Amino acid dipepetide frequency for Ornithinimicrobium sp. AMA3305

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.559AlaAla: 19.559 ± 0.181	0.901AlaCys: 0.901 ± 0.03	8.14AlaAsp: 8.14 ± 0.09	7.737AlaGlu: 7.737 ± 0.096	3.034AlaPhe: 3.034 ± 0.061	13.031AlaGly: 13.031 ± 0.135	2.642AlaHis: 2.642 ± 0.044	3.323AlaIle: 3.323 ± 0.065	1.798AlaLys: 1.798 ± 0.05	14.351AlaLeu: 14.351 ± 0.161	2.628AlaMet: 2.628 ± 0.047	1.613AlaAsn: 1.613 ± 0.039	6.545AlaPro: 6.545 ± 0.086	4.202AlaGln: 4.202 ± 0.065	10.671AlaArg: 10.671 ± 0.119	6.039AlaSer: 6.039 ± 0.07	7.299AlaThr: 7.299 ± 0.09	12.439AlaVal: 12.439 ± 0.138	2.11AlaTrp: 2.11 ± 0.046	2.418AlaTyr: 2.418 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	0.803CysAla: 0.803 ± 0.025	0.083CysCys: 0.083 ± 0.008	0.425CysAsp: 0.425 ± 0.019	0.354CysGlu: 0.354 ± 0.018	0.18CysPhe: 0.18 ± 0.012	0.81CysGly: 0.81 ± 0.031	0.167CysHis: 0.167 ± 0.012	0.174CysIle: 0.174 ± 0.013	0.085CysLys: 0.085 ± 0.01	0.585CysLeu: 0.585 ± 0.024	0.082CysMet: 0.082 ± 0.008	0.104CysAsn: 0.104 ± 0.009	0.439CysPro: 0.439 ± 0.023	0.176CysGln: 0.176 ± 0.012	0.494CysArg: 0.494 ± 0.023	0.386CysSer: 0.386 ± 0.017	0.421CysThr: 0.421 ± 0.021	0.553CysVal: 0.553 ± 0.022	0.104CysTrp: 0.104 ± 0.009	0.126CysTyr: 0.126 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	7.607AspAla: 7.607 ± 0.092	0.313AspCys: 0.313 ± 0.018	3.931AspAsp: 3.931 ± 0.07	4.315AspGlu: 4.315 ± 0.078	1.365AspPhe: 1.365 ± 0.038	6.541AspGly: 6.541 ± 0.1	1.568AspHis: 1.568 ± 0.038	1.56AspIle: 1.56 ± 0.048	0.901AspLys: 0.901 ± 0.032	7.51AspLeu: 7.51 ± 0.091	0.847AspMet: 0.847 ± 0.027	0.791AspAsn: 0.791 ± 0.029	4.957AspPro: 4.957 ± 0.075	1.854AspGln: 1.854 ± 0.041	5.141AspArg: 5.141 ± 0.077	2.201AspSer: 2.201 ± 0.053	2.818AspThr: 2.818 ± 0.053	6.133AspVal: 6.133 ± 0.082	0.935AspTrp: 0.935 ± 0.027	1.27AspTyr: 1.27 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	7.42GluAla: 7.42 ± 0.095	0.287GluCys: 0.287 ± 0.018	3.823GluAsp: 3.823 ± 0.065	4.233GluGlu: 4.233 ± 0.071	1.153GluPhe: 1.153 ± 0.032	5.093GluGly: 5.093 ± 0.08	1.984GluHis: 1.984 ± 0.041	1.955GluIle: 1.955 ± 0.04	1.06GluLys: 1.06 ± 0.037	6.827GluLeu: 6.827 ± 0.1	0.92GluMet: 0.92 ± 0.029	0.747GluAsn: 0.747 ± 0.029	3.189GluPro: 3.189 ± 0.059	2.77GluGln: 2.77 ± 0.055	5.502GluArg: 5.502 ± 0.086	2.234GluSer: 2.234 ± 0.048	2.562GluThr: 2.562 ± 0.049	5.969GluVal: 5.969 ± 0.07	0.725GluTrp: 0.725 ± 0.024	0.766GluTyr: 0.766 ± 0.027	0.0GluXaa: 0.0 ± 0.0
Phe	3.146PheAla: 3.146 ± 0.064	0.205PheCys: 0.205 ± 0.012	1.711PheAsp: 1.711 ± 0.041	1.309PheGlu: 1.309 ± 0.037	0.836PhePhe: 0.836 ± 0.033	2.757PheGly: 2.757 ± 0.055	0.526PheHis: 0.526 ± 0.021	0.683PheIle: 0.683 ± 0.026	0.351PheLys: 0.351 ± 0.018	2.479PheLeu: 2.479 ± 0.062	0.399PheMet: 0.399 ± 0.019	0.456PheAsn: 0.456 ± 0.022	1.216PhePro: 1.216 ± 0.026	0.554PheGln: 0.554 ± 0.021	1.495PheArg: 1.495 ± 0.04	1.331PheSer: 1.331 ± 0.038	1.641PheThr: 1.641 ± 0.04	2.61PheVal: 2.61 ± 0.055	0.435PheTrp: 0.435 ± 0.021	0.575PheTyr: 0.575 ± 0.024	0.0PheXaa: 0.0 ± 0.0
Gly	11.232GlyAla: 11.232 ± 0.113	0.705GlyCys: 0.705 ± 0.029	5.189GlyAsp: 5.189 ± 0.083	5.62GlyGlu: 5.62 ± 0.084	2.588GlyPhe: 2.588 ± 0.054	8.863GlyGly: 8.863 ± 0.123	2.205GlyHis: 2.205 ± 0.052	3.192GlyIle: 3.192 ± 0.061	1.738GlyLys: 1.738 ± 0.037	10.053GlyLeu: 10.053 ± 0.117	2.412GlyMet: 2.412 ± 0.05	1.355GlyAsn: 1.355 ± 0.041	5.168GlyPro: 5.168 ± 0.079	3.155GlyGln: 3.155 ± 0.061	8.225GlyArg: 8.225 ± 0.103	5.574GlySer: 5.574 ± 0.065	6.363GlyThr: 6.363 ± 0.081	8.551GlyVal: 8.551 ± 0.104	2.011GlyTrp: 2.011 ± 0.039	2.158GlyTyr: 2.158 ± 0.041	0.0GlyXaa: 0.0 ± 0.0
His	2.767HisAla: 2.767 ± 0.05	0.18HisCys: 0.18 ± 0.012	1.622HisAsp: 1.622 ± 0.042	1.463HisGlu: 1.463 ± 0.037	0.505HisPhe: 0.505 ± 0.024	2.494HisGly: 2.494 ± 0.048	0.695HisHis: 0.695 ± 0.028	0.453HisIle: 0.453 ± 0.021	0.276HisLys: 0.276 ± 0.018	2.659HisLeu: 2.659 ± 0.056	0.275HisMet: 0.275 ± 0.017	0.305HisAsn: 0.305 ± 0.016	1.738HisPro: 1.738 ± 0.041	0.694HisGln: 0.694 ± 0.024	2.087HisArg: 2.087 ± 0.047	0.811HisSer: 0.811 ± 0.03	1.159HisThr: 1.159 ± 0.036	2.175HisVal: 2.175 ± 0.044	0.315HisTrp: 0.315 ± 0.019	0.425HisTyr: 0.425 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	3.694IleAla: 3.694 ± 0.068	0.242IleCys: 0.242 ± 0.013	2.032IleAsp: 2.032 ± 0.051	1.883IleGlu: 1.883 ± 0.044	0.818IlePhe: 0.818 ± 0.033	2.878IleGly: 2.878 ± 0.061	0.539IleHis: 0.539 ± 0.018	0.939IleIle: 0.939 ± 0.033	0.56IleLys: 0.56 ± 0.022	2.449IleLeu: 2.449 ± 0.052	0.514IleMet: 0.514 ± 0.021	0.643IleAsn: 0.643 ± 0.028	1.576IlePro: 1.576 ± 0.04	0.677IleGln: 0.677 ± 0.025	1.745IleArg: 1.745 ± 0.039	1.65IleSer: 1.65 ± 0.047	2.061IleThr: 2.061 ± 0.042	2.777IleVal: 2.777 ± 0.056	0.337IleTrp: 0.337 ± 0.016	0.593IleTyr: 0.593 ± 0.025	0.0IleXaa: 0.0 ± 0.0
