Amino acid dipepetide frequency for Erwinia billingiae (strain Eb661)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.119AlaAla: 11.119 ± 0.12	1.003AlaCys: 1.003 ± 0.027	5.397AlaAsp: 5.397 ± 0.071	6.071AlaGlu: 6.071 ± 0.066	3.655AlaPhe: 3.655 ± 0.053	8.367AlaGly: 8.367 ± 0.108	1.799AlaHis: 1.799 ± 0.035	5.894AlaIle: 5.894 ± 0.072	3.958AlaLys: 3.958 ± 0.061	12.214AlaLeu: 12.214 ± 0.109	3.013AlaMet: 3.013 ± 0.048	3.081AlaAsn: 3.081 ± 0.052	3.689AlaPro: 3.689 ± 0.062	4.378AlaGln: 4.378 ± 0.064	5.41AlaArg: 5.41 ± 0.076	6.211AlaSer: 6.211 ± 0.075	5.153AlaThr: 5.153 ± 0.083	7.195AlaVal: 7.195 ± 0.072	1.555AlaTrp: 1.555 ± 0.033	2.035AlaTyr: 2.035 ± 0.041	0.0AlaXaa: 0.0 ± 0.0
Cys	0.841CysAla: 0.841 ± 0.023	0.158CysCys: 0.158 ± 0.011	0.513CysAsp: 0.513 ± 0.018	0.507CysGlu: 0.507 ± 0.019	0.406CysPhe: 0.406 ± 0.017	0.993CysGly: 0.993 ± 0.028	0.283CysHis: 0.283 ± 0.012	0.524CysIle: 0.524 ± 0.019	0.277CysLys: 0.277 ± 0.014	0.966CysLeu: 0.966 ± 0.023	0.214CysMet: 0.214 ± 0.012	0.287CysAsn: 0.287 ± 0.014	0.431CysPro: 0.431 ± 0.016	0.449CysGln: 0.449 ± 0.018	0.567CysArg: 0.567 ± 0.02	0.638CysSer: 0.638 ± 0.021	0.458CysThr: 0.458 ± 0.019	0.658CysVal: 0.658 ± 0.021	0.16CysTrp: 0.16 ± 0.01	0.293CysTyr: 0.293 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	5.403AspAla: 5.403 ± 0.071	0.465AspCys: 0.465 ± 0.019	2.897AspAsp: 2.897 ± 0.058	3.304AspGlu: 3.304 ± 0.061	2.172AspPhe: 2.172 ± 0.039	3.891AspGly: 3.891 ± 0.086	1.029AspHis: 1.029 ± 0.024	3.24AspIle: 3.24 ± 0.047	2.299AspLys: 2.299 ± 0.043	4.876AspLeu: 4.876 ± 0.061	1.283AspMet: 1.283 ± 0.029	2.126AspAsn: 2.126 ± 0.042	2.297AspPro: 2.297 ± 0.047	1.747AspGln: 1.747 ± 0.034	3.211AspArg: 3.211 ± 0.053	3.032AspSer: 3.032 ± 0.049	2.416AspThr: 2.416 ± 0.049	3.848AspVal: 3.848 ± 0.055	0.87AspTrp: 0.87 ± 0.026	1.817AspTyr: 1.817 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	5.464GluAla: 5.464 ± 0.07	0.4GluCys: 0.4 ± 0.019	2.347GluAsp: 2.347 ± 0.042	3.263GluGlu: 3.263 ± 0.053	1.74GluPhe: 1.74 ± 0.037	3.589GluGly: 3.589 ± 0.049	1.264GluHis: 1.264 ± 0.029	3.233GluIle: 3.233 ± 0.046	3.028GluLys: 3.028 ± 0.049	5.7GluLeu: 5.7 ± 0.065	1.768GluMet: 1.768 ± 0.037	2.181GluAsn: 2.181 ± 0.037	2.056GluPro: 2.056 ± 0.041	3.335GluGln: 3.335 ± 0.052	3.301GluArg: 3.301 ± 0.052	2.943GluSer: 2.943 ± 0.037	2.834GluThr: 2.834 ± 0.04	3.761GluVal: 3.761 ± 0.056	0.726GluTrp: 0.726 ± 0.022	1.295GluTyr: 1.295 ± 0.029	0.0GluXaa: 0.0 ± 0.0
Phe	3.724PheAla: 3.724 ± 0.056	0.524PheCys: 0.524 ± 0.021	2.311PheAsp: 2.311 ± 0.043	1.661PheGlu: 1.661 ± 0.038	1.649PhePhe: 1.649 ± 0.046	3.177PheGly: 3.177 ± 0.054	0.807PheHis: 0.807 ± 0.02	2.457PheIle: 2.457 ± 0.045	1.245PheLys: 1.245 ± 0.033	3.266PheLeu: 3.266 ± 0.06	0.997PheMet: 0.997 ± 0.029	1.689PheAsn: 1.689 ± 0.034	1.577PhePro: 1.577 ± 0.035	1.235PheGln: 1.235 ± 0.032	1.858PheArg: 1.858 ± 0.037	3.267PheSer: 3.267 ± 0.049	2.424PheThr: 2.424 ± 0.041	2.435PheVal: 2.435 ± 0.044	0.633PheTrp: 0.633 ± 0.024	1.144PheTyr: 1.144 ± 0.028	0.0PheXaa: 0.0 ± 0.0
Gly	6.345GlyAla: 6.345 ± 0.075	0.934GlyCys: 0.934 ± 0.028	3.804GlyAsp: 3.804 ± 0.065	4.505GlyGlu: 4.505 ± 0.059	3.359GlyPhe: 3.359 ± 0.05	5.524GlyGly: 5.524 ± 0.08	1.677GlyHis: 1.677 ± 0.036	4.877GlyIle: 4.877 ± 0.052	4.034GlyLys: 4.034 ± 0.054	7.824GlyLeu: 7.824 ± 0.083	2.381GlyMet: 2.381 ± 0.042	2.884GlyAsn: 2.884 ± 0.09	2.117GlyPro: 2.117 ± 0.043	3.096GlyGln: 3.096 ± 0.05	3.881GlyArg: 3.881 ± 0.058	4.671GlySer: 4.671 ± 0.083	4.015GlyThr: 4.015 ± 0.093	5.799GlyVal: 5.799 ± 0.069	1.348GlyTrp: 1.348 ± 0.033	2.563GlyTyr: 2.563 ± 0.042	0.0GlyXaa: 0.0 ± 0.0
His	1.951HisAla: 1.951 ± 0.042	0.291HisCys: 0.291 ± 0.015	1.124HisAsp: 1.124 ± 0.029	1.001HisGlu: 1.001 ± 0.029	1.011HisPhe: 1.011 ± 0.029	1.658HisGly: 1.658 ± 0.032	0.731HisHis: 0.731 ± 0.026	1.19HisIle: 1.19 ± 0.028	0.679HisLys: 0.679 ± 0.02	2.257HisLeu: 2.257 ± 0.046	0.509HisMet: 0.509 ± 0.018	0.801HisAsn: 0.801 ± 0.024	1.346HisPro: 1.346 ± 0.028	1.34HisGln: 1.34 ± 0.034	1.244HisArg: 1.244 ± 0.028	1.312HisSer: 1.312 ± 0.029	1.011HisThr: 1.011 ± 0.026	1.222HisVal: 1.222 ± 0.026	0.447HisTrp: 0.447 ± 0.016	0.792HisTyr: 0.792 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	6.574IleAla: 6.574 ± 0.078	0.61IleCys: 0.61 ± 0.022	3.378IleAsp: 3.378 ± 0.044	3.185IleGlu: 3.185 ± 0.051	1.988IlePhe: 1.988 ± 0.044	4.654IleGly: 4.654 ± 0.066	1.115IleHis: 1.115 ± 0.027	3.072IleIle: 3.072 ± 0.049	2.242IleLys: 2.242 ± 0.04	4.819IleLeu: 4.819 ± 0.073	1.197IleMet: 1.197 ± 0.033	2.409IleAsn: 2.409 ± 0.05	2.606IlePro: 2.606 ± 0.041	1.824IleGln: 1.824 ± 0.032	2.842IleArg: 2.842 ± 0.048	3.897IleSer: 3.897 ± 0.053	3.519IleThr: 3.519 ± 0.056	3.954IleVal: 3.954 ± 0.055	0.681IleTrp: 0.681 ± 0.022	1.443IleTyr: 1.443 ± 0.032	0.0IleXaa: 0.0 ± 0.0
Lys	4.171LysAla: 4.171 ± 0.067	0.206LysCys: 0.206 ± 0.013	2.099LysAsp: 2.099 ± 0.045	2.282LysGlu: 2.282 ± 0.045	1.079LysPhe: 1.079 ± 0.027	3.009LysGly: 3.009 ± 0.05	0.807LysHis: 0.807 ± 0.021	2.279LysIle: 2.279 ± 0.045	2.173LysLys: 2.173 ± 0.051	4.175LysLeu: 4.175 ± 0.058	1.268LysMet: 1.268 ± 0.03	1.621LysAsn: 1.621 ± 0.04	2.17LysPro: 2.17 ± 0.042	1.974LysGln: 1.974 ± 0.043	2.454LysArg: 2.454 ± 0.044	2.441LysSer: 2.441 ± 0.047	2.504LysThr: 2.504 ± 0.039	2.907LysVal: 2.907 ± 0.042	0.453LysTrp: 0.453 ± 0.018	1.008LysTyr: 1.008 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	11.837LeuAla: 11.837 ± 0.117	1.187LeuCys: 1.187 ± 0.034	5.399LeuAsp: 5.399 ± 0.07	5.17LeuGlu: 5.17 ± 0.072	4.25LeuPhe: 4.25 ± 0.061	7.31LeuGly: 7.31 ± 0.078	2.286LeuHis: 2.286 ± 0.049	5.992LeuIle: 5.992 ± 0.069	4.635LeuLys: 4.635 ± 0.059	12.018LeuLeu: 12.018 ± 0.149	3.134LeuMet: 3.134 ± 0.06	4.272LeuAsn: 4.272 ± 0.074	5.798LeuPro: 5.798 ± 0.064	4.445LeuGln: 4.445 ± 0.062	5.978LeuArg: 5.978 ± 0.071	7.934LeuSer: 7.934 ± 0.074	6.755LeuThr: 6.755 ± 0.084	7.133LeuVal: 7.133 ± 0.083	1.391LeuTrp: 1.391 ± 0.035	2.526LeuTyr: 2.526 ± 0.049	0.0LeuXaa: 0.0 ± 0.0
Met	3.052MetAla: 3.052 ± 0.054	0.175MetCys: 0.175 ± 0.01	1.2MetAsp: 1.2 ± 0.031	1.141MetGlu: 1.141 ± 0.027	0.88MetPhe: 0.88 ± 0.028	1.842MetGly: 1.842 ± 0.036	0.514MetHis: 0.514 ± 0.021	1.506MetIle: 1.506 ± 0.033	1.402MetLys: 1.402 ± 0.033	3.238MetLeu: 3.238 ± 0.061	0.873MetMet: 0.873 ± 0.025	1.076MetAsn: 1.076 ± 0.027	1.392MetPro: 1.392 ± 0.029	1.177MetGln: 1.177 ± 0.026	1.497MetArg: 1.497 ± 0.033	1.89MetSer: 1.89 ± 0.037	1.797MetThr: 1.797 ± 0.033	1.942MetVal: 1.942 ± 0.036	0.241MetTrp: 0.241 ± 0.013	0.466MetTyr: 0.466 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	3.58AsnAla: 3.58 ± 0.064	0.306AsnCys: 0.306 ± 0.016	1.972AsnAsp: 1.972 ± 0.036	1.794AsnGlu: 1.794 ± 0.039	1.294AsnPhe: 1.294 ± 0.032	3.111AsnGly: 3.111 ± 0.076	0.765AsnHis: 0.765 ± 0.023	2.172AsnIle: 2.172 ± 0.044	1.504AsnLys: 1.504 ± 0.034	3.54AsnLeu: 3.54 ± 0.053	0.873AsnMet: 0.873 ± 0.024	1.526AsnAsn: 1.526 ± 0.049	2.071AsnPro: 2.071 ± 0.04	1.6AsnGln: 1.6 ± 0.033	1.975AsnArg: 1.975 ± 0.039	2.167AsnSer: 2.167 ± 0.05	1.971AsnThr: 1.971 ± 0.05	2.565AsnVal: 2.565 ± 0.052	0.586AsnTrp: 0.586 ± 0.025	1.102AsnTyr: 1.102 ± 0.032	0.0AsnXaa: 0.0 ± 0.0
Pro	5.084ProAla: 5.084 ± 0.066	0.346ProCys: 0.346 ± 0.015	2.902ProAsp: 2.902 ± 0.045	3.381ProGlu: 3.381 ± 0.05	1.816ProPhe: 1.816 ± 0.035	3.555ProGly: 3.555 ± 0.049	1.007ProHis: 1.007 ± 0.031	1.831ProIle: 1.831 ± 0.04	1.488ProLys: 1.488 ± 0.038	5.138ProLeu: 5.138 ± 0.067	1.125ProMet: 1.125 ± 0.029	1.244ProAsn: 1.244 ± 0.029	1.697ProPro: 1.697 ± 0.038	2.304ProGln: 2.304 ± 0.048	1.896ProArg: 1.896 ± 0.04	2.334ProSer: 2.334 ± 0.039	2.146ProThr: 2.146 ± 0.043	4.011ProVal: 4.011 ± 0.061	0.714ProTrp: 0.714 ± 0.025	1.149ProTyr: 1.149 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	4.935GlnAla: 4.935 ± 0.069	0.318GlnCys: 0.318 ± 0.013	1.947GlnAsp: 1.947 ± 0.039	1.968GlnGlu: 1.968 ± 0.038	1.479GlnPhe: 1.479 ± 0.035	3.312GlnGly: 3.312 ± 0.048	1.303GlnHis: 1.303 ± 0.037	2.317GlnIle: 2.317 ± 0.042	1.7GlnLys: 1.7 ± 0.036	5.179GlnLeu: 5.179 ± 0.067	1.256GlnMet: 1.256 ± 0.027	1.457GlnAsn: 1.457 ± 0.035	2.423GlnPro: 2.423 ± 0.053	3.8GlnGln: 3.8 ± 0.08	3.205GlnArg: 3.205 ± 0.053	2.49GlnSer: 2.49 ± 0.042	2.239GlnThr: 2.239 ± 0.048	3.043GlnVal: 3.043 ± 0.05	0.656GlnTrp: 0.656 ± 0.018	1.108GlnTyr: 1.108 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	4.644ArgAla: 4.644 ± 0.064	0.547ArgCys: 0.547 ± 0.018	2.869ArgAsp: 2.869 ± 0.047	3.605ArgGlu: 3.605 ± 0.054	2.533ArgPhe: 2.533 ± 0.04	3.378ArgGly: 3.378 ± 0.048	1.535ArgHis: 1.535 ± 0.033	3.203ArgIle: 3.203 ± 0.053	2.264ArgLys: 2.264 ± 0.039	6.375ArgLeu: 6.375 ± 0.08	1.521ArgMet: 1.521 ± 0.036	2.023ArgAsn: 2.023 ± 0.036	2.248ArgPro: 2.248 ± 0.041	3.091ArgGln: 3.091 ± 0.056	3.394ArgArg: 3.394 ± 0.06	2.959ArgSer: 2.959 ± 0.044	2.544ArgThr: 2.544 ± 0.044	3.778ArgVal: 3.778 ± 0.055	1.002ArgTrp: 1.002 ± 0.028	2.074ArgTyr: 2.074 ± 0.034	0.0ArgXaa: 0.0 ± 0.0
Ser	6.226SerAla: 6.226 ± 0.08	0.534SerCys: 0.534 ± 0.02	3.303SerAsp: 3.303 ± 0.052	3.292SerGlu: 3.292 ± 0.044	2.398SerPhe: 2.398 ± 0.043	5.754SerGly: 5.754 ± 0.074	1.442SerHis: 1.442 ± 0.03	2.995SerIle: 2.995 ± 0.046	2.196SerLys: 2.196 ± 0.044	7.482SerLeu: 7.482 ± 0.091	1.575SerMet: 1.575 ± 0.034	2.034SerAsn: 2.034 ± 0.046	2.89SerPro: 2.89 ± 0.049	2.757SerGln: 2.757 ± 0.046	3.498SerArg: 3.498 ± 0.055	3.974SerSer: 3.974 ± 0.062	3.192SerThr: 3.192 ± 0.059	4.527SerVal: 4.527 ± 0.077	1.152SerTrp: 1.152 ± 0.028	1.683SerTyr: 1.683 ± 0.037	0.0SerXaa: 0.0 ± 0.0
Thr	5.523ThrAla: 5.523 ± 0.098	0.438ThrCys: 0.438 ± 0.017	2.862ThrAsp: 2.862 ± 0.07	2.633ThrGlu: 2.633 ± 0.042	2.064ThrPhe: 2.064 ± 0.034	4.612ThrGly: 4.612 ± 0.076	1.194ThrHis: 1.194 ± 0.026	2.699ThrIle: 2.699 ± 0.056	1.507ThrLys: 1.507 ± 0.035	7.596ThrLeu: 7.596 ± 0.087	1.07ThrMet: 1.07 ± 0.029	1.548ThrAsn: 1.548 ± 0.04	3.253ThrPro: 3.253 ± 0.06	2.241ThrGln: 2.241 ± 0.041	2.983ThrArg: 2.983 ± 0.046	3.153ThrSer: 3.153 ± 0.052	2.994ThrThr: 2.994 ± 0.094	4.187ThrVal: 4.187 ± 0.153	0.709ThrTrp: 0.709 ± 0.022	1.18ThrTyr: 1.18 ± 0.031	0.0ThrXaa: 0.0 ± 0.0
Val	7.305ValAla: 7.305 ± 0.08	0.695ValCys: 0.695 ± 0.026	3.689ValAsp: 3.689 ± 0.067	3.806ValGlu: 3.806 ± 0.059	2.573ValPhe: 2.573 ± 0.038	4.877ValGly: 4.877 ± 0.072	1.217ValHis: 1.217 ± 0.027	4.57ValIle: 4.57 ± 0.061	3.033ValLys: 3.033 ± 0.05	7.38ValLeu: 7.38 ± 0.076	2.241ValMet: 2.241 ± 0.041	2.781ValAsn: 2.781 ± 0.054	3.081ValPro: 3.081 ± 0.041	2.527ValGln: 2.527 ± 0.04	3.575ValArg: 3.575 ± 0.051	5.001ValSer: 5.001 ± 0.067	4.529ValThr: 4.529 ± 0.125	5.522ValVal: 5.522 ± 0.068	0.947ValTrp: 0.947 ± 0.025	1.663ValTyr: 1.663 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	1.029TrpAla: 1.029 ± 0.027	0.162TrpCys: 0.162 ± 0.011	0.666TrpAsp: 0.666 ± 0.02	0.574TrpGlu: 0.574 ± 0.021	0.647TrpPhe: 0.647 ± 0.022	0.916TrpGly: 0.916 ± 0.025	0.465TrpHis: 0.465 ± 0.018	0.735TrpIle: 0.735 ± 0.024	0.534TrpLys: 0.534 ± 0.019	2.339TrpLeu: 2.339 ± 0.045	0.441TrpMet: 0.441 ± 0.017	0.492TrpAsn: 0.492 ± 0.021	0.671TrpPro: 0.671 ± 0.024	1.22TrpGln: 1.22 ± 0.032	1.014TrpArg: 1.014 ± 0.03	0.889TrpSer: 0.889 ± 0.036	0.606TrpThr: 0.606 ± 0.02	0.879TrpVal: 0.879 ± 0.022	0.234TrpTrp: 0.234 ± 0.012	0.418TrpTyr: 0.418 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.392TyrAla: 2.392 ± 0.041	0.323TyrCys: 0.323 ± 0.015	1.544TyrAsp: 1.544 ± 0.035	1.086TyrGlu: 1.086 ± 0.025	1.087TyrPhe: 1.087 ± 0.032	2.11TyrGly: 2.11 ± 0.038	0.678TyrHis: 0.678 ± 0.02	1.222TyrIle: 1.222 ± 0.031	0.882TyrLys: 0.882 ± 0.026	3.066TyrLeu: 3.066 ± 0.042	0.56TyrMet: 0.56 ± 0.023	0.942TyrAsn: 0.942 ± 0.028	1.355TyrPro: 1.355 ± 0.027	1.592TyrGln: 1.592 ± 0.037	1.806TyrArg: 1.806 ± 0.034	1.699TyrSer: 1.699 ± 0.034	1.342TyrThr: 1.342 ± 0.037	1.643TyrVal: 1.643 ± 0.034	0.428TyrTrp: 0.428 ± 0.018	0.84TyrTyr: 0.84 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4915 proteins (1558479 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---