Amino acid dipepetide frequency for Aestuariirhabdus litorea

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.343AlaAla: 10.343 ± 0.126	1.211AlaCys: 1.211 ± 0.039	5.262AlaAsp: 5.262 ± 0.074	6.76AlaGlu: 6.76 ± 0.082	3.278AlaPhe: 3.278 ± 0.056	7.949AlaGly: 7.949 ± 0.09	1.837AlaHis: 1.837 ± 0.042	5.419AlaIle: 5.419 ± 0.086	2.918AlaLys: 2.918 ± 0.061	12.578AlaLeu: 12.578 ± 0.144	2.807AlaMet: 2.807 ± 0.054	2.817AlaAsn: 2.817 ± 0.049	4.123AlaPro: 4.123 ± 0.075	4.2AlaGln: 4.2 ± 0.069	6.671AlaArg: 6.671 ± 0.094	6.055AlaSer: 6.055 ± 0.076	4.579AlaThr: 4.579 ± 0.07	6.667AlaVal: 6.667 ± 0.095	1.108AlaTrp: 1.108 ± 0.03	2.406AlaTyr: 2.406 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	1.064CysAla: 1.064 ± 0.033	0.188CysCys: 0.188 ± 0.014	0.665CysAsp: 0.665 ± 0.025	0.724CysGlu: 0.724 ± 0.028	0.43CysPhe: 0.43 ± 0.02	1.079CysGly: 1.079 ± 0.034	0.399CysHis: 0.399 ± 0.028	0.544CysIle: 0.544 ± 0.023	0.318CysLys: 0.318 ± 0.017	1.178CysLeu: 1.178 ± 0.034	0.209CysMet: 0.209 ± 0.014	0.352CysAsn: 0.352 ± 0.016	0.608CysPro: 0.608 ± 0.026	0.484CysGln: 0.484 ± 0.023	0.767CysArg: 0.767 ± 0.028	0.732CysSer: 0.732 ± 0.025	0.538CysThr: 0.538 ± 0.023	0.679CysVal: 0.679 ± 0.024	0.187CysTrp: 0.187 ± 0.012	0.335CysTyr: 0.335 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	4.837AspAla: 4.837 ± 0.067	0.583AspCys: 0.583 ± 0.023	2.541AspAsp: 2.541 ± 0.067	3.597AspGlu: 3.597 ± 0.063	1.916AspPhe: 1.916 ± 0.041	3.716AspGly: 3.716 ± 0.062	1.26AspHis: 1.26 ± 0.035	2.788AspIle: 2.788 ± 0.051	1.769AspLys: 1.769 ± 0.045	5.606AspLeu: 5.606 ± 0.078	1.152AspMet: 1.152 ± 0.033	1.821AspAsn: 1.821 ± 0.049	2.977AspPro: 2.977 ± 0.053	2.382AspGln: 2.382 ± 0.045	3.605AspArg: 3.605 ± 0.069	3.264AspSer: 3.264 ± 0.054	2.505AspThr: 2.505 ± 0.043	2.737AspVal: 2.737 ± 0.061	0.775AspTrp: 0.775 ± 0.025	1.805AspTyr: 1.805 ± 0.041	0.0AspXaa: 0.0 ± 0.0
Glu	7.13GluAla: 7.13 ± 0.102	0.522GluCys: 0.522 ± 0.02	2.505GluAsp: 2.505 ± 0.052	4.346GluGlu: 4.346 ± 0.074	1.952GluPhe: 1.952 ± 0.047	5.165GluGly: 5.165 ± 0.065	1.418GluHis: 1.418 ± 0.033	3.465GluIle: 3.465 ± 0.063	2.282GluLys: 2.282 ± 0.055	7.869GluLeu: 7.869 ± 0.099	1.655GluMet: 1.655 ± 0.04	1.597GluAsn: 1.597 ± 0.042	2.693GluPro: 2.693 ± 0.056	4.578GluGln: 4.578 ± 0.064	5.302GluArg: 5.302 ± 0.083	3.721GluSer: 3.721 ± 0.055	2.844GluThr: 2.844 ± 0.05	4.843GluVal: 4.843 ± 0.079	0.728GluTrp: 0.728 ± 0.026	1.44GluTyr: 1.44 ± 0.038	0.001GluXaa: 0.001 ± 0.001
Phe	3.255PheAla: 3.255 ± 0.063	0.533PheCys: 0.533 ± 0.021	2.475PheAsp: 2.475 ± 0.049	2.361PheGlu: 2.361 ± 0.047	1.394PhePhe: 1.394 ± 0.045	2.94PheGly: 2.94 ± 0.059	0.742PheHis: 0.742 ± 0.023	1.933PheIle: 1.933 ± 0.044	1.188PheLys: 1.188 ± 0.032	3.107PheLeu: 3.107 ± 0.069	0.884PheMet: 0.884 ± 0.029	1.375PheAsn: 1.375 ± 0.034	1.435PhePro: 1.435 ± 0.036	1.124PheGln: 1.124 ± 0.037	1.856PheArg: 1.856 ± 0.049	2.81PheSer: 2.81 ± 0.051	1.865PheThr: 1.865 ± 0.04	2.4PheVal: 2.4 ± 0.044	0.448PheTrp: 0.448 ± 0.021	1.115PheTyr: 1.115 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	7.047GlyAla: 7.047 ± 0.098	1.104GlyCys: 1.104 ± 0.036	4.083GlyAsp: 4.083 ± 0.072	5.336GlyGlu: 5.336 ± 0.081	3.251GlyPhe: 3.251 ± 0.058	6.206GlyGly: 6.206 ± 0.11	1.762GlyHis: 1.762 ± 0.04	4.461GlyIle: 4.461 ± 0.08	3.071GlyLys: 3.071 ± 0.059	8.438GlyLeu: 8.438 ± 0.111	2.309GlyMet: 2.309 ± 0.047	2.381GlyAsn: 2.381 ± 0.056	2.287GlyPro: 2.287 ± 0.041	3.282GlyGln: 3.282 ± 0.062	4.765GlyArg: 4.765 ± 0.066	4.794GlySer: 4.794 ± 0.076	3.541GlyThr: 3.541 ± 0.062	6.343GlyVal: 6.343 ± 0.085	1.213GlyTrp: 1.213 ± 0.036	2.654GlyTyr: 2.654 ± 0.051	0.0GlyXaa: 0.0 ± 0.0
His	1.629HisAla: 1.629 ± 0.038	0.415HisCys: 0.415 ± 0.021	0.986HisAsp: 0.986 ± 0.032	1.127HisGlu: 1.127 ± 0.032	0.952HisPhe: 0.952 ± 0.035	1.544HisGly: 1.544 ± 0.038	0.735HisHis: 0.735 ± 0.029	1.032HisIle: 1.032 ± 0.029	0.66HisLys: 0.66 ± 0.025	2.534HisLeu: 2.534 ± 0.049	0.479HisMet: 0.479 ± 0.021	0.756HisAsn: 0.756 ± 0.026	1.568HisPro: 1.568 ± 0.04	1.197HisGln: 1.197 ± 0.035	1.726HisArg: 1.726 ± 0.039	1.492HisSer: 1.492 ± 0.044	0.985HisThr: 0.985 ± 0.031	0.919HisVal: 0.919 ± 0.027	0.412HisTrp: 0.412 ± 0.018	0.899HisTyr: 0.899 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	5.827IleAla: 5.827 ± 0.096	0.605IleCys: 0.605 ± 0.024	3.632IleAsp: 3.632 ± 0.057	4.057IleGlu: 4.057 ± 0.062	1.489IlePhe: 1.489 ± 0.04	4.194IleGly: 4.194 ± 0.08	1.1IleHis: 1.1 ± 0.032	2.389IleIle: 2.389 ± 0.057	2.046IleLys: 2.046 ± 0.045	4.449IleLeu: 4.449 ± 0.08	0.991IleMet: 0.991 ± 0.034	2.158IleAsn: 2.158 ± 0.049	2.559IlePro: 2.559 ± 0.05	1.726IleGln: 1.726 ± 0.045	3.26IleArg: 3.26 ± 0.057	3.491IleSer: 3.491 ± 0.058	2.674IleThr: 2.674 ± 0.049	2.96IleVal: 2.96 ± 0.052	0.509IleTrp: 0.509 ± 0.022	1.412IleTyr: 1.412 ± 0.04	0.0IleXaa: 0.0 ± 0.0
Lys	3.65LysAla: 3.65 ± 0.078	0.181LysCys: 0.181 ± 0.012	1.468LysAsp: 1.468 ± 0.039	2.165LysGlu: 2.165 ± 0.048	0.789LysPhe: 0.789 ± 0.028	2.818LysGly: 2.818 ± 0.054	0.664LysHis: 0.664 ± 0.025	1.564LysIle: 1.564 ± 0.04	1.388LysLys: 1.388 ± 0.051	3.553LysLeu: 3.553 ± 0.058	0.758LysMet: 0.758 ± 0.028	1.012LysAsn: 1.012 ± 0.033	1.885LysPro: 1.885 ± 0.043	1.811LysGln: 1.811 ± 0.042	2.564LysArg: 2.564 ± 0.053	1.882LysSer: 1.882 ± 0.049	1.653LysThr: 1.653 ± 0.043	2.52LysVal: 2.52 ± 0.058	0.308LysTrp: 0.308 ± 0.016	0.718LysTyr: 0.718 ± 0.03	0.0LysXaa: 0.0 ± 0.0
Leu	12.132LeuAla: 12.132 ± 0.136	1.507LeuCys: 1.507 ± 0.044	6.056LeuAsp: 6.056 ± 0.091	7.684LeuGlu: 7.684 ± 0.098	4.435LeuPhe: 4.435 ± 0.086	8.723LeuGly: 8.723 ± 0.119	2.268LeuHis: 2.268 ± 0.049	5.527LeuIle: 5.527 ± 0.085	4.321LeuLys: 4.321 ± 0.062	14.483LeuLeu: 14.483 ± 0.257	2.971LeuMet: 2.971 ± 0.054	3.563LeuAsn: 3.563 ± 0.061	5.741LeuPro: 5.741 ± 0.077	5.189LeuGln: 5.189 ± 0.079	6.83LeuArg: 6.83 ± 0.084	7.764LeuSer: 7.764 ± 0.09	5.001LeuThr: 5.001 ± 0.062	8.478LeuVal: 8.478 ± 0.1	1.379LeuTrp: 1.379 ± 0.041	2.914LeuTyr: 2.914 ± 0.058	0.0LeuXaa: 0.0 ± 0.0
Met	2.862MetAla: 2.862 ± 0.055	0.155MetCys: 0.155 ± 0.011	1.194MetAsp: 1.194 ± 0.031	1.568MetGlu: 1.568 ± 0.039	0.583MetPhe: 0.583 ± 0.026	2.113MetGly: 2.113 ± 0.049	0.472MetHis: 0.472 ± 0.018	1.323MetIle: 1.323 ± 0.039	1.022MetLys: 1.022 ± 0.028	2.692MetLeu: 2.692 ± 0.051	0.673MetMet: 0.673 ± 0.031	0.856MetAsn: 0.856 ± 0.03	1.265MetPro: 1.265 ± 0.038	1.037MetGln: 1.037 ± 0.03	1.411MetArg: 1.411 ± 0.033	1.716MetSer: 1.716 ± 0.045	1.323MetThr: 1.323 ± 0.038	1.969MetVal: 1.969 ± 0.044	0.182MetTrp: 0.182 ± 0.015	0.335MetTyr: 0.335 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	2.878AsnAla: 2.878 ± 0.055	0.372AsnCys: 0.372 ± 0.021	1.504AsnAsp: 1.504 ± 0.045	1.826AsnGlu: 1.826 ± 0.043	0.991AsnPhe: 0.991 ± 0.032	2.361AsnGly: 2.361 ± 0.048	0.729AsnHis: 0.729 ± 0.027	1.584AsnIle: 1.584 ± 0.039	1.007AsnLys: 1.007 ± 0.035	3.423AsnLeu: 3.423 ± 0.054	0.639AsnMet: 0.639 ± 0.024	1.037AsnAsn: 1.037 ± 0.032	2.127AsnPro: 2.127 ± 0.042	1.324AsnGln: 1.324 ± 0.037	2.356AsnArg: 2.356 ± 0.046	1.912AsnSer: 1.912 ± 0.045	1.55AsnThr: 1.55 ± 0.044	1.663AsnVal: 1.663 ± 0.036	0.419AsnTrp: 0.419 ± 0.02	0.87AsnTyr: 0.87 ± 0.025	0.0AsnXaa: 0.0 ± 0.0
Pro	4.87ProAla: 4.87 ± 0.081	0.434ProCys: 0.434 ± 0.021	2.76ProAsp: 2.76 ± 0.049	3.7ProGlu: 3.7 ± 0.056	1.803ProPhe: 1.803 ± 0.042	3.743ProGly: 3.743 ± 0.066	1.031ProHis: 1.031 ± 0.036	2.059ProIle: 2.059 ± 0.045	1.306ProLys: 1.306 ± 0.036	6.104ProLeu: 6.104 ± 0.086	1.203ProMet: 1.203 ± 0.033	1.263ProAsn: 1.263 ± 0.034	2.263ProPro: 2.263 ± 0.05	2.087ProGln: 2.087 ± 0.042	2.583ProArg: 2.583 ± 0.057	2.76ProSer: 2.76 ± 0.058	2.036ProThr: 2.036 ± 0.045	3.709ProVal: 3.709 ± 0.057	0.697ProTrp: 0.697 ± 0.026	1.282ProTyr: 1.282 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	4.886GlnAla: 4.886 ± 0.075	0.413GlnCys: 0.413 ± 0.021	1.598GlnAsp: 1.598 ± 0.041	2.517GlnGlu: 2.517 ± 0.053	1.421GlnPhe: 1.421 ± 0.036	3.683GlnGly: 3.683 ± 0.068	1.134GlnHis: 1.134 ± 0.033	2.097GlnIle: 2.097 ± 0.042	1.394GlnLys: 1.394 ± 0.036	6.235GlnLeu: 6.235 ± 0.106	1.12GlnMet: 1.12 ± 0.03	0.961GlnAsn: 0.961 ± 0.027	2.343GlnPro: 2.343 ± 0.054	3.897GlnGln: 3.897 ± 0.086	3.949GlnArg: 3.949 ± 0.073	2.45GlnSer: 2.45 ± 0.055	1.734GlnThr: 1.734 ± 0.039	3.257GlnVal: 3.257 ± 0.056	0.83GlnTrp: 0.83 ± 0.031	1.038GlnTyr: 1.038 ± 0.035	0.0GlnXaa: 0.0 ± 0.0
Arg	5.752ArgAla: 5.752 ± 0.076	0.806ArgCys: 0.806 ± 0.027	3.299ArgAsp: 3.299 ± 0.055	4.707ArgGlu: 4.707 ± 0.071	2.961ArgPhe: 2.961 ± 0.051	4.25ArgGly: 4.25 ± 0.059	1.639ArgHis: 1.639 ± 0.042	3.933ArgIle: 3.933 ± 0.059	2.115ArgLys: 2.115 ± 0.047	8.074ArgLeu: 8.074 ± 0.103	1.676ArgMet: 1.676 ± 0.041	1.898ArgAsn: 1.898 ± 0.04	2.752ArgPro: 2.752 ± 0.053	3.432ArgGln: 3.432 ± 0.057	4.241ArgArg: 4.241 ± 0.077	3.817ArgSer: 3.817 ± 0.069	2.639ArgThr: 2.639 ± 0.051	5.208ArgVal: 5.208 ± 0.083	1.135ArgTrp: 1.135 ± 0.036	2.308ArgTyr: 2.308 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	6.092SerAla: 6.092 ± 0.096	0.682SerCys: 0.682 ± 0.026	3.182SerAsp: 3.182 ± 0.051	3.71SerGlu: 3.71 ± 0.054	2.284SerPhe: 2.284 ± 0.053	5.731SerGly: 5.731 ± 0.087	1.431SerHis: 1.431 ± 0.037	3.211SerIle: 3.211 ± 0.056	1.803SerLys: 1.803 ± 0.042	7.631SerLeu: 7.631 ± 0.083	1.562SerMet: 1.562 ± 0.037	1.92SerAsn: 1.92 ± 0.051	2.978SerPro: 2.978 ± 0.053	2.598SerGln: 2.598 ± 0.051	4.094SerArg: 4.094 ± 0.062	3.892SerSer: 3.892 ± 0.08	2.779SerThr: 2.779 ± 0.054	4.039SerVal: 4.039 ± 0.057	0.827SerTrp: 0.827 ± 0.03	1.647SerTyr: 1.647 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	4.286ThrAla: 4.286 ± 0.073	0.438ThrCys: 0.438 ± 0.021	2.366ThrAsp: 2.366 ± 0.049	2.733ThrGlu: 2.733 ± 0.049	1.462ThrPhe: 1.462 ± 0.034	3.899ThrGly: 3.899 ± 0.059	1.12ThrHis: 1.12 ± 0.033	2.328ThrIle: 2.328 ± 0.049	1.116ThrLys: 1.116 ± 0.035	6.548ThrLeu: 6.548 ± 0.09	0.88ThrMet: 0.88 ± 0.029	1.263ThrAsn: 1.263 ± 0.04	3.064ThrPro: 3.064 ± 0.067	1.894ThrGln: 1.894 ± 0.044	3.092ThrArg: 3.092 ± 0.056	2.546ThrSer: 2.546 ± 0.048	2.415ThrThr: 2.415 ± 0.057	2.949ThrVal: 2.949 ± 0.052	0.435ThrTrp: 0.435 ± 0.019	1.067ThrTyr: 1.067 ± 0.031	0.0ThrXaa: 0.0 ± 0.0
Val	7.405ValAla: 7.405 ± 0.093	0.754ValCys: 0.754 ± 0.025	4.107ValAsp: 4.107 ± 0.08	5.027ValGlu: 5.027 ± 0.073	2.255ValPhe: 2.255 ± 0.046	5.113ValGly: 5.113 ± 0.077	1.301ValHis: 1.301 ± 0.04	4.055ValIle: 4.055 ± 0.064	2.428ValLys: 2.428 ± 0.063	7.261ValLeu: 7.261 ± 0.091	1.895ValMet: 1.895 ± 0.047	2.304ValAsn: 2.304 ± 0.044	2.98ValPro: 2.98 ± 0.056	2.34ValGln: 2.34 ± 0.046	4.144ValArg: 4.144 ± 0.06	4.437ValSer: 4.437 ± 0.068	3.658ValThr: 3.658 ± 0.06	5.907ValVal: 5.907 ± 0.087	0.744ValTrp: 0.744 ± 0.028	1.598ValTyr: 1.598 ± 0.042	0.0ValXaa: 0.0 ± 0.0
Trp	0.934TrpAla: 0.934 ± 0.026	0.178TrpCys: 0.178 ± 0.015	0.56TrpAsp: 0.56 ± 0.024	0.689TrpGlu: 0.689 ± 0.025	0.527TrpPhe: 0.527 ± 0.024	0.947TrpGly: 0.947 ± 0.031	0.311TrpHis: 0.311 ± 0.017	0.662TrpIle: 0.662 ± 0.023	0.406TrpLys: 0.406 ± 0.021	1.776TrpLeu: 1.776 ± 0.044	0.339TrpMet: 0.339 ± 0.019	0.393TrpAsn: 0.393 ± 0.018	0.582TrpPro: 0.582 ± 0.022	0.847TrpGln: 0.847 ± 0.034	0.924TrpArg: 0.924 ± 0.025	0.854TrpSer: 0.854 ± 0.031	0.429TrpThr: 0.429 ± 0.021	1.033TrpVal: 1.033 ± 0.028	0.216TrpTrp: 0.216 ± 0.015	0.353TrpTyr: 0.353 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.107TyrAla: 2.107 ± 0.042	0.399TyrCys: 0.399 ± 0.02	1.396TyrAsp: 1.396 ± 0.037	1.419TyrGlu: 1.419 ± 0.034	1.066TyrPhe: 1.066 ± 0.031	2.156TyrGly: 2.156 ± 0.043	0.691TyrHis: 0.691 ± 0.026	1.156TyrIle: 1.156 ± 0.036	0.791TyrLys: 0.791 ± 0.027	3.425TyrLeu: 3.425 ± 0.055	0.548TyrMet: 0.548 ± 0.019	0.847TyrAsn: 0.847 ± 0.032	1.461TyrPro: 1.461 ± 0.041	1.529TyrGln: 1.529 ± 0.04	2.502TyrArg: 2.502 ± 0.052	1.702TyrSer: 1.702 ± 0.04	1.156TyrThr: 1.156 ± 0.029	1.432TyrVal: 1.432 ± 0.041	0.411TyrTrp: 0.411 ± 0.024	0.909TyrTyr: 0.909 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.001XaaVal: 0.001 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3340 proteins (1102306 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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