Lys	1.841LysAla: 1.841 ± 0.05	0.05LysCys: 0.05 ± 0.007	1.12LysAsp: 1.12 ± 0.037	0.927LysGlu: 0.927 ± 0.03	0.353LysPhe: 0.353 ± 0.018	1.343LysGly: 1.343 ± 0.037	0.383LysHis: 0.383 ± 0.016	0.653LysIle: 0.653 ± 0.023	0.551LysLys: 0.551 ± 0.028	1.225LysLeu: 1.225 ± 0.036	0.285LysMet: 0.285 ± 0.016	0.324LysAsn: 0.324 ± 0.017	0.728LysPro: 0.728 ± 0.027	0.491LysGln: 0.491 ± 0.021	0.988LysArg: 0.988 ± 0.035	0.738LysSer: 0.738 ± 0.026	0.921LysThr: 0.921 ± 0.032	1.601LysVal: 1.601 ± 0.043	0.153LysTrp: 0.153 ± 0.012	0.296LysTyr: 0.296 ± 0.017	0.0LysXaa: 0.0 ± 0.0
Leu	15.574LeuAla: 15.574 ± 0.168	0.628LeuCys: 0.628 ± 0.024	7.101LeuAsp: 7.101 ± 0.081	5.77LeuGlu: 5.77 ± 0.089	2.303LeuPhe: 2.303 ± 0.055	10.394LeuGly: 10.394 ± 0.112	2.319LeuHis: 2.319 ± 0.051	2.578LeuIle: 2.578 ± 0.05	1.332LeuLys: 1.332 ± 0.038	11.571LeuLeu: 11.571 ± 0.148	1.758LeuMet: 1.758 ± 0.041	1.351LeuAsn: 1.351 ± 0.033	6.228LeuPro: 6.228 ± 0.083	2.555LeuGln: 2.555 ± 0.052	8.843LeuArg: 8.843 ± 0.092	5.349LeuSer: 5.349 ± 0.075	6.703LeuThr: 6.703 ± 0.08	11.363LeuVal: 11.363 ± 0.145	1.377LeuTrp: 1.377 ± 0.038	1.466LeuTyr: 1.466 ± 0.042	0.0LeuXaa: 0.0 ± 0.0
Met	2.32MetAla: 2.32 ± 0.048	0.12MetCys: 0.12 ± 0.01	0.997MetAsp: 0.997 ± 0.033	0.855MetGlu: 0.855 ± 0.028	0.453MetPhe: 0.453 ± 0.02	1.483MetGly: 1.483 ± 0.036	0.355MetHis: 0.355 ± 0.017	0.691MetIle: 0.691 ± 0.028	0.362MetLys: 0.362 ± 0.019	1.914MetLeu: 1.914 ± 0.045	0.349MetMet: 0.349 ± 0.019	0.346MetAsn: 0.346 ± 0.018	1.185MetPro: 1.185 ± 0.034	0.466MetGln: 0.466 ± 0.02	1.452MetArg: 1.452 ± 0.037	1.43MetSer: 1.43 ± 0.031	1.694MetThr: 1.694 ± 0.038	1.698MetVal: 1.698 ± 0.037	0.226MetTrp: 0.226 ± 0.014	0.28MetTyr: 0.28 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	1.767AsnAla: 1.767 ± 0.041	0.117AsnCys: 0.117 ± 0.008	0.805AsnAsp: 0.805 ± 0.028	0.694AsnGlu: 0.694 ± 0.025	0.425AsnPhe: 0.425 ± 0.022	1.305AsnGly: 1.305 ± 0.036	0.35AsnHis: 0.35 ± 0.017	0.517AsnIle: 0.517 ± 0.022	0.265AsnLys: 0.265 ± 0.016	1.553AsnLeu: 1.553 ± 0.041	0.243AsnMet: 0.243 ± 0.014	0.302AsnAsn: 0.302 ± 0.017	1.141AsnPro: 1.141 ± 0.036	0.43AsnGln: 0.43 ± 0.02	0.956AsnArg: 0.956 ± 0.031	0.598AsnSer: 0.598 ± 0.025	0.785AsnThr: 0.785 ± 0.025	1.322AsnVal: 1.322 ± 0.035	0.208AsnTrp: 0.208 ± 0.013	0.338AsnTyr: 0.338 ± 0.019	0.0AsnXaa: 0.0 ± 0.0
