Amino acid dipepetide frequency for Pleionea mediterranea

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.434AlaAla: 6.434 ± 0.102	0.811AlaCys: 0.811 ± 0.026	4.344AlaAsp: 4.344 ± 0.074	5.269AlaGlu: 5.269 ± 0.081	3.253AlaPhe: 3.253 ± 0.05	5.181AlaGly: 5.181 ± 0.078	1.501AlaHis: 1.501 ± 0.039	5.827AlaIle: 5.827 ± 0.087	4.653AlaLys: 4.653 ± 0.078	8.468AlaLeu: 8.468 ± 0.105	2.165AlaMet: 2.165 ± 0.045	3.636AlaAsn: 3.636 ± 0.062	2.493AlaPro: 2.493 ± 0.053	3.177AlaGln: 3.177 ± 0.058	3.245AlaArg: 3.245 ± 0.06	5.506AlaSer: 5.506 ± 0.08	4.114AlaThr: 4.114 ± 0.067	5.123AlaVal: 5.123 ± 0.071	0.743AlaTrp: 0.743 ± 0.028	2.244AlaTyr: 2.244 ± 0.047	0.0AlaXaa: 0.0 ± 0.0
Cys	0.609CysAla: 0.609 ± 0.023	0.135CysCys: 0.135 ± 0.012	0.61CysAsp: 0.61 ± 0.026	0.553CysGlu: 0.553 ± 0.02	0.459CysPhe: 0.459 ± 0.02	0.802CysGly: 0.802 ± 0.032	0.317CysHis: 0.317 ± 0.019	0.508CysIle: 0.508 ± 0.023	0.393CysLys: 0.393 ± 0.021	0.973CysLeu: 0.973 ± 0.031	0.169CysMet: 0.169 ± 0.013	0.372CysAsn: 0.372 ± 0.019	0.404CysPro: 0.404 ± 0.021	0.489CysGln: 0.489 ± 0.021	0.504CysArg: 0.504 ± 0.019	0.675CysSer: 0.675 ± 0.024	0.412CysThr: 0.412 ± 0.02	0.557CysVal: 0.557 ± 0.022	0.122CysTrp: 0.122 ± 0.01	0.316CysTyr: 0.316 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	4.381AspAla: 4.381 ± 0.081	0.557AspCys: 0.557 ± 0.024	3.932AspAsp: 3.932 ± 0.074	3.993AspGlu: 3.993 ± 0.07	2.664AspPhe: 2.664 ± 0.056	4.048AspGly: 4.048 ± 0.196	1.219AspHis: 1.219 ± 0.036	4.19AspIle: 4.19 ± 0.066	3.7AspLys: 3.7 ± 0.062	5.231AspLeu: 5.231 ± 0.069	1.269AspMet: 1.269 ± 0.035	3.204AspAsn: 3.204 ± 0.084	2.201AspPro: 2.201 ± 0.048	2.228AspGln: 2.228 ± 0.044	2.422AspArg: 2.422 ± 0.058	4.102AspSer: 4.102 ± 0.122	2.931AspThr: 2.931 ± 0.058	3.737AspVal: 3.737 ± 0.06	0.874AspTrp: 0.874 ± 0.029	2.233AspTyr: 2.233 ± 0.047	0.0AspXaa: 0.0 ± 0.0
Glu	4.62GluAla: 4.62 ± 0.07	0.468GluCys: 0.468 ± 0.021	2.839GluAsp: 2.839 ± 0.058	3.23GluGlu: 3.23 ± 0.072	2.667GluPhe: 2.667 ± 0.048	3.189GluGly: 3.189 ± 0.066	1.622GluHis: 1.622 ± 0.038	3.455GluIle: 3.455 ± 0.056	4.24GluLys: 4.24 ± 0.067	6.997GluLeu: 6.997 ± 0.085	1.464GluMet: 1.464 ± 0.038	2.874GluAsn: 2.874 ± 0.054	2.137GluPro: 2.137 ± 0.052	4.976GluGln: 4.976 ± 0.081	3.068GluArg: 3.068 ± 0.063	4.438GluSer: 4.438 ± 0.069	3.186GluThr: 3.186 ± 0.058	3.908GluVal: 3.908 ± 0.064	0.717GluTrp: 0.717 ± 0.023	1.91GluTyr: 1.91 ± 0.042	0.0GluXaa: 0.0 ± 0.0
Phe	3.096PheAla: 3.096 ± 0.059	0.492PheCys: 0.492 ± 0.021	3.029PheAsp: 3.029 ± 0.053	2.768PheGlu: 2.768 ± 0.047	1.814PhePhe: 1.814 ± 0.047	2.875PheGly: 2.875 ± 0.052	0.914PheHis: 0.914 ± 0.027	2.989PheIle: 2.989 ± 0.06	2.443PheLys: 2.443 ± 0.053	3.704PheLeu: 3.704 ± 0.077	0.948PheMet: 0.948 ± 0.03	2.402PheAsn: 2.402 ± 0.048	1.406PhePro: 1.406 ± 0.035	1.518PheGln: 1.518 ± 0.036	1.669PheArg: 1.669 ± 0.042	3.523PheSer: 3.523 ± 0.057	2.263PheThr: 2.263 ± 0.049	2.579PheVal: 2.579 ± 0.051	0.595PheTrp: 0.595 ± 0.023	1.529PheTyr: 1.529 ± 0.036	0.0PheXaa: 0.0 ± 0.0
Gly	4.657GlyAla: 4.657 ± 0.075	0.814GlyCys: 0.814 ± 0.029	3.883GlyAsp: 3.883 ± 0.108	4.076GlyGlu: 4.076 ± 0.068	3.218GlyPhe: 3.218 ± 0.059	4.407GlyGly: 4.407 ± 0.083	1.456GlyHis: 1.456 ± 0.039	4.416GlyIle: 4.416 ± 0.093	3.665GlyLys: 3.665 ± 0.062	6.178GlyLeu: 6.178 ± 0.081	1.754GlyMet: 1.754 ± 0.046	2.851GlyAsn: 2.851 ± 0.082	1.535GlyPro: 1.535 ± 0.041	2.565GlyGln: 2.565 ± 0.049	2.879GlyArg: 2.879 ± 0.055	4.215GlySer: 4.215 ± 0.078	3.114GlyThr: 3.114 ± 0.073	4.619GlyVal: 4.619 ± 0.067	0.953GlyTrp: 0.953 ± 0.028	2.358GlyTyr: 2.358 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	1.393HisAla: 1.393 ± 0.034	0.311HisCys: 0.311 ± 0.018	1.106HisAsp: 1.106 ± 0.033	1.034HisGlu: 1.034 ± 0.032	1.066HisPhe: 1.066 ± 0.031	1.367HisGly: 1.367 ± 0.036	0.693HisHis: 0.693 ± 0.025	1.412HisIle: 1.412 ± 0.035	1.225HisLys: 1.225 ± 0.034	2.244HisLeu: 2.244 ± 0.052	0.482HisMet: 0.482 ± 0.022	0.991HisAsn: 0.991 ± 0.032	1.168HisPro: 1.168 ± 0.033	1.471HisGln: 1.471 ± 0.04	1.119HisArg: 1.119 ± 0.032	1.618HisSer: 1.618 ± 0.039	1.061HisThr: 1.061 ± 0.033	1.096HisVal: 1.096 ± 0.03	0.453HisTrp: 0.453 ± 0.021	0.963HisTyr: 0.963 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	5.935IleAla: 5.935 ± 0.091	0.658IleCys: 0.658 ± 0.026	4.468IleAsp: 4.468 ± 0.066	4.947IleGlu: 4.947 ± 0.071	2.257IlePhe: 2.257 ± 0.054	4.286IleGly: 4.286 ± 0.073	1.317IleHis: 1.317 ± 0.036	4.071IleIle: 4.071 ± 0.063	4.204IleLys: 4.204 ± 0.07	5.118IleLeu: 5.118 ± 0.08	1.277IleMet: 1.277 ± 0.035	3.709IleAsn: 3.709 ± 0.064	2.57IlePro: 2.57 ± 0.057	2.295IleGln: 2.295 ± 0.044	2.731IleArg: 2.731 ± 0.057	4.684IleSer: 4.684 ± 0.072	3.931IleThr: 3.931 ± 0.069	3.819IleVal: 3.819 ± 0.059	0.689IleTrp: 0.689 ± 0.023	1.933IleTyr: 1.933 ± 0.043	0.0IleXaa: 0.0 ± 0.0
Lys	4.826LysAla: 4.826 ± 0.078	0.334LysCys: 0.334 ± 0.019	3.035LysAsp: 3.035 ± 0.05	3.348LysGlu: 3.348 ± 0.062	1.702LysPhe: 1.702 ± 0.04	3.337LysGly: 3.337 ± 0.052	1.43LysHis: 1.43 ± 0.039	3.098LysIle: 3.098 ± 0.06	3.727LysLys: 3.727 ± 0.083	5.749LysLeu: 5.749 ± 0.07	1.325LysMet: 1.325 ± 0.042	2.812LysAsn: 2.812 ± 0.046	2.637LysPro: 2.637 ± 0.051	4.242LysGln: 4.242 ± 0.08	2.834LysArg: 2.834 ± 0.05	4.158LysSer: 4.158 ± 0.066	3.202LysThr: 3.202 ± 0.054	4.094LysVal: 4.094 ± 0.061	0.586LysTrp: 0.586 ± 0.023	1.457LysTyr: 1.457 ± 0.04	0.0LysXaa: 0.0 ± 0.0
Leu	8.257LeuAla: 8.257 ± 0.102	0.908LeuCys: 0.908 ± 0.027	5.548LeuAsp: 5.548 ± 0.093	6.006LeuGlu: 6.006 ± 0.09	4.276LeuPhe: 4.276 ± 0.076	5.964LeuGly: 5.964 ± 0.077	1.903LeuHis: 1.903 ± 0.041	6.657LeuIle: 6.657 ± 0.091	6.397LeuLys: 6.397 ± 0.097	10.635LeuLeu: 10.635 ± 0.152	2.695LeuMet: 2.695 ± 0.049	5.212LeuAsn: 5.212 ± 0.082	4.361LeuPro: 4.361 ± 0.071	4.004LeuGln: 4.004 ± 0.075	3.869LeuArg: 3.869 ± 0.065	8.53LeuSer: 8.53 ± 0.097	6.081LeuThr: 6.081 ± 0.076	6.337LeuVal: 6.337 ± 0.079	1.128LeuTrp: 1.128 ± 0.038	2.688LeuTyr: 2.688 ± 0.052	0.0LeuXaa: 0.0 ± 0.0
Met	2.291MetAla: 2.291 ± 0.051	0.168MetCys: 0.168 ± 0.012	1.267MetAsp: 1.267 ± 0.034	1.223MetGlu: 1.223 ± 0.036	0.814MetPhe: 0.814 ± 0.028	1.53MetGly: 1.53 ± 0.041	0.486MetHis: 0.486 ± 0.021	1.45MetIle: 1.45 ± 0.035	1.384MetLys: 1.384 ± 0.033	2.255MetLeu: 2.255 ± 0.042	0.637MetMet: 0.637 ± 0.023	1.137MetAsn: 1.137 ± 0.031	1.111MetPro: 1.111 ± 0.031	1.02MetGln: 1.02 ± 0.034	1.042MetArg: 1.042 ± 0.033	1.937MetSer: 1.937 ± 0.041	1.514MetThr: 1.514 ± 0.036	1.593MetVal: 1.593 ± 0.037	0.201MetTrp: 0.201 ± 0.013	0.492MetTyr: 0.492 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	3.641AsnAla: 3.641 ± 0.059	0.421AsnCys: 0.421 ± 0.02	3.179AsnAsp: 3.179 ± 0.091	2.788AsnGlu: 2.788 ± 0.05	1.814AsnPhe: 1.814 ± 0.04	3.131AsnGly: 3.131 ± 0.068	1.123AsnHis: 1.123 ± 0.036	3.24AsnIle: 3.24 ± 0.054	3.04AsnLys: 3.04 ± 0.056	4.221AsnLeu: 4.221 ± 0.075	0.987AsnMet: 0.987 ± 0.028	3.052AsnAsn: 3.052 ± 0.06	2.131AsnPro: 2.131 ± 0.043	2.634AsnGln: 2.634 ± 0.055	2.305AsnArg: 2.305 ± 0.045	3.166AsnSer: 3.166 ± 0.06	2.672AsnThr: 2.672 ± 0.048	2.659AsnVal: 2.659 ± 0.05	0.737AsnTrp: 0.737 ± 0.027	1.577AsnTyr: 1.577 ± 0.045	0.0AsnXaa: 0.0 ± 0.0
Pro	2.786ProAla: 2.786 ± 0.052	0.276ProCys: 0.276 ± 0.018	2.787ProAsp: 2.787 ± 0.059	3.402ProGlu: 3.402 ± 0.063	1.686ProPhe: 1.686 ± 0.044	2.47ProGly: 2.47 ± 0.052	0.753ProHis: 0.753 ± 0.031	2.314ProIle: 2.314 ± 0.047	1.996ProLys: 1.996 ± 0.05	3.728ProLeu: 3.728 ± 0.068	0.941ProMet: 0.941 ± 0.029	1.653ProAsn: 1.653 ± 0.043	1.168ProPro: 1.168 ± 0.04	1.46ProGln: 1.46 ± 0.038	1.25ProArg: 1.25 ± 0.03	2.455ProSer: 2.455 ± 0.05	1.865ProThr: 1.865 ± 0.048	3.177ProVal: 3.177 ± 0.055	0.438ProTrp: 0.438 ± 0.022	1.212ProTyr: 1.212 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	4.129GlnAla: 4.129 ± 0.073	0.419GlnCys: 0.419 ± 0.021	2.12GlnAsp: 2.12 ± 0.048	2.205GlnGlu: 2.205 ± 0.048	1.965GlnPhe: 1.965 ± 0.045	2.687GlnGly: 2.687 ± 0.047	1.332GlnHis: 1.332 ± 0.04	2.52GlnIle: 2.52 ± 0.046	2.543GlnLys: 2.543 ± 0.053	6.032GlnLeu: 6.032 ± 0.091	1.12GlnMet: 1.12 ± 0.034	1.943GlnAsn: 1.943 ± 0.044	1.966GlnPro: 1.966 ± 0.043	4.281GlnGln: 4.281 ± 0.096	2.366GlnArg: 2.366 ± 0.049	3.963GlnSer: 3.963 ± 0.057	2.471GlnThr: 2.471 ± 0.053	3.203GlnVal: 3.203 ± 0.057	0.811GlnTrp: 0.811 ± 0.03	1.507GlnTyr: 1.507 ± 0.042	0.0GlnXaa: 0.0 ± 0.0
Arg	3.081ArgAla: 3.081 ± 0.048	0.432ArgCys: 0.432 ± 0.021	2.358ArgAsp: 2.358 ± 0.056	2.729ArgGlu: 2.729 ± 0.059	2.243ArgPhe: 2.243 ± 0.049	2.493ArgGly: 2.493 ± 0.055	1.121ArgHis: 1.121 ± 0.032	2.905ArgIle: 2.905 ± 0.051	2.427ArgLys: 2.427 ± 0.053	4.909ArgLeu: 4.909 ± 0.073	1.073ArgMet: 1.073 ± 0.032	1.927ArgAsn: 1.927 ± 0.038	1.496ArgPro: 1.496 ± 0.033	2.407ArgGln: 2.407 ± 0.052	2.251ArgArg: 2.251 ± 0.054	2.716ArgSer: 2.716 ± 0.052	1.9ArgThr: 1.9 ± 0.045	3.02ArgVal: 3.02 ± 0.056	0.71ArgTrp: 0.71 ± 0.026	1.772ArgTyr: 1.772 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	5.391SerAla: 5.391 ± 0.067	0.591SerCys: 0.591 ± 0.022	4.847SerAsp: 4.847 ± 0.143	4.702SerGlu: 4.702 ± 0.072	3.366SerPhe: 3.366 ± 0.061	5.326SerGly: 5.326 ± 0.095	1.612SerHis: 1.612 ± 0.037	4.908SerIle: 4.908 ± 0.072	3.804SerLys: 3.804 ± 0.07	7.674SerLeu: 7.674 ± 0.109	1.676SerMet: 1.676 ± 0.038	3.538SerAsn: 3.538 ± 0.06	2.507SerPro: 2.507 ± 0.053	3.239SerGln: 3.239 ± 0.057	2.991SerArg: 2.991 ± 0.053	5.654SerSer: 5.654 ± 0.097	3.444SerThr: 3.444 ± 0.055	4.894SerVal: 4.894 ± 0.068	0.888SerTrp: 0.888 ± 0.032	2.148SerTyr: 2.148 ± 0.046	0.0SerXaa: 0.0 ± 0.0
Thr	4.416ThrAla: 4.416 ± 0.077	0.421ThrCys: 0.421 ± 0.019	3.353ThrAsp: 3.353 ± 0.076	3.392ThrGlu: 3.392 ± 0.057	2.081ThrPhe: 2.081 ± 0.046	3.879ThrGly: 3.879 ± 0.069	1.183ThrHis: 1.183 ± 0.031	3.523ThrIle: 3.523 ± 0.064	2.255ThrLys: 2.255 ± 0.046	5.907ThrLeu: 5.907 ± 0.09	1.035ThrMet: 1.035 ± 0.03	2.225ThrAsn: 2.225 ± 0.051	2.469ThrPro: 2.469 ± 0.052	2.498ThrGln: 2.498 ± 0.051	2.288ThrArg: 2.288 ± 0.046	3.58ThrSer: 3.58 ± 0.07	2.788ThrThr: 2.788 ± 0.061	3.682ThrVal: 3.682 ± 0.068	0.494ThrTrp: 0.494 ± 0.021	1.428ThrTyr: 1.428 ± 0.039	0.0ThrXaa: 0.0 ± 0.0
Val	5.488ValAla: 5.488 ± 0.082	0.651ValCys: 0.651 ± 0.026	4.07ValAsp: 4.07 ± 0.066	4.315ValGlu: 4.315 ± 0.064	2.888ValPhe: 2.888 ± 0.051	3.924ValGly: 3.924 ± 0.065	1.117ValHis: 1.117 ± 0.031	4.812ValIle: 4.812 ± 0.073	3.739ValLys: 3.739 ± 0.059	6.176ValLeu: 6.176 ± 0.076	1.646ValMet: 1.646 ± 0.041	3.256ValAsn: 3.256 ± 0.058	2.263ValPro: 2.263 ± 0.051	1.96ValGln: 1.96 ± 0.043	2.617ValArg: 2.617 ± 0.047	5.062ValSer: 5.062 ± 0.065	3.901ValThr: 3.901 ± 0.069	4.635ValVal: 4.635 ± 0.079	0.741ValTrp: 0.741 ± 0.031	1.935ValTyr: 1.935 ± 0.042	0.0ValXaa: 0.0 ± 0.0
Trp	0.717TrpAla: 0.717 ± 0.026	0.144TrpCys: 0.144 ± 0.013	0.56TrpAsp: 0.56 ± 0.025	0.492TrpGlu: 0.492 ± 0.021	0.707TrpPhe: 0.707 ± 0.027	0.701TrpGly: 0.701 ± 0.023	0.369TrpHis: 0.369 ± 0.018	0.829TrpIle: 0.829 ± 0.025	0.531TrpLys: 0.531 ± 0.022	1.775TrpLeu: 1.775 ± 0.044	0.292TrpMet: 0.292 ± 0.016	0.47TrpAsn: 0.47 ± 0.021	0.466TrpPro: 0.466 ± 0.019	1.029TrpGln: 1.029 ± 0.031	0.699TrpArg: 0.699 ± 0.027	0.901TrpSer: 0.901 ± 0.029	0.519TrpThr: 0.519 ± 0.023	0.848TrpVal: 0.848 ± 0.026	0.178TrpTrp: 0.178 ± 0.013	0.364TrpTyr: 0.364 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.039TyrAla: 2.039 ± 0.044	0.369TyrCys: 0.369 ± 0.018	1.778TyrAsp: 1.778 ± 0.052	1.533TyrGlu: 1.533 ± 0.042	1.616TyrPhe: 1.616 ± 0.037	2.015TyrGly: 2.015 ± 0.044	0.806TyrHis: 0.806 ± 0.03	1.778TyrIle: 1.778 ± 0.042	1.566TyrLys: 1.566 ± 0.035	3.481TyrLeu: 3.481 ± 0.069	0.595TyrMet: 0.595 ± 0.024	1.254TyrAsn: 1.254 ± 0.041	1.331TyrPro: 1.331 ± 0.037	2.091TyrGln: 2.091 ± 0.043	1.82TyrArg: 1.82 ± 0.037	2.317TyrSer: 2.317 ± 0.05	1.527TyrThr: 1.527 ± 0.048	1.614TyrVal: 1.614 ± 0.038	0.535TyrTrp: 0.535 ± 0.023	1.19TyrTyr: 1.19 ± 0.034	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3566 proteins (1176721 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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