Amino acid dipepetide frequency for Ancylomarina euxinus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.085AlaAla: 4.085 ± 0.077
0.857AlaCys: 0.857 ± 0.03
3.647AlaAsp: 3.647 ± 0.052
3.966AlaGlu: 3.966 ± 0.057
3.275AlaPhe: 3.275 ± 0.061
4.181AlaGly: 4.181 ± 0.064
1.171AlaHis: 1.171 ± 0.03
5.401AlaIle: 5.401 ± 0.069
4.762AlaLys: 4.762 ± 0.076
6.334AlaLeu: 6.334 ± 0.092
1.633AlaMet: 1.633 ± 0.039
3.347AlaAsn: 3.347 ± 0.062
1.783AlaPro: 1.783 ± 0.042
2.249AlaGln: 2.249 ± 0.045
2.149AlaArg: 2.149 ± 0.044
4.162AlaSer: 4.162 ± 0.058
2.981AlaThr: 2.981 ± 0.059
3.697AlaVal: 3.697 ± 0.063
0.645AlaTrp: 0.645 ± 0.022
2.752AlaTyr: 2.752 ± 0.049
0.0AlaXaa: 0.0 ± 0.0
Cys
0.504CysAla: 0.504 ± 0.021
0.146CysCys: 0.146 ± 0.01
0.631CysAsp: 0.631 ± 0.023
0.661CysGlu: 0.661 ± 0.035
0.484CysPhe: 0.484 ± 0.021
0.772CysGly: 0.772 ± 0.033
0.273CysHis: 0.273 ± 0.023
0.715CysIle: 0.715 ± 0.027
0.665CysLys: 0.665 ± 0.028
0.889CysLeu: 0.889 ± 0.028
0.241CysMet: 0.241 ± 0.014
0.48CysAsn: 0.48 ± 0.019
0.445CysPro: 0.445 ± 0.023
0.382CysGln: 0.382 ± 0.019
0.358CysArg: 0.358 ± 0.017
0.709CysSer: 0.709 ± 0.025
0.483CysThr: 0.483 ± 0.022
0.575CysVal: 0.575 ± 0.024
0.102CysTrp: 0.102 ± 0.009
0.365CysTyr: 0.365 ± 0.016
0.0CysXaa: 0.0 ± 0.0
Asp
3.547AspAla: 3.547 ± 0.07
0.584AspCys: 0.584 ± 0.025
2.898AspAsp: 2.898 ± 0.052
4.074AspGlu: 4.074 ± 0.066
3.515AspPhe: 3.515 ± 0.056
3.538AspGly: 3.538 ± 0.071
0.982AspHis: 0.982 ± 0.025
4.752AspIle: 4.752 ± 0.075
4.508AspLys: 4.508 ± 0.057
6.021AspLeu: 6.021 ± 0.077
1.373AspMet: 1.373 ± 0.039
2.845AspAsn: 2.845 ± 0.053
1.745AspPro: 1.745 ± 0.043
1.796AspGln: 1.796 ± 0.037
2.106AspArg: 2.106 ± 0.035
3.419AspSer: 3.419 ± 0.061
2.401AspThr: 2.401 ± 0.049
3.46AspVal: 3.46 ± 0.052
0.707AspTrp: 0.707 ± 0.021
2.808AspTyr: 2.808 ± 0.054
0.0AspXaa: 0.0 ± 0.0
Glu
4.516GluAla: 4.516 ± 0.077
0.493GluCys: 0.493 ± 0.02
3.681GluAsp: 3.681 ± 0.065
4.809GluGlu: 4.809 ± 0.074
3.255GluPhe: 3.255 ± 0.053
3.769GluGly: 3.769 ± 0.068
1.134GluHis: 1.134 ± 0.028
5.813GluIle: 5.813 ± 0.074
6.038GluLys: 6.038 ± 0.083
6.908GluLeu: 6.908 ± 0.079
1.996GluMet: 1.996 ± 0.043
4.327GluAsn: 4.327 ± 0.06
1.373GluPro: 1.373 ± 0.033
2.233GluGln: 2.233 ± 0.046
2.561GluArg: 2.561 ± 0.044
3.898GluSer: 3.898 ± 0.064
3.289GluThr: 3.289 ± 0.054
4.24GluVal: 4.24 ± 0.061
0.676GluTrp: 0.676 ± 0.024
2.489GluTyr: 2.489 ± 0.041
0.0GluXaa: 0.0 ± 0.0
Phe
3.099PheAla: 3.099 ± 0.052
0.512PheCys: 0.512 ± 0.023
3.211PheAsp: 3.211 ± 0.061
3.426PheGlu: 3.426 ± 0.064
2.512PhePhe: 2.512 ± 0.062
3.308PheGly: 3.308 ± 0.056
0.849PheHis: 0.849 ± 0.029
3.951PheIle: 3.951 ± 0.073
3.571PheLys: 3.571 ± 0.054
4.535PheLeu: 4.535 ± 0.069
1.249PheMet: 1.249 ± 0.038
3.006PheAsn: 3.006 ± 0.056
1.676PhePro: 1.676 ± 0.034
1.53PheGln: 1.53 ± 0.04
1.788PheArg: 1.788 ± 0.035
4.029PheSer: 4.029 ± 0.072
2.773PheThr: 2.773 ± 0.043
3.014PheVal: 3.014 ± 0.05
0.524PheTrp: 0.524 ± 0.022
2.047PheTyr: 2.047 ± 0.042
0.0PheXaa: 0.0 ± 0.0
Gly
3.996GlyAla: 3.996 ± 0.077
0.673GlyCys: 0.673 ± 0.027
3.47GlyAsp: 3.47 ± 0.063
3.973GlyGlu: 3.973 ± 0.066
3.463GlyPhe: 3.463 ± 0.06
4.359GlyGly: 4.359 ± 0.079
1.178GlyHis: 1.178 ± 0.032
5.48GlyIle: 5.48 ± 0.082
5.025GlyLys: 5.025 ± 0.072
5.977GlyLeu: 5.977 ± 0.095
1.765GlyMet: 1.765 ± 0.044
3.275GlyAsn: 3.275 ± 0.059
1.215GlyPro: 1.215 ± 0.031
1.901GlyGln: 1.901 ± 0.045
2.293GlyArg: 2.293 ± 0.047
4.0GlySer: 4.0 ± 0.062
3.596GlyThr: 3.596 ± 0.073
4.174GlyVal: 4.174 ± 0.061
0.707GlyTrp: 0.707 ± 0.026
2.592GlyTyr: 2.592 ± 0.041
0.0GlyXaa: 0.0 ± 0.0
His
1.014HisAla: 1.014 ± 0.029
0.238HisCys: 0.238 ± 0.016
0.87HisAsp: 0.87 ± 0.03
1.095HisGlu: 1.095 ± 0.03
1.098HisPhe: 1.098 ± 0.032
1.065HisGly: 1.065 ± 0.036
0.467HisHis: 0.467 ± 0.021
1.515HisIle: 1.515 ± 0.034
1.327HisLys: 1.327 ± 0.034
1.847HisLeu: 1.847 ± 0.039
0.42HisMet: 0.42 ± 0.019
0.918HisAsn: 0.918 ± 0.027
0.933HisPro: 0.933 ± 0.027
0.71HisGln: 0.71 ± 0.024
0.702HisArg: 0.702 ± 0.025
1.219HisSer: 1.219 ± 0.027
0.895HisThr: 0.895 ± 0.035
0.947HisVal: 0.947 ± 0.031
0.241HisTrp: 0.241 ± 0.015
0.878HisTyr: 0.878 ± 0.029
0.0HisXaa: 0.0 ± 0.0
Ile
5.441IleAla: 5.441 ± 0.081
0.866IleCys: 0.866 ± 0.029
5.153IleAsp: 5.153 ± 0.066
5.861IleGlu: 5.861 ± 0.068
3.572IlePhe: 3.572 ± 0.057
5.085IleGly: 5.085 ± 0.084
1.534IleHis: 1.534 ± 0.038
6.128IleIle: 6.128 ± 0.101
6.197IleLys: 6.197 ± 0.075
7.514IleLeu: 7.514 ± 0.085
1.614IleMet: 1.614 ± 0.042
4.607IleAsn: 4.607 ± 0.066
3.181IlePro: 3.181 ± 0.048
2.751IleGln: 2.751 ± 0.041
3.031IleArg: 3.031 ± 0.045
6.149IleSer: 6.149 ± 0.083
3.994IleThr: 3.994 ± 0.064
4.731IleVal: 4.731 ± 0.067
0.735IleTrp: 0.735 ± 0.029
2.987IleTyr: 2.987 ± 0.051
0.0IleXaa: 0.0 ± 0.0
Lys
5.363LysAla: 5.363 ± 0.077
0.566LysCys: 0.566 ± 0.025
4.714LysAsp: 4.714 ± 0.069
6.182LysGlu: 6.182 ± 0.08
3.046LysPhe: 3.046 ± 0.043
4.937LysGly: 4.937 ± 0.069
1.547LysHis: 1.547 ± 0.042
5.942LysIle: 5.942 ± 0.073
6.593LysLys: 6.593 ± 0.092
7.319LysLeu: 7.319 ± 0.086
2.199LysMet: 2.199 ± 0.044
4.773LysAsn: 4.773 ± 0.06
2.212LysPro: 2.212 ± 0.051
2.783LysGln: 2.783 ± 0.054
3.101LysArg: 3.101 ± 0.052
4.831LysSer: 4.831 ± 0.064
4.153LysThr: 4.153 ± 0.059
4.544LysVal: 4.544 ± 0.062
0.794LysTrp: 0.794 ± 0.024
3.182LysTyr: 3.182 ± 0.051
0.0LysXaa: 0.0 ± 0.0
Leu
6.206LeuAla: 6.206 ± 0.091
0.919LeuCys: 0.919 ± 0.026
5.256LeuAsp: 5.256 ± 0.072
6.183LeuGlu: 6.183 ± 0.069
4.927LeuPhe: 4.927 ± 0.08
5.946LeuGly: 5.946 ± 0.071
1.572LeuHis: 1.572 ± 0.033
7.909LeuIle: 7.909 ± 0.102
8.198LeuLys: 8.198 ± 0.094
9.114LeuLeu: 9.114 ± 0.109
2.345LeuMet: 2.345 ± 0.047
6.097LeuAsn: 6.097 ± 0.084
3.419LeuPro: 3.419 ± 0.055
2.861LeuGln: 2.861 ± 0.056
3.528LeuArg: 3.528 ± 0.061
7.733LeuSer: 7.733 ± 0.089
4.579LeuThr: 4.579 ± 0.07
5.44LeuVal: 5.44 ± 0.079
0.815LeuTrp: 0.815 ± 0.027
3.176LeuTyr: 3.176 ± 0.047
0.0LeuXaa: 0.0 ± 0.0
Met
1.823MetAla: 1.823 ± 0.042
0.175MetCys: 0.175 ± 0.011
1.42MetAsp: 1.42 ± 0.032
1.473MetGlu: 1.473 ± 0.033
0.971MetPhe: 0.971 ± 0.029
1.884MetGly: 1.884 ± 0.042
0.424MetHis: 0.424 ± 0.02
1.938MetIle: 1.938 ± 0.042
2.212MetLys: 2.212 ± 0.046
2.137MetLeu: 2.137 ± 0.041
0.709MetMet: 0.709 ± 0.024
1.655MetAsn: 1.655 ± 0.039
0.983MetPro: 0.983 ± 0.029
0.826MetGln: 0.826 ± 0.029
0.978MetArg: 0.978 ± 0.025
1.602MetSer: 1.602 ± 0.033
1.303MetThr: 1.303 ± 0.034
1.433MetVal: 1.433 ± 0.039
0.207MetTrp: 0.207 ± 0.014
0.673MetTyr: 0.673 ± 0.023
0.0MetXaa: 0.0 ± 0.0
Asn
3.283AsnAla: 3.283 ± 0.052
0.524AsnCys: 0.524 ± 0.022
2.837AsnAsp: 2.837 ± 0.052
3.704AsnGlu: 3.704 ± 0.06
2.817AsnPhe: 2.817 ± 0.054
3.455AsnGly: 3.455 ± 0.065
1.131AsnHis: 1.131 ± 0.036
4.764AsnIle: 4.764 ± 0.073
4.534AsnLys: 4.534 ± 0.07
5.576AsnLeu: 5.576 ± 0.078
1.505AsnMet: 1.505 ± 0.035
3.2AsnAsn: 3.2 ± 0.058
2.496AsnPro: 2.496 ± 0.051
2.291AsnGln: 2.291 ± 0.055
2.311AsnArg: 2.311 ± 0.044
3.815AsnSer: 3.815 ± 0.069
2.974AsnThr: 2.974 ± 0.055
3.009AsnVal: 3.009 ± 0.056
0.741AsnTrp: 0.741 ± 0.028
2.679AsnTyr: 2.679 ± 0.047
0.0AsnXaa: 0.0 ± 0.0
Pro
1.949ProAla: 1.949 ± 0.04
0.282ProCys: 0.282 ± 0.018
2.044ProAsp: 2.044 ± 0.039
2.822ProGlu: 2.822 ± 0.054
1.681ProPhe: 1.681 ± 0.036
1.851ProGly: 1.851 ± 0.041
0.594ProHis: 0.594 ± 0.019
2.715ProIle: 2.715 ± 0.05
2.311ProLys: 2.311 ± 0.047
2.828ProLeu: 2.828 ± 0.049
0.758ProMet: 0.758 ± 0.024
1.998ProAsn: 1.998 ± 0.039
0.693ProPro: 0.693 ± 0.028
1.132ProGln: 1.132 ± 0.035
0.964ProArg: 0.964 ± 0.029
2.034ProSer: 2.034 ± 0.04
1.606ProThr: 1.606 ± 0.04
2.184ProVal: 2.184 ± 0.046
0.327ProTrp: 0.327 ± 0.015
1.329ProTyr: 1.329 ± 0.032
0.0ProXaa: 0.0 ± 0.0
Gln
2.34GlnAla: 2.34 ± 0.046
0.251GlnCys: 0.251 ± 0.015
1.777GlnAsp: 1.777 ± 0.042
2.345GlnGlu: 2.345 ± 0.048
1.648GlnPhe: 1.648 ± 0.036
1.719GlnGly: 1.719 ± 0.035
0.56GlnHis: 0.56 ± 0.022
2.995GlnIle: 2.995 ± 0.045
2.817GlnLys: 2.817 ± 0.047
3.455GlnLeu: 3.455 ± 0.063
0.916GlnMet: 0.916 ± 0.032
2.058GlnAsn: 2.058 ± 0.044
0.865GlnPro: 0.865 ± 0.029
1.117GlnGln: 1.117 ± 0.029
1.13GlnArg: 1.13 ± 0.032
2.121GlnSer: 2.121 ± 0.045
1.749GlnThr: 1.749 ± 0.04
2.137GlnVal: 2.137 ± 0.043
0.354GlnTrp: 0.354 ± 0.016
1.307GlnTyr: 1.307 ± 0.032
0.0GlnXaa: 0.0 ± 0.0
Arg
2.073ArgAla: 2.073 ± 0.045
0.295ArgCys: 0.295 ± 0.017
1.915ArgAsp: 1.915 ± 0.036
2.46ArgGlu: 2.46 ± 0.049
2.063ArgPhe: 2.063 ± 0.039
1.957ArgGly: 1.957 ± 0.041
0.661ArgHis: 0.661 ± 0.024
3.258ArgIle: 3.258 ± 0.056
3.067ArgLys: 3.067 ± 0.059
3.668ArgLeu: 3.668 ± 0.06
1.062ArgMet: 1.062 ± 0.028
2.178ArgAsn: 2.178 ± 0.044
1.134ArgPro: 1.134 ± 0.031
1.186ArgGln: 1.186 ± 0.033
1.519ArgArg: 1.519 ± 0.05
2.26ArgSer: 2.26 ± 0.053
1.833ArgThr: 1.833 ± 0.037
2.355ArgVal: 2.355 ± 0.046
0.436ArgTrp: 0.436 ± 0.02
1.614ArgTyr: 1.614 ± 0.042
0.0ArgXaa: 0.0 ± 0.0
Ser
3.933SerAla: 3.933 ± 0.054
0.78SerCys: 0.78 ± 0.027
3.988SerAsp: 3.988 ± 0.063
4.381SerGlu: 4.381 ± 0.071
3.949SerPhe: 3.949 ± 0.061
4.649SerGly: 4.649 ± 0.071
1.331SerHis: 1.331 ± 0.034
5.668SerIle: 5.668 ± 0.071
5.004SerLys: 5.004 ± 0.064
6.853SerLeu: 6.853 ± 0.091
1.549SerMet: 1.549 ± 0.04
3.695SerAsn: 3.695 ± 0.065
2.157SerPro: 2.157 ± 0.041
2.382SerGln: 2.382 ± 0.045
2.425SerArg: 2.425 ± 0.045
4.814SerSer: 4.814 ± 0.072
3.288SerThr: 3.288 ± 0.053
4.05SerVal: 4.05 ± 0.063
0.741SerTrp: 0.741 ± 0.025
2.921SerTyr: 2.921 ± 0.055
0.0SerXaa: 0.0 ± 0.0
Thr
3.209ThrAla: 3.209 ± 0.063
0.46ThrCys: 0.46 ± 0.021
3.009ThrAsp: 3.009 ± 0.056
3.082ThrGlu: 3.082 ± 0.05
2.388ThrPhe: 2.388 ± 0.049
3.659ThrGly: 3.659 ± 0.067
1.007ThrHis: 1.007 ± 0.03
4.086ThrIle: 4.086 ± 0.071
3.423ThrLys: 3.423 ± 0.056
4.66ThrLeu: 4.66 ± 0.073
0.906ThrMet: 0.906 ± 0.031
2.775ThrAsn: 2.775 ± 0.049
2.095ThrPro: 2.095 ± 0.049
1.694ThrGln: 1.694 ± 0.039
1.709ThrArg: 1.709 ± 0.037
3.438ThrSer: 3.438 ± 0.058
2.649ThrThr: 2.649 ± 0.054
3.124ThrVal: 3.124 ± 0.068
0.504ThrTrp: 0.504 ± 0.022
2.154ThrTyr: 2.154 ± 0.053
0.0ThrXaa: 0.0 ± 0.0
Val
3.717ValAla: 3.717 ± 0.064
0.685ValCys: 0.685 ± 0.029
3.762ValAsp: 3.762 ± 0.062
4.01ValGlu: 4.01 ± 0.068
3.079ValPhe: 3.079 ± 0.061
3.793ValGly: 3.793 ± 0.073
0.927ValHis: 0.927 ± 0.03
4.614ValIle: 4.614 ± 0.07
4.595ValLys: 4.595 ± 0.069
5.682ValLeu: 5.682 ± 0.072
1.41ValMet: 1.41 ± 0.039
3.451ValAsn: 3.451 ± 0.064
1.993ValPro: 1.993 ± 0.039
1.62ValGln: 1.62 ± 0.037
2.176ValArg: 2.176 ± 0.047
4.565ValSer: 4.565 ± 0.063
2.72ValThr: 2.72 ± 0.056
3.945ValVal: 3.945 ± 0.063
0.632ValTrp: 0.632 ± 0.025
2.235ValTyr: 2.235 ± 0.05
0.0ValXaa: 0.0 ± 0.0
Trp
0.629TrpAla: 0.629 ± 0.023
0.111TrpCys: 0.111 ± 0.01
0.649TrpAsp: 0.649 ± 0.023
0.728TrpGlu: 0.728 ± 0.026
0.524TrpPhe: 0.524 ± 0.022
0.741TrpGly: 0.741 ± 0.027
0.203TrpHis: 0.203 ± 0.012
0.751TrpIle: 0.751 ± 0.029
0.777TrpLys: 0.777 ± 0.026
0.97TrpLeu: 0.97 ± 0.032
0.337TrpMet: 0.337 ± 0.016
0.613TrpAsn: 0.613 ± 0.023
0.208TrpPro: 0.208 ± 0.013
0.428TrpGln: 0.428 ± 0.021
0.424TrpArg: 0.424 ± 0.017
0.645TrpSer: 0.645 ± 0.027
0.559TrpThr: 0.559 ± 0.022
0.649TrpVal: 0.649 ± 0.023
0.136TrpTrp: 0.136 ± 0.011
0.406TrpTyr: 0.406 ± 0.019
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.351TyrAla: 2.351 ± 0.044
0.463TyrCys: 0.463 ± 0.018
2.147TyrAsp: 2.147 ± 0.045
2.262TyrGlu: 2.262 ± 0.043
2.339TyrPhe: 2.339 ± 0.045
2.446TyrGly: 2.446 ± 0.052
0.857TyrHis: 0.857 ± 0.023
2.737TyrIle: 2.737 ± 0.052
3.155TyrLys: 3.155 ± 0.061
3.937TyrLeu: 3.937 ± 0.061
0.837TyrMet: 0.837 ± 0.028
2.348TyrAsn: 2.348 ± 0.057
1.496TyrPro: 1.496 ± 0.034
1.789TyrGln: 1.789 ± 0.037
1.741TyrArg: 1.741 ± 0.037
3.117TyrSer: 3.117 ± 0.058
2.209TyrThr: 2.209 ± 0.045
1.902TyrVal: 1.902 ± 0.043
0.463TyrTrp: 0.463 ± 0.02
1.708TyrTyr: 1.708 ± 0.045
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3457 proteins (1249026 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski