Amino acid dipepetide frequency for Vibrio virus VpV262

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.8AlaAla: 8.8 ± 1.383
1.065AlaCys: 1.065 ± 0.319
5.535AlaAsp: 5.535 ± 0.613
6.174AlaGlu: 6.174 ± 0.678
2.981AlaPhe: 2.981 ± 0.51
6.103AlaGly: 6.103 ± 0.686
2.129AlaHis: 2.129 ± 0.325
5.252AlaIle: 5.252 ± 0.634
5.677AlaLys: 5.677 ± 0.842
5.181AlaLeu: 5.181 ± 0.626
2.271AlaMet: 2.271 ± 0.564
3.548AlaAsn: 3.548 ± 0.624
2.555AlaPro: 2.555 ± 0.355
3.335AlaGln: 3.335 ± 0.531
4.329AlaArg: 4.329 ± 0.679
4.755AlaSer: 4.755 ± 0.516
6.103AlaThr: 6.103 ± 0.641
4.968AlaVal: 4.968 ± 0.719
0.994AlaTrp: 0.994 ± 0.304
3.264AlaTyr: 3.264 ± 0.527
0.0AlaXaa: 0.0 ± 0.0
Cys
0.639CysAla: 0.639 ± 0.26
0.426CysCys: 0.426 ± 0.195
0.781CysAsp: 0.781 ± 0.24
0.781CysGlu: 0.781 ± 0.249
0.213CysPhe: 0.213 ± 0.133
0.355CysGly: 0.355 ± 0.168
0.497CysHis: 0.497 ± 0.218
0.639CysIle: 0.639 ± 0.228
0.568CysLys: 0.568 ± 0.191
0.923CysLeu: 0.923 ± 0.274
0.284CysMet: 0.284 ± 0.16
0.71CysAsn: 0.71 ± 0.205
0.426CysPro: 0.426 ± 0.168
0.497CysGln: 0.497 ± 0.208
0.781CysArg: 0.781 ± 0.32
0.497CysSer: 0.497 ± 0.19
0.568CysThr: 0.568 ± 0.238
0.781CysVal: 0.781 ± 0.235
0.071CysTrp: 0.071 ± 0.065
0.284CysTyr: 0.284 ± 0.132
0.0CysXaa: 0.0 ± 0.0
Asp
6.813AspAla: 6.813 ± 0.762
0.568AspCys: 0.568 ± 0.197
5.535AspAsp: 5.535 ± 0.585
5.677AspGlu: 5.677 ± 0.585
2.697AspPhe: 2.697 ± 0.394
6.032AspGly: 6.032 ± 0.786
1.49AspHis: 1.49 ± 0.393
3.974AspIle: 3.974 ± 0.592
4.4AspLys: 4.4 ± 0.62
5.252AspLeu: 5.252 ± 0.515
2.626AspMet: 2.626 ± 0.473
2.91AspAsn: 2.91 ± 0.306
2.981AspPro: 2.981 ± 0.541
1.703AspGln: 1.703 ± 0.322
2.484AspArg: 2.484 ± 0.434
3.619AspSer: 3.619 ± 0.569
4.116AspThr: 4.116 ± 0.553
5.11AspVal: 5.11 ± 0.573
1.632AspTrp: 1.632 ± 0.291
2.839AspTyr: 2.839 ± 0.418
0.0AspXaa: 0.0 ± 0.0
Glu
5.323GluAla: 5.323 ± 0.602
0.781GluCys: 0.781 ± 0.215
4.613GluAsp: 4.613 ± 0.842
5.464GluGlu: 5.464 ± 0.512
3.619GluPhe: 3.619 ± 0.483
4.897GluGly: 4.897 ± 0.512
1.419GluHis: 1.419 ± 0.374
3.619GluIle: 3.619 ± 0.508
3.832GluLys: 3.832 ± 0.727
6.671GluLeu: 6.671 ± 0.853
2.697GluMet: 2.697 ± 0.431
2.129GluAsn: 2.129 ± 0.509
2.768GluPro: 2.768 ± 0.394
3.69GluGln: 3.69 ± 0.587
4.116GluArg: 4.116 ± 0.515
3.335GluSer: 3.335 ± 0.467
2.981GluThr: 2.981 ± 0.4
5.89GluVal: 5.89 ± 0.599
1.206GluTrp: 1.206 ± 0.272
2.768GluTyr: 2.768 ± 0.422
0.0GluXaa: 0.0 ± 0.0
Phe
2.91PheAla: 2.91 ± 0.481
0.497PheCys: 0.497 ± 0.184
3.264PheAsp: 3.264 ± 0.484
2.839PheGlu: 2.839 ± 0.452
0.852PhePhe: 0.852 ± 0.205
3.477PheGly: 3.477 ± 0.677
0.639PheHis: 0.639 ± 0.304
2.058PheIle: 2.058 ± 0.313
1.845PheLys: 1.845 ± 0.416
2.484PheLeu: 2.484 ± 0.411
1.065PheMet: 1.065 ± 0.298
1.987PheAsn: 1.987 ± 0.29
1.135PhePro: 1.135 ± 0.276
1.277PheGln: 1.277 ± 0.278
1.632PheArg: 1.632 ± 0.324
1.419PheSer: 1.419 ± 0.243
2.981PheThr: 2.981 ± 0.405
1.987PheVal: 1.987 ± 0.428
0.71PheTrp: 0.71 ± 0.242
1.49PheTyr: 1.49 ± 0.41
0.0PheXaa: 0.0 ± 0.0
Gly
6.316GlyAla: 6.316 ± 0.789
0.497GlyCys: 0.497 ± 0.222
5.464GlyAsp: 5.464 ± 0.585
4.187GlyGlu: 4.187 ± 0.594
2.555GlyPhe: 2.555 ± 0.472
6.671GlyGly: 6.671 ± 1.001
0.852GlyHis: 0.852 ± 0.203
3.761GlyIle: 3.761 ± 0.533
4.471GlyLys: 4.471 ± 0.71
5.323GlyLeu: 5.323 ± 0.842
1.916GlyMet: 1.916 ± 0.335
3.548GlyAsn: 3.548 ± 0.83
1.987GlyPro: 1.987 ± 0.373
2.626GlyGln: 2.626 ± 0.393
3.619GlyArg: 3.619 ± 0.574
4.4GlySer: 4.4 ± 0.823
5.748GlyThr: 5.748 ± 0.963
5.677GlyVal: 5.677 ± 0.6
0.994GlyTrp: 0.994 ± 0.302
3.264GlyTyr: 3.264 ± 0.554
0.0GlyXaa: 0.0 ± 0.0
His
1.419HisAla: 1.419 ± 0.306
0.355HisCys: 0.355 ± 0.169
1.703HisAsp: 1.703 ± 0.339
1.277HisGlu: 1.277 ± 0.302
0.568HisPhe: 0.568 ± 0.223
1.561HisGly: 1.561 ± 0.396
0.71HisHis: 0.71 ± 0.256
1.277HisIle: 1.277 ± 0.343
0.923HisLys: 0.923 ± 0.281
2.484HisLeu: 2.484 ± 0.437
0.781HisMet: 0.781 ± 0.306
1.065HisAsn: 1.065 ± 0.295
1.065HisPro: 1.065 ± 0.254
0.781HisGln: 0.781 ± 0.24
1.632HisArg: 1.632 ± 0.317
1.277HisSer: 1.277 ± 0.301
1.206HisThr: 1.206 ± 0.226
1.49HisVal: 1.49 ± 0.304
0.213HisTrp: 0.213 ± 0.13
0.71HisTyr: 0.71 ± 0.256
0.0HisXaa: 0.0 ± 0.0
Ile
4.329IleAla: 4.329 ± 0.618
0.497IleCys: 0.497 ± 0.226
3.406IleAsp: 3.406 ± 0.455
4.116IleGlu: 4.116 ± 0.613
1.206IlePhe: 1.206 ± 0.295
4.045IleGly: 4.045 ± 0.465
1.135IleHis: 1.135 ± 0.294
2.697IleIle: 2.697 ± 0.366
3.194IleLys: 3.194 ± 0.505
3.194IleLeu: 3.194 ± 0.496
0.71IleMet: 0.71 ± 0.205
2.697IleAsn: 2.697 ± 0.332
2.413IlePro: 2.413 ± 0.334
1.774IleGln: 1.774 ± 0.341
3.619IleArg: 3.619 ± 0.52
3.194IleSer: 3.194 ± 0.494
3.335IleThr: 3.335 ± 0.547
3.123IleVal: 3.123 ± 0.479
0.852IleTrp: 0.852 ± 0.228
1.277IleTyr: 1.277 ± 0.343
0.0IleXaa: 0.0 ± 0.0
Lys
5.464LysAla: 5.464 ± 0.888
1.065LysCys: 1.065 ± 0.288
3.974LysAsp: 3.974 ± 0.488
4.613LysGlu: 4.613 ± 0.561
2.484LysPhe: 2.484 ± 0.471
3.903LysGly: 3.903 ± 0.509
1.561LysHis: 1.561 ± 0.359
1.632LysIle: 1.632 ± 0.391
4.613LysLys: 4.613 ± 0.84
5.181LysLeu: 5.181 ± 0.546
1.987LysMet: 1.987 ± 0.337
1.774LysAsn: 1.774 ± 0.333
2.484LysPro: 2.484 ± 0.473
2.342LysGln: 2.342 ± 0.42
3.548LysArg: 3.548 ± 0.513
2.91LysSer: 2.91 ± 0.488
2.626LysThr: 2.626 ± 0.439
4.258LysVal: 4.258 ± 0.509
0.923LysTrp: 0.923 ± 0.296
2.2LysTyr: 2.2 ± 0.523
0.0LysXaa: 0.0 ± 0.0
Leu
6.6LeuAla: 6.6 ± 0.807
0.994LeuCys: 0.994 ± 0.296
6.387LeuAsp: 6.387 ± 0.772
5.464LeuGlu: 5.464 ± 0.639
2.768LeuPhe: 2.768 ± 0.389
5.89LeuGly: 5.89 ± 0.893
2.058LeuHis: 2.058 ± 0.509
3.052LeuIle: 3.052 ± 0.539
3.69LeuLys: 3.69 ± 0.555
6.103LeuLeu: 6.103 ± 0.62
2.413LeuMet: 2.413 ± 0.506
2.697LeuAsn: 2.697 ± 0.428
2.839LeuPro: 2.839 ± 0.395
4.4LeuGln: 4.4 ± 0.703
3.619LeuArg: 3.619 ± 0.526
4.826LeuSer: 4.826 ± 0.669
5.039LeuThr: 5.039 ± 0.736
5.819LeuVal: 5.819 ± 0.74
1.065LeuTrp: 1.065 ± 0.273
2.555LeuTyr: 2.555 ± 0.454
0.0LeuXaa: 0.0 ± 0.0
Met
2.342MetAla: 2.342 ± 0.333
0.213MetCys: 0.213 ± 0.118
1.845MetAsp: 1.845 ± 0.384
2.2MetGlu: 2.2 ± 0.441
0.852MetPhe: 0.852 ± 0.223
1.49MetGly: 1.49 ± 0.317
0.284MetHis: 0.284 ± 0.138
1.348MetIle: 1.348 ± 0.265
2.129MetLys: 2.129 ± 0.424
2.342MetLeu: 2.342 ± 0.469
0.568MetMet: 0.568 ± 0.16
1.277MetAsn: 1.277 ± 0.271
1.348MetPro: 1.348 ± 0.348
1.135MetGln: 1.135 ± 0.223
1.632MetArg: 1.632 ± 0.441
2.129MetSer: 2.129 ± 0.383
1.916MetThr: 1.916 ± 0.384
1.774MetVal: 1.774 ± 0.391
0.284MetTrp: 0.284 ± 0.133
1.135MetTyr: 1.135 ± 0.272
0.0MetXaa: 0.0 ± 0.0
Asn
3.619AsnAla: 3.619 ± 0.532
0.213AsnCys: 0.213 ± 0.134
2.91AsnAsp: 2.91 ± 0.337
2.768AsnGlu: 2.768 ± 0.552
1.135AsnPhe: 1.135 ± 0.325
4.542AsnGly: 4.542 ± 0.658
1.277AsnHis: 1.277 ± 0.334
2.626AsnIle: 2.626 ± 0.451
2.058AsnLys: 2.058 ± 0.329
3.903AsnLeu: 3.903 ± 0.543
1.135AsnMet: 1.135 ± 0.271
2.058AsnAsn: 2.058 ± 0.446
2.626AsnPro: 2.626 ± 0.43
1.135AsnGln: 1.135 ± 0.297
2.058AsnArg: 2.058 ± 0.293
2.484AsnSer: 2.484 ± 0.425
2.697AsnThr: 2.697 ± 0.368
2.484AsnVal: 2.484 ± 0.507
0.426AsnTrp: 0.426 ± 0.175
2.2AsnTyr: 2.2 ± 0.393
0.0AsnXaa: 0.0 ± 0.0
Pro
2.91ProAla: 2.91 ± 0.468
0.284ProCys: 0.284 ± 0.193
3.123ProAsp: 3.123 ± 0.598
2.271ProGlu: 2.271 ± 0.338
1.561ProPhe: 1.561 ± 0.288
0.0ProGly: 0.0 ± 0.0
0.639ProHis: 0.639 ± 0.237
1.916ProIle: 1.916 ± 0.318
2.981ProLys: 2.981 ± 0.438
3.264ProLeu: 3.264 ± 0.554
0.852ProMet: 0.852 ± 0.274
2.058ProAsn: 2.058 ± 0.36
1.065ProPro: 1.065 ± 0.212
1.348ProGln: 1.348 ± 0.359
1.845ProArg: 1.845 ± 0.384
2.626ProSer: 2.626 ± 0.421
2.342ProThr: 2.342 ± 0.396
3.335ProVal: 3.335 ± 0.505
0.426ProTrp: 0.426 ± 0.176
1.419ProTyr: 1.419 ± 0.254
0.0ProXaa: 0.0 ± 0.0
Gln
3.619GlnAla: 3.619 ± 0.536
0.213GlnCys: 0.213 ± 0.121
2.626GlnAsp: 2.626 ± 0.503
2.981GlnGlu: 2.981 ± 0.468
2.129GlnPhe: 2.129 ± 0.373
2.697GlnGly: 2.697 ± 0.546
0.71GlnHis: 0.71 ± 0.24
1.987GlnIle: 1.987 ± 0.54
2.342GlnLys: 2.342 ± 0.48
4.045GlnLeu: 4.045 ± 0.544
1.561GlnMet: 1.561 ± 0.28
1.845GlnAsn: 1.845 ± 0.408
0.71GlnPro: 0.71 ± 0.194
1.916GlnGln: 1.916 ± 0.531
2.342GlnArg: 2.342 ± 0.479
2.2GlnSer: 2.2 ± 0.314
2.697GlnThr: 2.697 ± 0.431
1.987GlnVal: 1.987 ± 0.401
0.426GlnTrp: 0.426 ± 0.169
1.49GlnTyr: 1.49 ± 0.277
0.0GlnXaa: 0.0 ± 0.0
Arg
4.258ArgAla: 4.258 ± 0.572
0.284ArgCys: 0.284 ± 0.127
3.194ArgAsp: 3.194 ± 0.436
4.045ArgGlu: 4.045 ± 0.712
2.058ArgPhe: 2.058 ± 0.356
3.477ArgGly: 3.477 ± 0.732
1.277ArgHis: 1.277 ± 0.277
2.839ArgIle: 2.839 ± 0.404
3.335ArgLys: 3.335 ± 0.603
3.477ArgLeu: 3.477 ± 0.492
1.419ArgMet: 1.419 ± 0.298
2.697ArgAsn: 2.697 ± 0.485
1.419ArgPro: 1.419 ± 0.273
2.484ArgGln: 2.484 ± 0.431
3.548ArgArg: 3.548 ± 0.562
2.342ArgSer: 2.342 ± 0.504
3.761ArgThr: 3.761 ± 0.486
4.258ArgVal: 4.258 ± 0.533
0.71ArgTrp: 0.71 ± 0.24
1.419ArgTyr: 1.419 ± 0.413
0.0ArgXaa: 0.0 ± 0.0
Ser
4.4SerAla: 4.4 ± 0.566
0.284SerCys: 0.284 ± 0.144
3.123SerAsp: 3.123 ± 0.496
4.116SerGlu: 4.116 ± 0.543
2.058SerPhe: 2.058 ± 0.376
5.535SerGly: 5.535 ± 0.723
1.065SerHis: 1.065 ± 0.217
3.477SerIle: 3.477 ± 0.467
3.264SerLys: 3.264 ± 0.456
4.045SerLeu: 4.045 ± 0.413
1.277SerMet: 1.277 ± 0.288
3.264SerAsn: 3.264 ± 0.543
1.916SerPro: 1.916 ± 0.376
2.555SerGln: 2.555 ± 0.558
3.194SerArg: 3.194 ± 0.597
2.342SerSer: 2.342 ± 0.418
2.129SerThr: 2.129 ± 0.307
3.335SerVal: 3.335 ± 0.417
0.923SerTrp: 0.923 ± 0.187
0.994SerTyr: 0.994 ± 0.319
0.0SerXaa: 0.0 ± 0.0
Thr
6.813ThrAla: 6.813 ± 0.889
0.568ThrCys: 0.568 ± 0.218
5.535ThrAsp: 5.535 ± 0.678
3.974ThrGlu: 3.974 ± 0.704
2.058ThrPhe: 2.058 ± 0.528
5.039ThrGly: 5.039 ± 0.559
1.419ThrHis: 1.419 ± 0.378
3.335ThrIle: 3.335 ± 0.476
3.335ThrLys: 3.335 ± 0.445
4.542ThrLeu: 4.542 ± 0.837
1.277ThrMet: 1.277 ± 0.312
1.774ThrAsn: 1.774 ± 0.424
2.555ThrPro: 2.555 ± 0.476
2.484ThrGln: 2.484 ± 0.411
2.768ThrArg: 2.768 ± 0.486
2.981ThrSer: 2.981 ± 0.442
4.755ThrThr: 4.755 ± 0.777
4.684ThrVal: 4.684 ± 0.753
0.71ThrTrp: 0.71 ± 0.235
1.49ThrTyr: 1.49 ± 0.313
0.0ThrXaa: 0.0 ± 0.0
Val
5.039ValAla: 5.039 ± 0.646
1.277ValCys: 1.277 ± 0.332
5.606ValAsp: 5.606 ± 0.557
5.323ValGlu: 5.323 ± 0.613
2.626ValPhe: 2.626 ± 0.412
5.039ValGly: 5.039 ± 0.621
1.632ValHis: 1.632 ± 0.423
2.839ValIle: 2.839 ± 0.421
3.974ValLys: 3.974 ± 0.543
6.103ValLeu: 6.103 ± 0.607
1.561ValMet: 1.561 ± 0.372
3.974ValAsn: 3.974 ± 0.721
2.413ValPro: 2.413 ± 0.311
2.413ValGln: 2.413 ± 0.452
2.981ValArg: 2.981 ± 0.458
3.548ValSer: 3.548 ± 0.453
4.329ValThr: 4.329 ± 0.627
5.181ValVal: 5.181 ± 0.731
0.994ValTrp: 0.994 ± 0.246
3.477ValTyr: 3.477 ± 0.542
0.0ValXaa: 0.0 ± 0.0
Trp
0.994TrpAla: 0.994 ± 0.376
0.142TrpCys: 0.142 ± 0.097
1.135TrpAsp: 1.135 ± 0.281
1.206TrpGlu: 1.206 ± 0.306
0.71TrpPhe: 0.71 ± 0.2
0.568TrpGly: 0.568 ± 0.182
0.497TrpHis: 0.497 ± 0.211
0.781TrpIle: 0.781 ± 0.224
0.994TrpLys: 0.994 ± 0.325
0.994TrpLeu: 0.994 ± 0.286
0.426TrpMet: 0.426 ± 0.254
0.71TrpAsn: 0.71 ± 0.202
0.071TrpPro: 0.071 ± 0.065
0.568TrpGln: 0.568 ± 0.245
0.497TrpArg: 0.497 ± 0.148
0.923TrpSer: 0.923 ± 0.228
1.065TrpThr: 1.065 ± 0.283
1.49TrpVal: 1.49 ± 0.27
0.497TrpTrp: 0.497 ± 0.192
0.497TrpTyr: 0.497 ± 0.178
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.413TyrAla: 2.413 ± 0.442
0.497TyrCys: 0.497 ± 0.181
2.697TyrAsp: 2.697 ± 0.453
2.342TyrGlu: 2.342 ± 0.418
1.419TyrPhe: 1.419 ± 0.403
2.555TyrGly: 2.555 ± 0.385
1.206TyrHis: 1.206 ± 0.307
1.703TyrIle: 1.703 ± 0.37
1.916TyrLys: 1.916 ± 0.322
2.768TyrLeu: 2.768 ± 0.501
1.348TyrMet: 1.348 ± 0.308
1.632TyrAsn: 1.632 ± 0.312
1.49TyrPro: 1.49 ± 0.36
2.058TyrGln: 2.058 ± 0.381
2.058TyrArg: 2.058 ± 0.527
1.49TyrSer: 1.49 ± 0.378
1.703TyrThr: 1.703 ± 0.365
2.768TyrVal: 2.768 ± 0.407
0.71TyrTrp: 0.71 ± 0.186
1.49TyrTyr: 1.49 ± 0.498
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 67 proteins (14092 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski