Amino acid dipepetide frequency for Seonamhaeicola algicola

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.26AlaAla: 4.26 ± 0.086	0.645AlaCys: 0.645 ± 0.027	3.23AlaAsp: 3.23 ± 0.062	3.808AlaGlu: 3.808 ± 0.076	3.655AlaPhe: 3.655 ± 0.068	4.002AlaGly: 4.002 ± 0.069	1.298AlaHis: 1.298 ± 0.038	5.53AlaIle: 5.53 ± 0.075	4.978AlaLys: 4.978 ± 0.083	6.732AlaLeu: 6.732 ± 0.095	1.387AlaMet: 1.387 ± 0.04	4.316AlaAsn: 4.316 ± 0.069	2.059AlaPro: 2.059 ± 0.054	2.58AlaGln: 2.58 ± 0.059	1.838AlaArg: 1.838 ± 0.047	4.389AlaSer: 4.389 ± 0.07	3.968AlaThr: 3.968 ± 0.086	4.183AlaVal: 4.183 ± 0.077	0.662AlaTrp: 0.662 ± 0.026	2.614AlaTyr: 2.614 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	0.493CysAla: 0.493 ± 0.022	0.098CysCys: 0.098 ± 0.009	0.39CysAsp: 0.39 ± 0.022	0.457CysGlu: 0.457 ± 0.023	0.474CysPhe: 0.474 ± 0.021	0.555CysGly: 0.555 ± 0.026	0.204CysHis: 0.204 ± 0.017	0.604CysIle: 0.604 ± 0.023	0.553CysLys: 0.553 ± 0.025	0.65CysLeu: 0.65 ± 0.024	0.132CysMet: 0.132 ± 0.01	0.497CysAsn: 0.497 ± 0.019	0.275CysPro: 0.275 ± 0.019	0.199CysGln: 0.199 ± 0.011	0.178CysArg: 0.178 ± 0.012	0.525CysSer: 0.525 ± 0.026	0.437CysThr: 0.437 ± 0.022	0.467CysVal: 0.467 ± 0.019	0.068CysTrp: 0.068 ± 0.008	0.332CysTyr: 0.332 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	4.095AspAla: 4.095 ± 0.059	0.385AspCys: 0.385 ± 0.019	3.144AspAsp: 3.144 ± 0.07	3.417AspGlu: 3.417 ± 0.06	3.416AspPhe: 3.416 ± 0.064	3.548AspGly: 3.548 ± 0.084	0.768AspHis: 0.768 ± 0.03	4.353AspIle: 4.353 ± 0.06	3.719AspLys: 3.719 ± 0.063	4.594AspLeu: 4.594 ± 0.067	1.029AspMet: 1.029 ± 0.032	3.433AspAsn: 3.433 ± 0.071	1.461AspPro: 1.461 ± 0.048	1.063AspGln: 1.063 ± 0.031	1.592AspArg: 1.592 ± 0.036	2.718AspSer: 2.718 ± 0.056	3.001AspThr: 3.001 ± 0.059	4.035AspVal: 4.035 ± 0.062	0.673AspTrp: 0.673 ± 0.024	2.666AspTyr: 2.666 ± 0.056	0.0AspXaa: 0.0 ± 0.0
Glu	4.757GluAla: 4.757 ± 0.079	0.305GluCys: 0.305 ± 0.019	3.404GluAsp: 3.404 ± 0.065	3.764GluGlu: 3.764 ± 0.068	2.693GluPhe: 2.693 ± 0.05	3.514GluGly: 3.514 ± 0.07	1.154GluHis: 1.154 ± 0.031	4.761GluIle: 4.761 ± 0.069	5.076GluLys: 5.076 ± 0.076	5.316GluLeu: 5.316 ± 0.059	1.226GluMet: 1.226 ± 0.035	4.856GluAsn: 4.856 ± 0.061	1.519GluPro: 1.519 ± 0.034	2.078GluGln: 2.078 ± 0.045	2.232GluArg: 2.232 ± 0.051	2.96GluSer: 2.96 ± 0.05	4.266GluThr: 4.266 ± 0.072	3.909GluVal: 3.909 ± 0.057	0.573GluTrp: 0.573 ± 0.028	2.134GluTyr: 2.134 ± 0.045	0.0GluXaa: 0.0 ± 0.0
Phe	2.802PheAla: 2.802 ± 0.05	0.427PheCys: 0.427 ± 0.017	3.218PheAsp: 3.218 ± 0.069	3.338PheGlu: 3.338 ± 0.053	2.705PhePhe: 2.705 ± 0.062	3.476PheGly: 3.476 ± 0.058	0.786PheHis: 0.786 ± 0.027	3.882PheIle: 3.882 ± 0.072	4.43PheLys: 4.43 ± 0.081	4.439PheLeu: 4.439 ± 0.081	1.06PheMet: 1.06 ± 0.026	4.302PheAsn: 4.302 ± 0.076	1.601PhePro: 1.601 ± 0.041	1.409PheGln: 1.409 ± 0.035	1.407PheArg: 1.407 ± 0.035	3.924PheSer: 3.924 ± 0.061	3.359PheThr: 3.359 ± 0.072	2.933PheVal: 2.933 ± 0.053	0.57PheTrp: 0.57 ± 0.023	2.109PheTyr: 2.109 ± 0.049	0.0PheXaa: 0.0 ± 0.0
Gly	4.246GlyAla: 4.246 ± 0.077	0.582GlyCys: 0.582 ± 0.032	3.134GlyAsp: 3.134 ± 0.058	3.416GlyGlu: 3.416 ± 0.058	3.542GlyPhe: 3.542 ± 0.071	4.395GlyGly: 4.395 ± 0.088	1.13GlyHis: 1.13 ± 0.033	5.05GlyIle: 5.05 ± 0.076	4.75GlyLys: 4.75 ± 0.077	5.545GlyLeu: 5.545 ± 0.081	1.389GlyMet: 1.389 ± 0.041	4.167GlyAsn: 4.167 ± 0.074	1.4GlyPro: 1.4 ± 0.042	1.749GlyGln: 1.749 ± 0.036	1.921GlyArg: 1.921 ± 0.05	3.712GlySer: 3.712 ± 0.066	4.006GlyThr: 4.006 ± 0.09	4.488GlyVal: 4.488 ± 0.071	0.798GlyTrp: 0.798 ± 0.028	2.826GlyTyr: 2.826 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	1.116HisAla: 1.116 ± 0.037	0.191HisCys: 0.191 ± 0.015	0.921HisAsp: 0.921 ± 0.026	0.949HisGlu: 0.949 ± 0.036	1.173HisPhe: 1.173 ± 0.034	1.075HisGly: 1.075 ± 0.032	0.485HisHis: 0.485 ± 0.025	1.558HisIle: 1.558 ± 0.043	1.422HisLys: 1.422 ± 0.039	1.758HisLeu: 1.758 ± 0.043	0.355HisMet: 0.355 ± 0.017	1.302HisAsn: 1.302 ± 0.038	0.873HisPro: 0.873 ± 0.03	0.66HisGln: 0.66 ± 0.027	0.598HisArg: 0.598 ± 0.023	0.966HisSer: 0.966 ± 0.03	1.054HisThr: 1.054 ± 0.031	1.101HisVal: 1.101 ± 0.034	0.241HisTrp: 0.241 ± 0.014	0.905HisTyr: 0.905 ± 0.029	0.0HisXaa: 0.0 ± 0.0
Ile	5.523IleAla: 5.523 ± 0.081	0.609IleCys: 0.609 ± 0.023	4.734IleAsp: 4.734 ± 0.057	5.492IleGlu: 5.492 ± 0.07	3.371IlePhe: 3.371 ± 0.062	4.888IleGly: 4.888 ± 0.07	1.3IleHis: 1.3 ± 0.034	5.984IleIle: 5.984 ± 0.093	6.248IleLys: 6.248 ± 0.083	6.476IleLeu: 6.476 ± 0.088	1.341IleMet: 1.341 ± 0.038	5.597IleAsn: 5.597 ± 0.092	3.042IlePro: 3.042 ± 0.058	2.285IleGln: 2.285 ± 0.05	2.188IleArg: 2.188 ± 0.04	5.195IleSer: 5.195 ± 0.071	5.428IleThr: 5.428 ± 0.089	4.652IleVal: 4.652 ± 0.071	0.705IleTrp: 0.705 ± 0.028	2.785IleTyr: 2.785 ± 0.056	0.0IleXaa: 0.0 ± 0.0
Lys	5.557LysAla: 5.557 ± 0.085	0.345LysCys: 0.345 ± 0.018	4.315LysAsp: 4.315 ± 0.075	5.328LysGlu: 5.328 ± 0.088	3.06LysPhe: 3.06 ± 0.058	4.474LysGly: 4.474 ± 0.075	1.931LysHis: 1.931 ± 0.048	5.807LysIle: 5.807 ± 0.079	6.945LysLys: 6.945 ± 0.111	6.944LysLeu: 6.944 ± 0.09	1.742LysMet: 1.742 ± 0.043	6.216LysAsn: 6.216 ± 0.082	2.861LysPro: 2.861 ± 0.061	3.417LysGln: 3.417 ± 0.067	2.794LysArg: 2.794 ± 0.046	4.29LysSer: 4.29 ± 0.067	5.714LysThr: 5.714 ± 0.074	4.642LysVal: 4.642 ± 0.08	0.839LysTrp: 0.839 ± 0.029	3.098LysTyr: 3.098 ± 0.054	0.0LysXaa: 0.0 ± 0.0
Leu	5.729LeuAla: 5.729 ± 0.089	0.681LeuCys: 0.681 ± 0.028	4.527LeuAsp: 4.527 ± 0.065	5.459LeuGlu: 5.459 ± 0.079	4.556LeuPhe: 4.556 ± 0.079	5.467LeuGly: 5.467 ± 0.082	1.611LeuHis: 1.611 ± 0.04	6.607LeuIle: 6.607 ± 0.097	8.367LeuLys: 8.367 ± 0.118	8.128LeuLeu: 8.128 ± 0.118	1.83LeuMet: 1.83 ± 0.047	6.856LeuAsn: 6.856 ± 0.089	3.475LeuPro: 3.475 ± 0.065	3.259LeuGln: 3.259 ± 0.059	2.758LeuArg: 2.758 ± 0.06	6.168LeuSer: 6.168 ± 0.091	5.343LeuThr: 5.343 ± 0.086	5.307LeuVal: 5.307 ± 0.078	0.828LeuTrp: 0.828 ± 0.028	3.181LeuTyr: 3.181 ± 0.06	0.0LeuXaa: 0.0 ± 0.0
Met	1.542MetAla: 1.542 ± 0.038	0.151MetCys: 0.151 ± 0.011	0.9MetAsp: 0.9 ± 0.029	1.009MetGlu: 1.009 ± 0.03	0.905MetPhe: 0.905 ± 0.038	1.217MetGly: 1.217 ± 0.036	0.419MetHis: 0.419 ± 0.017	1.242MetIle: 1.242 ± 0.039	1.93MetLys: 1.93 ± 0.038	1.931MetLeu: 1.931 ± 0.05	0.467MetMet: 0.467 ± 0.024	1.185MetAsn: 1.185 ± 0.028	0.862MetPro: 0.862 ± 0.032	0.851MetGln: 0.851 ± 0.028	0.746MetArg: 0.746 ± 0.023	1.258MetSer: 1.258 ± 0.034	0.999MetThr: 0.999 ± 0.032	1.274MetVal: 1.274 ± 0.04	0.178MetTrp: 0.178 ± 0.013	0.772MetTyr: 0.772 ± 0.026	0.0MetXaa: 0.0 ± 0.0
Asn	4.938AsnAla: 4.938 ± 0.075	0.546AsnCys: 0.546 ± 0.026	3.74AsnAsp: 3.74 ± 0.073	4.176AsnGlu: 4.176 ± 0.063	3.584AsnPhe: 3.584 ± 0.06	4.657AsnGly: 4.657 ± 0.089	1.224AsnHis: 1.224 ± 0.036	5.894AsnIle: 5.894 ± 0.084	5.468AsnLys: 5.468 ± 0.093	6.221AsnLeu: 6.221 ± 0.081	1.393AsnMet: 1.393 ± 0.039	6.238AsnAsn: 6.238 ± 0.14	3.008AsnPro: 3.008 ± 0.062	2.359AsnGln: 2.359 ± 0.057	2.154AsnArg: 2.154 ± 0.045	3.968AsnSer: 3.968 ± 0.071	5.395AsnThr: 5.395 ± 0.104	4.432AsnVal: 4.432 ± 0.079	0.923AsnTrp: 0.923 ± 0.029	3.479AsnTyr: 3.479 ± 0.067	0.0AsnXaa: 0.0 ± 0.0
Pro	1.834ProAla: 1.834 ± 0.048	0.208ProCys: 0.208 ± 0.014	1.939ProAsp: 1.939 ± 0.05	2.788ProGlu: 2.788 ± 0.049	1.938ProPhe: 1.938 ± 0.045	1.805ProGly: 1.805 ± 0.046	0.7ProHis: 0.7 ± 0.027	2.581ProIle: 2.581 ± 0.049	2.725ProLys: 2.725 ± 0.059	2.876ProLeu: 2.876 ± 0.059	0.658ProMet: 0.658 ± 0.025	2.68ProAsn: 2.68 ± 0.054	0.777ProPro: 0.777 ± 0.03	1.159ProGln: 1.159 ± 0.032	0.881ProArg: 0.881 ± 0.029	2.134ProSer: 2.134 ± 0.049	2.074ProThr: 2.074 ± 0.05	2.292ProVal: 2.292 ± 0.043	0.388ProTrp: 0.388 ± 0.02	1.413ProTyr: 1.413 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	2.136GlnAla: 2.136 ± 0.048	0.201GlnCys: 0.201 ± 0.015	1.593GlnAsp: 1.593 ± 0.036	1.922GlnGlu: 1.922 ± 0.042	1.674GlnPhe: 1.674 ± 0.034	1.868GlnGly: 1.868 ± 0.042	0.669GlnHis: 0.669 ± 0.023	2.537GlnIle: 2.537 ± 0.044	2.618GlnLys: 2.618 ± 0.055	3.304GlnLeu: 3.304 ± 0.065	0.71GlnMet: 0.71 ± 0.024	2.445GlnAsn: 2.445 ± 0.049	1.156GlnPro: 1.156 ± 0.037	1.454GlnGln: 1.454 ± 0.045	1.148GlnArg: 1.148 ± 0.034	1.732GlnSer: 1.732 ± 0.044	2.151GlnThr: 2.151 ± 0.044	1.878GlnVal: 1.878 ± 0.038	0.38GlnTrp: 0.38 ± 0.019	1.37GlnTyr: 1.37 ± 0.037	0.0GlnXaa: 0.0 ± 0.0
Arg	2.045ArgAla: 2.045 ± 0.048	0.193ArgCys: 0.193 ± 0.014	1.63ArgAsp: 1.63 ± 0.039	1.669ArgGlu: 1.669 ± 0.04	1.776ArgPhe: 1.776 ± 0.04	1.87ArgGly: 1.87 ± 0.039	0.618ArgHis: 0.618 ± 0.024	2.494ArgIle: 2.494 ± 0.047	2.362ArgLys: 2.362 ± 0.059	2.97ArgLeu: 2.97 ± 0.05	0.737ArgMet: 0.737 ± 0.029	2.006ArgAsn: 2.006 ± 0.047	1.047ArgPro: 1.047 ± 0.036	0.972ArgGln: 0.972 ± 0.03	1.158ArgArg: 1.158 ± 0.04	1.604ArgSer: 1.604 ± 0.04	1.727ArgThr: 1.727 ± 0.043	2.045ArgVal: 2.045 ± 0.046	0.408ArgTrp: 0.408 ± 0.02	1.396ArgTyr: 1.396 ± 0.036	0.001ArgXaa: 0.001 ± 0.001
Ser	3.773SerAla: 3.773 ± 0.058	0.618SerCys: 0.618 ± 0.024	2.847SerAsp: 2.847 ± 0.057	3.471SerGlu: 3.471 ± 0.054	3.617SerPhe: 3.617 ± 0.066	4.262SerGly: 4.262 ± 0.08	1.056SerHis: 1.056 ± 0.03	5.053SerIle: 5.053 ± 0.082	5.004SerLys: 5.004 ± 0.07	5.352SerLeu: 5.352 ± 0.073	1.127SerMet: 1.127 ± 0.033	4.566SerAsn: 4.566 ± 0.086	1.798SerPro: 1.798 ± 0.043	1.867SerGln: 1.867 ± 0.038	1.833SerArg: 1.833 ± 0.047	3.758SerSer: 3.758 ± 0.068	3.539SerThr: 3.539 ± 0.073	4.017SerVal: 4.017 ± 0.06	0.698SerTrp: 0.698 ± 0.032	2.622SerTyr: 2.622 ± 0.051	0.0SerXaa: 0.0 ± 0.0
Thr	3.887ThrAla: 3.887 ± 0.083	0.412ThrCys: 0.412 ± 0.023	3.461ThrAsp: 3.461 ± 0.07	3.499ThrGlu: 3.499 ± 0.056	3.441ThrPhe: 3.441 ± 0.06	4.116ThrGly: 4.116 ± 0.083	1.226ThrHis: 1.226 ± 0.033	5.432ThrIle: 5.432 ± 0.09	4.573ThrLys: 4.573 ± 0.069	6.071ThrLeu: 6.071 ± 0.075	0.97ThrMet: 0.97 ± 0.029	4.583ThrAsn: 4.583 ± 0.096	2.745ThrPro: 2.745 ± 0.058	2.037ThrGln: 2.037 ± 0.049	1.586ThrArg: 1.586 ± 0.042	4.13ThrSer: 4.13 ± 0.086	4.177ThrThr: 4.177 ± 0.092	4.176ThrVal: 4.176 ± 0.081	0.707ThrTrp: 0.707 ± 0.029	2.673ThrTyr: 2.673 ± 0.06	0.0ThrXaa: 0.0 ± 0.0
Val	4.185ValAla: 4.185 ± 0.067	0.562ValCys: 0.562 ± 0.025	3.333ValAsp: 3.333 ± 0.058	3.769ValGlu: 3.769 ± 0.064	3.513ValPhe: 3.513 ± 0.066	3.74ValGly: 3.74 ± 0.058	1.032ValHis: 1.032 ± 0.035	4.972ValIle: 4.972 ± 0.071	4.717ValLys: 4.717 ± 0.073	6.093ValLeu: 6.093 ± 0.086	1.256ValMet: 1.256 ± 0.039	4.367ValAsn: 4.367 ± 0.079	2.128ValPro: 2.128 ± 0.048	1.581ValGln: 1.581 ± 0.04	1.838ValArg: 1.838 ± 0.044	4.444ValSer: 4.444 ± 0.066	3.996ValThr: 3.996 ± 0.095	4.373ValVal: 4.373 ± 0.078	0.635ValTrp: 0.635 ± 0.026	2.581ValTyr: 2.581 ± 0.055	0.0ValXaa: 0.0 ± 0.0
Trp	0.641TrpAla: 0.641 ± 0.028	0.115TrpCys: 0.115 ± 0.01	0.613TrpAsp: 0.613 ± 0.021	0.669TrpGlu: 0.669 ± 0.026	0.635TrpPhe: 0.635 ± 0.024	0.712TrpGly: 0.712 ± 0.024	0.273TrpHis: 0.273 ± 0.017	0.671TrpIle: 0.671 ± 0.027	0.829TrpLys: 0.829 ± 0.032	1.009TrpLeu: 1.009 ± 0.034	0.292TrpMet: 0.292 ± 0.016	0.8TrpAsn: 0.8 ± 0.037	0.268TrpPro: 0.268 ± 0.016	0.498TrpGln: 0.498 ± 0.023	0.4TrpArg: 0.4 ± 0.02	0.638TrpSer: 0.638 ± 0.028	0.546TrpThr: 0.546 ± 0.024	0.678TrpVal: 0.678 ± 0.025	0.167TrpTrp: 0.167 ± 0.013	0.489TrpTyr: 0.489 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.575TyrAla: 2.575 ± 0.048	0.315TyrCys: 0.315 ± 0.018	2.034TyrAsp: 2.034 ± 0.051	2.099TyrGlu: 2.099 ± 0.049	2.452TyrPhe: 2.452 ± 0.048	2.604TyrGly: 2.604 ± 0.055	0.818TyrHis: 0.818 ± 0.028	2.829TyrIle: 2.829 ± 0.05	3.605TyrLys: 3.605 ± 0.061	3.728TyrLeu: 3.728 ± 0.062	0.736TyrMet: 0.736 ± 0.024	3.386TyrAsn: 3.386 ± 0.06	1.495TyrPro: 1.495 ± 0.045	1.47TyrGln: 1.47 ± 0.038	1.476TyrArg: 1.476 ± 0.04	2.366TyrSer: 2.366 ± 0.051	2.723TyrThr: 2.723 ± 0.074	2.234TyrVal: 2.234 ± 0.038	0.499TyrTrp: 0.499 ± 0.022	1.809TyrTyr: 1.809 ± 0.044	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.001	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3062 proteins (1125401 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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