Amino acid dipepetide frequency for Mesonia sp. K7

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.934AlaAla: 3.934 ± 0.098	0.596AlaCys: 0.596 ± 0.031	3.151AlaAsp: 3.151 ± 0.079	4.317AlaGlu: 4.317 ± 0.085	3.332AlaPhe: 3.332 ± 0.064	4.002AlaGly: 4.002 ± 0.094	1.111AlaHis: 1.111 ± 0.042	5.506AlaIle: 5.506 ± 0.096	4.809AlaLys: 4.809 ± 0.088	5.788AlaLeu: 5.788 ± 0.101	1.499AlaMet: 1.499 ± 0.05	3.455AlaAsn: 3.455 ± 0.091	1.708AlaPro: 1.708 ± 0.053	2.778AlaGln: 2.778 ± 0.061	1.938AlaArg: 1.938 ± 0.054	3.787AlaSer: 3.787 ± 0.082	3.619AlaThr: 3.619 ± 0.098	3.974AlaVal: 3.974 ± 0.081	0.558AlaTrp: 0.558 ± 0.03	2.585AlaTyr: 2.585 ± 0.055	0.0AlaXaa: 0.0 ± 0.0
Cys	0.403CysAla: 0.403 ± 0.024	0.101CysCys: 0.101 ± 0.011	0.431CysAsp: 0.431 ± 0.028	0.562CysGlu: 0.562 ± 0.038	0.342CysPhe: 0.342 ± 0.02	0.618CysGly: 0.618 ± 0.031	0.168CysHis: 0.168 ± 0.015	0.523CysIle: 0.523 ± 0.031	0.437CysLys: 0.437 ± 0.024	0.636CysLeu: 0.636 ± 0.03	0.124CysMet: 0.124 ± 0.013	0.377CysAsn: 0.377 ± 0.024	0.318CysPro: 0.318 ± 0.024	0.271CysGln: 0.271 ± 0.021	0.178CysArg: 0.178 ± 0.016	0.512CysSer: 0.512 ± 0.027	0.399CysThr: 0.399 ± 0.024	0.45CysVal: 0.45 ± 0.025	0.073CysTrp: 0.073 ± 0.009	0.283CysTyr: 0.283 ± 0.021	0.0CysXaa: 0.0 ± 0.0
Asp	3.424AspAla: 3.424 ± 0.081	0.447AspCys: 0.447 ± 0.029	2.893AspAsp: 2.893 ± 0.07	4.045AspGlu: 4.045 ± 0.083	3.883AspPhe: 3.883 ± 0.092	3.311AspGly: 3.311 ± 0.084	0.904AspHis: 0.904 ± 0.035	4.397AspIle: 4.397 ± 0.076	4.17AspLys: 4.17 ± 0.086	5.05AspLeu: 5.05 ± 0.091	1.015AspMet: 1.015 ± 0.041	3.026AspAsn: 3.026 ± 0.076	1.581AspPro: 1.581 ± 0.06	1.717AspGln: 1.717 ± 0.043	1.783AspArg: 1.783 ± 0.05	2.841AspSer: 2.841 ± 0.061	2.702AspThr: 2.702 ± 0.067	3.469AspVal: 3.469 ± 0.072	0.7AspTrp: 0.7 ± 0.031	2.935AspTyr: 2.935 ± 0.064	0.0AspXaa: 0.0 ± 0.0
Glu	4.631GluAla: 4.631 ± 0.098	0.299GluCys: 0.299 ± 0.02	3.942GluAsp: 3.942 ± 0.08	6.205GluGlu: 6.205 ± 0.125	2.996GluPhe: 2.996 ± 0.065	3.781GluGly: 3.781 ± 0.083	1.146GluHis: 1.146 ± 0.038	6.452GluIle: 6.452 ± 0.094	7.031GluLys: 7.031 ± 0.132	6.242GluLeu: 6.242 ± 0.092	1.69GluMet: 1.69 ± 0.052	5.999GluAsn: 5.999 ± 0.113	1.61GluPro: 1.61 ± 0.042	2.427GluGln: 2.427 ± 0.06	2.635GluArg: 2.635 ± 0.065	3.492GluSer: 3.492 ± 0.07	3.928GluThr: 3.928 ± 0.068	5.218GluVal: 5.218 ± 0.094	0.56GluTrp: 0.56 ± 0.029	2.465GluTyr: 2.465 ± 0.062	0.0GluXaa: 0.0 ± 0.0
Phe	2.965PheAla: 2.965 ± 0.059	0.474PheCys: 0.474 ± 0.031	3.229PheAsp: 3.229 ± 0.071	3.582PheGlu: 3.582 ± 0.066	2.892PhePhe: 2.892 ± 0.077	3.479PheGly: 3.479 ± 0.077	0.874PheHis: 0.874 ± 0.031	4.02PheIle: 4.02 ± 0.086	3.595PheLys: 3.595 ± 0.083	5.124PheLeu: 5.124 ± 0.102	1.097PheMet: 1.097 ± 0.038	2.865PheAsn: 2.865 ± 0.074	1.801PhePro: 1.801 ± 0.045	1.723PheGln: 1.723 ± 0.056	1.57PheArg: 1.57 ± 0.048	3.834PheSer: 3.834 ± 0.084	3.186PheThr: 3.186 ± 0.062	3.042PheVal: 3.042 ± 0.068	0.569PheTrp: 0.569 ± 0.025	2.415PheTyr: 2.415 ± 0.057	0.0PheXaa: 0.0 ± 0.0
Gly	3.814GlyAla: 3.814 ± 0.093	0.569GlyCys: 0.569 ± 0.035	3.258GlyAsp: 3.258 ± 0.081	3.955GlyGlu: 3.955 ± 0.069	3.642GlyPhe: 3.642 ± 0.071	4.274GlyGly: 4.274 ± 0.131	1.003GlyHis: 1.003 ± 0.041	5.0GlyIle: 5.0 ± 0.088	5.081GlyLys: 5.081 ± 0.095	5.29GlyLeu: 5.29 ± 0.089	1.447GlyMet: 1.447 ± 0.046	3.737GlyAsn: 3.737 ± 0.084	1.249GlyPro: 1.249 ± 0.047	1.755GlyGln: 1.755 ± 0.063	1.86GlyArg: 1.86 ± 0.063	3.723GlySer: 3.723 ± 0.095	3.623GlyThr: 3.623 ± 0.089	4.141GlyVal: 4.141 ± 0.078	0.645GlyTrp: 0.645 ± 0.027	2.697GlyTyr: 2.697 ± 0.059	0.0GlyXaa: 0.0 ± 0.0
His	0.858HisAla: 0.858 ± 0.034	0.154HisCys: 0.154 ± 0.014	0.787HisAsp: 0.787 ± 0.029	0.985HisGlu: 0.985 ± 0.04	1.165HisPhe: 1.165 ± 0.039	0.963HisGly: 0.963 ± 0.037	0.541HisHis: 0.541 ± 0.032	1.509HisIle: 1.509 ± 0.045	1.31HisLys: 1.31 ± 0.051	1.905HisLeu: 1.905 ± 0.057	0.337HisMet: 0.337 ± 0.023	0.988HisAsn: 0.988 ± 0.038	0.929HisPro: 0.929 ± 0.037	1.179HisGln: 1.179 ± 0.045	0.685HisArg: 0.685 ± 0.028	0.917HisSer: 0.917 ± 0.034	1.006HisThr: 1.006 ± 0.036	0.86HisVal: 0.86 ± 0.04	0.208HisTrp: 0.208 ± 0.017	0.905HisTyr: 0.905 ± 0.038	0.0HisXaa: 0.0 ± 0.0
Ile	5.652IleAla: 5.652 ± 0.1	0.618IleCys: 0.618 ± 0.029	5.096IleAsp: 5.096 ± 0.079	6.237IleGlu: 6.237 ± 0.1	3.819IlePhe: 3.819 ± 0.075	4.981IleGly: 4.981 ± 0.092	1.35IleHis: 1.35 ± 0.042	5.978IleIle: 5.978 ± 0.106	6.051IleLys: 6.051 ± 0.101	7.052IleLeu: 7.052 ± 0.128	1.183IleMet: 1.183 ± 0.038	4.866IleAsn: 4.866 ± 0.082	3.26IlePro: 3.26 ± 0.07	2.793IleGln: 2.793 ± 0.066	2.488IleArg: 2.488 ± 0.067	5.5IleSer: 5.5 ± 0.084	4.847IleThr: 4.847 ± 0.081	4.597IleVal: 4.597 ± 0.077	0.644IleTrp: 0.644 ± 0.027	2.99IleTyr: 2.99 ± 0.069	0.0IleXaa: 0.0 ± 0.0
Lys	5.127LysAla: 5.127 ± 0.102	0.335LysCys: 0.335 ± 0.022	4.281LysAsp: 4.281 ± 0.097	6.864LysGlu: 6.864 ± 0.121	3.029LysPhe: 3.029 ± 0.072	4.164LysGly: 4.164 ± 0.086	1.42LysHis: 1.42 ± 0.043	6.782LysIle: 6.782 ± 0.119	7.7LysLys: 7.7 ± 0.114	6.632LysLeu: 6.632 ± 0.092	2.051LysMet: 2.051 ± 0.057	5.769LysAsn: 5.769 ± 0.1	2.394LysPro: 2.394 ± 0.059	2.865LysGln: 2.865 ± 0.068	2.84LysArg: 2.84 ± 0.06	4.551LysSer: 4.551 ± 0.097	4.624LysThr: 4.624 ± 0.091	5.014LysVal: 5.014 ± 0.1	0.668LysTrp: 0.668 ± 0.031	3.159LysTyr: 3.159 ± 0.068	0.0LysXaa: 0.0 ± 0.0
Leu	5.834LeuAla: 5.834 ± 0.094	0.646LeuCys: 0.646 ± 0.033	4.955LeuAsp: 4.955 ± 0.082	6.631LeuGlu: 6.631 ± 0.097	4.734LeuPhe: 4.734 ± 0.101	5.737LeuGly: 5.737 ± 0.108	1.738LeuHis: 1.738 ± 0.047	6.907LeuIle: 6.907 ± 0.125	7.588LeuLys: 7.588 ± 0.124	8.546LeuLeu: 8.546 ± 0.156	2.083LeuMet: 2.083 ± 0.051	5.387LeuAsn: 5.387 ± 0.088	3.438LeuPro: 3.438 ± 0.064	3.764LeuGln: 3.764 ± 0.08	3.055LeuArg: 3.055 ± 0.059	6.32LeuSer: 6.32 ± 0.097	4.883LeuThr: 4.883 ± 0.085	5.445LeuVal: 5.445 ± 0.094	0.74LeuTrp: 0.74 ± 0.033	3.163LeuTyr: 3.163 ± 0.07	0.0LeuXaa: 0.0 ± 0.0
Met	1.538MetAla: 1.538 ± 0.05	0.117MetCys: 0.117 ± 0.013	0.908MetAsp: 0.908 ± 0.033	1.261MetGlu: 1.261 ± 0.04	0.826MetPhe: 0.826 ± 0.038	1.327MetGly: 1.327 ± 0.046	0.408MetHis: 0.408 ± 0.021	1.574MetIle: 1.574 ± 0.051	2.132MetLys: 2.132 ± 0.051	1.951MetLeu: 1.951 ± 0.051	0.654MetMet: 0.654 ± 0.026	1.192MetAsn: 1.192 ± 0.038	0.831MetPro: 0.831 ± 0.034	0.978MetGln: 0.978 ± 0.034	0.837MetArg: 0.837 ± 0.032	1.341MetSer: 1.341 ± 0.043	1.169MetThr: 1.169 ± 0.036	1.419MetVal: 1.419 ± 0.043	0.136MetTrp: 0.136 ± 0.016	0.66MetTyr: 0.66 ± 0.029	0.0MetXaa: 0.0 ± 0.0
Asn	3.651AsnAla: 3.651 ± 0.065	0.464AsnCys: 0.464 ± 0.03	3.277AsnAsp: 3.277 ± 0.076	3.926AsnGlu: 3.926 ± 0.077	3.319AsnPhe: 3.319 ± 0.081	3.717AsnGly: 3.717 ± 0.098	1.241AsnHis: 1.241 ± 0.039	4.949AsnIle: 4.949 ± 0.086	4.393AsnLys: 4.393 ± 0.089	5.745AsnLeu: 5.745 ± 0.101	1.2AsnMet: 1.2 ± 0.039	3.905AsnAsn: 3.905 ± 0.106	2.897AsnPro: 2.897 ± 0.067	2.893AsnGln: 2.893 ± 0.064	2.101AsnArg: 2.101 ± 0.068	3.715AsnSer: 3.715 ± 0.087	3.636AsnThr: 3.636 ± 0.089	3.237AsnVal: 3.237 ± 0.068	0.806AsnTrp: 0.806 ± 0.038	3.069AsnTyr: 3.069 ± 0.085	0.0AsnXaa: 0.0 ± 0.0
Pro	1.899ProAla: 1.899 ± 0.056	0.217ProCys: 0.217 ± 0.017	1.829ProAsp: 1.829 ± 0.053	2.849ProGlu: 2.849 ± 0.069	1.744ProPhe: 1.744 ± 0.047	1.79ProGly: 1.79 ± 0.055	0.629ProHis: 0.629 ± 0.035	2.763ProIle: 2.763 ± 0.056	2.635ProLys: 2.635 ± 0.066	2.865ProLeu: 2.865 ± 0.058	0.695ProMet: 0.695 ± 0.032	2.174ProAsn: 2.174 ± 0.06	0.791ProPro: 0.791 ± 0.033	1.34ProGln: 1.34 ± 0.043	0.891ProArg: 0.891 ± 0.041	2.067ProSer: 2.067 ± 0.062	2.19ProThr: 2.19 ± 0.075	2.261ProVal: 2.261 ± 0.052	0.278ProTrp: 0.278 ± 0.021	1.42ProTyr: 1.42 ± 0.047	0.0ProXaa: 0.0 ± 0.0
Gln	2.386GlnAla: 2.386 ± 0.061	0.174GlnCys: 0.174 ± 0.016	1.891GlnAsp: 1.891 ± 0.057	3.177GlnGlu: 3.177 ± 0.083	1.623GlnPhe: 1.623 ± 0.048	1.924GlnGly: 1.924 ± 0.055	0.723GlnHis: 0.723 ± 0.031	2.955GlnIle: 2.955 ± 0.065	3.636GlnLys: 3.636 ± 0.079	3.826GlnLeu: 3.826 ± 0.068	0.923GlnMet: 0.923 ± 0.036	2.641GlnAsn: 2.641 ± 0.073	1.327GlnPro: 1.327 ± 0.041	2.06GlnGln: 2.06 ± 0.058	1.338GlnArg: 1.338 ± 0.039	1.976GlnSer: 1.976 ± 0.048	2.178GlnThr: 2.178 ± 0.059	2.305GlnVal: 2.305 ± 0.065	0.351GlnTrp: 0.351 ± 0.022	1.323GlnTyr: 1.323 ± 0.043	0.0GlnXaa: 0.0 ± 0.0
Arg	1.964ArgAla: 1.964 ± 0.051	0.173ArgCys: 0.173 ± 0.016	1.677ArgAsp: 1.677 ± 0.048	2.444ArgGlu: 2.444 ± 0.064	1.795ArgPhe: 1.795 ± 0.054	1.774ArgGly: 1.774 ± 0.053	0.605ArgHis: 0.605 ± 0.03	2.774ArgIle: 2.774 ± 0.069	3.077ArgLys: 3.077 ± 0.069	3.208ArgLeu: 3.208 ± 0.067	0.828ArgMet: 0.828 ± 0.032	2.027ArgAsn: 2.027 ± 0.06	0.99ArgPro: 0.99 ± 0.042	1.218ArgGln: 1.218 ± 0.043	1.295ArgArg: 1.295 ± 0.046	1.714ArgSer: 1.714 ± 0.05	1.6ArgThr: 1.6 ± 0.049	1.981ArgVal: 1.981 ± 0.051	0.333ArgTrp: 0.333 ± 0.017	1.474ArgTyr: 1.474 ± 0.049	0.0ArgXaa: 0.0 ± 0.0
Ser	3.579SerAla: 3.579 ± 0.067	0.542SerCys: 0.542 ± 0.027	3.147SerAsp: 3.147 ± 0.077	4.264SerGlu: 4.264 ± 0.071	3.683SerPhe: 3.683 ± 0.075	4.238SerGly: 4.238 ± 0.09	1.028SerHis: 1.028 ± 0.039	4.743SerIle: 4.743 ± 0.083	4.543SerLys: 4.543 ± 0.085	5.933SerLeu: 5.933 ± 0.117	1.149SerMet: 1.149 ± 0.041	3.361SerAsn: 3.361 ± 0.074	2.023SerPro: 2.023 ± 0.052	2.246SerGln: 2.246 ± 0.049	1.924SerArg: 1.924 ± 0.051	3.954SerSer: 3.954 ± 0.084	3.483SerThr: 3.483 ± 0.087	3.829SerVal: 3.829 ± 0.083	0.64SerTrp: 0.64 ± 0.031	2.724SerTyr: 2.724 ± 0.068	0.0SerXaa: 0.0 ± 0.0
Thr	3.76ThrAla: 3.76 ± 0.099	0.345ThrCys: 0.345 ± 0.022	3.079ThrAsp: 3.079 ± 0.071	3.664ThrGlu: 3.664 ± 0.069	2.952ThrPhe: 2.952 ± 0.075	3.887ThrGly: 3.887 ± 0.101	1.124ThrHis: 1.124 ± 0.04	4.622ThrIle: 4.622 ± 0.092	3.767ThrLys: 3.767 ± 0.078	5.142ThrLeu: 5.142 ± 0.078	0.883ThrMet: 0.883 ± 0.034	3.313ThrAsn: 3.313 ± 0.086	2.459ThrPro: 2.459 ± 0.074	2.34ThrGln: 2.34 ± 0.062	1.585ThrArg: 1.585 ± 0.047	3.805ThrSer: 3.805 ± 0.084	3.777ThrThr: 3.777 ± 0.123	3.56ThrVal: 3.56 ± 0.079	0.553ThrTrp: 0.553 ± 0.033	2.645ThrTyr: 2.645 ± 0.075	0.0ThrXaa: 0.0 ± 0.0
Val	4.06ValAla: 4.06 ± 0.08	0.528ValCys: 0.528 ± 0.026	3.423ValAsp: 3.423 ± 0.069	4.355ValGlu: 4.355 ± 0.079	3.456ValPhe: 3.456 ± 0.077	3.77ValGly: 3.77 ± 0.078	0.995ValHis: 0.995 ± 0.034	4.984ValIle: 4.984 ± 0.081	4.511ValLys: 4.511 ± 0.082	5.834ValLeu: 5.834 ± 0.105	1.403ValMet: 1.403 ± 0.047	3.828ValAsn: 3.828 ± 0.083	1.997ValPro: 1.997 ± 0.057	1.861ValGln: 1.861 ± 0.051	1.977ValArg: 1.977 ± 0.056	4.081ValSer: 4.081 ± 0.083	3.572ValThr: 3.572 ± 0.097	4.225ValVal: 4.225 ± 0.09	0.569ValTrp: 0.569 ± 0.027	2.506ValTyr: 2.506 ± 0.06	0.0ValXaa: 0.0 ± 0.0
Trp	0.509TrpAla: 0.509 ± 0.024	0.09TrpCys: 0.09 ± 0.012	0.577TrpAsp: 0.577 ± 0.033	0.674TrpGlu: 0.674 ± 0.033	0.532TrpPhe: 0.532 ± 0.031	0.517TrpGly: 0.517 ± 0.029	0.206TrpHis: 0.206 ± 0.017	0.654TrpIle: 0.654 ± 0.028	0.735TrpLys: 0.735 ± 0.036	0.973TrpLeu: 0.973 ± 0.038	0.305TrpMet: 0.305 ± 0.02	0.627TrpAsn: 0.627 ± 0.028	0.217TrpPro: 0.217 ± 0.017	0.437TrpGln: 0.437 ± 0.023	0.333TrpArg: 0.333 ± 0.021	0.531TrpSer: 0.531 ± 0.028	0.426TrpThr: 0.426 ± 0.027	0.66TrpVal: 0.66 ± 0.029	0.128TrpTrp: 0.128 ± 0.014	0.476TrpTyr: 0.476 ± 0.033	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.459TyrAla: 2.459 ± 0.061	0.315TyrCys: 0.315 ± 0.02	2.463TyrAsp: 2.463 ± 0.066	2.754TyrGlu: 2.754 ± 0.061	2.574TyrPhe: 2.574 ± 0.065	2.508TyrGly: 2.508 ± 0.066	0.976TyrHis: 0.976 ± 0.035	2.911TyrIle: 2.911 ± 0.066	3.068TyrLys: 3.068 ± 0.064	3.854TyrLeu: 3.854 ± 0.074	0.691TyrMet: 0.691 ± 0.03	2.604TyrAsn: 2.604 ± 0.072	1.506TyrPro: 1.506 ± 0.043	2.091TyrGln: 2.091 ± 0.057	1.636TyrArg: 1.636 ± 0.051	2.377TyrSer: 2.377 ± 0.058	2.413TyrThr: 2.413 ± 0.067	2.249TyrVal: 2.249 ± 0.057	0.447TyrTrp: 0.447 ± 0.024	1.996TyrTyr: 1.996 ± 0.061	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2375 proteins (780029 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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