Amino acid dipepetide frequency for Leptolyngbya sp. O-77

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.64AlaAla: 11.64 ± 0.126
0.944AlaCys: 0.944 ± 0.027
5.29AlaAsp: 5.29 ± 0.063
6.672AlaGlu: 6.672 ± 0.077
3.134AlaPhe: 3.134 ± 0.044
7.17AlaGly: 7.17 ± 0.078
1.762AlaHis: 1.762 ± 0.041
7.504AlaIle: 7.504 ± 0.082
2.983AlaLys: 2.983 ± 0.05
11.513AlaLeu: 11.513 ± 0.111
2.0AlaMet: 2.0 ± 0.039
3.014AlaAsn: 3.014 ± 0.058
4.829AlaPro: 4.829 ± 0.075
5.322AlaGln: 5.322 ± 0.071
5.14AlaArg: 5.14 ± 0.063
5.503AlaSer: 5.503 ± 0.069
5.196AlaThr: 5.196 ± 0.065
6.725AlaVal: 6.725 ± 0.07
1.269AlaTrp: 1.269 ± 0.033
2.403AlaTyr: 2.403 ± 0.037
0.0AlaXaa: 0.0 ± 0.0
Cys
0.718CysAla: 0.718 ± 0.023
0.173CysCys: 0.173 ± 0.011
0.644CysAsp: 0.644 ± 0.02
0.509CysGlu: 0.509 ± 0.017
0.351CysPhe: 0.351 ± 0.015
0.798CysGly: 0.798 ± 0.027
0.253CysHis: 0.253 ± 0.014
0.464CysIle: 0.464 ± 0.016
0.27CysLys: 0.27 ± 0.015
1.095CysLeu: 1.095 ± 0.028
0.18CysMet: 0.18 ± 0.011
0.292CysAsn: 0.292 ± 0.014
0.604CysPro: 0.604 ± 0.024
0.501CysGln: 0.501 ± 0.019
0.63CysArg: 0.63 ± 0.022
0.524CysSer: 0.524 ± 0.02
0.496CysThr: 0.496 ± 0.02
0.617CysVal: 0.617 ± 0.024
0.18CysTrp: 0.18 ± 0.012
0.322CysTyr: 0.322 ± 0.016
0.0CysXaa: 0.0 ± 0.0
Asp
4.815AspAla: 4.815 ± 0.06
0.556AspCys: 0.556 ± 0.023
2.42AspAsp: 2.42 ± 0.05
3.105AspGlu: 3.105 ± 0.052
2.105AspPhe: 2.105 ± 0.044
3.922AspGly: 3.922 ± 0.067
0.906AspHis: 0.906 ± 0.029
2.471AspIle: 2.471 ± 0.045
1.286AspLys: 1.286 ± 0.033
6.92AspLeu: 6.92 ± 0.074
0.846AspMet: 0.846 ± 0.026
1.315AspAsn: 1.315 ± 0.034
3.286AspPro: 3.286 ± 0.052
2.094AspGln: 2.094 ± 0.04
4.891AspArg: 4.891 ± 0.06
2.915AspSer: 2.915 ± 0.042
2.514AspThr: 2.514 ± 0.053
3.309AspVal: 3.309 ± 0.046
1.024AspTrp: 1.024 ± 0.026
1.788AspTyr: 1.788 ± 0.043
0.0AspXaa: 0.0 ± 0.0
Glu
6.573GluAla: 6.573 ± 0.075
0.443GluCys: 0.443 ± 0.018
2.665GluAsp: 2.665 ± 0.051
3.375GluGlu: 3.375 ± 0.058
2.212GluPhe: 2.212 ± 0.041
3.529GluGly: 3.529 ± 0.053
0.895GluHis: 0.895 ± 0.026
3.383GluIle: 3.383 ± 0.051
2.154GluLys: 2.154 ± 0.043
6.253GluLeu: 6.253 ± 0.075
1.423GluMet: 1.423 ± 0.033
1.8GluAsn: 1.8 ± 0.032
3.098GluPro: 3.098 ± 0.055
3.312GluGln: 3.312 ± 0.047
3.992GluArg: 3.992 ± 0.055
3.236GluSer: 3.236 ± 0.048
3.402GluThr: 3.402 ± 0.044
4.138GluVal: 4.138 ± 0.056
0.807GluTrp: 0.807 ± 0.022