Pro	7.638ProAla: 7.638 ± 0.091	0.286ProCys: 0.286 ± 0.017	4.457ProAsp: 4.457 ± 0.075	4.04ProGlu: 4.04 ± 0.065	1.441ProPhe: 1.441 ± 0.031	6.625ProGly: 6.625 ± 0.087	1.279ProHis: 1.279 ± 0.036	1.218ProIle: 1.218 ± 0.032	0.701ProLys: 0.701 ± 0.025	4.996ProLeu: 4.996 ± 0.079	1.105ProMet: 1.105 ± 0.03	0.718ProAsn: 0.718 ± 0.025	3.188ProPro: 3.188 ± 0.081	1.89ProGln: 1.89 ± 0.043	4.064ProArg: 4.064 ± 0.062	2.974ProSer: 2.974 ± 0.052	3.53ProThr: 3.53 ± 0.054	5.98ProVal: 5.98 ± 0.071	1.041ProTrp: 1.041 ± 0.03	1.061ProTyr: 1.061 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	3.902GlnAla: 3.902 ± 0.065	0.125GlnCys: 0.125 ± 0.011	1.957GlnAsp: 1.957 ± 0.045	1.976GlnGlu: 1.976 ± 0.041	0.638GlnPhe: 0.638 ± 0.026	2.49GlnGly: 2.49 ± 0.052	0.793GlnHis: 0.793 ± 0.028	1.136GlnIle: 1.136 ± 0.032	0.427GlnLys: 0.427 ± 0.019	3.321GlnLeu: 3.321 ± 0.054	0.605GlnMet: 0.605 ± 0.025	0.412GlnAsn: 0.412 ± 0.022	1.66GlnPro: 1.66 ± 0.042	1.364GlnGln: 1.364 ± 0.049	2.508GlnArg: 2.508 ± 0.057	1.11GlnSer: 1.11 ± 0.03	1.657GlnThr: 1.657 ± 0.042	3.554GlnVal: 3.554 ± 0.054	0.423GlnTrp: 0.423 ± 0.019	0.423GlnTyr: 0.423 ± 0.02	0.0GlnXaa: 0.0 ± 0.0
Arg	10.19ArgAla: 10.19 ± 0.111	0.532ArgCys: 0.532 ± 0.024	4.533ArgAsp: 4.533 ± 0.065	4.926ArgGlu: 4.926 ± 0.078	2.066ArgPhe: 2.066 ± 0.045	6.38ArgGly: 6.38 ± 0.081	2.093ArgHis: 2.093 ± 0.043	2.644ArgIle: 2.644 ± 0.058	1.159ArgLys: 1.159 ± 0.035	8.498ArgLeu: 8.498 ± 0.098	1.819ArgMet: 1.819 ± 0.04	1.039ArgAsn: 1.039 ± 0.029	4.985ArgPro: 4.985 ± 0.077	2.444ArgGln: 2.444 ± 0.049	8.124ArgArg: 8.124 ± 0.12	4.421ArgSer: 4.421 ± 0.058	5.231ArgThr: 5.231 ± 0.074	6.883ArgVal: 6.883 ± 0.087	1.579ArgTrp: 1.579 ± 0.037	1.658ArgTyr: 1.658 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	6.147SerAla: 6.147 ± 0.072	0.346SerCys: 0.346 ± 0.017	2.501SerAsp: 2.501 ± 0.045	2.303SerGlu: 2.303 ± 0.043	1.577SerPhe: 1.577 ± 0.041	5.69SerGly: 5.69 ± 0.087	0.958SerHis: 0.958 ± 0.028	1.455SerIle: 1.455 ± 0.044	0.719SerLys: 0.719 ± 0.027	4.839SerLeu: 4.839 ± 0.062	1.147SerMet: 1.147 ± 0.029	0.752SerAsn: 0.752 ± 0.027	2.998SerPro: 2.998 ± 0.052	1.367SerGln: 1.367 ± 0.037	3.89SerArg: 3.89 ± 0.066	3.049SerSer: 3.049 ± 0.061	3.524SerThr: 3.524 ± 0.064	4.618SerVal: 4.618 ± 0.066	0.979SerTrp: 0.979 ± 0.029	1.135SerTyr: 1.135 ± 0.036	0.0SerXaa: 0.0 ± 0.0
Thr	7.584ThrAla: 7.584 ± 0.097	0.439ThrCys: 0.439 ± 0.023	3.708ThrAsp: 3.708 ± 0.063	2.973ThrGlu: 2.973 ± 0.045	1.687ThrPhe: 1.687 ± 0.034	6.439ThrGly: 6.439 ± 0.069	1.27ThrHis: 1.27 ± 0.031	1.877ThrIle: 1.877 ± 0.042	0.911ThrLys: 0.911 ± 0.028	5.974ThrLeu: 5.974 ± 0.07	1.135ThrMet: 1.135 ± 0.031	0.883ThrAsn: 0.883 ± 0.029	3.692ThrPro: 3.692 ± 0.056	1.557ThrGln: 1.557 ± 0.041	4.173ThrArg: 4.173 ± 0.06	3.44ThrSer: 3.44 ± 0.056	4.202ThrThr: 4.202 ± 0.075	6.169ThrVal: 6.169 ± 0.074	1.065ThrTrp: 1.065 ± 0.032	1.269ThrTyr: 1.269 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	12.975ValAla: 12.975 ± 0.156	0.695ValCys: 0.695 ± 0.027	6.327ValAsp: 6.327 ± 0.08	6.054ValGlu: 6.054 ± 0.086	2.236ValPhe: 2.236 ± 0.05	8.712ValGly: 8.712 ± 0.118	2.205ValHis: 2.205 ± 0.053	2.689ValIle: 2.689 ± 0.053	1.262ValLys: 1.262 ± 0.039	11.673ValLeu: 11.673 ± 0.135	1.657ValMet: 1.657 ± 0.037	1.437ValAsn: 1.437 ± 0.036	5.732ValPro: 5.732 ± 0.084	2.653ValGln: 2.653 ± 0.052	7.918ValArg: 7.918 ± 0.087	4.799ValSer: 4.799 ± 0.067	5.805ValThr: 5.805 ± 0.073	11.666ValVal: 11.666 ± 0.137	1.272ValTrp: 1.272 ± 0.029	1.476ValTyr: 1.476 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	1.872TrpAla: 1.872 ± 0.047	0.163TrpCys: 0.163 ± 0.012	0.844TrpAsp: 0.844 ± 0.029	0.755TrpGlu: 0.755 ± 0.025	0.537TrpPhe: 0.537 ± 0.022	1.174TrpGly: 1.174 ± 0.034	0.377TrpHis: 0.377 ± 0.019	0.492TrpIle: 0.492 ± 0.023	0.236TrpLys: 0.236 ± 0.016	1.907TrpLeu: 1.907 ± 0.046	0.295TrpMet: 0.295 ± 0.016	0.254TrpAsn: 0.254 ± 0.017	0.808TrpPro: 0.808 ± 0.026	0.593TrpGln: 0.593 ± 0.022	1.41TrpArg: 1.41 ± 0.036	1.059TrpSer: 1.059 ± 0.03	1.059TrpThr: 1.059 ± 0.034	1.462TrpVal: 1.462 ± 0.038	0.477TrpTrp: 0.477 ± 0.023	0.281TrpTyr: 0.281 ± 0.014	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.443TyrAla: 2.443 ± 0.044	0.137TyrCys: 0.137 ± 0.011	1.335TyrAsp: 1.335 ± 0.042	1.031TyrGlu: 1.031 ± 0.033	0.519TyrPhe: 0.519 ± 0.024	1.856TyrGly: 1.856 ± 0.044	0.389TyrHis: 0.389 ± 0.018	0.38TyrIle: 0.38 ± 0.02	0.276TyrLys: 0.276 ± 0.016	2.181TyrLeu: 2.181 ± 0.045	0.199TyrMet: 0.199 ± 0.014	0.287TyrAsn: 0.287 ± 0.019	1.06TyrPro: 1.06 ± 0.029	0.587TyrGln: 0.587 ± 0.021	1.516TyrArg: 1.516 ± 0.042	0.804TyrSer: 0.804 ± 0.032	1.01TyrThr: 1.01 ± 0.029	1.72TyrVal: 1.72 ± 0.041	0.285TyrTrp: 0.285 ± 0.018	0.42TyrTyr: 0.42 ± 0.019	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3428 proteins (1146953 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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