Amino acid dipepetide frequency for Lysobacter tolerans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.217AlaAla: 15.217 ± 0.217	1.106AlaCys: 1.106 ± 0.037	6.875AlaAsp: 6.875 ± 0.118	7.114AlaGlu: 7.114 ± 0.122	3.999AlaPhe: 3.999 ± 0.074	9.993AlaGly: 9.993 ± 0.138	2.52AlaHis: 2.52 ± 0.065	5.73AlaIle: 5.73 ± 0.09	4.433AlaLys: 4.433 ± 0.116	14.046AlaLeu: 14.046 ± 0.159	3.776AlaMet: 3.776 ± 0.074	3.286AlaAsn: 3.286 ± 0.076	5.573AlaPro: 5.573 ± 0.11	4.852AlaGln: 4.852 ± 0.092	8.622AlaArg: 8.622 ± 0.114	6.787AlaSer: 6.787 ± 0.099	5.962AlaThr: 5.962 ± 0.101	7.65AlaVal: 7.65 ± 0.122	1.966AlaTrp: 1.966 ± 0.055	2.405AlaTyr: 2.405 ± 0.059	0.0AlaXaa: 0.0 ± 0.0
Cys	0.895CysAla: 0.895 ± 0.038	0.089CysCys: 0.089 ± 0.011	0.508CysAsp: 0.508 ± 0.026	0.446CysGlu: 0.446 ± 0.025	0.267CysPhe: 0.267 ± 0.019	0.851CysGly: 0.851 ± 0.035	0.207CysHis: 0.207 ± 0.015	0.375CysIle: 0.375 ± 0.022	0.212CysLys: 0.212 ± 0.016	0.678CysLeu: 0.678 ± 0.028	0.165CysMet: 0.165 ± 0.015	0.222CysAsn: 0.222 ± 0.018	0.421CysPro: 0.421 ± 0.026	0.21CysGln: 0.21 ± 0.017	0.539CysArg: 0.539 ± 0.03	0.413CysSer: 0.413 ± 0.023	0.436CysThr: 0.436 ± 0.029	0.679CysVal: 0.679 ± 0.031	0.091CysTrp: 0.091 ± 0.011	0.166CysTyr: 0.166 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	9.03AspAla: 9.03 ± 0.126	0.408AspCys: 0.408 ± 0.023	3.805AspAsp: 3.805 ± 0.075	3.754AspGlu: 3.754 ± 0.075	2.297AspPhe: 2.297 ± 0.059	5.626AspGly: 5.626 ± 0.105	1.236AspHis: 1.236 ± 0.042	3.198AspIle: 3.198 ± 0.065	1.934AspLys: 1.934 ± 0.052	5.369AspLeu: 5.369 ± 0.089	1.313AspMet: 1.313 ± 0.04	1.55AspAsn: 1.55 ± 0.049	3.039AspPro: 3.039 ± 0.069	1.768AspGln: 1.768 ± 0.044	3.808AspArg: 3.808 ± 0.07	2.536AspSer: 2.536 ± 0.057	2.85AspThr: 2.85 ± 0.071	4.896AspVal: 4.896 ± 0.088	1.106AspTrp: 1.106 ± 0.039	1.652AspTyr: 1.652 ± 0.053	0.0AspXaa: 0.0 ± 0.0
Glu	7.327GluAla: 7.327 ± 0.131	0.366GluCys: 0.366 ± 0.022	2.729GluAsp: 2.729 ± 0.06	2.751GluGlu: 2.751 ± 0.071	1.875GluPhe: 1.875 ± 0.062	4.35GluGly: 4.35 ± 0.082	1.341GluHis: 1.341 ± 0.044	2.829GluIle: 2.829 ± 0.052	1.894GluLys: 1.894 ± 0.059	5.657GluLeu: 5.657 ± 0.109	1.389GluMet: 1.389 ± 0.045	1.393GluAsn: 1.393 ± 0.044	2.288GluPro: 2.288 ± 0.056	2.217GluGln: 2.217 ± 0.055	5.022GluArg: 5.022 ± 0.101	2.888GluSer: 2.888 ± 0.07	2.794GluThr: 2.794 ± 0.066	4.202GluVal: 4.202 ± 0.089	0.833GluTrp: 0.833 ± 0.033	1.235GluTyr: 1.235 ± 0.047	0.0GluXaa: 0.0 ± 0.0
Phe	4.093PheAla: 4.093 ± 0.079	0.319PheCys: 0.319 ± 0.016	2.909PheAsp: 2.909 ± 0.057	1.955PheGlu: 1.955 ± 0.047	1.193PhePhe: 1.193 ± 0.044	3.322PheGly: 3.322 ± 0.073	0.764PheHis: 0.764 ± 0.028	1.534PheIle: 1.534 ± 0.044	1.048PheLys: 1.048 ± 0.044	2.933PheLeu: 2.933 ± 0.074	0.763PheMet: 0.763 ± 0.034	1.216PheAsn: 1.216 ± 0.045	1.389PhePro: 1.389 ± 0.042	0.928PheGln: 0.928 ± 0.032	2.068PheArg: 2.068 ± 0.059	1.988PheSer: 1.988 ± 0.058	1.717PheThr: 1.717 ± 0.05	2.545PheVal: 2.545 ± 0.056	0.531PheTrp: 0.531 ± 0.031	0.827PheTyr: 0.827 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	8.26GlyAla: 8.26 ± 0.133	0.775GlyCys: 0.775 ± 0.035	5.081GlyAsp: 5.081 ± 0.078	4.983GlyGlu: 4.983 ± 0.089	3.397GlyPhe: 3.397 ± 0.072	7.046GlyGly: 7.046 ± 0.137	2.003GlyHis: 2.003 ± 0.052	4.512GlyIle: 4.512 ± 0.085	3.652GlyLys: 3.652 ± 0.075	8.463GlyLeu: 8.463 ± 0.109	2.578GlyMet: 2.578 ± 0.055	2.585GlyAsn: 2.585 ± 0.065	2.901GlyPro: 2.901 ± 0.068	3.122GlyGln: 3.122 ± 0.07	5.719GlyArg: 5.719 ± 0.097	4.512GlySer: 4.512 ± 0.095	4.046GlyThr: 4.046 ± 0.079	6.288GlyVal: 6.288 ± 0.082	1.739GlyTrp: 1.739 ± 0.049	2.316GlyTyr: 2.316 ± 0.062	0.0GlyXaa: 0.0 ± 0.0
His	2.888HisAla: 2.888 ± 0.078	0.222HisCys: 0.222 ± 0.016	1.393HisAsp: 1.393 ± 0.047	1.18HisGlu: 1.18 ± 0.042	0.828HisPhe: 0.828 ± 0.033	2.213HisGly: 2.213 ± 0.055	0.656HisHis: 0.656 ± 0.032	0.935HisIle: 0.935 ± 0.034	0.584HisLys: 0.584 ± 0.028	2.127HisLeu: 2.127 ± 0.053	0.48HisMet: 0.48 ± 0.028	0.505HisAsn: 0.505 ± 0.025	1.448HisPro: 1.448 ± 0.046	0.628HisGln: 0.628 ± 0.027	1.655HisArg: 1.655 ± 0.046	0.936HisSer: 0.936 ± 0.038	0.976HisThr: 0.976 ± 0.035	1.726HisVal: 1.726 ± 0.052	0.428HisTrp: 0.428 ± 0.024	0.63HisTyr: 0.63 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	7.02IleAla: 7.02 ± 0.102	0.375IleCys: 0.375 ± 0.024	3.985IleAsp: 3.985 ± 0.072	3.442IleGlu: 3.442 ± 0.078	1.314IlePhe: 1.314 ± 0.049	4.79IleGly: 4.79 ± 0.088	0.968IleHis: 0.968 ± 0.036	1.791IleIle: 1.791 ± 0.053	1.505IleLys: 1.505 ± 0.04	3.424IleLeu: 3.424 ± 0.069	0.665IleMet: 0.665 ± 0.028	1.47IleAsn: 1.47 ± 0.042	2.452IlePro: 2.452 ± 0.056	1.277IleGln: 1.277 ± 0.044	3.005IleArg: 3.005 ± 0.064	2.442IleSer: 2.442 ± 0.058	2.553IleThr: 2.553 ± 0.056	3.495IleVal: 3.495 ± 0.078	0.496IleTrp: 0.496 ± 0.029	0.959IleTyr: 0.959 ± 0.033	0.0IleXaa: 0.0 ± 0.0
Lys	3.962LysAla: 3.962 ± 0.098	0.148LysCys: 0.148 ± 0.015	1.82LysAsp: 1.82 ± 0.051	1.573LysGlu: 1.573 ± 0.049	0.972LysPhe: 0.972 ± 0.037	2.427LysGly: 2.427 ± 0.065	0.746LysHis: 0.746 ± 0.034	1.508LysIle: 1.508 ± 0.044	1.516LysLys: 1.516 ± 0.101	3.743LysLeu: 3.743 ± 0.081	0.829LysMet: 0.829 ± 0.032	0.845LysAsn: 0.845 ± 0.033	2.37LysPro: 2.37 ± 0.06	1.511LysGln: 1.511 ± 0.047	2.716LysArg: 2.716 ± 0.06	1.866LysSer: 1.866 ± 0.049	1.948LysThr: 1.948 ± 0.044	2.509LysVal: 2.509 ± 0.069	0.408LysTrp: 0.408 ± 0.022	0.719LysTyr: 0.719 ± 0.027	0.0LysXaa: 0.0 ± 0.0
Leu	13.324LeuAla: 13.324 ± 0.144	0.854LeuCys: 0.854 ± 0.035	6.506LeuAsp: 6.506 ± 0.101	5.115LeuGlu: 5.115 ± 0.089	3.221LeuPhe: 3.221 ± 0.077	8.293LeuGly: 8.293 ± 0.114	2.374LeuHis: 2.374 ± 0.067	4.65LeuIle: 4.65 ± 0.087	3.568LeuLys: 3.568 ± 0.076	10.695LeuLeu: 10.695 ± 0.178	2.591LeuMet: 2.591 ± 0.057	2.43LeuAsn: 2.43 ± 0.06	6.13LeuPro: 6.13 ± 0.097	3.799LeuGln: 3.799 ± 0.069	7.977LeuArg: 7.977 ± 0.126	6.021LeuSer: 6.021 ± 0.084	4.947LeuThr: 4.947 ± 0.073	7.127LeuVal: 7.127 ± 0.107	1.339LeuTrp: 1.339 ± 0.044	2.104LeuTyr: 2.104 ± 0.056	0.0LeuXaa: 0.0 ± 0.0
Met	2.964MetAla: 2.964 ± 0.076	0.161MetCys: 0.161 ± 0.016	1.339MetAsp: 1.339 ± 0.042	1.081MetGlu: 1.081 ± 0.04	0.787MetPhe: 0.787 ± 0.032	1.893MetGly: 1.893 ± 0.045	0.566MetHis: 0.566 ± 0.028	1.033MetIle: 1.033 ± 0.036	1.084MetLys: 1.084 ± 0.036	2.797MetLeu: 2.797 ± 0.06	0.602MetMet: 0.602 ± 0.031	0.809MetAsn: 0.809 ± 0.033	1.741MetPro: 1.741 ± 0.046	1.15MetGln: 1.15 ± 0.045	2.137MetArg: 2.137 ± 0.05	1.865MetSer: 1.865 ± 0.043	1.591MetThr: 1.591 ± 0.043	1.667MetVal: 1.667 ± 0.047	0.274MetTrp: 0.274 ± 0.021	0.399MetTyr: 0.399 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	3.58AsnAla: 3.58 ± 0.062	0.228AsnCys: 0.228 ± 0.02	1.625AsnAsp: 1.625 ± 0.045	1.454AsnGlu: 1.454 ± 0.043	0.986AsnPhe: 0.986 ± 0.039	2.549AsnGly: 2.549 ± 0.073	0.557AsnHis: 0.557 ± 0.024	1.355AsnIle: 1.355 ± 0.038	0.841AsnLys: 0.841 ± 0.036	2.506AsnLeu: 2.506 ± 0.061	0.543AsnMet: 0.543 ± 0.027	0.772AsnAsn: 0.772 ± 0.041	1.88AsnPro: 1.88 ± 0.047	0.883AsnGln: 0.883 ± 0.037	1.848AsnArg: 1.848 ± 0.051	1.308AsnSer: 1.308 ± 0.042	1.528AsnThr: 1.528 ± 0.049	1.943AsnVal: 1.943 ± 0.062	0.437AsnTrp: 0.437 ± 0.027	0.674AsnTyr: 0.674 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	6.38ProAla: 6.38 ± 0.116	0.318ProCys: 0.318 ± 0.023	3.53ProAsp: 3.53 ± 0.065	3.244ProGlu: 3.244 ± 0.066	1.557ProPhe: 1.557 ± 0.044	4.422ProGly: 4.422 ± 0.078	1.027ProHis: 1.027 ± 0.035	2.182ProIle: 2.182 ± 0.053	1.759ProLys: 1.759 ± 0.046	5.009ProLeu: 5.009 ± 0.084	1.517ProMet: 1.517 ± 0.051	1.415ProAsn: 1.415 ± 0.05	2.56ProPro: 2.56 ± 0.085	1.935ProGln: 1.935 ± 0.053	3.202ProArg: 3.202 ± 0.064	2.767ProSer: 2.767 ± 0.064	2.634ProThr: 2.634 ± 0.076	4.094ProVal: 4.094 ± 0.082	0.802ProTrp: 0.802 ± 0.036	1.187ProTyr: 1.187 ± 0.04	0.0ProXaa: 0.0 ± 0.0
Gln	5.009GlnAla: 5.009 ± 0.081	0.247GlnCys: 0.247 ± 0.018	1.652GlnAsp: 1.652 ± 0.056	1.429GlnGlu: 1.429 ± 0.046	1.124GlnPhe: 1.124 ± 0.038	2.796GlnGly: 2.796 ± 0.065	0.819GlnHis: 0.819 ± 0.031	1.647GlnIle: 1.647 ± 0.046	1.148GlnLys: 1.148 ± 0.038	4.082GlnLeu: 4.082 ± 0.072	0.919GlnMet: 0.919 ± 0.035	0.826GlnAsn: 0.826 ± 0.04	2.225GlnPro: 2.225 ± 0.06	1.856GlnGln: 1.856 ± 0.055	3.243GlnArg: 3.243 ± 0.07	1.966GlnSer: 1.966 ± 0.057	1.643GlnThr: 1.643 ± 0.042	2.846GlnVal: 2.846 ± 0.062	0.57GlnTrp: 0.57 ± 0.025	0.778GlnTyr: 0.778 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	7.662ArgAla: 7.662 ± 0.121	0.504ArgCys: 0.504 ± 0.028	4.848ArgAsp: 4.848 ± 0.083	4.694ArgGlu: 4.694 ± 0.085	2.792ArgPhe: 2.792 ± 0.06	5.277ArgGly: 5.277 ± 0.101	1.836ArgHis: 1.836 ± 0.048	4.132ArgIle: 4.132 ± 0.074	2.339ArgLys: 2.339 ± 0.062	7.518ArgLeu: 7.518 ± 0.114	2.146ArgMet: 2.146 ± 0.06	2.087ArgAsn: 2.087 ± 0.049	3.095ArgPro: 3.095 ± 0.059	2.652ArgGln: 2.652 ± 0.056	5.173ArgArg: 5.173 ± 0.105	3.549ArgSer: 3.549 ± 0.066	3.138ArgThr: 3.138 ± 0.066	5.106ArgVal: 5.106 ± 0.088	1.376ArgTrp: 1.376 ± 0.041	2.181ArgTyr: 2.181 ± 0.052	0.0ArgXaa: 0.0 ± 0.0
Ser	6.046SerAla: 6.046 ± 0.089	0.373SerCys: 0.373 ± 0.023	3.023SerAsp: 3.023 ± 0.054	2.815SerGlu: 2.815 ± 0.057	1.88SerPhe: 1.88 ± 0.049	5.158SerGly: 5.158 ± 0.088	1.289SerHis: 1.289 ± 0.036	2.52SerIle: 2.52 ± 0.058	1.849SerLys: 1.849 ± 0.056	5.568SerLeu: 5.568 ± 0.087	1.449SerMet: 1.449 ± 0.046	1.601SerAsn: 1.601 ± 0.049	2.932SerPro: 2.932 ± 0.063	1.961SerGln: 1.961 ± 0.046	3.734SerArg: 3.734 ± 0.067	3.021SerSer: 3.021 ± 0.085	2.881SerThr: 2.881 ± 0.063	3.662SerVal: 3.662 ± 0.069	0.784SerTrp: 0.784 ± 0.033	1.179SerTyr: 1.179 ± 0.046	0.0SerXaa: 0.0 ± 0.0
Thr	5.495ThrAla: 5.495 ± 0.092	0.419ThrCys: 0.419 ± 0.025	2.742ThrAsp: 2.742 ± 0.06	2.349ThrGlu: 2.349 ± 0.056	1.537ThrPhe: 1.537 ± 0.044	4.467ThrGly: 4.467 ± 0.082	1.166ThrHis: 1.166 ± 0.039	2.105ThrIle: 2.105 ± 0.054	1.295ThrLys: 1.295 ± 0.048	5.99ThrLeu: 5.99 ± 0.107	1.135ThrMet: 1.135 ± 0.036	1.272ThrAsn: 1.272 ± 0.048	3.453ThrPro: 3.453 ± 0.074	1.816ThrGln: 1.816 ± 0.052	3.518ThrArg: 3.518 ± 0.07	2.801ThrSer: 2.801 ± 0.064	2.681ThrThr: 2.681 ± 0.071	3.786ThrVal: 3.786 ± 0.083	0.67ThrTrp: 0.67 ± 0.027	1.137ThrTyr: 1.137 ± 0.038	0.0ThrXaa: 0.0 ± 0.0
Val	8.64ValAla: 8.64 ± 0.112	0.625ValCys: 0.625 ± 0.03	4.745ValAsp: 4.745 ± 0.084	4.355ValGlu: 4.355 ± 0.091	2.47ValPhe: 2.47 ± 0.056	5.499ValGly: 5.499 ± 0.089	1.506ValHis: 1.506 ± 0.048	3.814ValIle: 3.814 ± 0.069	2.292ValLys: 2.292 ± 0.056	7.794ValLeu: 7.794 ± 0.1	2.043ValMet: 2.043 ± 0.058	2.078ValAsn: 2.078 ± 0.063	3.696ValPro: 3.696 ± 0.07	2.481ValGln: 2.481 ± 0.058	4.798ValArg: 4.798 ± 0.078	3.967ValSer: 3.967 ± 0.082	3.673ValThr: 3.673 ± 0.093	5.836ValVal: 5.836 ± 0.109	0.962ValTrp: 0.962 ± 0.036	1.403ValTyr: 1.403 ± 0.042	0.0ValXaa: 0.0 ± 0.0
Trp	1.334TrpAla: 1.334 ± 0.039	0.141TrpCys: 0.141 ± 0.013	0.664TrpAsp: 0.664 ± 0.027	0.54TrpGlu: 0.54 ± 0.03	0.642TrpPhe: 0.642 ± 0.031	0.985TrpGly: 0.985 ± 0.039	0.391TrpHis: 0.391 ± 0.023	0.691TrpIle: 0.691 ± 0.033	0.539TrpLys: 0.539 ± 0.024	2.353TrpLeu: 2.353 ± 0.063	0.554TrpMet: 0.554 ± 0.03	0.468TrpAsn: 0.468 ± 0.03	0.77TrpPro: 0.77 ± 0.03	0.886TrpGln: 0.886 ± 0.037	1.385TrpArg: 1.385 ± 0.048	0.892TrpSer: 0.892 ± 0.035	0.682TrpThr: 0.682 ± 0.027	0.999TrpVal: 0.999 ± 0.038	0.354TrpTrp: 0.354 ± 0.024	0.307TrpTyr: 0.307 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.787TyrAla: 2.787 ± 0.067	0.192TyrCys: 0.192 ± 0.015	1.395TyrAsp: 1.395 ± 0.046	1.105TyrGlu: 1.105 ± 0.038	0.901TyrPhe: 0.901 ± 0.037	2.021TyrGly: 2.021 ± 0.062	0.466TyrHis: 0.466 ± 0.025	0.887TyrIle: 0.887 ± 0.033	0.643TyrLys: 0.643 ± 0.029	2.312TyrLeu: 2.312 ± 0.052	0.478TyrMet: 0.478 ± 0.025	0.669TyrAsn: 0.669 ± 0.035	1.182TyrPro: 1.182 ± 0.04	0.894TyrGln: 0.894 ± 0.036	1.937TyrArg: 1.937 ± 0.05	1.201TyrSer: 1.201 ± 0.039	1.157TyrThr: 1.157 ± 0.05	1.62TyrVal: 1.62 ± 0.052	0.41TyrTrp: 0.41 ± 0.023	0.601TyrTyr: 0.601 ± 0.033	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2386 proteins (777642 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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