1.414GluTyr: 1.414 ± 0.036
0.0GluXaa: 0.0 ± 0.0
Phe
3.297PheAla: 3.297 ± 0.042
0.529PheCys: 0.529 ± 0.02
2.118PheAsp: 2.118 ± 0.042
1.989PheGlu: 1.989 ± 0.036
1.515PhePhe: 1.515 ± 0.038
3.035PheGly: 3.035 ± 0.049
0.708PheHis: 0.708 ± 0.021
1.578PheIle: 1.578 ± 0.031
0.937PheLys: 0.937 ± 0.028
3.887PheLeu: 3.887 ± 0.062
0.62PheMet: 0.62 ± 0.018
1.281PheAsn: 1.281 ± 0.032
1.882PhePro: 1.882 ± 0.038
1.738PheGln: 1.738 ± 0.032
2.171PheArg: 2.171 ± 0.041
2.734PheSer: 2.734 ± 0.049
1.906PheThr: 1.906 ± 0.037
2.417PheVal: 2.417 ± 0.044
0.726PheTrp: 0.726 ± 0.023
1.157PheTyr: 1.157 ± 0.029
0.0PheXaa: 0.0 ± 0.0
Gly
6.325GlyAla: 6.325 ± 0.074
0.813GlyCys: 0.813 ± 0.025
4.477GlyAsp: 4.477 ± 0.079
3.908GlyGlu: 3.908 ± 0.053
2.982GlyPhe: 2.982 ± 0.055
5.649GlyGly: 5.649 ± 0.117
1.325GlyHis: 1.325 ± 0.034
4.509GlyIle: 4.509 ± 0.059
2.892GlyLys: 2.892 ± 0.05
8.146GlyLeu: 8.146 ± 0.098
1.791GlyMet: 1.791 ± 0.048
2.754GlyAsn: 2.754 ± 0.07
1.938GlyPro: 1.938 ± 0.039
3.461GlyGln: 3.461 ± 0.061
4.595GlyArg: 4.595 ± 0.059
4.5GlySer: 4.5 ± 0.062
4.21GlyThr: 4.21 ± 0.078
5.167GlyVal: 5.167 ± 0.066
1.35GlyTrp: 1.35 ± 0.035
2.369GlyTyr: 2.369 ± 0.043
0.0GlyXaa: 0.0 ± 0.0
His
1.509HisAla: 1.509 ± 0.038
0.289HisCys: 0.289 ± 0.014
0.808HisAsp: 0.808 ± 0.026
0.941HisGlu: 0.941 ± 0.026
0.773HisPhe: 0.773 ± 0.021
1.23HisGly: 1.23 ± 0.035
0.612HisHis: 0.612 ± 0.027
0.821HisIle: 0.821 ± 0.024
0.477HisLys: 0.477 ± 0.019
2.554HisLeu: 2.554 ± 0.045
0.265HisMet: 0.265 ± 0.014
0.512HisAsn: 0.512 ± 0.019
1.584HisPro: 1.584 ± 0.041
1.102HisGln: 1.102 ± 0.028
1.407HisArg: 1.407 ± 0.032
1.146HisSer: 1.146 ± 0.035
1.003HisThr: 1.003 ± 0.031
0.94HisVal: 0.94 ± 0.028
0.431HisTrp: 0.431 ± 0.018
0.676HisTyr: 0.676 ± 0.024
0.0HisXaa: 0.0 ± 0.0
Ile
7.795IleAla: 7.795 ± 0.077
0.523IleCys: 0.523 ± 0.021
3.031IleAsp: 3.031 ± 0.048
3.088IleGlu: 3.088 ± 0.047
1.774IlePhe: 1.774 ± 0.041
3.923IleGly: 3.923 ± 0.059
1.112IleHis: 1.112 ± 0.031
1.97IleIle: 1.97 ± 0.04
1.348IleLys: 1.348 ± 0.03
5.314IleLeu: 5.314 ± 0.069
0.696IleMet: 0.696 ± 0.022
1.616IleAsn: 1.616 ± 0.035
2.995IlePro: 2.995 ± 0.047
2.423IleGln: 2.423 ± 0.037
3.207IleArg: 3.207 ± 0.047
3.157IleSer: 3.157 ± 0.045
2.833IleThr: 2.833 ± 0.047
3.532IleVal: 3.532 ± 0.05
0.701IleTrp: 0.701 ± 0.022
1.416IleTyr: 1.416 ± 0.03
0.0IleXaa: 0.0 ± 0.0
Lys
3.039LysAla: 3.039 ± 0.052
0.191LysCys: 0.191 ± 0.012
1.5LysAsp: 1.5 ± 0.034
1.574LysGlu: 1.574 ± 0.035
1.011LysPhe: 1.011 ± 0.029
1.934LysGly: 1.934 ± 0.044
0.57LysHis: 0.57 ± 0.02
1.75LysIle: 1.75 ± 0.041
1.11LysLys: 1.11 ± 0.029
3.557LysLeu: 3.557 ± 0.052
0.634LysMet: 0.634 ± 0.02
0.912LysAsn: 0.912 ± 0.024
2.01LysPro: 2.01 ± 0.039
1.606LysGln: 1.606 ± 0.037
2.059LysArg: 2.059 ± 0.041
1.81LysSer: 1.81 ± 0.038
2.097LysThr: 2.097 ± 0.046
2.039LysVal: 2.039 ± 0.039
0.307LysTrp: 0.307 ± 0.015
0.724LysTyr: 0.724 ± 0.021
0.0LysXaa: 0.0 ± 0.0
Leu
11.197LeuAla: 11.197 ± 0.104
1.083LeuCys: 1.083 ± 0.026
5.967LeuAsp: 5.967 ± 0.068
7.157LeuGlu: 7.157 ± 0.076
3.765LeuPhe: 3.765 ± 0.063
8.812LeuGly: 8.812 ± 0.096
2.164LeuHis: 2.164 ± 0.05
5.411LeuIle: 5.411 ± 0.067
4.016LeuLys: 4.016 ± 0.059
12.753LeuLeu: 12.753 ± 0.139
2.398LeuMet: 2.398 ± 0.04
3.742LeuAsn: 3.742 ± 0.05
6.841LeuPro: 6.841 ± 0.075
5.613LeuGln: 5.613 ± 0.07
7.442LeuArg: 7.442 ± 0.085
8.083LeuSer: 8.083 ± 0.077
6.425LeuThr: 6.425 ± 0.07
7.961LeuVal: 7.961 ± 0.086
1.716LeuTrp: 1.716 ± 0.04
2.712LeuTyr: 2.712 ± 0.049
0.0LeuXaa: 0.0 ± 0.0
Met
2.051MetAla: 2.051 ± 0.04
0.119MetCys: 0.119 ± 0.008
0.882MetAsp: 0.882 ± 0.025
0.958MetGlu: 0.958 ± 0.026
0.484MetPhe: 0.484 ± 0.016
1.57MetGly: 1.57 ± 0.035
0.342MetHis: 0.342 ± 0.015
0.954MetIle: 0.954 ± 0.028
0.74MetLys: 0.74 ± 0.024
2.188MetLeu: 2.188 ± 0.043
0.46MetMet: 0.46 ± 0.018
0.723MetAsn: 0.723 ± 0.024
1.26MetPro: 1.26 ± 0.029
1.088MetGln: 1.088 ± 0.026
1.21MetArg: 1.21 ± 0.028
1.303MetSer: 1.303 ± 0.034
1.443MetThr: 1.443 ± 0.033
1.41MetVal: 1.41 ± 0.034
0.139MetTrp: 0.139 ± 0.011
0.309MetTyr: 0.309 ± 0.019
0.0MetXaa: 0.0 ± 0.0
Asn
2.96AsnAla: 2.96 ± 0.047
0.316AsnCys: 0.316 ± 0.016
1.431AsnAsp: 1.431 ± 0.044
1.319AsnGlu: 1.319 ± 0.033
1.239AsnPhe: 1.239 ± 0.034
2.449AsnGly: 2.449 ± 0.056
0.64AsnHis: 0.64 ± 0.02
1.418AsnIle: 1.418 ± 0.034
0.666AsnLys: 0.666 ± 0.019
4.165AsnLeu: 4.165 ± 0.07
0.472AsnMet: 0.472 ± 0.017
0.955AsnAsn: 0.955 ± 0.033
2.643AsnPro: 2.643 ± 0.048
1.674AsnGln: 1.674 ± 0.037
2.335AsnArg: 2.335 ± 0.042
1.797AsnSer: 1.797 ± 0.041
1.637AsnThr: 1.637 ± 0.036
1.807AsnVal: 1.807 ± 0.043
0.543AsnTrp: 0.543 ± 0.022
0.832AsnTyr: 0.832 ± 0.021
0.0AsnXaa: 0.0 ± 0.0
Pro
5.853ProAla: 5.853 ± 0.074
0.407ProCys: 0.407 ± 0.016
4.051ProAsp: 4.051 ± 0.063
4.122ProGlu: 4.122 ± 0.065
1.857ProPhe: 1.857 ± 0.037
3.988ProGly: 3.988 ± 0.058
1.105ProHis: 1.105 ± 0.03
2.829ProIle: 2.829 ± 0.052
1.752ProLys: 1.752 ± 0.035
5.746ProLeu: 5.746 ± 0.073
1.051ProMet: 1.051 ± 0.032
1.978ProAsn: 1.978 ± 0.045
3.765ProPro: 3.765 ± 0.102
2.733ProGln: 2.733 ± 0.042
2.64ProArg: 2.64 ± 0.041
3.702ProSer: 3.702 ± 0.067
3.398ProThr: 3.398 ± 0.062
4.245ProVal: 4.245 ± 0.068
0.719ProTrp: 0.719 ± 0.022
1.417ProTyr: 1.417 ± 0.03
0.0ProXaa: 0.0 ± 0.0
Gln
5.386GlnAla: 5.386 ± 0.077
0.357GlnCys: 0.357 ± 0.016
2.259GlnAsp: 2.259 ± 0.039
2.776GlnGlu: 2.776 ± 0.056
1.941GlnPhe: 1.941 ± 0.039
3.349GlnGly: 3.349 ± 0.054
1.046GlnHis: 1.046 ± 0.027
3.017GlnIle: 3.017 ± 0.05
1.574GlnLys: 1.574 ± 0.031
5.23GlnLeu: 5.23 ± 0.065
1.087GlnMet: 1.087 ± 0.03
1.481GlnAsn: 1.481 ± 0.031
3.287GlnPro: 3.287 ± 0.051
3.684GlnGln: 3.684 ± 0.069
3.749GlnArg: 3.749 ± 0.054
3.003GlnSer: 3.003 ± 0.048
3.075GlnThr: 3.075 ± 0.055
4.035GlnVal: 4.035 ± 0.055
0.698GlnTrp: 0.698 ± 0.026
1.082GlnTyr: 1.082 ± 0.027
0.0GlnXaa: 0.0 ± 0.0
Arg
5.325ArgAla: 5.325 ± 0.063
0.634ArgCys: 0.634 ± 0.022
3.347ArgAsp: 3.347 ± 0.052
3.554ArgGlu: 3.554 ± 0.053
2.617ArgPhe: 2.617 ± 0.047
3.879ArgGly: 3.879 ± 0.046
1.264ArgHis: 1.264 ± 0.03
3.303ArgIle: 3.303 ± 0.048
1.878ArgLys: 1.878 ± 0.038
8.046ArgLeu: 8.046 ± 0.085
1.313ArgMet: 1.313 ± 0.028
1.932ArgAsn: 1.932 ± 0.04
3.475ArgPro: 3.475 ± 0.062
4.091ArgGln: 4.091 ± 0.057
4.682ArgArg: 4.682 ± 0.064
4.446ArgSer: 4.446 ± 0.061
2.993ArgThr: 2.993 ± 0.043
4.558ArgVal: 4.558 ± 0.061
1.181ArgTrp: 1.181 ± 0.03
2.222ArgTyr: 2.222 ± 0.048
0.0ArgXaa: 0.0 ± 0.0
Ser
5.636SerAla: 5.636 ± 0.067
0.541SerCys: 0.541 ± 0.019
3.148SerAsp: 3.148 ± 0.051
3.294SerGlu: 3.294 ± 0.048
2.262SerPhe: 2.262 ± 0.049
4.962SerGly: 4.962 ± 0.07
1.261SerHis: 1.261 ± 0.039
2.917SerIle: 2.917 ± 0.046
1.728SerLys: 1.728 ± 0.038
7.547SerLeu: 7.547 ± 0.086
1.228SerMet: 1.228 ± 0.036
1.851SerAsn: 1.851 ± 0.037
4.508SerPro: 4.508 ± 0.075
3.037SerGln: 3.037 ± 0.045
3.899SerArg: 3.899 ± 0.059
4.25SerSer: 4.25 ± 0.063
3.39SerThr: 3.39 ± 0.051
4.049SerVal: 4.049 ± 0.058
0.788SerTrp: 0.788 ± 0.025
1.547SerTyr: 1.547 ± 0.034
0.0SerXaa: 0.0 ± 0.0
Thr
5.504ThrAla: 5.504 ± 0.071
0.517ThrCys: 0.517 ± 0.018
2.757ThrAsp: 2.757 ± 0.054
2.905ThrGlu: 2.905 ± 0.045
1.935ThrPhe: 1.935 ± 0.038
4.416ThrGly: 4.416 ± 0.072
1.128ThrHis: 1.128 ± 0.028
2.709ThrIle: 2.709 ± 0.049
1.296ThrLys: 1.296 ± 0.031
7.157ThrLeu: 7.157 ± 0.081
0.802ThrMet: 0.802 ± 0.024
1.483ThrAsn: 1.483 ± 0.037
3.834ThrPro: 3.834 ± 0.065
2.692ThrGln: 2.692 ± 0.053
2.999ThrArg: 2.999 ± 0.042
2.953ThrSer: 2.953 ± 0.046
3.086ThrThr: 3.086 ± 0.056
4.346ThrVal: 4.346 ± 0.064
0.743ThrTrp: 0.743 ± 0.024
1.549ThrTyr: 1.549 ± 0.039
0.0ThrXaa: 0.0 ± 0.0
Val
6.769ValAla: 6.769 ± 0.069
0.713ValCys: 0.713 ± 0.024
3.523ValAsp: 3.523 ± 0.052
4.431ValGlu: 4.431 ± 0.054
2.553ValPhe: 2.553 ± 0.048
5.297ValGly: 5.297 ± 0.065
1.095ValHis: 1.095 ± 0.029
3.5ValIle: 3.5 ± 0.06
2.158ValLys: 2.158 ± 0.039
7.843ValLeu: 7.843 ± 0.074
1.62ValMet: 1.62 ± 0.034
2.365ValAsn: 2.365 ± 0.047
3.636ValPro: 3.636 ± 0.045
3.446ValGln: 3.446 ± 0.052
4.265ValArg: 4.265 ± 0.06
4.36ValSer: 4.36 ± 0.063
3.634ValThr: 3.634 ± 0.054
5.266ValVal: 5.266 ± 0.069
1.011ValTrp: 1.011 ± 0.027
1.857ValTyr: 1.857 ± 0.035
0.0ValXaa: 0.0 ± 0.0
Trp
1.19TrpAla: 1.19 ± 0.032
0.144TrpCys: 0.144 ± 0.011
0.655TrpAsp: 0.655 ± 0.025
0.832TrpGlu: 0.832 ± 0.025
0.617TrpPhe: 0.617 ± 0.024
1.104TrpGly: 1.104 ± 0.029
0.326TrpHis: 0.326 ± 0.017
0.81TrpIle: 0.81 ± 0.025
0.501TrpLys: 0.501 ± 0.021
2.194TrpLeu: 2.194 ± 0.044
0.383TrpMet: 0.383 ± 0.016
0.533TrpAsn: 0.533 ± 0.024
0.332TrpPro: 0.332 ± 0.017
1.114TrpGln: 1.114 ± 0.033
1.099TrpArg: 1.099 ± 0.03
0.84TrpSer: 0.84 ± 0.026
0.652TrpThr: 0.652 ± 0.021
1.16TrpVal: 1.16 ± 0.031
0.244TrpTrp: 0.244 ± 0.014
0.353TrpTyr: 0.353 ± 0.019
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.429TyrAla: 2.429 ± 0.041
0.327TyrCys: 0.327 ± 0.016
1.516TyrAsp: 1.516 ± 0.036
1.597TyrGlu: 1.597 ± 0.038
1.097TyrPhe: 1.097 ± 0.027
2.145TyrGly: 2.145 ± 0.042
0.568TyrHis: 0.568 ± 0.017
1.134TyrIle: 1.134 ± 0.032
0.667TyrLys: 0.667 ± 0.023
3.149TyrLeu: 3.149 ± 0.054
0.363TyrMet: 0.363 ± 0.015
0.759TyrAsn: 0.759 ± 0.026
1.552TyrPro: 1.552 ± 0.035
1.384TyrGln: 1.384 ± 0.035
2.329TyrArg: 2.329 ± 0.044
1.58TyrSer: 1.58 ± 0.04
1.421TyrThr: 1.421 ± 0.033
1.621TyrVal: 1.621 ± 0.029
0.507TyrTrp: 0.507 ± 0.016
0.8TyrTyr: 0.8 ± 0.024
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4814 proteins (1474271 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski