ± 0.042
3.391GlyGlu: 3.391 ± 0.042
3.354GlyPhe: 3.354 ± 0.037
5.07GlyGly: 5.07 ± 0.071
1.365GlyHis: 1.365 ± 0.024
5.204GlyIle: 5.204 ± 0.059
4.966GlyLys: 4.966 ± 0.053
5.967GlyLeu: 5.967 ± 0.054
1.912GlyMet: 1.912 ± 0.027
3.987GlyAsn: 3.987 ± 0.059
1.755GlyPro: 1.755 ± 0.034
2.437GlyGln: 2.437 ± 0.032
2.801GlyArg: 2.801 ± 0.033
4.358GlySer: 4.358 ± 0.059
4.764GlyThr: 4.764 ± 0.085
4.647GlyVal: 4.647 ± 0.054
1.079GlyTrp: 1.079 ± 0.024
3.331GlyTyr: 3.331 ± 0.04
0.0GlyXaa: 0.0 ± 0.0
His
1.424HisAla: 1.424 ± 0.026
0.226HisCys: 0.226 ± 0.01
0.92HisAsp: 0.92 ± 0.022
1.013HisGlu: 1.013 ± 0.022
1.211HisPhe: 1.211 ± 0.022
1.206HisGly: 1.206 ± 0.021
0.615HisHis: 0.615 ± 0.02
1.489HisIle: 1.489 ± 0.026
1.032HisLys: 1.032 ± 0.02
2.153HisLeu: 2.153 ± 0.035
0.474HisMet: 0.474 ± 0.014
0.948HisAsn: 0.948 ± 0.018
1.187HisPro: 1.187 ± 0.026
0.854HisGln: 0.854 ± 0.022
0.84HisArg: 0.84 ± 0.02
1.143HisSer: 1.143 ± 0.021
1.253HisThr: 1.253 ± 0.023
1.101HisVal: 1.101 ± 0.023
0.3HisTrp: 0.3 ± 0.011
1.037HisTyr: 1.037 ± 0.021
0.0HisXaa: 0.0 ± 0.0
Ile
5.673IleAla: 5.673 ± 0.055
0.714IleCys: 0.714 ± 0.019
3.655IleAsp: 3.655 ± 0.044
3.453IleGlu: 3.453 ± 0.044
2.901IlePhe: 2.901 ± 0.035
4.503IleGly: 4.503 ± 0.052
1.44IleHis: 1.44 ± 0.026
4.456IleIle: 4.456 ± 0.061
3.874IleLys: 3.874 ± 0.048
5.963IleLeu: 5.963 ± 0.066
1.431IleMet: 1.431 ± 0.024
3.649IleAsn: 3.649 ± 0.04
3.236IlePro: 3.236 ± 0.04
2.403IleGln: 2.403 ± 0.033
3.352IleArg: 3.352 ± 0.042
4.942IleSer: 4.942 ± 0.051
4.633IleThr: 4.633 ± 0.055
4.096IleVal: 4.096 ± 0.043
0.746IleTrp: 0.746 ± 0.017
2.642IleTyr: 2.642 ± 0.035
0.0IleXaa: 0.0 ± 0.0
Lys
4.927LysAla: 4.927 ± 0.055
0.338LysCys: 0.338 ± 0.012
3.939LysAsp: 3.939 ± 0.043
4.386LysGlu: 4.386 ± 0.056
2.072LysPhe: 2.072 ± 0.031
4.523LysGly: 4.523 ± 0.045
1.191LysHis: 1.191 ± 0.023
4.12LysIle: 4.12 ± 0.046
4.549LysLys: 4.549 ± 0.057
5.232LysLeu: 5.232 ± 0.05
1.8LysMet: 1.8 ± 0.028
3.168LysAsn: 3.168 ± 0.047
2.343LysPro: 2.343 ± 0.035
2.61LysGln: 2.61 ± 0.035
2.575LysArg: 2.575 ± 0.035
3.265LysSer: 3.265 ± 0.037
3.552LysThr: 3.552 ± 0.043
4.253LysVal: 4.253 ± 0.045
0.82LysTrp: 0.82 ± 0.02
2.63LysTyr: 2.63 ± 0.033
0.0LysXaa: 0.0 ± 0.0
Leu
6.917LeuAla: 6.917 ± 0.067
0.882LeuCys: 0.882 ± 0.019
4.71LeuAsp: 4.71 ± 0.044
4.885LeuGlu: 4.885 ± 0.063
4.475LeuPhe: 4.475 ± 0.057
5.657LeuGly: 5.657 ± 0.057
2.097LeuHis: 2.097 ± 0.037
5.86LeuIle: 5.86 ± 0.061
6.251LeuLys: 6.251 ± 0.051
10.095LeuLeu: 10.095 ± 0.104
2.168LeuMet: 2.168 ± 0.031
4.911LeuAsn: 4.911 ± 0.054
4.555LeuPro: 4.555 ± 0.05
4.476LeuGln: 4.476 ± 0.055
4.018LeuArg: 4.018 ± 0.051
6.96LeuSer: 6.96 ± 0.056
5.535LeuThr: 5.535 ± 0.061
5.604LeuVal: 5.604 ± 0.053
0.932LeuTrp: 0.932 ± 0.02
3.597LeuTyr: 3.597 ± 0.047
0.0LeuXaa: 0.0 ± 0.0
Met
2.032MetAla: 2.032 ± 0.029
0.144MetCys: 0.144 ± 0.009
1.331MetAsp: 1.331 ± 0.025
1.508MetGlu: 1.508 ± 0.029
0.815MetPhe: 0.815 ± 0.017
1.57MetGly: 1.57 ± 0.032
0.535MetHis: 0.535 ± 0.015
1.585MetIle: 1.585 ± 0.027
1.939MetLys: 1.939 ± 0.03
2.218MetLeu: 2.218 ± 0.035
0.661MetMet: 0.661 ± 0.021
1.337MetAsn: 1.337 ± 0.025
1.18MetPro: 1.18 ± 0.022
1.187MetGln: 1.187 ± 0.021
1.147MetArg: 1.147 ± 0.024
1.458MetSer: 1.458 ± 0.028
1.294MetThr: 1.294 ± 0.024
1.532MetVal: 1.532 ± 0.027
0.204MetTrp: 0.204 ± 0.009
0.79MetTyr: 0.79 ± 0.016
0.0MetXaa: 0.0 ± 0.0
Asn
4.113AsnAla: 4.113 ± 0.049
0.406AsnCys: 0.406 ± 0.016
2.714AsnAsp: 2.714 ± 0.037
2.746AsnGlu: 2.746 ± 0.037
2.303AsnPhe: 2.303 ± 0.03
4.297AsnGly: 4.297 ± 0.059
0.954AsnHis: 0.954 ± 0.022
3.957AsnIle: 3.957 ± 0.044
3.188AsnLys: 3.188 ± 0.041
4.36AsnLeu: 4.36 ± 0.051
1.27AsnMet: 1.27 ± 0.024
3.251AsnAsn: 3.251 ± 0.058
2.488AsnPro: 2.488 ± 0.04
1.784AsnGln: 1.784 ± 0.028
2.266AsnArg: 2.266 ± 0.033
3.156AsnSer: 3.156 ± 0.044
3.561AsnThr: 3.561 ± 0.046
3.238AsnVal: 3.238 ± 0.045
0.767AsnTrp: 0.767 ± 0.019
2.62AsnTyr: 2.62 ± 0.036
0.0AsnXaa: 0.0 ± 0.0
Pro
4.21ProAla: 4.21 ± 0.054
0.271ProCys: 0.271 ± 0.012
2.761ProAsp: 2.761 ± 0.04
2.694ProGlu: 2.694 ± 0.036
1.961ProPhe: 1.961 ± 0.03
3.29ProGly: 3.29 ± 0.039
0.729ProHis: 0.729 ± 0.019
2.142ProIle: 2.142 ± 0.036
1.847ProLys: 1.847 ± 0.035
3.689ProLeu: 3.689 ± 0.049
0.835ProMet: 0.835 ± 0.019
1.798ProAsn: 1.798 ± 0.036
1.268ProPro: 1.268 ± 0.033
1.401ProGln: 1.401 ± 0.027
1.221ProArg: 1.221 ± 0.027
2.275ProSer: 2.275 ± 0.034
2.093ProThr: 2.093 ± 0.038
3.781ProVal: 3.781 ± 0.043
0.461ProTrp: 0.461 ± 0.014
1.736ProTyr: 1.736 ± 0.029
0.0ProXaa: 0.0 ± 0.0
Gln
3.029GlnAla: 3.029 ± 0.04
0.249GlnCys: 0.249 ± 0.011
1.859GlnAsp: 1.859 ± 0.026
2.339GlnGlu: 2.339 ± 0.034
1.742GlnPhe: 1.742 ± 0.029
2.19GlnGly: 2.19 ± 0.032
1.052GlnHis: 1.052 ± 0.023
2.282GlnIle: 2.282 ± 0.032
2.208GlnLys: 2.208 ± 0.035
4.62GlnLeu: 4.62 ± 0.058
0.919GlnMet: 0.919 ± 0.021
1.69GlnAsn: 1.69 ± 0.028
1.669GlnPro: 1.669 ± 0.025
2.66GlnGln: 2.66 ± 0.059
1.696GlnArg: 1.696 ± 0.029
2.153GlnSer: 2.153 ± 0.027
2.103GlnThr: 2.103 ± 0.032
2.719GlnVal: 2.719 ± 0.031
0.558GlnTrp: 0.558 ± 0.016
1.812GlnTyr: 1.812 ± 0.034
0.0GlnXaa: 0.0 ± 0.0
Arg
2.605ArgAla: 2.605 ± 0.034
0.274ArgCys: 0.274 ± 0.011
1.999ArgAsp: 1.999 ± 0.029
2.523ArgGlu: 2.523 ± 0.037
2.15ArgPhe: 2.15 ± 0.031
2.233ArgGly: 2.233 ± 0.03
0.922ArgHis: 0.922 ± 0.021
3.198ArgIle: 3.198 ± 0.038
2.966ArgLys: 2.966 ± 0.042
4.224ArgLeu: 4.224 ± 0.048
1.232ArgMet: 1.232 ± 0.026
2.421ArgAsn: 2.421 ± 0.037
1.517ArgPro: 1.517 ± 0.026
1.824ArgGln: 1.824 ± 0.029
1.803ArgArg: 1.803 ± 0.034
2.364ArgSer: 2.364 ± 0.036
2.246ArgThr: 2.246 ± 0.034
2.531ArgVal: 2.531 ± 0.037
0.613ArgTrp: 0.613 ± 0.016
2.142ArgTyr: 2.142 ± 0.033
0.0ArgXaa: 0.0 ± 0.0
Ser
4.825SerAla: 4.825 ± 0.055
0.624SerCys: 0.624 ± 0.02
3.004SerAsp: 3.004 ± 0.032
2.759SerGlu: 2.759 ± 0.039
3.427SerPhe: 3.427 ± 0.043
5.089SerGly: 5.089 ± 0.068
1.149SerHis: 1.149 ± 0.023
4.314SerIle: 4.314 ± 0.043
3.337SerLys: 3.337 ± 0.045
6.388SerLeu: 6.388 ± 0.054
1.423SerMet: 1.423 ± 0.023
3.194SerAsn: 3.194 ± 0.047
2.445SerPro: 2.445 ± 0.036
2.079SerGln: 2.079 ± 0.028
2.633SerArg: 2.633 ± 0.042
4.137SerSer: 4.137 ± 0.065
3.877SerThr: 3.877 ± 0.058
4.059SerVal: 4.059 ± 0.049
0.908SerTrp: 0.908 ± 0.019
2.855SerTyr: 2.855 ± 0.041
0.0SerXaa: 0.0 ± 0.0
Thr
5.5ThrAla: 5.5 ± 0.082
0.5ThrCys: 0.5 ± 0.015
3.323ThrAsp: 3.323 ± 0.041
2.637ThrGlu: 2.637 ± 0.036
2.755ThrPhe: 2.755 ± 0.039
5.261ThrGly: 5.261 ± 0.068
1.128ThrHis: 1.128 ± 0.021
4.462ThrIle: 4.462 ± 0.052
2.939ThrLys: 2.939 ± 0.04
5.822ThrLeu: 5.822 ± 0.06
1.204ThrMet: 1.204 ± 0.025
2.948ThrAsn: 2.948 ± 0.047
3.048ThrPro: 3.048 ± 0.048
1.978ThrGln: 1.978 ± 0.03
2.29ThrArg: 2.29 ± 0.033
3.729ThrSer: 3.729 ± 0.061
4.224ThrThr: 4.224 ± 0.071
4.386ThrVal: 4.386 ± 0.074
0.766ThrTrp: 0.766 ± 0.022
2.7ThrTyr: 2.7 ± 0.05
0.0ThrXaa: 0.0 ± 0.0
Val
5.083ValAla: 5.083 ± 0.049
0.606ValCys: 0.606 ± 0.02
3.274ValAsp: 3.274 ± 0.041
3.09ValGlu: 3.09 ± 0.042
2.956ValPhe: 2.956 ± 0.04
3.639ValGly: 3.639 ± 0.05
1.201ValHis: 1.201 ± 0.025
4.654ValIle: 4.654 ± 0.053
4.422ValLys: 4.422 ± 0.051
6.157ValLeu: 6.157 ± 0.062
1.64ValMet: 1.64 ± 0.031
3.759ValAsn: 3.759 ± 0.046
2.776ValPro: 2.776 ± 0.037
2.339ValGln: 2.339 ± 0.028
2.581ValArg: 2.581 ± 0.031
4.498ValSer: 4.498 ± 0.058
4.315ValThr: 4.315 ± 0.073
4.446ValVal: 4.446 ± 0.057
0.743ValTrp: 0.743 ± 0.018
2.729ValTyr: 2.729 ± 0.037
0.0ValXaa: 0.0 ± 0.0
Trp
0.784TrpAla: 0.784 ± 0.017
0.116TrpCys: 0.116 ± 0.008
0.669TrpAsp: 0.669 ± 0.018
0.74TrpGlu: 0.74 ± 0.017
0.587TrpPhe: 0.587 ± 0.015
0.854TrpGly: 0.854 ± 0.019
0.293TrpHis: 0.293 ± 0.011
0.77TrpIle: 0.77 ± 0.021
0.901TrpLys: 0.901 ± 0.022
1.277TrpLeu: 1.277 ± 0.026
0.392TrpMet: 0.392 ± 0.011
0.766TrpAsn: 0.766 ± 0.02
0.37TrpPro: 0.37 ± 0.014
0.717TrpGln: 0.717 ± 0.018
0.531TrpArg: 0.531 ± 0.014
0.745TrpSer: 0.745 ± 0.02
0.761TrpThr: 0.761 ± 0.023
0.761TrpVal: 0.761 ± 0.018
0.237TrpTrp: 0.237 ± 0.01
0.556TrpTyr: 0.556 ± 0.018
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.114TyrAla: 3.114 ± 0.038
0.429TyrCys: 0.429 ± 0.012
2.464TyrAsp: 2.464 ± 0.042
2.097TyrGlu: 2.097 ± 0.03
2.212TyrPhe: 2.212 ± 0.031
2.864TyrGly: 2.864 ± 0.042
0.95TyrHis: 0.95 ± 0.022
2.623TyrIle: 2.623 ± 0.033
2.66TyrLys: 2.66 ± 0.037
4.099TyrLeu: 4.099 ± 0.043
0.924TyrMet: 0.924 ± 0.019
2.772TyrAsn: 2.772 ± 0.041
1.81TyrPro: 1.81 ± 0.027
1.681TyrGln: 1.681 ± 0.028
1.98TyrArg: 1.98 ± 0.032
2.823TyrSer: 2.823 ± 0.041
3.041TyrThr: 3.041 ± 0.045
2.393TyrVal: 2.393 ± 0.035
0.586TyrTrp: 0.586 ± 0.016
2.249TyrTyr: 2.249 ± 0.04
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6697 proteins (2424268 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski