Amino acid dipepetide frequency for Klebsiella phage vB_KpnM_KpV79

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
8.491AlaAla: 8.491 ± 1.037
0.679AlaCys: 0.679 ± 0.217
5.027AlaAsp: 5.027 ± 0.411
4.619AlaGlu: 4.619 ± 0.538
2.513AlaPhe: 2.513 ± 0.386
6.453AlaGly: 6.453 ± 0.636
1.359AlaHis: 1.359 ± 0.327
4.348AlaIle: 4.348 ± 0.623
4.483AlaLys: 4.483 ± 0.664
6.046AlaLeu: 6.046 ± 0.618
2.785AlaMet: 2.785 ± 0.391
3.397AlaAsn: 3.397 ± 0.41
3.261AlaPro: 3.261 ± 0.495
4.28AlaGln: 4.28 ± 0.516
4.619AlaArg: 4.619 ± 0.655
5.91AlaSer: 5.91 ± 0.675
6.385AlaThr: 6.385 ± 0.639
5.434AlaVal: 5.434 ± 0.739
0.747AlaTrp: 0.747 ± 0.257
2.785AlaTyr: 2.785 ± 0.382
0.0AlaXaa: 0.0 ± 0.0
Cys
1.427CysAla: 1.427 ± 0.329
0.272CysCys: 0.272 ± 0.124
1.291CysAsp: 1.291 ± 0.302
1.223CysGlu: 1.223 ± 0.204
0.204CysPhe: 0.204 ± 0.115
0.951CysGly: 0.951 ± 0.243
0.408CysHis: 0.408 ± 0.165
1.087CysIle: 1.087 ± 0.288
0.747CysLys: 0.747 ± 0.274
0.883CysLeu: 0.883 ± 0.215
0.136CysMet: 0.136 ± 0.096
0.408CysAsn: 0.408 ± 0.192
1.359CysPro: 1.359 ± 0.405
0.408CysGln: 0.408 ± 0.169
0.815CysArg: 0.815 ± 0.219
1.291CysSer: 1.291 ± 0.249
0.679CysThr: 0.679 ± 0.211
0.747CysVal: 0.747 ± 0.236
0.136CysTrp: 0.136 ± 0.088
0.272CysTyr: 0.272 ± 0.129
0.0CysXaa: 0.0 ± 0.0
Asp
6.318AspAla: 6.318 ± 0.596
0.951AspCys: 0.951 ± 0.305
3.6AspAsp: 3.6 ± 0.61
4.076AspGlu: 4.076 ± 0.588
3.329AspPhe: 3.329 ± 0.51
6.385AspGly: 6.385 ± 0.657
1.087AspHis: 1.087 ± 0.276
4.28AspIle: 4.28 ± 0.542
3.125AspLys: 3.125 ± 0.359
3.397AspLeu: 3.397 ± 0.535
1.427AspMet: 1.427 ± 0.398
2.513AspAsn: 2.513 ± 0.443
2.445AspPro: 2.445 ± 0.334
1.291AspGln: 1.291 ± 0.244
2.921AspArg: 2.921 ± 0.425
3.464AspSer: 3.464 ± 0.436
3.736AspThr: 3.736 ± 0.416
5.095AspVal: 5.095 ± 0.595
1.359AspTrp: 1.359 ± 0.285
1.359AspTyr: 1.359 ± 0.242
0.0AspXaa: 0.0 ± 0.0
Glu
4.619GluAla: 4.619 ± 0.667
0.951GluCys: 0.951 ± 0.247
2.853GluAsp: 2.853 ± 0.488
2.853GluGlu: 2.853 ± 0.445
1.766GluPhe: 1.766 ± 0.359
3.125GluGly: 3.125 ± 0.4
1.223GluHis: 1.223 ± 0.246
3.668GluIle: 3.668 ± 0.423
2.649GluLys: 2.649 ± 0.431
6.861GluLeu: 6.861 ± 0.683
2.174GluMet: 2.174 ± 0.458
2.174GluAsn: 2.174 ± 0.41
1.63GluPro: 1.63 ± 0.398
3.532GluGln: 3.532 ± 0.594
3.804GluArg: 3.804 ± 0.577
2.717GluSer: 2.717 ± 0.407
3.261GluThr: 3.261 ± 0.461
3.872GluVal: 3.872 ± 0.589
1.427GluTrp: 1.427 ± 0.353
2.106GluTyr: 2.106 ± 0.379
0.0GluXaa: 0.0 ± 0.0
Phe
2.378PheAla: 2.378 ± 0.429
0.543PheCys: 0.543 ± 0.183
2.581PheAsp: 2.581 ± 0.379
1.902PheGlu: 1.902 ± 0.34
1.291PhePhe: 1.291 ± 0.293
2.378PheGly: 2.378 ± 0.327
0.543PheHis: 0.543 ± 0.169
2.038PheIle: 2.038 ± 0.333
2.106PheLys: 2.106 ± 0.323
1.902PheLeu: 1.902 ± 0.407
0.679PheMet: 0.679 ± 0.181
1.97PheAsn: 1.97 ± 0.376
1.359PhePro: 1.359 ± 0.281
1.291PheGln: 1.291 ± 0.327
1.834PheArg: 1.834 ± 0.32
1.834PheSer: 1.834 ± 0.388
2.853PheThr: 2.853 ± 0.368
2.989PheVal: 2.989 ± 0.359
0.34PheTrp: 0.34 ± 0.15
1.427PheTyr: 1.427 ± 0.296
0.0PheXaa: 0.0 ± 0.0
Gly
5.299GlyAla: 5.299 ± 0.679
1.155GlyCys: 1.155 ± 0.382
4.959GlyAsp: 4.959 ± 0.737
3.736GlyGlu: 3.736 ± 0.676
2.853GlyPhe: 2.853 ± 0.478
4.755GlyGly: 4.755 ± 0.655
1.494GlyHis: 1.494 ± 0.323
4.755GlyIle: 4.755 ± 0.647
4.348GlyLys: 4.348 ± 0.654
5.299GlyLeu: 5.299 ± 0.608
1.766GlyMet: 1.766 ± 0.352
3.193GlyAsn: 3.193 ± 0.475
1.494GlyPro: 1.494 ± 0.283
2.921GlyGln: 2.921 ± 0.438
4.28GlyArg: 4.28 ± 0.498
5.366GlySer: 5.366 ± 0.751
5.366GlyThr: 5.366 ± 0.866
5.706GlyVal: 5.706 ± 0.517
1.155GlyTrp: 1.155 ± 0.261
3.804GlyTyr: 3.804 ± 0.346
0.0GlyXaa: 0.0 ± 0.0
His
1.63HisAla: 1.63 ± 0.396
0.815HisCys: 0.815 ± 0.243
1.223HisAsp: 1.223 ± 0.266
1.019HisGlu: 1.019 ± 0.275
0.543HisPhe: 0.543 ± 0.169
1.766HisGly: 1.766 ± 0.421
0.815HisHis: 0.815 ± 0.264
1.087HisIle: 1.087 ± 0.294
0.679HisLys: 0.679 ± 0.227
1.223HisLeu: 1.223 ± 0.273
0.408HisMet: 0.408 ± 0.17
1.019HisAsn: 1.019 ± 0.208
0.747HisPro: 0.747 ± 0.215
0.272HisGln: 0.272 ± 0.124
0.883HisArg: 0.883 ± 0.26
1.223HisSer: 1.223 ± 0.269
0.883HisThr: 0.883 ± 0.244
1.291HisVal: 1.291 ± 0.27
0.476HisTrp: 0.476 ± 0.184
0.951HisTyr: 0.951 ± 0.239
0.0HisXaa: 0.0 ± 0.0
Ile
5.027IleAla: 5.027 ± 0.519
0.815IleCys: 0.815 ± 0.259
4.008IleAsp: 4.008 ± 0.423
3.6IleGlu: 3.6 ± 0.44
1.63IlePhe: 1.63 ± 0.367
3.872IleGly: 3.872 ± 0.583
1.223IleHis: 1.223 ± 0.282
3.057IleIle: 3.057 ± 0.487
3.329IleLys: 3.329 ± 0.494
3.329IleLeu: 3.329 ± 0.478
1.902IleMet: 1.902 ± 0.308
2.989IleAsn: 2.989 ± 0.466
3.804IlePro: 3.804 ± 0.566
1.97IleGln: 1.97 ± 0.394
2.921IleArg: 2.921 ± 0.434
3.125IleSer: 3.125 ± 0.424
4.076IleThr: 4.076 ± 0.458
5.163IleVal: 5.163 ± 0.591
0.747IleTrp: 0.747 ± 0.198
2.106IleTyr: 2.106 ± 0.336
0.0IleXaa: 0.0 ± 0.0
Lys
4.959LysAla: 4.959 ± 0.552
1.223LysCys: 1.223 ± 0.363
3.397LysAsp: 3.397 ± 0.562
2.717LysGlu: 2.717 ± 0.554
2.378LysPhe: 2.378 ± 0.298
3.193LysGly: 3.193 ± 0.509
1.087LysHis: 1.087 ± 0.317
2.785LysIle: 2.785 ± 0.46
2.242LysLys: 2.242 ± 0.419
4.619LysLeu: 4.619 ± 0.638
1.766LysMet: 1.766 ± 0.335
2.717LysAsn: 2.717 ± 0.372
2.649LysPro: 2.649 ± 0.336
2.853LysGln: 2.853 ± 0.527
4.144LysArg: 4.144 ± 0.607
3.125LysSer: 3.125 ± 0.463
2.785LysThr: 2.785 ± 0.406
3.261LysVal: 3.261 ± 0.424
0.883LysTrp: 0.883 ± 0.246
1.698LysTyr: 1.698 ± 0.387
0.0LysXaa: 0.0 ± 0.0
Leu
5.163LeuAla: 5.163 ± 0.748
1.359LeuCys: 1.359 ± 0.301
6.318LeuAsp: 6.318 ± 0.677
4.823LeuGlu: 4.823 ± 0.642
1.97LeuPhe: 1.97 ± 0.347
4.144LeuGly: 4.144 ± 0.482
1.291LeuHis: 1.291 ± 0.274
4.415LeuIle: 4.415 ± 0.636
4.28LeuLys: 4.28 ± 0.689
4.891LeuLeu: 4.891 ± 0.607
1.97LeuMet: 1.97 ± 0.381
4.551LeuAsn: 4.551 ± 0.706
2.513LeuPro: 2.513 ± 0.371
2.378LeuGln: 2.378 ± 0.363
4.144LeuArg: 4.144 ± 0.453
5.299LeuSer: 5.299 ± 0.672
5.706LeuThr: 5.706 ± 0.531
4.959LeuVal: 4.959 ± 0.474
1.019LeuTrp: 1.019 ± 0.286
2.378LeuTyr: 2.378 ± 0.346
0.0LeuXaa: 0.0 ± 0.0
Met
2.445MetAla: 2.445 ± 0.428
0.408MetCys: 0.408 ± 0.191
1.223MetAsp: 1.223 ± 0.268
1.291MetGlu: 1.291 ± 0.325
1.359MetPhe: 1.359 ± 0.331
1.359MetGly: 1.359 ± 0.288
0.204MetHis: 0.204 ± 0.106
1.63MetIle: 1.63 ± 0.393
0.951MetLys: 0.951 ± 0.249
1.834MetLeu: 1.834 ± 0.318
0.815MetMet: 0.815 ± 0.203
1.359MetAsn: 1.359 ± 0.334
0.679MetPro: 0.679 ± 0.182
1.019MetGln: 1.019 ± 0.271
2.242MetArg: 2.242 ± 0.486
2.581MetSer: 2.581 ± 0.423
2.378MetThr: 2.378 ± 0.409
1.494MetVal: 1.494 ± 0.311
0.204MetTrp: 0.204 ± 0.123
0.951MetTyr: 0.951 ± 0.206
0.0MetXaa: 0.0 ± 0.0
Asn
3.804AsnAla: 3.804 ± 0.555
0.951AsnCys: 0.951 ± 0.366
2.989AsnAsp: 2.989 ± 0.397
1.97AsnGlu: 1.97 ± 0.338
1.494AsnPhe: 1.494 ± 0.338
4.687AsnGly: 4.687 ± 0.701
0.951AsnHis: 0.951 ± 0.281
2.717AsnIle: 2.717 ± 0.579
2.989AsnLys: 2.989 ± 0.578
2.649AsnLeu: 2.649 ± 0.445
1.155AsnMet: 1.155 ± 0.246
2.785AsnAsn: 2.785 ± 0.525
2.242AsnPro: 2.242 ± 0.427
1.291AsnGln: 1.291 ± 0.268
1.902AsnArg: 1.902 ± 0.33
3.397AsnSer: 3.397 ± 0.595
3.125AsnThr: 3.125 ± 0.503
3.6AsnVal: 3.6 ± 0.5
0.679AsnTrp: 0.679 ± 0.187
1.562AsnTyr: 1.562 ± 0.364
0.0AsnXaa: 0.0 ± 0.0
Pro
3.532ProAla: 3.532 ± 0.496
0.204ProCys: 0.204 ± 0.104
2.106ProAsp: 2.106 ± 0.355
2.174ProGlu: 2.174 ± 0.356
1.019ProPhe: 1.019 ± 0.267
3.261ProGly: 3.261 ± 0.545
0.747ProHis: 0.747 ± 0.194
2.174ProIle: 2.174 ± 0.435
2.038ProLys: 2.038 ± 0.397
3.261ProLeu: 3.261 ± 0.408
0.679ProMet: 0.679 ± 0.206
2.174ProAsn: 2.174 ± 0.357
2.513ProPro: 2.513 ± 0.516
1.63ProGln: 1.63 ± 0.255
2.513ProArg: 2.513 ± 0.301
2.853ProSer: 2.853 ± 0.398
2.31ProThr: 2.31 ± 0.383
4.008ProVal: 4.008 ± 0.593
0.611ProTrp: 0.611 ± 0.173
1.427ProTyr: 1.427 ± 0.238
0.0ProXaa: 0.0 ± 0.0
Gln
2.174GlnAla: 2.174 ± 0.462
0.476GlnCys: 0.476 ± 0.161
1.834GlnAsp: 1.834 ± 0.285
2.513GlnGlu: 2.513 ± 0.393
1.698GlnPhe: 1.698 ± 0.37
2.174GlnGly: 2.174 ± 0.409
0.815GlnHis: 0.815 ± 0.219
2.445GlnIle: 2.445 ± 0.534
1.766GlnLys: 1.766 ± 0.455
4.483GlnLeu: 4.483 ± 0.584
1.155GlnMet: 1.155 ± 0.284
1.766GlnAsn: 1.766 ± 0.359
1.359GlnPro: 1.359 ± 0.263
2.649GlnGln: 2.649 ± 0.401
2.174GlnArg: 2.174 ± 0.45
2.717GlnSer: 2.717 ± 0.478
2.989GlnThr: 2.989 ± 0.404
2.31GlnVal: 2.31 ± 0.337
1.087GlnTrp: 1.087 ± 0.293
1.766GlnTyr: 1.766 ± 0.335
0.0GlnXaa: 0.0 ± 0.0
Arg
4.551ArgAla: 4.551 ± 0.573
0.679ArgCys: 0.679 ± 0.261
2.853ArgAsp: 2.853 ± 0.441
3.397ArgGlu: 3.397 ± 0.535
1.359ArgPhe: 1.359 ± 0.322
3.193ArgGly: 3.193 ± 0.483
1.087ArgHis: 1.087 ± 0.269
3.872ArgIle: 3.872 ± 0.529
3.872ArgLys: 3.872 ± 0.612
4.415ArgLeu: 4.415 ± 0.496
1.155ArgMet: 1.155 ± 0.271
2.174ArgAsn: 2.174 ± 0.37
2.242ArgPro: 2.242 ± 0.325
2.445ArgGln: 2.445 ± 0.426
2.445ArgArg: 2.445 ± 0.348
3.668ArgSer: 3.668 ± 0.414
2.31ArgThr: 2.31 ± 0.302
4.28ArgVal: 4.28 ± 0.56
1.359ArgTrp: 1.359 ± 0.289
2.174ArgTyr: 2.174 ± 0.341
0.0ArgXaa: 0.0 ± 0.0
Ser
5.299SerAla: 5.299 ± 0.661
0.476SerCys: 0.476 ± 0.193
3.397SerAsp: 3.397 ± 0.457
3.329SerGlu: 3.329 ± 0.491
1.902SerPhe: 1.902 ± 0.442
6.521SerGly: 6.521 ± 0.678
1.155SerHis: 1.155 ± 0.265
3.6SerIle: 3.6 ± 0.477
4.28SerLys: 4.28 ± 0.587
4.823SerLeu: 4.823 ± 0.455
1.562SerMet: 1.562 ± 0.308
2.921SerAsn: 2.921 ± 0.458
2.581SerPro: 2.581 ± 0.41
2.989SerGln: 2.989 ± 0.435
2.581SerArg: 2.581 ± 0.402
3.94SerSer: 3.94 ± 0.587
3.736SerThr: 3.736 ± 0.654
5.299SerVal: 5.299 ± 0.571
0.815SerTrp: 0.815 ± 0.221
2.717SerTyr: 2.717 ± 0.378
0.0SerXaa: 0.0 ± 0.0
Thr
5.163ThrAla: 5.163 ± 0.583
0.815ThrCys: 0.815 ± 0.266
4.212ThrAsp: 4.212 ± 0.5
4.348ThrGlu: 4.348 ± 0.604
2.106ThrPhe: 2.106 ± 0.364
6.453ThrGly: 6.453 ± 0.556
1.494ThrHis: 1.494 ± 0.297
4.348ThrIle: 4.348 ± 0.52
2.989ThrLys: 2.989 ± 0.512
5.095ThrLeu: 5.095 ± 0.645
1.427ThrMet: 1.427 ± 0.286
2.378ThrAsn: 2.378 ± 0.357
3.94ThrPro: 3.94 ± 0.513
2.31ThrGln: 2.31 ± 0.39
2.581ThrArg: 2.581 ± 0.432
4.144ThrSer: 4.144 ± 0.545
5.638ThrThr: 5.638 ± 0.706
6.25ThrVal: 6.25 ± 0.819
1.155ThrTrp: 1.155 ± 0.295
2.31ThrTyr: 2.31 ± 0.372
0.0ThrXaa: 0.0 ± 0.0
Val
7.133ValAla: 7.133 ± 0.72
1.155ValCys: 1.155 ± 0.316
5.231ValAsp: 5.231 ± 0.717
4.415ValGlu: 4.415 ± 0.581
2.853ValPhe: 2.853 ± 0.472
4.415ValGly: 4.415 ± 0.618
0.815ValHis: 0.815 ± 0.244
3.94ValIle: 3.94 ± 0.522
4.551ValLys: 4.551 ± 0.454
4.551ValLeu: 4.551 ± 0.539
2.106ValMet: 2.106 ± 0.398
3.872ValAsn: 3.872 ± 0.485
2.785ValPro: 2.785 ± 0.525
2.649ValGln: 2.649 ± 0.318
3.736ValArg: 3.736 ± 0.477
4.008ValSer: 4.008 ± 0.551
7.201ValThr: 7.201 ± 0.814
4.551ValVal: 4.551 ± 0.545
0.815ValTrp: 0.815 ± 0.22
3.329ValTyr: 3.329 ± 0.535
0.0ValXaa: 0.0 ± 0.0
Trp
1.155TrpAla: 1.155 ± 0.276
0.204TrpCys: 0.204 ± 0.119
0.883TrpAsp: 0.883 ± 0.257
0.815TrpGlu: 0.815 ± 0.209
0.611TrpPhe: 0.611 ± 0.199
0.951TrpGly: 0.951 ± 0.233
0.408TrpHis: 0.408 ± 0.21
0.747TrpIle: 0.747 ± 0.194
1.291TrpLys: 1.291 ± 0.326
1.494TrpLeu: 1.494 ± 0.323
0.204TrpMet: 0.204 ± 0.107
0.543TrpAsn: 0.543 ± 0.192
0.611TrpPro: 0.611 ± 0.189
0.679TrpGln: 0.679 ± 0.243
1.087TrpArg: 1.087 ± 0.32
1.019TrpSer: 1.019 ± 0.245
1.019TrpThr: 1.019 ± 0.256
1.291TrpVal: 1.291 ± 0.308
0.204TrpTrp: 0.204 ± 0.115
0.679TrpTyr: 0.679 ± 0.186
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.057TyrAla: 3.057 ± 0.409
0.611TyrCys: 0.611 ± 0.222
2.174TyrAsp: 2.174 ± 0.392
2.445TyrGlu: 2.445 ± 0.421
1.359TyrPhe: 1.359 ± 0.312
3.736TyrGly: 3.736 ± 0.463
0.747TyrHis: 0.747 ± 0.23
1.698TyrIle: 1.698 ± 0.281
1.766TyrLys: 1.766 ± 0.304
2.513TyrLeu: 2.513 ± 0.449
1.087TyrMet: 1.087 ± 0.259
2.038TyrAsn: 2.038 ± 0.401
1.019TyrPro: 1.019 ± 0.284
1.494TyrGln: 1.494 ± 0.281
1.902TyrArg: 1.902 ± 0.389
2.242TyrSer: 2.242 ± 0.422
2.717TyrThr: 2.717 ± 0.356
2.513TyrVal: 2.513 ± 0.431
0.679TyrTrp: 0.679 ± 0.242
1.223TyrTyr: 1.223 ± 0.259
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 75 proteins (14722 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski