Amino acid dipepetide frequency for Candidatus Tokpelaia sp.

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
20.78AlaAla: 20.78 ± 0.355
1.335AlaCys: 1.335 ± 0.057
6.749AlaAsp: 6.749 ± 0.136
8.517AlaGlu: 8.517 ± 0.164
4.572AlaPhe: 4.572 ± 0.102
11.616AlaGly: 11.616 ± 0.208
2.166AlaHis: 2.166 ± 0.065
6.002AlaIle: 6.002 ± 0.113
5.401AlaLys: 5.401 ± 0.114
13.028AlaLeu: 13.028 ± 0.19
2.964AlaMet: 2.964 ± 0.079
3.464AlaAsn: 3.464 ± 0.102
5.366AlaPro: 5.366 ± 0.113
5.265AlaGln: 5.265 ± 0.128
7.932AlaArg: 7.932 ± 0.126
4.262AlaSer: 4.262 ± 0.098
4.109AlaThr: 4.109 ± 0.146
8.764AlaVal: 8.764 ± 0.132
1.316AlaTrp: 1.316 ± 0.055
3.023AlaTyr: 3.023 ± 0.09
0.0AlaXaa: 0.0 ± 0.0
Cys
1.226CysAla: 1.226 ± 0.046
0.249CysCys: 0.249 ± 0.023
0.496CysAsp: 0.496 ± 0.033
0.435CysGlu: 0.435 ± 0.029
0.632CysPhe: 0.632 ± 0.039
1.171CysGly: 1.171 ± 0.047
0.251CysHis: 0.251 ± 0.023
0.483CysIle: 0.483 ± 0.031
0.359CysLys: 0.359 ± 0.028
1.329CysLeu: 1.329 ± 0.055
0.149CysMet: 0.149 ± 0.016
0.336CysAsn: 0.336 ± 0.024
0.524CysPro: 0.524 ± 0.035
0.304CysGln: 0.304 ± 0.022
1.034CysArg: 1.034 ± 0.049
0.618CysSer: 0.618 ± 0.033
0.426CysThr: 0.426 ± 0.043
0.546CysVal: 0.546 ± 0.032
0.105CysTrp: 0.105 ± 0.013
0.282CysTyr: 0.282 ± 0.026
0.0CysXaa: 0.0 ± 0.0
Asp
3.877AspAla: 3.877 ± 0.11
0.5AspCys: 0.5 ± 0.031
2.17AspAsp: 2.17 ± 0.075
2.732AspGlu: 2.732 ± 0.082
2.609AspPhe: 2.609 ± 0.068
3.281AspGly: 3.281 ± 0.087
0.701AspHis: 0.701 ± 0.042
4.284AspIle: 4.284 ± 0.111
4.251AspLys: 4.251 ± 0.104
4.059AspLeu: 4.059 ± 0.095
1.445AspMet: 1.445 ± 0.056
2.553AspAsn: 2.553 ± 0.091
1.724AspPro: 1.724 ± 0.07
0.916AspGln: 0.916 ± 0.044
2.824AspArg: 2.824 ± 0.075
2.999AspSer: 2.999 ± 0.099
2.188AspThr: 2.188 ± 0.091
2.076AspVal: 2.076 ± 0.065
0.828AspTrp: 0.828 ± 0.045
1.989AspTyr: 1.989 ± 0.058
0.0AspXaa: 0.0 ± 0.0
Glu
7.024GluAla: 7.024 ± 0.146
0.334GluCys: 0.334 ± 0.024
2.387GluAsp: 2.387 ± 0.072
3.976GluGlu: 3.976 ± 0.113
1.796GluPhe: 1.796 ± 0.056
3.436GluGly: 3.436 ± 0.082
1.066GluHis: 1.066 ± 0.047
4.087GluIle: 4.087 ± 0.096
4.301GluLys: 4.301 ± 0.097
4.463GluLeu: 4.463 ± 0.114
1.386GluMet: 1.386 ± 0.055
2.627GluAsn: 2.627 ± 0.074
2.114GluPro: 2.114 ± 0.071
2.907GluGln: 2.907 ± 0.081
3.691GluArg: 3.691 ± 0.088
2.225GluSer: 2.225 ± 0.072
3.176GluThr: 3.176 ± 0.077
2.561GluVal: 2.561 ± 0.081
0.568GluTrp: 0.568 ± 0.032
1.143GluTyr: 1.143 ± 0.046
0.0GluXaa: 0.0 ± 0.0
Phe
5.431PheAla: 5.431 ± 0.126
0.824PheCys: 0.824 ± 0.045
2.179PheAsp: 2.179 ± 0.068
1.661PheGlu: 1.661 ± 0.058
1.995PhePhe: 1.995 ± 0.083
3.493PheGly: 3.493 ± 0.102
0.806PheHis: 0.806 ± 0.042
3.204PheIle: 3.204 ± 0.085
1.359PheLys: 1.359 ± 0.053
4.065PheLeu: 4.065 ± 0.099
1.077PheMet: 1.077 ± 0.052
1.412PheAsn: 1.412 ± 0.047
1.606PhePro: 1.606 ± 0.059
1.051PheGln: 1.051 ± 0.045
2.135PheArg: 2.135 ± 0.073
3.003PheSer: 3.003 ± 0.089
2.173PheThr: 2.173 ± 0.095
2.409PheVal: 2.409 ± 0.067
0.544PheTrp: 0.544 ± 0.035
1.558PheTyr: 1.558 ± 0.06
0.0PheXaa: 0.0 ± 0.0
Gly
8.677GlyAla: 8.677 ± 0.168
0.809GlyCys: 0.809 ± 0.041
3.792GlyAsp: 3.792 ± 0.112
4.371GlyGlu: 4.371 ± 0.091
3.74GlyPhe: 3.74 ± 0.081
6.795GlyGly: 6.795 ± 0.167
1.469GlyHis: 1.469 ± 0.057
4.194GlyIle: 4.194 ± 0.091
4.787GlyLys: 4.787 ± 0.103
8.144GlyLeu: 8.144 ± 0.158
1.622GlyMet: 1.622 ± 0.052
2.879GlyAsn: 2.879 ± 0.088
1.897GlyPro: 1.897 ± 0.06
3.421GlyGln: 3.421 ± 0.077
6.174GlyArg: 6.174 ± 0.12
4.546GlySer: 4.546 ± 0.123
3.991GlyThr: 3.991 ± 0.176
4.249GlyVal: 4.249 ± 0.091
1.029GlyTrp: 1.029 ± 0.052
2.098GlyTyr: 2.098 ± 0.062
0.0GlyXaa: 0.0 ± 0.0
His
1.617HisAla: 1.617 ± 0.054
0.3HisCys: 0.3 ± 0.03
0.863HisAsp: 0.863 ± 0.043
0.959HisGlu: 0.959 ± 0.043
1.025HisPhe: 1.025 ± 0.039
1.545HisGly: 1.545 ± 0.05
0.433HisHis: 0.433 ± 0.033
1.703HisIle: 1.703 ± 0.059
1.202HisLys: 1.202 ± 0.05
1.74HisLeu: 1.74 ± 0.064
0.518HisMet: 0.518 ± 0.03
0.979HisAsn: 0.979 ± 0.044
0.796HisPro: 0.796 ± 0.037
0.492HisGln: 0.492 ± 0.029
1.2HisArg: 1.2 ± 0.051
1.106HisSer: 1.106 ± 0.047
0.579HisThr: 0.579 ± 0.032
0.861HisVal: 0.861 ± 0.041
0.289HisTrp: 0.289 ± 0.023
1.016HisTyr: 1.016 ± 0.046
0.0HisXaa: 0.0 ± 0.0
Ile
8.426IleAla: 8.426 ± 0.139
0.914IleCys: 0.914 ± 0.042
3.497IleAsp: 3.497 ± 0.088
3.418IleGlu: 3.418 ± 0.089
2.627IlePhe: 2.627 ± 0.078
5.178IleGly: 5.178 ± 0.128
1.016IleHis: 1.016 ± 0.044
5.164IleIle: 5.164 ± 0.116
3.007IleLys: 3.007 ± 0.082
5.744IleLeu: 5.744 ± 0.112
1.816IleMet: 1.816 ± 0.063
1.96IleAsn: 1.96 ± 0.064
2.264IlePro: 2.264 ± 0.078
1.25IleGln: 1.25 ± 0.055
3.272IleArg: 3.272 ± 0.085
3.421IleSer: 3.421 ± 0.083
3.103IleThr: 3.103 ± 0.104
3.798IleVal: 3.798 ± 0.082
0.651IleTrp: 0.651 ± 0.038
1.912IleTyr: 1.912 ± 0.067
0.0IleXaa: 0.0 ± 0.0
Lys
6.813LysAla: 6.813 ± 0.128
0.273LysCys: 0.273 ± 0.024
2.207LysAsp: 2.207 ± 0.073
2.662LysGlu: 2.662 ± 0.088
1.495LysPhe: 1.495 ± 0.056
3.692LysGly: 3.692 ± 0.08
0.876LysHis: 0.876 ± 0.037
3.834LysIle: 3.834 ± 0.106
3.294LysLys: 3.294 ± 0.088
4.347LysLeu: 4.347 ± 0.111
1.362LysMet: 1.362 ± 0.054
2.538LysAsn: 2.538 ± 0.075
2.487LysPro: 2.487 ± 0.078
2.291LysGln: 2.291 ± 0.068
3.114LysArg: 3.114 ± 0.093
2.903LysSer: 2.903 ± 0.076
3.449LysThr: 3.449 ± 0.085
2.146LysVal: 2.146 ± 0.073
0.457LysTrp: 0.457 ± 0.03
1.202LysTyr: 1.202 ± 0.052
0.0LysXaa: 0.0 ± 0.0
Leu
12.996LeuAla: 12.996 ± 0.206
1.37LeuCys: 1.37 ± 0.056
4.555LeuAsp: 4.555 ± 0.108
4.688LeuGlu: 4.688 ± 0.098
4.128LeuPhe: 4.128 ± 0.116
6.559LeuGly: 6.559 ± 0.119
2.074LeuHis: 2.074 ± 0.064
5.429LeuIle: 5.429 ± 0.114
4.402LeuLys: 4.402 ± 0.089
10.163LeuLeu: 10.163 ± 0.209
2.146LeuMet: 2.146 ± 0.068
2.974LeuAsn: 2.974 ± 0.081
6.423LeuPro: 6.423 ± 0.122
4.281LeuGln: 4.281 ± 0.095
6.577LeuArg: 6.577 ± 0.149
6.389LeuSer: 6.389 ± 0.116
4.894LeuThr: 4.894 ± 0.147
5.634LeuVal: 5.634 ± 0.118
1.255LeuTrp: 1.255 ± 0.055
2.896LeuTyr: 2.896 ± 0.085
0.0LeuXaa: 0.0 ± 0.0
Met
3.127MetAla: 3.127 ± 0.078
0.155MetCys: 0.155 ± 0.017
0.946MetAsp: 0.946 ± 0.048
1.189MetGlu: 1.189 ± 0.051
0.607MetPhe: 0.607 ± 0.033
1.49MetGly: 1.49 ± 0.051
0.337MetHis: 0.337 ± 0.023
1.252MetIle: 1.252 ± 0.05
1.054MetLys: 1.054 ± 0.046
2.256MetLeu: 2.256 ± 0.067
0.542MetMet: 0.542 ± 0.033
0.724MetAsn: 0.724 ± 0.04
1.788MetPro: 1.788 ± 0.066
1.228MetGln: 1.228 ± 0.05
1.98MetArg: 1.98 ± 0.069
1.359MetSer: 1.359 ± 0.045
1.344MetThr: 1.344 ± 0.052
1.259MetVal: 1.259 ± 0.05
0.184MetTrp: 0.184 ± 0.017
0.273MetTyr: 0.273 ± 0.026
0.0MetXaa: 0.0 ± 0.0
Asn
3.919AsnAla: 3.919 ± 0.109
0.367AsnCys: 0.367 ± 0.025
1.353AsnAsp: 1.353 ± 0.063
1.532AsnGlu: 1.532 ± 0.062
1.65AsnPhe: 1.65 ± 0.061
3.069AsnGly: 3.069 ± 0.11
0.619AsnHis: 0.619 ± 0.032
3.337AsnIle: 3.337 ± 0.098
1.718AsnLys: 1.718 ± 0.059
3.521AsnLeu: 3.521 ± 0.101
0.953AsnMet: 0.953 ± 0.042
1.622AsnAsn: 1.622 ± 0.085
1.965AsnPro: 1.965 ± 0.077
0.96AsnGln: 0.96 ± 0.047
2.404AsnArg: 2.404 ± 0.063
2.345AsnSer: 2.345 ± 0.087
1.666AsnThr: 1.666 ± 0.1
1.995AsnVal: 1.995 ± 0.073
0.507AsnTrp: 0.507 ± 0.031
1.224AsnTyr: 1.224 ± 0.054
0.0AsnXaa: 0.0 ± 0.0
Pro
7.042ProAla: 7.042 ± 0.158
0.518ProCys: 0.518 ± 0.059
2.585ProAsp: 2.585 ± 0.079
3.071ProGlu: 3.071 ± 0.083
2.107ProPhe: 2.107 ± 0.065
3.645ProGly: 3.645 ± 0.082
1.042ProHis: 1.042 ± 0.045
2.067ProIle: 2.067 ± 0.062
1.808ProLys: 1.808 ± 0.064
4.712ProLeu: 4.712 ± 0.104
0.852ProMet: 0.852 ± 0.039
1.189ProAsn: 1.189 ± 0.056
2.671ProPro: 2.671 ± 0.082
2.422ProGln: 2.422 ± 0.075
2.232ProArg: 2.232 ± 0.067
1.661ProSer: 1.661 ± 0.052
1.447ProThr: 1.447 ± 0.058
3.963ProVal: 3.963 ± 0.083
0.487ProTrp: 0.487 ± 0.027
1.355ProTyr: 1.355 ± 0.049
0.0ProXaa: 0.0 ± 0.0
Gln
5.954GlnAla: 5.954 ± 0.13
0.308GlnCys: 0.308 ± 0.023
1.615GlnAsp: 1.615 ± 0.056
2.203GlnGlu: 2.203 ± 0.076
1.283GlnPhe: 1.283 ± 0.047
2.821GlnGly: 2.821 ± 0.083
0.713GlnHis: 0.713 ± 0.039
2.562GlnIle: 2.562 ± 0.063
2.986GlnLys: 2.986 ± 0.071
2.933GlnLeu: 2.933 ± 0.077
1.032GlnMet: 1.032 ± 0.045
1.984GlnAsn: 1.984 ± 0.078
1.655GlnPro: 1.655 ± 0.061
1.993GlnGln: 1.993 ± 0.077
2.33GlnArg: 2.33 ± 0.073
2.186GlnSer: 2.186 ± 0.067
2.061GlnThr: 2.061 ± 0.071
1.792GlnVal: 1.792 ± 0.06
0.444GlnTrp: 0.444 ± 0.03
0.903GlnTyr: 0.903 ± 0.043
0.0GlnXaa: 0.0 ± 0.0
Arg
6.909ArgAla: 6.909 ± 0.144
0.573ArgCys: 0.573 ± 0.03
2.979ArgAsp: 2.979 ± 0.078
3.523ArgGlu: 3.523 ± 0.09
3.162ArgPhe: 3.162 ± 0.079
4.109ArgGly: 4.109 ± 0.103
1.7ArgHis: 1.7 ± 0.058
3.479ArgIle: 3.479 ± 0.09
3.021ArgLys: 3.021 ± 0.092
8.426ArgLeu: 8.426 ± 0.156
1.058ArgMet: 1.058 ± 0.043
2.271ArgAsn: 2.271 ± 0.063
3.637ArgPro: 3.637 ± 0.093
3.862ArgGln: 3.862 ± 0.089
5.567ArgArg: 5.567 ± 0.134
3.053ArgSer: 3.053 ± 0.072
1.965ArgThr: 1.965 ± 0.07
3.15ArgVal: 3.15 ± 0.083
0.553ArgTrp: 0.553 ± 0.036
1.746ArgTyr: 1.746 ± 0.06
0.0ArgXaa: 0.0 ± 0.0
Ser
6.437SerAla: 6.437 ± 0.109
0.594SerCys: 0.594 ± 0.03
2.627SerAsp: 2.627 ± 0.082
2.295SerGlu: 2.295 ± 0.086
2.782SerPhe: 2.782 ± 0.072
5.578SerGly: 5.578 ± 0.125
0.992SerHis: 0.992 ± 0.044
2.57SerIle: 2.57 ± 0.073
1.88SerLys: 1.88 ± 0.066
6.0SerLeu: 6.0 ± 0.103
1.025SerMet: 1.025 ± 0.044
1.65SerAsn: 1.65 ± 0.061
2.597SerPro: 2.597 ± 0.076
1.608SerGln: 1.608 ± 0.06
3.53SerArg: 3.53 ± 0.079
3.044SerSer: 3.044 ± 0.095
2.137SerThr: 2.137 ± 0.089
3.245SerVal: 3.245 ± 0.091
0.614SerTrp: 0.614 ± 0.031
1.595SerTyr: 1.595 ± 0.071
0.0SerXaa: 0.0 ± 0.0
Thr
6.568ThrAla: 6.568 ± 0.189
0.402ThrCys: 0.402 ± 0.031
2.297ThrAsp: 2.297 ± 0.112
2.524ThrGlu: 2.524 ± 0.071
1.252ThrPhe: 1.252 ± 0.05
4.747ThrGly: 4.747 ± 0.129
0.848ThrHis: 0.848 ± 0.039
2.955ThrIle: 2.955 ± 0.069
1.768ThrLys: 1.768 ± 0.066
4.046ThrLeu: 4.046 ± 0.157
1.032ThrMet: 1.032 ± 0.044
1.768ThrAsn: 1.768 ± 0.18
2.282ThrPro: 2.282 ± 0.083
1.574ThrGln: 1.574 ± 0.06
2.36ThrArg: 2.36 ± 0.06
1.973ThrSer: 1.973 ± 0.081
1.965ThrThr: 1.965 ± 0.147
3.39ThrVal: 3.39 ± 0.103
0.323ThrTrp: 0.323 ± 0.025
1.22ThrTyr: 1.22 ± 0.089
0.0ThrXaa: 0.0 ± 0.0
Val
5.781ValAla: 5.781 ± 0.108
0.566ValCys: 0.566 ± 0.036
2.68ValAsp: 2.68 ± 0.077
3.689ValGlu: 3.689 ± 0.089
2.763ValPhe: 2.763 ± 0.074
3.46ValGly: 3.46 ± 0.082
1.051ValHis: 1.051 ± 0.048
3.445ValIle: 3.445 ± 0.075
3.053ValLys: 3.053 ± 0.093
6.577ValLeu: 6.577 ± 0.129
1.388ValMet: 1.388 ± 0.053
2.22ValAsn: 2.22 ± 0.063
3.233ValPro: 3.233 ± 0.085
1.928ValGln: 1.928 ± 0.066
3.412ValArg: 3.412 ± 0.101
3.584ValSer: 3.584 ± 0.104
2.974ValThr: 2.974 ± 0.104
2.821ValVal: 2.821 ± 0.077
0.642ValTrp: 0.642 ± 0.032
1.416ValTyr: 1.416 ± 0.059
0.0ValXaa: 0.0 ± 0.0
Trp
1.032TrpAla: 1.032 ± 0.043
0.129TrpCys: 0.129 ± 0.016
0.431TrpAsp: 0.431 ± 0.031
0.461TrpGlu: 0.461 ± 0.029
0.498TrpPhe: 0.498 ± 0.032
0.782TrpGly: 0.782 ± 0.034
0.33TrpHis: 0.33 ± 0.023
0.514TrpIle: 0.514 ± 0.032
0.422TrpLys: 0.422 ± 0.028
1.624TrpLeu: 1.624 ± 0.075
0.092TrpMet: 0.092 ± 0.014
0.406TrpAsn: 0.406 ± 0.032
0.642TrpPro: 0.642 ± 0.037
0.925TrpGln: 0.925 ± 0.04
1.032TrpArg: 1.032 ± 0.044
0.549TrpSer: 0.549 ± 0.031
0.468TrpThr: 0.468 ± 0.032
0.605TrpVal: 0.605 ± 0.032
0.214TrpTrp: 0.214 ± 0.023
0.278TrpTyr: 0.278 ± 0.025
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.994TyrAla: 2.994 ± 0.08
0.435TyrCys: 0.435 ± 0.027
1.598TyrAsp: 1.598 ± 0.054
1.362TyrGlu: 1.362 ± 0.052
1.263TyrPhe: 1.263 ± 0.045
2.221TyrGly: 2.221 ± 0.074
0.736TyrHis: 0.736 ± 0.036
1.871TyrIle: 1.871 ± 0.066
1.368TyrLys: 1.368 ± 0.052
2.653TyrLeu: 2.653 ± 0.072
0.63TyrMet: 0.63 ± 0.038
1.172TyrAsn: 1.172 ± 0.047
1.204TyrPro: 1.204 ± 0.047
1.08TyrGln: 1.08 ± 0.052
1.943TyrArg: 1.943 ± 0.058
1.572TyrSer: 1.572 ± 0.064
1.178TyrThr: 1.178 ± 0.087
1.421TyrVal: 1.421 ± 0.054
0.426TyrTrp: 0.426 ± 0.028
0.995TyrTyr: 0.995 ± 0.042
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1880 proteins (542457 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski