Amino acid dipepetide frequency for Mycobacterium phage Xeno

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
19.294AlaAla: 19.294 ± 2.576
0.725AlaCys: 0.725 ± 0.309
8.341AlaAsp: 8.341 ± 0.788
9.792AlaGlu: 9.792 ± 1.259
2.901AlaPhe: 2.901 ± 0.467
9.574AlaGly: 9.574 ± 1.282
1.741AlaHis: 1.741 ± 0.336
4.932AlaIle: 4.932 ± 0.556
3.772AlaLys: 3.772 ± 0.681
9.357AlaLeu: 9.357 ± 0.732
2.248AlaMet: 2.248 ± 0.404
3.191AlaAsn: 3.191 ± 0.56
7.253AlaPro: 7.253 ± 0.745
4.932AlaGln: 4.932 ± 0.768
8.124AlaArg: 8.124 ± 0.826
6.165AlaSer: 6.165 ± 0.641
8.051AlaThr: 8.051 ± 0.719
6.6AlaVal: 6.6 ± 0.797
1.886AlaTrp: 1.886 ± 0.485
2.611AlaTyr: 2.611 ± 0.382
0.0AlaXaa: 0.0 ± 0.0
Cys
1.596CysAla: 1.596 ± 0.441
0.145CysCys: 0.145 ± 0.107
0.798CysAsp: 0.798 ± 0.241
0.363CysGlu: 0.363 ± 0.188
0.0CysPhe: 0.0 ± 0.0
1.523CysGly: 1.523 ± 0.44
0.145CysHis: 0.145 ± 0.089
0.29CysIle: 0.29 ± 0.164
0.145CysLys: 0.145 ± 0.094
0.725CysLeu: 0.725 ± 0.24
0.145CysMet: 0.145 ± 0.096
0.435CysAsn: 0.435 ± 0.18
1.378CysPro: 1.378 ± 0.405
0.435CysGln: 0.435 ± 0.158
1.161CysArg: 1.161 ± 0.273
0.435CysSer: 0.435 ± 0.146
0.725CysThr: 0.725 ± 0.221
0.435CysVal: 0.435 ± 0.205
0.145CysTrp: 0.145 ± 0.129
0.218CysTyr: 0.218 ± 0.137
0.0CysXaa: 0.0 ± 0.0
Asp
8.269AspAla: 8.269 ± 0.734
1.088AspCys: 1.088 ± 0.287
5.658AspAsp: 5.658 ± 0.754
4.424AspGlu: 4.424 ± 0.74
1.523AspPhe: 1.523 ± 0.388
6.745AspGly: 6.745 ± 0.774
1.088AspHis: 1.088 ± 0.287
2.974AspIle: 2.974 ± 0.479
1.813AspLys: 1.813 ± 0.364
5.44AspLeu: 5.44 ± 0.597
1.523AspMet: 1.523 ± 0.336
2.031AspAsn: 2.031 ± 0.43
4.207AspPro: 4.207 ± 0.534
1.886AspGln: 1.886 ± 0.396
3.917AspArg: 3.917 ± 0.628
3.844AspSer: 3.844 ± 0.773
3.482AspThr: 3.482 ± 0.595
3.264AspVal: 3.264 ± 0.46
1.088AspTrp: 1.088 ± 0.283
1.306AspTyr: 1.306 ± 0.287
0.0AspXaa: 0.0 ± 0.0
Glu
6.02GluAla: 6.02 ± 0.697
0.943GluCys: 0.943 ± 0.267
3.699GluAsp: 3.699 ± 0.615
2.248GluGlu: 2.248 ± 0.4
2.901GluPhe: 2.901 ± 0.542
3.336GluGly: 3.336 ± 0.52
1.596GluHis: 1.596 ± 0.379
2.829GluIle: 2.829 ± 0.506
2.103GluLys: 2.103 ± 0.351
5.948GluLeu: 5.948 ± 0.658
1.813GluMet: 1.813 ± 0.489
2.103GluAsn: 2.103 ± 0.305
3.046GluPro: 3.046 ± 0.474
2.829GluGln: 2.829 ± 0.439
4.787GluArg: 4.787 ± 0.66
2.466GluSer: 2.466 ± 0.472
3.772GluThr: 3.772 ± 0.588
4.207GluVal: 4.207 ± 0.568
0.943GluTrp: 0.943 ± 0.269
1.161GluTyr: 1.161 ± 0.282
0.0GluXaa: 0.0 ± 0.0
Phe
3.627PheAla: 3.627 ± 0.555
0.145PheCys: 0.145 ± 0.099
1.741PheAsp: 1.741 ± 0.487
1.668PheGlu: 1.668 ± 0.372
0.725PhePhe: 0.725 ± 0.275
3.264PheGly: 3.264 ± 0.493
0.725PheHis: 0.725 ± 0.258
1.523PheIle: 1.523 ± 0.296
0.87PheLys: 0.87 ± 0.235
1.451PheLeu: 1.451 ± 0.321
0.58PheMet: 0.58 ± 0.24
0.943PheAsn: 0.943 ± 0.266
1.378PhePro: 1.378 ± 0.327
0.653PheGln: 0.653 ± 0.183
1.741PheArg: 1.741 ± 0.296
1.451PheSer: 1.451 ± 0.328
2.031PheThr: 2.031 ± 0.428
2.539PheVal: 2.539 ± 0.471
0.218PheTrp: 0.218 ± 0.107
0.725PheTyr: 0.725 ± 0.234
0.0PheXaa: 0.0 ± 0.0
Gly
8.921GlyAla: 8.921 ± 1.379
1.015GlyCys: 1.015 ± 0.316
5.658GlyAsp: 5.658 ± 0.642
3.989GlyGlu: 3.989 ± 0.6
2.684GlyPhe: 2.684 ± 0.494
10.009GlyGly: 10.009 ± 1.662
1.813GlyHis: 1.813 ± 0.349
3.917GlyIle: 3.917 ± 0.778
2.539GlyLys: 2.539 ± 0.407
6.02GlyLeu: 6.02 ± 0.569
1.596GlyMet: 1.596 ± 0.298
3.409GlyAsn: 3.409 ± 0.531
4.424GlyPro: 4.424 ± 0.692
3.699GlyGln: 3.699 ± 0.388
5.585GlyArg: 5.585 ± 0.471
5.585GlySer: 5.585 ± 0.82
6.383GlyThr: 6.383 ± 0.657
7.398GlyVal: 7.398 ± 0.697
2.321GlyTrp: 2.321 ± 0.332
2.684GlyTyr: 2.684 ± 0.599
0.0GlyXaa: 0.0 ± 0.0
His
1.523HisAla: 1.523 ± 0.32
0.363HisCys: 0.363 ± 0.163
1.596HisAsp: 1.596 ± 0.318
1.741HisGlu: 1.741 ± 0.399
0.29HisPhe: 0.29 ± 0.164
1.378HisGly: 1.378 ± 0.32
0.653HisHis: 0.653 ± 0.195
0.943HisIle: 0.943 ± 0.227
0.58HisLys: 0.58 ± 0.182
1.088HisLeu: 1.088 ± 0.342
0.363HisMet: 0.363 ± 0.16
0.435HisAsn: 0.435 ± 0.186
1.015HisPro: 1.015 ± 0.275
0.87HisGln: 0.87 ± 0.293
1.886HisArg: 1.886 ± 0.416
0.58HisSer: 0.58 ± 0.191
1.306HisThr: 1.306 ± 0.268
1.378HisVal: 1.378 ± 0.264
0.508HisTrp: 0.508 ± 0.151
0.653HisTyr: 0.653 ± 0.184
0.0HisXaa: 0.0 ± 0.0
Ile
5.367IleAla: 5.367 ± 0.516
0.145IleCys: 0.145 ± 0.091
3.409IleAsp: 3.409 ± 0.496
4.279IleGlu: 4.279 ± 0.667
0.87IlePhe: 0.87 ± 0.247
4.787IleGly: 4.787 ± 0.688
1.015IleHis: 1.015 ± 0.282
1.306IleIle: 1.306 ± 0.353
0.87IleLys: 0.87 ± 0.325
2.248IleLeu: 2.248 ± 0.41
0.145IleMet: 0.145 ± 0.108
2.176IleAsn: 2.176 ± 0.379
2.539IlePro: 2.539 ± 0.454
1.233IleGln: 1.233 ± 0.358
3.844IleArg: 3.844 ± 0.53
2.103IleSer: 2.103 ± 0.465
3.989IleThr: 3.989 ± 0.535
3.336IleVal: 3.336 ± 0.544
0.87IleTrp: 0.87 ± 0.222
0.87IleTyr: 0.87 ± 0.19
0.0IleXaa: 0.0 ± 0.0
Lys
4.57LysAla: 4.57 ± 1.104
0.29LysCys: 0.29 ± 0.191
0.798LysAsp: 0.798 ± 0.258
1.233LysGlu: 1.233 ± 0.269
1.233LysPhe: 1.233 ± 0.259
2.466LysGly: 2.466 ± 0.508
0.58LysHis: 0.58 ± 0.193
1.378LysIle: 1.378 ± 0.3
0.508LysLys: 0.508 ± 0.164
2.321LysLeu: 2.321 ± 0.402
0.798LysMet: 0.798 ± 0.244
0.58LysAsn: 0.58 ± 0.192
3.336LysPro: 3.336 ± 0.587
1.306LysGln: 1.306 ± 0.348
2.248LysArg: 2.248 ± 0.486
2.031LysSer: 2.031 ± 0.409
1.813LysThr: 1.813 ± 0.387
1.813LysVal: 1.813 ± 0.363
0.508LysTrp: 0.508 ± 0.203
0.798LysTyr: 0.798 ± 0.187
0.0LysXaa: 0.0 ± 0.0
Leu
10.372LeuAla: 10.372 ± 0.954
0.943LeuCys: 0.943 ± 0.279
5.73LeuAsp: 5.73 ± 0.737
3.119LeuGlu: 3.119 ± 0.388
2.539LeuPhe: 2.539 ± 0.505
7.833LeuGly: 7.833 ± 0.855
1.451LeuHis: 1.451 ± 0.319
3.627LeuIle: 3.627 ± 0.477
2.684LeuLys: 2.684 ± 0.423
6.745LeuLeu: 6.745 ± 0.806
1.015LeuMet: 1.015 ± 0.314
2.248LeuAsn: 2.248 ± 0.456
4.279LeuPro: 4.279 ± 0.708
2.321LeuGln: 2.321 ± 0.419
5.005LeuArg: 5.005 ± 0.744
4.279LeuSer: 4.279 ± 0.588
5.077LeuThr: 5.077 ± 0.688
6.02LeuVal: 6.02 ± 0.555
0.87LeuTrp: 0.87 ± 0.236
1.161LeuTyr: 1.161 ± 0.278
0.0LeuXaa: 0.0 ± 0.0
Met
2.974MetAla: 2.974 ± 0.542
0.0MetCys: 0.0 ± 0.0
0.653MetAsp: 0.653 ± 0.247
0.798MetGlu: 0.798 ± 0.249
0.725MetPhe: 0.725 ± 0.235
0.58MetGly: 0.58 ± 0.182
0.218MetHis: 0.218 ± 0.108
0.943MetIle: 0.943 ± 0.261
0.58MetLys: 0.58 ± 0.241
1.161MetLeu: 1.161 ± 0.276
0.58MetMet: 0.58 ± 0.174
1.088MetAsn: 1.088 ± 0.319
1.088MetPro: 1.088 ± 0.232
0.725MetGln: 0.725 ± 0.213
1.378MetArg: 1.378 ± 0.306
3.191MetSer: 3.191 ± 0.461
1.451MetThr: 1.451 ± 0.296
0.798MetVal: 0.798 ± 0.208
0.798MetTrp: 0.798 ± 0.276
0.29MetTyr: 0.29 ± 0.141
0.0MetXaa: 0.0 ± 0.0
Asn
3.917AsnAla: 3.917 ± 0.624
0.435AsnCys: 0.435 ± 0.169
1.378AsnAsp: 1.378 ± 0.282
1.015AsnGlu: 1.015 ± 0.271
1.161AsnPhe: 1.161 ± 0.228
3.989AsnGly: 3.989 ± 0.591
0.653AsnHis: 0.653 ± 0.266
1.596AsnIle: 1.596 ± 0.371
0.653AsnLys: 0.653 ± 0.241
2.829AsnLeu: 2.829 ± 0.391
0.508AsnMet: 0.508 ± 0.181
1.161AsnAsn: 1.161 ± 0.301
2.684AsnPro: 2.684 ± 0.435
1.233AsnGln: 1.233 ± 0.354
1.958AsnArg: 1.958 ± 0.359
1.523AsnSer: 1.523 ± 0.334
1.741AsnThr: 1.741 ± 0.427
1.958AsnVal: 1.958 ± 0.349
0.58AsnTrp: 0.58 ± 0.185
0.653AsnTyr: 0.653 ± 0.268
0.0AsnXaa: 0.0 ± 0.0
Pro
6.455ProAla: 6.455 ± 0.945
0.435ProCys: 0.435 ± 0.193
4.787ProAsp: 4.787 ± 0.581
4.932ProGlu: 4.932 ± 0.667
1.958ProPhe: 1.958 ± 0.355
6.31ProGly: 6.31 ± 0.946
1.233ProHis: 1.233 ± 0.266
2.248ProIle: 2.248 ± 0.46
1.088ProLys: 1.088 ± 0.375
4.715ProLeu: 4.715 ± 0.558
1.378ProMet: 1.378 ± 0.385
1.741ProAsn: 1.741 ± 0.359
3.989ProPro: 3.989 ± 0.627
2.321ProGln: 2.321 ± 0.315
3.046ProArg: 3.046 ± 0.518
2.611ProSer: 2.611 ± 0.401
4.207ProThr: 4.207 ± 0.528
4.57ProVal: 4.57 ± 0.516
1.741ProTrp: 1.741 ± 0.413
1.451ProTyr: 1.451 ± 0.406
0.0ProXaa: 0.0 ± 0.0
Gln
4.86GlnAla: 4.86 ± 0.979
0.363GlnCys: 0.363 ± 0.163
1.813GlnAsp: 1.813 ± 0.515
1.741GlnGlu: 1.741 ± 0.356
0.725GlnPhe: 0.725 ± 0.157
1.958GlnGly: 1.958 ± 0.262
0.87GlnHis: 0.87 ± 0.278
2.684GlnIle: 2.684 ± 0.496
1.161GlnLys: 1.161 ± 0.283
3.699GlnLeu: 3.699 ± 0.564
0.943GlnMet: 0.943 ± 0.256
0.508GlnAsn: 0.508 ± 0.19
2.321GlnPro: 2.321 ± 0.553
1.451GlnGln: 1.451 ± 0.389
3.409GlnArg: 3.409 ± 0.498
1.668GlnSer: 1.668 ± 0.377
2.031GlnThr: 2.031 ± 0.379
2.829GlnVal: 2.829 ± 0.4
0.58GlnTrp: 0.58 ± 0.205
0.943GlnTyr: 0.943 ± 0.302
0.0GlnXaa: 0.0 ± 0.0
Arg
6.6ArgAla: 6.6 ± 0.807
1.088ArgCys: 1.088 ± 0.357
4.134ArgAsp: 4.134 ± 0.592
4.424ArgGlu: 4.424 ± 0.637
1.813ArgPhe: 1.813 ± 0.376
4.86ArgGly: 4.86 ± 0.648
1.306ArgHis: 1.306 ± 0.341
3.699ArgIle: 3.699 ± 0.522
2.974ArgLys: 2.974 ± 0.538
5.367ArgLeu: 5.367 ± 0.559
2.248ArgMet: 2.248 ± 0.565
2.103ArgAsn: 2.103 ± 0.318
4.207ArgPro: 4.207 ± 0.614
2.829ArgGln: 2.829 ± 0.641
6.093ArgArg: 6.093 ± 1.021
3.119ArgSer: 3.119 ± 0.498
3.917ArgThr: 3.917 ± 0.568
5.222ArgVal: 5.222 ± 0.66
1.596ArgTrp: 1.596 ± 0.332
2.031ArgTyr: 2.031 ± 0.45
0.0ArgXaa: 0.0 ± 0.0
Ser
7.036SerAla: 7.036 ± 0.786
0.363SerCys: 0.363 ± 0.15
3.046SerAsp: 3.046 ± 0.486
2.248SerGlu: 2.248 ± 0.489
1.233SerPhe: 1.233 ± 0.253
5.585SerGly: 5.585 ± 0.996
0.725SerHis: 0.725 ± 0.249
1.958SerIle: 1.958 ± 0.435
1.813SerLys: 1.813 ± 0.36
3.482SerLeu: 3.482 ± 0.485
1.958SerMet: 1.958 ± 0.328
1.668SerAsn: 1.668 ± 0.324
3.191SerPro: 3.191 ± 0.466
1.813SerGln: 1.813 ± 0.418
3.119SerArg: 3.119 ± 0.484
3.191SerSer: 3.191 ± 0.413
3.699SerThr: 3.699 ± 0.474
3.699SerVal: 3.699 ± 0.531
0.798SerTrp: 0.798 ± 0.212
1.596SerTyr: 1.596 ± 0.33
0.0SerXaa: 0.0 ± 0.0
Thr
8.341ThrAla: 8.341 ± 0.641
0.508ThrCys: 0.508 ± 0.225
4.642ThrAsp: 4.642 ± 0.558
3.554ThrGlu: 3.554 ± 0.533
1.886ThrPhe: 1.886 ± 0.414
6.818ThrGly: 6.818 ± 0.906
0.725ThrHis: 0.725 ± 0.233
3.699ThrIle: 3.699 ± 0.588
2.466ThrLys: 2.466 ± 0.386
5.658ThrLeu: 5.658 ± 0.496
0.87ThrMet: 0.87 ± 0.275
1.596ThrAsn: 1.596 ± 0.327
5.367ThrPro: 5.367 ± 0.6
2.031ThrGln: 2.031 ± 0.352
3.554ThrArg: 3.554 ± 0.543
2.829ThrSer: 2.829 ± 0.598
5.44ThrThr: 5.44 ± 0.542
5.875ThrVal: 5.875 ± 0.83
1.306ThrTrp: 1.306 ± 0.304
1.596ThrTyr: 1.596 ± 0.281
0.0ThrXaa: 0.0 ± 0.0
Val
8.486ValAla: 8.486 ± 0.94
1.161ValCys: 1.161 ± 0.279
4.715ValAsp: 4.715 ± 0.539
5.15ValGlu: 5.15 ± 0.736
1.668ValPhe: 1.668 ± 0.393
5.585ValGly: 5.585 ± 0.609
1.378ValHis: 1.378 ± 0.346
2.974ValIle: 2.974 ± 0.568
2.829ValLys: 2.829 ± 0.601
5.367ValLeu: 5.367 ± 0.505
0.798ValMet: 0.798 ± 0.301
2.756ValAsn: 2.756 ± 0.411
3.844ValPro: 3.844 ± 0.519
2.103ValGln: 2.103 ± 0.364
5.005ValArg: 5.005 ± 0.561
3.336ValSer: 3.336 ± 0.504
6.093ValThr: 6.093 ± 0.711
5.077ValVal: 5.077 ± 0.652
0.943ValTrp: 0.943 ± 0.237
1.378ValTyr: 1.378 ± 0.297
0.0ValXaa: 0.0 ± 0.0
Trp
1.523TrpAla: 1.523 ± 0.311
0.58TrpCys: 0.58 ± 0.239
1.161TrpAsp: 1.161 ± 0.206
0.29TrpGlu: 0.29 ± 0.146
0.508TrpPhe: 0.508 ± 0.233
1.161TrpGly: 1.161 ± 0.311
0.508TrpHis: 0.508 ± 0.223
0.798TrpIle: 0.798 ± 0.235
0.363TrpLys: 0.363 ± 0.179
1.886TrpLeu: 1.886 ± 0.397
0.218TrpMet: 0.218 ± 0.145
0.653TrpAsn: 0.653 ± 0.183
0.87TrpPro: 0.87 ± 0.27
1.161TrpGln: 1.161 ± 0.295
1.813TrpArg: 1.813 ± 0.424
0.725TrpSer: 0.725 ± 0.171
1.596TrpThr: 1.596 ± 0.308
1.741TrpVal: 1.741 ± 0.351
0.435TrpTrp: 0.435 ± 0.168
0.653TrpTyr: 0.653 ± 0.214
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.741TyrAla: 1.741 ± 0.398
0.508TyrCys: 0.508 ± 0.189
1.813TyrAsp: 1.813 ± 0.347
1.741TyrGlu: 1.741 ± 0.37
0.653TyrPhe: 0.653 ± 0.239
1.886TyrGly: 1.886 ± 0.371
0.725TyrHis: 0.725 ± 0.24
1.088TyrIle: 1.088 ± 0.277
0.798TyrLys: 0.798 ± 0.248
1.813TyrLeu: 1.813 ± 0.314
0.218TyrMet: 0.218 ± 0.131
0.798TyrAsn: 0.798 ± 0.222
0.798TyrPro: 0.798 ± 0.252
0.725TyrGln: 0.725 ± 0.197
1.958TyrArg: 1.958 ± 0.371
1.088TyrSer: 1.088 ± 0.276
1.958TyrThr: 1.958 ± 0.375
1.886TyrVal: 1.886 ± 0.524
0.58TyrTrp: 0.58 ± 0.266
0.725TyrTyr: 0.725 ± 0.218
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 69 proteins (13788 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski