Amino acid dipepetide frequency for Brevundimonas viscosa

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	24.53AlaAla: 24.53 ± 0.32	1.263AlaCys: 1.263 ± 0.04	8.23AlaAsp: 8.23 ± 0.124	9.251AlaGlu: 9.251 ± 0.118	4.934AlaPhe: 4.934 ± 0.072	13.182AlaGly: 13.182 ± 0.146	2.181AlaHis: 2.181 ± 0.048	4.998AlaIle: 4.998 ± 0.08	2.907AlaLys: 2.907 ± 0.07	14.896AlaLeu: 14.896 ± 0.181	3.566AlaMet: 3.566 ± 0.064	2.585AlaAsn: 2.585 ± 0.07	7.959AlaPro: 7.959 ± 0.126	4.005AlaGln: 4.005 ± 0.064	11.853AlaArg: 11.853 ± 0.152	6.295AlaSer: 6.295 ± 0.096	6.043AlaThr: 6.043 ± 0.088	10.756AlaVal: 10.756 ± 0.148	2.146AlaTrp: 2.146 ± 0.058	2.499AlaTyr: 2.499 ± 0.054	0.0AlaXaa: 0.0 ± 0.0
Cys	1.029CysAla: 1.029 ± 0.04	0.094CysCys: 0.094 ± 0.011	0.497CysAsp: 0.497 ± 0.023	0.386CysGlu: 0.386 ± 0.022	0.23CysPhe: 0.23 ± 0.016	0.859CysGly: 0.859 ± 0.029	0.168CysHis: 0.168 ± 0.013	0.256CysIle: 0.256 ± 0.018	0.126CysLys: 0.126 ± 0.013	0.669CysLeu: 0.669 ± 0.027	0.124CysMet: 0.124 ± 0.011	0.147CysAsn: 0.147 ± 0.014	0.43CysPro: 0.43 ± 0.021	0.192CysGln: 0.192 ± 0.012	0.591CysArg: 0.591 ± 0.027	0.353CysSer: 0.353 ± 0.02	0.329CysThr: 0.329 ± 0.021	0.6CysVal: 0.6 ± 0.029	0.095CysTrp: 0.095 ± 0.011	0.137CysTyr: 0.137 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	8.15AspAla: 8.15 ± 0.109	0.407AspCys: 0.407 ± 0.025	3.343AspAsp: 3.343 ± 0.066	3.568AspGlu: 3.568 ± 0.073	2.055AspPhe: 2.055 ± 0.058	5.884AspGly: 5.884 ± 0.075	1.238AspHis: 1.238 ± 0.034	2.301AspIle: 2.301 ± 0.057	1.171AspLys: 1.171 ± 0.034	6.242AspLeu: 6.242 ± 0.091	1.222AspMet: 1.222 ± 0.034	1.071AspAsn: 1.071 ± 0.035	4.319AspPro: 4.319 ± 0.076	1.807AspGln: 1.807 ± 0.047	5.438AspArg: 5.438 ± 0.079	1.963AspSer: 1.963 ± 0.048	2.146AspThr: 2.146 ± 0.056	4.183AspVal: 4.183 ± 0.07	1.147AspTrp: 1.147 ± 0.035	1.4AspTyr: 1.4 ± 0.043	0.0AspXaa: 0.0 ± 0.0
Glu	10.329GluAla: 10.329 ± 0.132	0.283GluCys: 0.283 ± 0.018	3.043GluAsp: 3.043 ± 0.072	3.01GluGlu: 3.01 ± 0.066	1.524GluPhe: 1.524 ± 0.046	5.243GluGly: 5.243 ± 0.082	1.094GluHis: 1.094 ± 0.032	2.972GluIle: 2.972 ± 0.063	1.608GluLys: 1.608 ± 0.052	5.365GluLeu: 5.365 ± 0.076	1.363GluMet: 1.363 ± 0.038	1.167GluAsn: 1.167 ± 0.037	3.398GluPro: 3.398 ± 0.063	2.116GluGln: 2.116 ± 0.051	5.84GluArg: 5.84 ± 0.086	2.289GluSer: 2.289 ± 0.054	3.767GluThr: 3.767 ± 0.075	4.379GluVal: 4.379 ± 0.074	0.743GluTrp: 0.743 ± 0.036	0.873GluTyr: 0.873 ± 0.033	0.0GluXaa: 0.0 ± 0.0
Phe	4.586PheAla: 4.586 ± 0.077	0.299PheCys: 0.299 ± 0.02	2.617PheAsp: 2.617 ± 0.053	2.306PheGlu: 2.306 ± 0.055	1.118PhePhe: 1.118 ± 0.044	3.465PheGly: 3.465 ± 0.075	0.651PheHis: 0.651 ± 0.03	1.272PheIle: 1.272 ± 0.046	0.611PheLys: 0.611 ± 0.028	2.992PheLeu: 2.992 ± 0.064	0.753PheMet: 0.753 ± 0.028	0.853PheAsn: 0.853 ± 0.032	1.443PhePro: 1.443 ± 0.042	0.934PheGln: 0.934 ± 0.031	2.46PheArg: 2.46 ± 0.047	1.754PheSer: 1.754 ± 0.046	1.804PheThr: 1.804 ± 0.042	2.672PheVal: 2.672 ± 0.057	0.561PheTrp: 0.561 ± 0.028	0.744PheTyr: 0.744 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	11.443GlyAla: 11.443 ± 0.135	0.819GlyCys: 0.819 ± 0.031	5.211GlyAsp: 5.211 ± 0.076	5.883GlyGlu: 5.883 ± 0.085	3.513GlyPhe: 3.513 ± 0.066	8.823GlyGly: 8.823 ± 0.137	1.702GlyHis: 1.702 ± 0.039	2.775GlyIle: 2.775 ± 0.069	2.352GlyLys: 2.352 ± 0.059	9.778GlyLeu: 9.778 ± 0.117	2.161GlyMet: 2.161 ± 0.059	1.429GlyAsn: 1.429 ± 0.044	4.67GlyPro: 4.67 ± 0.074	3.137GlyGln: 3.137 ± 0.06	8.101GlyArg: 8.101 ± 0.078	4.381GlySer: 4.381 ± 0.085	3.539GlyThr: 3.539 ± 0.066	7.798GlyVal: 7.798 ± 0.105	1.853GlyTrp: 1.853 ± 0.058	2.124GlyTyr: 2.124 ± 0.051	0.0GlyXaa: 0.0 ± 0.0
His	2.387HisAla: 2.387 ± 0.057	0.178HisCys: 0.178 ± 0.012	1.074HisAsp: 1.074 ± 0.036	1.067HisGlu: 1.067 ± 0.035	0.607HisPhe: 0.607 ± 0.024	1.863HisGly: 1.863 ± 0.053	0.5HisHis: 0.5 ± 0.024	0.615HisIle: 0.615 ± 0.027	0.314HisLys: 0.314 ± 0.02	1.768HisLeu: 1.768 ± 0.047	0.399HisMet: 0.399 ± 0.022	0.322HisAsn: 0.322 ± 0.018	1.248HisPro: 1.248 ± 0.036	0.489HisGln: 0.489 ± 0.021	1.383HisArg: 1.383 ± 0.038	0.688HisSer: 0.688 ± 0.025	0.684HisThr: 0.684 ± 0.028	1.39HisVal: 1.39 ± 0.044	0.298HisTrp: 0.298 ± 0.019	0.41HisTyr: 0.41 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	5.807IleAla: 5.807 ± 0.085	0.329IleCys: 0.329 ± 0.022	2.982IleAsp: 2.982 ± 0.053	2.99IleGlu: 2.99 ± 0.055	1.096IlePhe: 1.096 ± 0.04	4.035IleGly: 4.035 ± 0.071	0.736IleHis: 0.736 ± 0.035	1.328IleIle: 1.328 ± 0.043	0.856IleLys: 0.856 ± 0.036	3.474IleLeu: 3.474 ± 0.066	0.723IleMet: 0.723 ± 0.027	0.948IleAsn: 0.948 ± 0.034	1.804IlePro: 1.804 ± 0.045	1.05IleGln: 1.05 ± 0.032	2.976IleArg: 2.976 ± 0.055	1.994IleSer: 1.994 ± 0.053	1.953IleThr: 1.953 ± 0.049	3.524IleVal: 3.524 ± 0.057	0.504IleTrp: 0.504 ± 0.025	0.769IleTyr: 0.769 ± 0.03	0.0IleXaa: 0.0 ± 0.0
Lys	3.743LysAla: 3.743 ± 0.073	0.091LysCys: 0.091 ± 0.01	1.172LysAsp: 1.172 ± 0.044	1.004LysGlu: 1.004 ± 0.037	0.614LysPhe: 0.614 ± 0.028	2.173LysGly: 2.173 ± 0.058	0.442LysHis: 0.442 ± 0.023	1.05LysIle: 1.05 ± 0.038	0.895LysLys: 0.895 ± 0.043	2.235LysLeu: 2.235 ± 0.049	0.471LysMet: 0.471 ± 0.025	0.477LysAsn: 0.477 ± 0.025	1.564LysPro: 1.564 ± 0.044	0.636LysGln: 0.636 ± 0.028	1.91LysArg: 1.91 ± 0.059	1.196LysSer: 1.196 ± 0.04	1.39LysThr: 1.39 ± 0.042	1.849LysVal: 1.849 ± 0.048	0.299LysTrp: 0.299 ± 0.019	0.414LysTyr: 0.414 ± 0.021	0.0LysXaa: 0.0 ± 0.0
Leu	14.959LeuAla: 14.959 ± 0.162	0.682LeuCys: 0.682 ± 0.028	6.215LeuAsp: 6.215 ± 0.087	5.989LeuGlu: 5.989 ± 0.095	3.455LeuPhe: 3.455 ± 0.077	8.405LeuGly: 8.405 ± 0.102	1.697LeuHis: 1.697 ± 0.046	4.414LeuIle: 4.414 ± 0.073	3.166LeuLys: 3.166 ± 0.07	8.974LeuLeu: 8.974 ± 0.141	2.256LeuMet: 2.256 ± 0.051	2.512LeuAsn: 2.512 ± 0.056	5.289LeuPro: 5.289 ± 0.082	2.701LeuGln: 2.701 ± 0.058	7.276LeuArg: 7.276 ± 0.119	5.64LeuSer: 5.64 ± 0.081	5.967LeuThr: 5.967 ± 0.085	7.332LeuVal: 7.332 ± 0.103	1.311LeuTrp: 1.311 ± 0.048	1.886LeuTyr: 1.886 ± 0.05	0.0LeuXaa: 0.0 ± 0.0
Met	3.252MetAla: 3.252 ± 0.067	0.115MetCys: 0.115 ± 0.012	1.154MetAsp: 1.154 ± 0.036	0.949MetGlu: 0.949 ± 0.037	0.645MetPhe: 0.645 ± 0.031	1.754MetGly: 1.754 ± 0.049	0.368MetHis: 0.368 ± 0.018	1.086MetIle: 1.086 ± 0.039	0.877MetLys: 0.877 ± 0.03	2.045MetLeu: 2.045 ± 0.053	0.491MetMet: 0.491 ± 0.022	0.629MetAsn: 0.629 ± 0.024	1.203MetPro: 1.203 ± 0.036	0.649MetGln: 0.649 ± 0.024	1.761MetArg: 1.761 ± 0.038	1.466MetSer: 1.466 ± 0.037	1.879MetThr: 1.879 ± 0.043	1.495MetVal: 1.495 ± 0.036	0.21MetTrp: 0.21 ± 0.016	0.251MetTyr: 0.251 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	2.861AsnAla: 2.861 ± 0.06	0.181AsnCys: 0.181 ± 0.015	1.085AsnAsp: 1.085 ± 0.037	0.937AsnGlu: 0.937 ± 0.03	0.657AsnPhe: 0.657 ± 0.031	1.949AsnGly: 1.949 ± 0.044	0.386AsnHis: 0.386 ± 0.019	0.893AsnIle: 0.893 ± 0.036	0.357AsnLys: 0.357 ± 0.019	2.322AsnLeu: 2.322 ± 0.058	0.43AsnMet: 0.43 ± 0.023	0.445AsnAsn: 0.445 ± 0.027	1.603AsnPro: 1.603 ± 0.054	0.598AsnGln: 0.598 ± 0.028	1.687AsnArg: 1.687 ± 0.044	0.897AsnSer: 0.897 ± 0.033	0.973AsnThr: 0.973 ± 0.039	1.675AsnVal: 1.675 ± 0.048	0.321AsnTrp: 0.321 ± 0.021	0.529AsnTyr: 0.529 ± 0.032	0.0AsnXaa: 0.0 ± 0.0
Pro	8.703ProAla: 8.703 ± 0.118	0.311ProCys: 0.311 ± 0.018	4.095ProAsp: 4.095 ± 0.069	4.385ProGlu: 4.385 ± 0.08	2.016ProPhe: 2.016 ± 0.052	5.587ProGly: 5.587 ± 0.088	1.015ProHis: 1.015 ± 0.035	1.922ProIle: 1.922 ± 0.05	1.29ProLys: 1.29 ± 0.039	4.993ProLeu: 4.993 ± 0.087	1.128ProMet: 1.128 ± 0.036	1.175ProAsn: 1.175 ± 0.038	3.824ProPro: 3.824 ± 0.103	1.597ProGln: 1.597 ± 0.049	3.664ProArg: 3.664 ± 0.067	2.714ProSer: 2.714 ± 0.058	2.84ProThr: 2.84 ± 0.059	4.703ProVal: 4.703 ± 0.078	0.856ProTrp: 0.856 ± 0.035	1.091ProTyr: 1.091 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	4.566GlnAla: 4.566 ± 0.078	0.16GlnCys: 0.16 ± 0.013	1.332GlnAsp: 1.332 ± 0.042	1.348GlnGlu: 1.348 ± 0.042	0.84GlnPhe: 0.84 ± 0.032	2.516GlnGly: 2.516 ± 0.054	0.499GlnHis: 0.499 ± 0.026	1.385GlnIle: 1.385 ± 0.04	0.747GlnLys: 0.747 ± 0.03	2.67GlnLeu: 2.67 ± 0.056	0.742GlnMet: 0.742 ± 0.03	0.617GlnAsn: 0.617 ± 0.028	1.988GlnPro: 1.988 ± 0.051	1.036GlnGln: 1.036 ± 0.037	2.352GlnArg: 2.352 ± 0.06	1.473GlnSer: 1.473 ± 0.036	1.878GlnThr: 1.878 ± 0.049	2.277GlnVal: 2.277 ± 0.05	0.369GlnTrp: 0.369 ± 0.02	0.502GlnTyr: 0.502 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	10.385ArgAla: 10.385 ± 0.131	0.512ArgCys: 0.512 ± 0.024	4.594ArgAsp: 4.594 ± 0.078	4.86ArgGlu: 4.86 ± 0.075	3.138ArgPhe: 3.138 ± 0.061	5.868ArgGly: 5.868 ± 0.109	1.415ArgHis: 1.415 ± 0.042	3.791ArgIle: 3.791 ± 0.06	1.86ArgLys: 1.86 ± 0.052	9.958ArgLeu: 9.958 ± 0.127	2.066ArgMet: 2.066 ± 0.051	1.668ArgAsn: 1.668 ± 0.046	5.245ArgPro: 5.245 ± 0.091	2.525ArgGln: 2.525 ± 0.052	7.691ArgArg: 7.691 ± 0.115	3.711ArgSer: 3.711 ± 0.073	4.016ArgThr: 4.016 ± 0.069	5.678ArgVal: 5.678 ± 0.089	1.367ArgTrp: 1.367 ± 0.036	1.779ArgTyr: 1.779 ± 0.048	0.0ArgXaa: 0.0 ± 0.0
Ser	6.19SerAla: 6.19 ± 0.087	0.312SerCys: 0.312 ± 0.02	2.766SerAsp: 2.766 ± 0.048	2.533SerGlu: 2.533 ± 0.052	1.674SerPhe: 1.674 ± 0.044	5.046SerGly: 5.046 ± 0.08	0.848SerHis: 0.848 ± 0.035	2.046SerIle: 2.046 ± 0.053	1.045SerLys: 1.045 ± 0.037	4.793SerLeu: 4.793 ± 0.079	1.073SerMet: 1.073 ± 0.04	1.075SerAsn: 1.075 ± 0.036	2.963SerPro: 2.963 ± 0.061	1.39SerGln: 1.39 ± 0.04	3.674SerArg: 3.674 ± 0.055	2.252SerSer: 2.252 ± 0.06	2.339SerThr: 2.339 ± 0.052	3.531SerVal: 3.531 ± 0.064	0.739SerTrp: 0.739 ± 0.028	1.024SerTyr: 1.024 ± 0.034	0.0SerXaa: 0.0 ± 0.0
Thr	6.757ThrAla: 6.757 ± 0.085	0.351ThrCys: 0.351 ± 0.022	2.806ThrAsp: 2.806 ± 0.055	2.471ThrGlu: 2.471 ± 0.05	1.745ThrPhe: 1.745 ± 0.051	5.334ThrGly: 5.334 ± 0.073	0.852ThrHis: 0.852 ± 0.034	1.95ThrIle: 1.95 ± 0.051	0.858ThrLys: 0.858 ± 0.033	5.443ThrLeu: 5.443 ± 0.07	0.817ThrMet: 0.817 ± 0.029	1.053ThrAsn: 1.053 ± 0.038	3.907ThrPro: 3.907 ± 0.066	1.209ThrGln: 1.209 ± 0.033	3.662ThrArg: 3.662 ± 0.071	2.282ThrSer: 2.282 ± 0.048	2.628ThrThr: 2.628 ± 0.053	4.463ThrVal: 4.463 ± 0.073	0.691ThrTrp: 0.691 ± 0.028	0.97ThrTyr: 0.97 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	10.249ValAla: 10.249 ± 0.128	0.635ValCys: 0.635 ± 0.025	4.733ValAsp: 4.733 ± 0.084	5.572ValGlu: 5.572 ± 0.084	2.735ValPhe: 2.735 ± 0.061	6.245ValGly: 6.245 ± 0.09	1.321ValHis: 1.321 ± 0.038	3.484ValIle: 3.484 ± 0.065	1.775ValLys: 1.775 ± 0.048	7.769ValLeu: 7.769 ± 0.108	1.731ValMet: 1.731 ± 0.049	1.763ValAsn: 1.763 ± 0.051	3.329ValPro: 3.329 ± 0.067	2.212ValGln: 2.212 ± 0.047	6.392ValArg: 6.392 ± 0.08	4.045ValSer: 4.045 ± 0.072	4.255ValThr: 4.255 ± 0.076	6.749ValVal: 6.749 ± 0.09	1.253ValTrp: 1.253 ± 0.04	1.385ValTyr: 1.385 ± 0.046	0.0ValXaa: 0.0 ± 0.0
Trp	1.671TrpAla: 1.671 ± 0.046	0.115TrpCys: 0.115 ± 0.01	0.722TrpAsp: 0.722 ± 0.027	0.651TrpGlu: 0.651 ± 0.031	0.611TrpPhe: 0.611 ± 0.023	1.092TrpGly: 1.092 ± 0.038	0.244TrpHis: 0.244 ± 0.017	0.734TrpIle: 0.734 ± 0.031	0.463TrpLys: 0.463 ± 0.021	1.853TrpLeu: 1.853 ± 0.055	0.405TrpMet: 0.405 ± 0.021	0.394TrpAsn: 0.394 ± 0.021	0.814TrpPro: 0.814 ± 0.03	0.425TrpGln: 0.425 ± 0.025	1.658TrpArg: 1.658 ± 0.044	0.994TrpSer: 0.994 ± 0.032	1.018TrpThr: 1.018 ± 0.036	0.929TrpVal: 0.929 ± 0.031	0.29TrpTrp: 0.29 ± 0.019	0.26TrpTyr: 0.26 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.484TyrAla: 2.484 ± 0.054	0.175TyrCys: 0.175 ± 0.015	1.385TyrAsp: 1.385 ± 0.043	1.242TyrGlu: 1.242 ± 0.038	0.688TyrPhe: 0.688 ± 0.028	2.167TyrGly: 2.167 ± 0.061	0.325TyrHis: 0.325 ± 0.018	0.606TyrIle: 0.606 ± 0.021	0.347TyrLys: 0.347 ± 0.021	1.89TyrLeu: 1.89 ± 0.043	0.356TyrMet: 0.356 ± 0.023	0.457TyrAsn: 0.457 ± 0.026	0.908TyrPro: 0.908 ± 0.033	0.588TyrGln: 0.588 ± 0.022	1.758TyrArg: 1.758 ± 0.052	0.928TyrSer: 0.928 ± 0.036	0.8TyrThr: 0.8 ± 0.034	1.65TyrVal: 1.65 ± 0.044	0.291TyrTrp: 0.291 ± 0.017	0.457TyrTyr: 0.457 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3072 proteins (904085 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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