Amino acid dipepetide frequency for Thermobacillus composti (strain DSM 18247 / JCM 13945 / KWC4)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.315AlaAla: 14.315 ± 0.203	0.909AlaCys: 0.909 ± 0.03	5.773AlaAsp: 5.773 ± 0.084	7.946AlaGlu: 7.946 ± 0.105	3.712AlaPhe: 3.712 ± 0.062	9.635AlaGly: 9.635 ± 0.117	1.697AlaHis: 1.697 ± 0.045	5.306AlaIle: 5.306 ± 0.065	3.886AlaLys: 3.886 ± 0.059	10.059AlaLeu: 10.059 ± 0.113	2.72AlaMet: 2.72 ± 0.046	2.409AlaAsn: 2.409 ± 0.047	3.421AlaPro: 3.421 ± 0.069	2.6AlaGln: 2.6 ± 0.044	6.097AlaArg: 6.097 ± 0.076	5.066AlaSer: 5.066 ± 0.077	3.21AlaThr: 3.21 ± 0.062	8.426AlaVal: 8.426 ± 0.12	1.303AlaTrp: 1.303 ± 0.034	2.838AlaTyr: 2.838 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	0.745CysAla: 0.745 ± 0.028	0.134CysCys: 0.134 ± 0.011	0.403CysAsp: 0.403 ± 0.019	0.471CysGlu: 0.471 ± 0.022	0.277CysPhe: 0.277 ± 0.015	0.949CysGly: 0.949 ± 0.034	0.183CysHis: 0.183 ± 0.012	0.425CysIle: 0.425 ± 0.017	0.24CysLys: 0.24 ± 0.014	0.772CysLeu: 0.772 ± 0.027	0.218CysMet: 0.218 ± 0.012	0.249CysAsn: 0.249 ± 0.015	0.425CysPro: 0.425 ± 0.02	0.179CysGln: 0.179 ± 0.012	0.673CysArg: 0.673 ± 0.025	0.468CysSer: 0.468 ± 0.018	0.412CysThr: 0.412 ± 0.021	0.498CysVal: 0.498 ± 0.02	0.103CysTrp: 0.103 ± 0.009	0.232CysTyr: 0.232 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	5.315AspAla: 5.315 ± 0.079	0.396AspCys: 0.396 ± 0.021	2.846AspAsp: 2.846 ± 0.054	4.282AspGlu: 4.282 ± 0.071	1.932AspPhe: 1.932 ± 0.041	5.034AspGly: 5.034 ± 0.081	1.061AspHis: 1.061 ± 0.03	3.215AspIle: 3.215 ± 0.055	2.095AspLys: 2.095 ± 0.048	4.989AspLeu: 4.989 ± 0.067	1.21AspMet: 1.21 ± 0.032	1.46AspAsn: 1.46 ± 0.039	2.99AspPro: 2.99 ± 0.046	1.431AspGln: 1.431 ± 0.04	4.117AspArg: 4.117 ± 0.071	2.361AspSer: 2.361 ± 0.049	2.196AspThr: 2.196 ± 0.051	3.675AspVal: 3.675 ± 0.052	0.974AspTrp: 0.974 ± 0.03	1.872AspTyr: 1.872 ± 0.041	0.0AspXaa: 0.0 ± 0.0
Glu	8.065GluAla: 8.065 ± 0.113	0.398GluCys: 0.398 ± 0.018	3.284GluAsp: 3.284 ± 0.051	5.296GluGlu: 5.296 ± 0.088	1.996GluPhe: 1.996 ± 0.039	4.692GluGly: 4.692 ± 0.069	1.405GluHis: 1.405 ± 0.038	4.099GluIle: 4.099 ± 0.06	3.131GluLys: 3.131 ± 0.069	7.496GluLeu: 7.496 ± 0.103	1.858GluMet: 1.858 ± 0.04	2.047GluAsn: 2.047 ± 0.044	3.097GluPro: 3.097 ± 0.058	3.09GluGln: 3.09 ± 0.062	6.163GluArg: 6.163 ± 0.094	3.297GluSer: 3.297 ± 0.045	3.783GluThr: 3.783 ± 0.062	4.082GluVal: 4.082 ± 0.067	1.123GluTrp: 1.123 ± 0.036	1.969GluTyr: 1.969 ± 0.047	0.0GluXaa: 0.0 ± 0.0
Phe	3.769PheAla: 3.769 ± 0.058	0.349PheCys: 0.349 ± 0.018	2.37PheAsp: 2.37 ± 0.05	2.51PheGlu: 2.51 ± 0.046	1.679PhePhe: 1.679 ± 0.045	3.413PheGly: 3.413 ± 0.055	0.829PheHis: 0.829 ± 0.028	2.331PheIle: 2.331 ± 0.052	1.505PheLys: 1.505 ± 0.035	3.589PheLeu: 3.589 ± 0.065	0.961PheMet: 0.961 ± 0.026	1.182PheAsn: 1.182 ± 0.034	1.535PhePro: 1.535 ± 0.033	0.992PheGln: 0.992 ± 0.032	2.802PheArg: 2.802 ± 0.045	2.074PheSer: 2.074 ± 0.043	2.062PheThr: 2.062 ± 0.044	2.935PheVal: 2.935 ± 0.051	0.578PheTrp: 0.578 ± 0.02	1.275PheTyr: 1.275 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	7.013GlyAla: 7.013 ± 0.097	0.844GlyCys: 0.844 ± 0.027	3.807GlyAsp: 3.807 ± 0.066	5.378GlyGlu: 5.378 ± 0.078	3.272GlyPhe: 3.272 ± 0.058	7.051GlyGly: 7.051 ± 0.104	1.575GlyHis: 1.575 ± 0.04	5.461GlyIle: 5.461 ± 0.076	4.137GlyLys: 4.137 ± 0.06	7.663GlyLeu: 7.663 ± 0.093	2.562GlyMet: 2.562 ± 0.054	2.371GlyAsn: 2.371 ± 0.053	2.634GlyPro: 2.634 ± 0.05	2.32GlyGln: 2.32 ± 0.048	5.884GlyArg: 5.884 ± 0.086	4.605GlySer: 4.605 ± 0.075	4.335GlyThr: 4.335 ± 0.062	5.6GlyVal: 5.6 ± 0.076	1.366GlyTrp: 1.366 ± 0.036	2.867GlyTyr: 2.867 ± 0.047	0.0GlyXaa: 0.0 ± 0.0
His	1.987HisAla: 1.987 ± 0.039	0.206HisCys: 0.206 ± 0.012	1.069HisAsp: 1.069 ± 0.029	1.307HisGlu: 1.307 ± 0.033	0.916HisPhe: 0.916 ± 0.027	1.622HisGly: 1.622 ± 0.039	0.584HisHis: 0.584 ± 0.026	1.1HisIle: 1.1 ± 0.029	0.68HisLys: 0.68 ± 0.024	2.072HisLeu: 2.072 ± 0.056	0.454HisMet: 0.454 ± 0.02	0.545HisAsn: 0.545 ± 0.022	1.427HisPro: 1.427 ± 0.038	0.623HisGln: 0.623 ± 0.022	1.385HisArg: 1.385 ± 0.037	0.936HisSer: 0.936 ± 0.029	0.911HisThr: 0.911 ± 0.028	1.539HisVal: 1.539 ± 0.034	0.308HisTrp: 0.308 ± 0.016	0.826HisTyr: 0.826 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	6.44IleAla: 6.44 ± 0.074	0.511IleCys: 0.511 ± 0.021	3.611IleAsp: 3.611 ± 0.056	4.398IleGlu: 4.398 ± 0.065	1.987IlePhe: 1.987 ± 0.05	5.379IleGly: 5.379 ± 0.075	1.181IleHis: 1.181 ± 0.032	3.183IleIle: 3.183 ± 0.061	2.012IleLys: 2.012 ± 0.049	4.816IleLeu: 4.816 ± 0.07	1.32IleMet: 1.32 ± 0.036	1.674IleAsn: 1.674 ± 0.045	2.772IlePro: 2.772 ± 0.055	1.666IleGln: 1.666 ± 0.041	5.277IleArg: 5.277 ± 0.064	2.977IleSer: 2.977 ± 0.053	2.806IleThr: 2.806 ± 0.054	5.136IleVal: 5.136 ± 0.064	0.646IleTrp: 0.646 ± 0.023	1.776IleTyr: 1.776 ± 0.042	0.0IleXaa: 0.0 ± 0.0
Lys	4.071LysAla: 4.071 ± 0.07	0.236LysCys: 0.236 ± 0.015	2.087LysAsp: 2.087 ± 0.045	3.131LysGlu: 3.131 ± 0.06	1.322LysPhe: 1.322 ± 0.033	2.846LysGly: 2.846 ± 0.052	0.932LysHis: 0.932 ± 0.028	2.402LysIle: 2.402 ± 0.056	2.164LysLys: 2.164 ± 0.049	4.461LysLeu: 4.461 ± 0.063	1.14LysMet: 1.14 ± 0.034	1.397LysAsn: 1.397 ± 0.039	2.285LysPro: 2.285 ± 0.043	1.682LysGln: 1.682 ± 0.044	3.358LysArg: 3.358 ± 0.06	2.052LysSer: 2.052 ± 0.045	2.394LysThr: 2.394 ± 0.053	2.812LysVal: 2.812 ± 0.047	0.571LysTrp: 0.571 ± 0.022	1.316LysTyr: 1.316 ± 0.031	0.0LysXaa: 0.0 ± 0.0
Leu	10.644LeuAla: 10.644 ± 0.113	0.767LeuCys: 0.767 ± 0.025	5.521LeuAsp: 5.521 ± 0.075	6.652LeuGlu: 6.652 ± 0.083	4.256LeuPhe: 4.256 ± 0.069	6.946LeuGly: 6.946 ± 0.083	2.131LeuHis: 2.131 ± 0.043	5.95LeuIle: 5.95 ± 0.089	4.651LeuLys: 4.651 ± 0.064	11.236LeuLeu: 11.236 ± 0.135	2.418LeuMet: 2.418 ± 0.047	3.154LeuAsn: 3.154 ± 0.052	4.952LeuPro: 4.952 ± 0.063	3.289LeuGln: 3.289 ± 0.058	6.8LeuArg: 6.8 ± 0.089	5.797LeuSer: 5.797 ± 0.082	5.349LeuThr: 5.349 ± 0.072	6.361LeuVal: 6.361 ± 0.081	1.087LeuTrp: 1.087 ± 0.034	3.055LeuTyr: 3.055 ± 0.052	0.0LeuXaa: 0.0 ± 0.0
Met	2.599MetAla: 2.599 ± 0.047	0.151MetCys: 0.151 ± 0.01	1.352MetAsp: 1.352 ± 0.035	1.744MetGlu: 1.744 ± 0.036	0.955MetPhe: 0.955 ± 0.025	1.448MetGly: 1.448 ± 0.038	0.475MetHis: 0.475 ± 0.018	1.6MetIle: 1.6 ± 0.039	1.555MetLys: 1.555 ± 0.037	3.029MetLeu: 3.029 ± 0.054	0.764MetMet: 0.764 ± 0.023	1.096MetAsn: 1.096 ± 0.031	1.318MetPro: 1.318 ± 0.033	0.863MetGln: 0.863 ± 0.029	1.955MetArg: 1.955 ± 0.047	1.511MetSer: 1.511 ± 0.037	1.689MetThr: 1.689 ± 0.037	1.585MetVal: 1.585 ± 0.038	0.201MetTrp: 0.201 ± 0.012	0.641MetTyr: 0.641 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	2.878AsnAla: 2.878 ± 0.052	0.214AsnCys: 0.214 ± 0.014	1.448AsnAsp: 1.448 ± 0.034	1.869AsnGlu: 1.869 ± 0.044	1.035AsnPhe: 1.035 ± 0.026	2.739AsnGly: 2.739 ± 0.06	0.614AsnHis: 0.614 ± 0.026	1.84AsnIle: 1.84 ± 0.045	1.177AsnLys: 1.177 ± 0.033	2.844AsnLeu: 2.844 ± 0.056	0.794AsnMet: 0.794 ± 0.027	0.972AsnAsn: 0.972 ± 0.033	1.903AsnPro: 1.903 ± 0.037	0.909AsnGln: 0.909 ± 0.029	2.36AsnArg: 2.36 ± 0.043	1.271AsnSer: 1.271 ± 0.042	1.481AsnThr: 1.481 ± 0.037	2.332AsnVal: 2.332 ± 0.047	0.434AsnTrp: 0.434 ± 0.019	0.979AsnTyr: 0.979 ± 0.032	0.0AsnXaa: 0.0 ± 0.0
Pro	4.791ProAla: 4.791 ± 0.084	0.313ProCys: 0.313 ± 0.015	3.53ProAsp: 3.53 ± 0.061	4.144ProGlu: 4.144 ± 0.061	1.892ProPhe: 1.892 ± 0.047	4.053ProGly: 4.053 ± 0.07	1.063ProHis: 1.063 ± 0.033	2.284ProIle: 2.284 ± 0.038	1.705ProLys: 1.705 ± 0.035	4.225ProLeu: 4.225 ± 0.061	0.983ProMet: 0.983 ± 0.029	1.405ProAsn: 1.405 ± 0.036	1.728ProPro: 1.728 ± 0.045	1.355ProGln: 1.355 ± 0.042	2.158ProArg: 2.158 ± 0.045	2.326ProSer: 2.326 ± 0.045	1.693ProThr: 1.693 ± 0.038	3.688ProVal: 3.688 ± 0.054	0.641ProTrp: 0.641 ± 0.023	1.55ProTyr: 1.55 ± 0.039	0.0ProXaa: 0.0 ± 0.0
Gln	3.433GlnAla: 3.433 ± 0.054	0.179GlnCys: 0.179 ± 0.012	1.384GlnAsp: 1.384 ± 0.032	1.959GlnGlu: 1.959 ± 0.042	1.233GlnPhe: 1.233 ± 0.032	2.082GlnGly: 2.082 ± 0.038	0.689GlnHis: 0.689 ± 0.024	1.852GlnIle: 1.852 ± 0.043	1.266GlnLys: 1.266 ± 0.036	3.283GlnLeu: 3.283 ± 0.059	0.904GlnMet: 0.904 ± 0.027	0.925GlnAsn: 0.925 ± 0.03	1.557GlnPro: 1.557 ± 0.034	1.36GlnGln: 1.36 ± 0.045	2.115GlnArg: 2.115 ± 0.045	1.604GlnSer: 1.604 ± 0.038	1.716GlnThr: 1.716 ± 0.047	1.987GlnVal: 1.987 ± 0.042	0.457GlnTrp: 0.457 ± 0.017	1.063GlnTyr: 1.063 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	5.555ArgAla: 5.555 ± 0.09	0.549ArgCys: 0.549 ± 0.024	3.475ArgAsp: 3.475 ± 0.054	5.763ArgGlu: 5.763 ± 0.077	2.961ArgPhe: 2.961 ± 0.054	4.444ArgGly: 4.444 ± 0.071	1.739ArgHis: 1.739 ± 0.043	4.947ArgIle: 4.947 ± 0.061	3.517ArgLys: 3.517 ± 0.053	8.125ArgLeu: 8.125 ± 0.099	2.297ArgMet: 2.297 ± 0.043	2.169ArgAsn: 2.169 ± 0.041	3.058ArgPro: 3.058 ± 0.055	2.657ArgGln: 2.657 ± 0.053	5.803ArgArg: 5.803 ± 0.106	3.814ArgSer: 3.814 ± 0.065	3.719ArgThr: 3.719 ± 0.059	4.303ArgVal: 4.303 ± 0.068	0.969ArgTrp: 0.969 ± 0.03	2.47ArgTyr: 2.47 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	4.954SerAla: 4.954 ± 0.071	0.426SerCys: 0.426 ± 0.02	2.621SerAsp: 2.621 ± 0.05	3.069SerGlu: 3.069 ± 0.051	2.266SerPhe: 2.266 ± 0.048	5.701SerGly: 5.701 ± 0.078	0.947SerHis: 0.947 ± 0.028	3.022SerIle: 3.022 ± 0.068	1.96SerLys: 1.96 ± 0.039	5.072SerLeu: 5.072 ± 0.066	1.38SerMet: 1.38 ± 0.038	1.48SerAsn: 1.48 ± 0.042	2.412SerPro: 2.412 ± 0.05	1.271SerGln: 1.271 ± 0.032	3.696SerArg: 3.696 ± 0.059	2.9SerSer: 2.9 ± 0.06	2.343SerThr: 2.343 ± 0.051	4.004SerVal: 4.004 ± 0.063	0.713SerTrp: 0.713 ± 0.027	1.621SerTyr: 1.621 ± 0.037	0.0SerXaa: 0.0 ± 0.0
Thr	5.155ThrAla: 5.155 ± 0.07	0.343ThrCys: 0.343 ± 0.017	2.775ThrAsp: 2.775 ± 0.049	2.903ThrGlu: 2.903 ± 0.051	2.178ThrPhe: 2.178 ± 0.05	4.718ThrGly: 4.718 ± 0.076	0.917ThrHis: 0.917 ± 0.027	3.238ThrIle: 3.238 ± 0.053	1.758ThrLys: 1.758 ± 0.04	4.854ThrLeu: 4.854 ± 0.064	1.289ThrMet: 1.289 ± 0.035	1.482ThrAsn: 1.482 ± 0.038	2.441ThrPro: 2.441 ± 0.048	1.109ThrGln: 1.109 ± 0.033	2.653ThrArg: 2.653 ± 0.045	2.477ThrSer: 2.477 ± 0.053	2.297ThrThr: 2.297 ± 0.056	4.328ThrVal: 4.328 ± 0.067	0.587ThrTrp: 0.587 ± 0.023	1.511ThrTyr: 1.511 ± 0.043	0.0ThrXaa: 0.0 ± 0.0
Val	5.543ValAla: 5.543 ± 0.078	0.736ValCys: 0.736 ± 0.027	3.658ValAsp: 3.658 ± 0.058	4.479ValGlu: 4.479 ± 0.064	2.934ValPhe: 2.934 ± 0.057	4.526ValGly: 4.526 ± 0.066	1.465ValHis: 1.465 ± 0.041	4.572ValIle: 4.572 ± 0.068	3.343ValLys: 3.343 ± 0.051	7.631ValLeu: 7.631 ± 0.088	2.026ValMet: 2.026 ± 0.045	2.355ValAsn: 2.355 ± 0.046	3.621ValPro: 3.621 ± 0.06	2.193ValGln: 2.193 ± 0.044	5.481ValArg: 5.481 ± 0.067	4.107ValSer: 4.107 ± 0.065	4.252ValThr: 4.252 ± 0.074	5.313ValVal: 5.313 ± 0.067	0.97ValTrp: 0.97 ± 0.027	2.382ValTyr: 2.382 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	1.024TrpAla: 1.024 ± 0.036	0.111TrpCys: 0.111 ± 0.011	0.68TrpAsp: 0.68 ± 0.026	0.867TrpGlu: 0.867 ± 0.027	0.608TrpPhe: 0.608 ± 0.023	0.812TrpGly: 0.812 ± 0.026	0.326TrpHis: 0.326 ± 0.019	0.939TrpIle: 0.939 ± 0.026	0.628TrpLys: 0.628 ± 0.022	1.719TrpLeu: 1.719 ± 0.044	0.484TrpMet: 0.484 ± 0.021	0.619TrpAsn: 0.619 ± 0.023	0.516TrpPro: 0.516 ± 0.02	0.511TrpGln: 0.511 ± 0.02	0.986TrpArg: 0.986 ± 0.03	0.751TrpSer: 0.751 ± 0.03	0.785TrpThr: 0.785 ± 0.026	0.74TrpVal: 0.74 ± 0.026	0.204TrpTrp: 0.204 ± 0.012	0.416TrpTyr: 0.416 ± 0.02	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.032TyrAla: 3.032 ± 0.054	0.283TyrCys: 0.283 ± 0.017	1.756TyrAsp: 1.756 ± 0.04	2.203TyrGlu: 2.203 ± 0.046	1.33TyrPhe: 1.33 ± 0.034	2.653TyrGly: 2.653 ± 0.046	0.686TyrHis: 0.686 ± 0.023	1.799TyrIle: 1.799 ± 0.041	1.249TyrLys: 1.249 ± 0.039	3.078TyrLeu: 3.078 ± 0.052	0.748TyrMet: 0.748 ± 0.024	1.103TyrAsn: 1.103 ± 0.031	1.437TyrPro: 1.437 ± 0.033	0.948TyrGln: 0.948 ± 0.033	2.567TyrArg: 2.567 ± 0.047	1.467TyrSer: 1.467 ± 0.037	1.582TyrThr: 1.582 ± 0.039	2.243TyrVal: 2.243 ± 0.043	0.493TyrTrp: 0.493 ± 0.021	1.187TyrTyr: 1.187 ± 0.036	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3802 proteins (1222205 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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