Amino acid dipepetide frequency for Gordonia phage Fairfaxidum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
17.953AlaAla: 17.953 ± 1.543
0.925AlaCys: 0.925 ± 0.262
8.205AlaAsp: 8.205 ± 0.811
7.65AlaGlu: 7.65 ± 0.708
3.27AlaPhe: 3.27 ± 0.548
8.39AlaGly: 8.39 ± 0.858
1.542AlaHis: 1.542 ± 0.346
5.676AlaIle: 5.676 ± 0.614
3.517AlaLys: 3.517 ± 0.679
9.933AlaLeu: 9.933 ± 0.825
2.591AlaMet: 2.591 ± 0.514
3.27AlaAsn: 3.27 ± 0.459
4.936AlaPro: 4.936 ± 0.724
4.936AlaGln: 4.936 ± 0.667
10.118AlaArg: 10.118 ± 0.809
6.169AlaSer: 6.169 ± 1.179
7.835AlaThr: 7.835 ± 0.921
9.007AlaVal: 9.007 ± 0.762
1.974AlaTrp: 1.974 ± 0.474
2.283AlaTyr: 2.283 ± 0.377
0.0AlaXaa: 0.0 ± 0.0
Cys
0.74CysAla: 0.74 ± 0.202
0.062CysCys: 0.062 ± 0.062
1.11CysAsp: 1.11 ± 0.408
0.37CysGlu: 0.37 ± 0.136
0.123CysPhe: 0.123 ± 0.087
0.802CysGly: 0.802 ± 0.253
0.308CysHis: 0.308 ± 0.161
0.308CysIle: 0.308 ± 0.15
0.247CysLys: 0.247 ± 0.139
0.308CysLeu: 0.308 ± 0.137
0.062CysMet: 0.062 ± 0.06
0.185CysAsn: 0.185 ± 0.107
0.617CysPro: 0.617 ± 0.21
0.308CysGln: 0.308 ± 0.171
0.617CysArg: 0.617 ± 0.226
0.555CysSer: 0.555 ± 0.178
0.494CysThr: 0.494 ± 0.19
0.247CysVal: 0.247 ± 0.119
0.247CysTrp: 0.247 ± 0.126
0.308CysTyr: 0.308 ± 0.144
0.0CysXaa: 0.0 ± 0.0
Asp
8.575AspAla: 8.575 ± 0.771
0.308AspCys: 0.308 ± 0.145
5.491AspAsp: 5.491 ± 0.917
4.689AspGlu: 4.689 ± 0.621
1.727AspPhe: 1.727 ± 0.292
7.28AspGly: 7.28 ± 0.893
1.913AspHis: 1.913 ± 0.357
2.961AspIle: 2.961 ± 0.314
1.542AspLys: 1.542 ± 0.494
5.676AspLeu: 5.676 ± 0.621
1.296AspMet: 1.296 ± 0.261
1.604AspAsn: 1.604 ± 0.255
4.38AspPro: 4.38 ± 0.464
3.085AspGln: 3.085 ± 0.573
4.504AspArg: 4.504 ± 0.695
2.838AspSer: 2.838 ± 0.371
4.627AspThr: 4.627 ± 0.42
5.429AspVal: 5.429 ± 0.63
0.679AspTrp: 0.679 ± 0.196
1.727AspTyr: 1.727 ± 0.347
0.0AspXaa: 0.0 ± 0.0
Glu
5.923GluAla: 5.923 ± 0.579
0.308GluCys: 0.308 ± 0.134
2.9GluAsp: 2.9 ± 0.441
2.653GluGlu: 2.653 ± 0.472
2.283GluPhe: 2.283 ± 0.403
3.455GluGly: 3.455 ± 0.329
1.604GluHis: 1.604 ± 0.333
2.776GluIle: 2.776 ± 0.404
2.159GluLys: 2.159 ± 0.339
4.565GluLeu: 4.565 ± 0.595
1.481GluMet: 1.481 ± 0.299
1.357GluAsn: 1.357 ± 0.318
3.27GluPro: 3.27 ± 0.51
3.208GluGln: 3.208 ± 0.523
4.38GluArg: 4.38 ± 0.629
3.331GluSer: 3.331 ± 0.518
2.838GluThr: 2.838 ± 0.367
5.182GluVal: 5.182 ± 0.545
1.296GluTrp: 1.296 ± 0.309
1.481GluTyr: 1.481 ± 0.392
0.0GluXaa: 0.0 ± 0.0
Phe
3.085PheAla: 3.085 ± 0.511
0.185PheCys: 0.185 ± 0.116
2.406PheAsp: 2.406 ± 0.436
1.913PheGlu: 1.913 ± 0.296
0.802PhePhe: 0.802 ± 0.201
2.406PheGly: 2.406 ± 0.354
0.432PheHis: 0.432 ± 0.172
1.357PheIle: 1.357 ± 0.268
0.987PheLys: 0.987 ± 0.315
1.974PheLeu: 1.974 ± 0.402
0.308PheMet: 0.308 ± 0.127
0.617PheAsn: 0.617 ± 0.239
1.234PhePro: 1.234 ± 0.24
0.432PheGln: 0.432 ± 0.156
1.666PheArg: 1.666 ± 0.373
1.172PheSer: 1.172 ± 0.229
1.974PheThr: 1.974 ± 0.283
2.9PheVal: 2.9 ± 0.364
0.37PheTrp: 0.37 ± 0.142
0.555PheTyr: 0.555 ± 0.182
0.0PheXaa: 0.0 ± 0.0
Gly
7.218GlyAla: 7.218 ± 1.108
0.74GlyCys: 0.74 ± 0.238
4.997GlyAsp: 4.997 ± 0.438
4.75GlyGlu: 4.75 ± 0.622
2.468GlyPhe: 2.468 ± 0.406
7.773GlyGly: 7.773 ± 1.016
2.344GlyHis: 2.344 ± 0.474
4.442GlyIle: 4.442 ± 0.735
3.825GlyLys: 3.825 ± 0.516
7.588GlyLeu: 7.588 ± 0.955
1.234GlyMet: 1.234 ± 0.209
2.529GlyAsn: 2.529 ± 0.455
4.134GlyPro: 4.134 ± 0.619
3.208GlyGln: 3.208 ± 0.406
7.218GlyArg: 7.218 ± 0.692
4.257GlySer: 4.257 ± 0.643
5.059GlyThr: 5.059 ± 0.849
6.354GlyVal: 6.354 ± 0.531
2.159GlyTrp: 2.159 ± 0.378
2.468GlyTyr: 2.468 ± 0.416
0.0GlyXaa: 0.0 ± 0.0
His
2.159HisAla: 2.159 ± 0.323
0.37HisCys: 0.37 ± 0.167
1.481HisAsp: 1.481 ± 0.395
0.802HisGlu: 0.802 ± 0.201
0.37HisPhe: 0.37 ± 0.13
2.283HisGly: 2.283 ± 0.369
0.432HisHis: 0.432 ± 0.181
0.925HisIle: 0.925 ± 0.269
0.864HisLys: 0.864 ± 0.21
2.159HisLeu: 2.159 ± 0.414
0.247HisMet: 0.247 ± 0.107
0.37HisAsn: 0.37 ± 0.148
1.481HisPro: 1.481 ± 0.286
0.987HisGln: 0.987 ± 0.315
1.172HisArg: 1.172 ± 0.274
1.11HisSer: 1.11 ± 0.255
1.234HisThr: 1.234 ± 0.222
1.481HisVal: 1.481 ± 0.348
0.555HisTrp: 0.555 ± 0.179
0.185HisTyr: 0.185 ± 0.113
0.0HisXaa: 0.0 ± 0.0
Ile
5.676IleAla: 5.676 ± 0.582
0.494IleCys: 0.494 ± 0.212
4.565IleAsp: 4.565 ± 0.697
3.331IleGlu: 3.331 ± 0.406
0.802IlePhe: 0.802 ± 0.229
4.134IleGly: 4.134 ± 0.993
0.679IleHis: 0.679 ± 0.197
1.542IleIle: 1.542 ± 0.581
1.789IleLys: 1.789 ± 0.657
2.036IleLeu: 2.036 ± 0.285
0.74IleMet: 0.74 ± 0.207
0.925IleAsn: 0.925 ± 0.199
3.208IlePro: 3.208 ± 0.419
0.802IleGln: 0.802 ± 0.24
3.825IleArg: 3.825 ± 0.588
1.913IleSer: 1.913 ± 0.328
3.208IleThr: 3.208 ± 0.377
3.887IleVal: 3.887 ± 0.526
0.247IleTrp: 0.247 ± 0.137
1.234IleTyr: 1.234 ± 0.314
0.0IleXaa: 0.0 ± 0.0
Lys
4.319LysAla: 4.319 ± 0.773
0.123LysCys: 0.123 ± 0.094
1.789LysAsp: 1.789 ± 0.46
1.542LysGlu: 1.542 ± 0.303
1.234LysPhe: 1.234 ± 0.355
3.023LysGly: 3.023 ± 0.553
0.679LysHis: 0.679 ± 0.227
1.049LysIle: 1.049 ± 0.254
1.542LysLys: 1.542 ± 0.365
2.838LysLeu: 2.838 ± 0.464
0.679LysMet: 0.679 ± 0.216
1.172LysAsn: 1.172 ± 0.322
2.715LysPro: 2.715 ± 0.375
0.925LysGln: 0.925 ± 0.266
2.098LysArg: 2.098 ± 0.373
1.974LysSer: 1.974 ± 0.412
1.913LysThr: 1.913 ± 0.432
2.529LysVal: 2.529 ± 0.319
0.679LysTrp: 0.679 ± 0.199
0.802LysTyr: 0.802 ± 0.228
0.0LysXaa: 0.0 ± 0.0
Leu
9.624LeuAla: 9.624 ± 0.824
0.74LeuCys: 0.74 ± 0.224
6.54LeuAsp: 6.54 ± 0.742
3.023LeuGlu: 3.023 ± 0.415
1.974LeuPhe: 1.974 ± 0.388
6.046LeuGly: 6.046 ± 0.615
1.542LeuHis: 1.542 ± 0.295
3.578LeuIle: 3.578 ± 0.515
2.344LeuLys: 2.344 ± 0.416
5.182LeuLeu: 5.182 ± 0.668
1.913LeuMet: 1.913 ± 0.338
1.851LeuAsn: 1.851 ± 0.403
4.689LeuPro: 4.689 ± 0.585
1.913LeuGln: 1.913 ± 0.388
5.738LeuArg: 5.738 ± 0.547
5.059LeuSer: 5.059 ± 0.575
5.306LeuThr: 5.306 ± 0.579
6.725LeuVal: 6.725 ± 0.609
2.036LeuTrp: 2.036 ± 0.336
1.542LeuTyr: 1.542 ± 0.309
0.0LeuXaa: 0.0 ± 0.0
Met
2.961MetAla: 2.961 ± 0.496
0.247MetCys: 0.247 ± 0.162
0.679MetAsp: 0.679 ± 0.22
0.555MetGlu: 0.555 ± 0.153
0.617MetPhe: 0.617 ± 0.217
1.481MetGly: 1.481 ± 0.316
0.247MetHis: 0.247 ± 0.131
1.11MetIle: 1.11 ± 0.244
0.74MetLys: 0.74 ± 0.161
1.172MetLeu: 1.172 ± 0.245
0.494MetMet: 0.494 ± 0.257
0.679MetAsn: 0.679 ± 0.182
1.604MetPro: 1.604 ± 0.333
0.494MetGln: 0.494 ± 0.183
1.542MetArg: 1.542 ± 0.396
2.036MetSer: 2.036 ± 0.355
1.789MetThr: 1.789 ± 0.328
1.11MetVal: 1.11 ± 0.238
0.679MetTrp: 0.679 ± 0.269
0.308MetTyr: 0.308 ± 0.122
0.0MetXaa: 0.0 ± 0.0
Asn
3.023AsnAla: 3.023 ± 0.438
0.123AsnCys: 0.123 ± 0.076
1.974AsnAsp: 1.974 ± 0.434
1.172AsnGlu: 1.172 ± 0.277
0.802AsnPhe: 0.802 ± 0.224
2.468AsnGly: 2.468 ± 0.31
0.37AsnHis: 0.37 ± 0.143
0.925AsnIle: 0.925 ± 0.243
0.74AsnLys: 0.74 ± 0.268
2.159AsnLeu: 2.159 ± 0.34
0.37AsnMet: 0.37 ± 0.156
0.37AsnAsn: 0.37 ± 0.151
2.653AsnPro: 2.653 ± 0.32
1.049AsnGln: 1.049 ± 0.201
2.221AsnArg: 2.221 ± 0.351
1.666AsnSer: 1.666 ± 0.399
1.913AsnThr: 1.913 ± 0.421
1.666AsnVal: 1.666 ± 0.431
0.494AsnTrp: 0.494 ± 0.155
0.679AsnTyr: 0.679 ± 0.235
0.0AsnXaa: 0.0 ± 0.0
Pro
7.588ProAla: 7.588 ± 0.836
0.432ProCys: 0.432 ± 0.162
4.565ProAsp: 4.565 ± 0.722
3.64ProGlu: 3.64 ± 0.512
1.049ProPhe: 1.049 ± 0.277
5.429ProGly: 5.429 ± 0.594
1.234ProHis: 1.234 ± 0.318
2.715ProIle: 2.715 ± 0.433
2.529ProLys: 2.529 ± 0.424
3.023ProLeu: 3.023 ± 0.477
1.542ProMet: 1.542 ± 0.254
1.851ProAsn: 1.851 ± 0.334
3.023ProPro: 3.023 ± 0.584
1.789ProGln: 1.789 ± 0.241
3.085ProArg: 3.085 ± 0.45
3.27ProSer: 3.27 ± 0.376
4.565ProThr: 4.565 ± 0.718
3.702ProVal: 3.702 ± 0.43
1.296ProTrp: 1.296 ± 0.262
0.987ProTyr: 0.987 ± 0.242
0.0ProXaa: 0.0 ± 0.0
Gln
3.331GlnAla: 3.331 ± 0.46
0.185GlnCys: 0.185 ± 0.14
1.357GlnAsp: 1.357 ± 0.288
1.481GlnGlu: 1.481 ± 0.291
1.357GlnPhe: 1.357 ± 0.317
2.653GlnGly: 2.653 ± 0.438
0.617GlnHis: 0.617 ± 0.223
1.542GlnIle: 1.542 ± 0.316
1.234GlnLys: 1.234 ± 0.311
3.455GlnLeu: 3.455 ± 0.405
0.679GlnMet: 0.679 ± 0.183
1.11GlnAsn: 1.11 ± 0.282
1.851GlnPro: 1.851 ± 0.352
1.481GlnGln: 1.481 ± 0.347
3.578GlnArg: 3.578 ± 0.446
1.419GlnSer: 1.419 ± 0.318
2.653GlnThr: 2.653 ± 0.497
2.9GlnVal: 2.9 ± 0.437
0.925GlnTrp: 0.925 ± 0.268
0.74GlnTyr: 0.74 ± 0.22
0.0GlnXaa: 0.0 ± 0.0
Arg
8.082ArgAla: 8.082 ± 0.68
0.617ArgCys: 0.617 ± 0.193
5.923ArgAsp: 5.923 ± 0.682
5.244ArgGlu: 5.244 ± 0.601
1.913ArgPhe: 1.913 ± 0.349
7.095ArgGly: 7.095 ± 0.773
1.604ArgHis: 1.604 ± 0.324
3.393ArgIle: 3.393 ± 0.504
2.036ArgLys: 2.036 ± 0.279
6.231ArgLeu: 6.231 ± 0.631
2.098ArgMet: 2.098 ± 0.345
2.036ArgAsn: 2.036 ± 0.32
3.023ArgPro: 3.023 ± 0.537
2.221ArgGln: 2.221 ± 0.432
6.416ArgArg: 6.416 ± 0.947
4.134ArgSer: 4.134 ± 0.58
4.195ArgThr: 4.195 ± 0.48
4.75ArgVal: 4.75 ± 0.631
1.666ArgTrp: 1.666 ± 0.359
1.789ArgTyr: 1.789 ± 0.335
0.0ArgXaa: 0.0 ± 0.0
Ser
7.033SerAla: 7.033 ± 1.1
0.185SerCys: 0.185 ± 0.098
3.578SerAsp: 3.578 ± 0.509
2.591SerGlu: 2.591 ± 0.394
0.925SerPhe: 0.925 ± 0.227
5.676SerGly: 5.676 ± 0.855
1.11SerHis: 1.11 ± 0.238
2.9SerIle: 2.9 ± 0.379
1.727SerLys: 1.727 ± 0.293
4.134SerLeu: 4.134 ± 0.704
1.172SerMet: 1.172 ± 0.315
1.234SerAsn: 1.234 ± 0.383
3.331SerPro: 3.331 ± 0.396
1.049SerGln: 1.049 ± 0.289
3.887SerArg: 3.887 ± 0.53
2.468SerSer: 2.468 ± 0.374
4.072SerThr: 4.072 ± 0.468
4.812SerVal: 4.812 ± 0.541
1.234SerTrp: 1.234 ± 0.26
1.11SerTyr: 1.11 ± 0.294
0.0SerXaa: 0.0 ± 0.0
Thr
8.575ThrAla: 8.575 ± 1.202
0.37ThrCys: 0.37 ± 0.142
4.442ThrAsp: 4.442 ± 0.735
3.331ThrGlu: 3.331 ± 0.533
1.851ThrPhe: 1.851 ± 0.394
5.923ThrGly: 5.923 ± 0.71
1.357ThrHis: 1.357 ± 0.325
3.331ThrIle: 3.331 ± 0.504
2.529ThrLys: 2.529 ± 0.405
5.614ThrLeu: 5.614 ± 0.671
1.172ThrMet: 1.172 ± 0.272
1.172ThrAsn: 1.172 ± 0.287
4.072ThrPro: 4.072 ± 0.627
1.666ThrGln: 1.666 ± 0.332
3.702ThrArg: 3.702 ± 0.413
4.072ThrSer: 4.072 ± 0.594
3.455ThrThr: 3.455 ± 0.674
6.108ThrVal: 6.108 ± 0.681
1.727ThrTrp: 1.727 ± 0.309
1.481ThrTyr: 1.481 ± 0.282
0.0ThrXaa: 0.0 ± 0.0
Val
9.686ValAla: 9.686 ± 0.765
0.987ValCys: 0.987 ± 0.272
6.354ValAsp: 6.354 ± 0.731
5.491ValGlu: 5.491 ± 0.75
1.974ValPhe: 1.974 ± 0.357
5.799ValGly: 5.799 ± 0.576
1.419ValHis: 1.419 ± 0.275
3.023ValIle: 3.023 ± 0.399
2.344ValLys: 2.344 ± 0.473
5.923ValLeu: 5.923 ± 0.613
1.296ValMet: 1.296 ± 0.429
2.283ValAsn: 2.283 ± 0.493
4.01ValPro: 4.01 ± 0.61
2.961ValGln: 2.961 ± 0.371
4.936ValArg: 4.936 ± 0.643
4.134ValSer: 4.134 ± 0.532
6.108ValThr: 6.108 ± 1.038
7.28ValVal: 7.28 ± 0.633
1.789ValTrp: 1.789 ± 0.374
1.789ValTyr: 1.789 ± 0.344
0.0ValXaa: 0.0 ± 0.0
Trp
1.727TrpAla: 1.727 ± 0.395
0.37TrpCys: 0.37 ± 0.146
1.172TrpAsp: 1.172 ± 0.316
0.925TrpGlu: 0.925 ± 0.268
0.617TrpPhe: 0.617 ± 0.234
0.802TrpGly: 0.802 ± 0.199
0.555TrpHis: 0.555 ± 0.211
0.74TrpIle: 0.74 ± 0.19
0.432TrpLys: 0.432 ± 0.156
2.098TrpLeu: 2.098 ± 0.437
0.679TrpMet: 0.679 ± 0.183
1.419TrpAsn: 1.419 ± 0.342
1.727TrpPro: 1.727 ± 0.306
0.864TrpGln: 0.864 ± 0.267
1.789TrpArg: 1.789 ± 0.295
1.296TrpSer: 1.296 ± 0.321
1.357TrpThr: 1.357 ± 0.246
1.727TrpVal: 1.727 ± 0.326
0.617TrpTrp: 0.617 ± 0.222
0.185TrpTyr: 0.185 ± 0.101
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.9TyrAla: 2.9 ± 0.502
0.247TyrCys: 0.247 ± 0.131
0.802TyrAsp: 0.802 ± 0.218
1.296TyrGlu: 1.296 ± 0.34
0.617TyrPhe: 0.617 ± 0.216
1.851TyrGly: 1.851 ± 0.381
0.679TyrHis: 0.679 ± 0.168
0.74TyrIle: 0.74 ± 0.269
0.494TyrLys: 0.494 ± 0.16
1.296TyrLeu: 1.296 ± 0.304
0.432TyrMet: 0.432 ± 0.146
0.802TyrAsn: 0.802 ± 0.194
1.357TyrPro: 1.357 ± 0.277
1.172TyrGln: 1.172 ± 0.273
2.036TyrArg: 2.036 ± 0.363
1.357TyrSer: 1.357 ± 0.324
1.357TyrThr: 1.357 ± 0.326
1.789TyrVal: 1.789 ± 0.388
0.432TyrTrp: 0.432 ± 0.16
0.555TyrTyr: 0.555 ± 0.236
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 81 proteins (16210 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski