Amino acid dipepetide frequency for Plantactinospora sp. KBS50

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
24.506AlaAla: 24.506 ± 0.21
0.993AlaCys: 0.993 ± 0.024
9.333AlaAsp: 9.333 ± 0.096
8.42AlaGlu: 8.42 ± 0.103
3.116AlaPhe: 3.116 ± 0.045
16.568AlaGly: 16.568 ± 0.143
2.415AlaHis: 2.415 ± 0.038
3.963AlaIle: 3.963 ± 0.053
1.882AlaLys: 1.882 ± 0.041
14.18AlaLeu: 14.18 ± 0.122
2.328AlaMet: 2.328 ± 0.039
2.133AlaAsn: 2.133 ± 0.041
7.42AlaPro: 7.42 ± 0.092
3.693AlaGln: 3.693 ± 0.051
10.815AlaArg: 10.815 ± 0.097
5.456AlaSer: 5.456 ± 0.068
7.751AlaThr: 7.751 ± 0.08
13.089AlaVal: 13.089 ± 0.103
1.865AlaTrp: 1.865 ± 0.033
2.703AlaTyr: 2.703 ± 0.038
0.0AlaXaa: 0.0 ± 0.0
Cys
1.074CysAla: 1.074 ± 0.028
0.136CysCys: 0.136 ± 0.01
0.503CysAsp: 0.503 ± 0.019
0.317CysGlu: 0.317 ± 0.011
0.209CysPhe: 0.209 ± 0.011
0.941CysGly: 0.941 ± 0.025
0.193CysHis: 0.193 ± 0.01
0.143CysIle: 0.143 ± 0.008
0.077CysLys: 0.077 ± 0.007
0.755CysLeu: 0.755 ± 0.023
0.11CysMet: 0.11 ± 0.008
0.139CysAsn: 0.139 ± 0.009
0.512CysPro: 0.512 ± 0.019
0.191CysGln: 0.191 ± 0.01
0.713CysArg: 0.713 ± 0.022
0.418CysSer: 0.418 ± 0.015
0.493CysThr: 0.493 ± 0.018
0.648CysVal: 0.648 ± 0.018
0.158CysTrp: 0.158 ± 0.01
0.179CysTyr: 0.179 ± 0.011
0.0CysXaa: 0.0 ± 0.0
Asp
7.557AspAla: 7.557 ± 0.078
0.426AspCys: 0.426 ± 0.016
3.493AspAsp: 3.493 ± 0.047
3.59AspGlu: 3.59 ± 0.048
1.522AspPhe: 1.522 ± 0.032
6.601AspGly: 6.601 ± 0.07
1.176AspHis: 1.176 ± 0.027
1.717AspIle: 1.717 ± 0.036
0.767AspLys: 0.767 ± 0.027
6.96AspLeu: 6.96 ± 0.081
0.696AspMet: 0.696 ± 0.02
0.949AspAsn: 0.949 ± 0.024
5.452AspPro: 5.452 ± 0.065
1.674AspGln: 1.674 ± 0.033
6.388AspArg: 6.388 ± 0.07
2.208AspSer: 2.208 ± 0.036
2.744AspThr: 2.744 ± 0.045
4.746AspVal: 4.746 ± 0.053
1.055AspTrp: 1.055 ± 0.025
1.143AspTyr: 1.143 ± 0.028
0.0AspXaa: 0.0 ± 0.0
Glu
5.957GluAla: 5.957 ± 0.075
0.335GluCys: 0.335 ± 0.015
2.095GluAsp: 2.095 ± 0.043
2.171GluGlu: 2.171 ± 0.039
1.47GluPhe: 1.47 ± 0.028
2.783GluGly: 2.783 ± 0.048
1.398GluHis: 1.398 ± 0.034
2.135GluIle: 2.135 ± 0.04
0.836GluLys: 0.836 ± 0.028
6.466GluLeu: 6.466 ± 0.089
0.771GluMet: 0.771 ± 0.025
0.74GluAsn: 0.74 ± 0.022
3.571GluPro: 3.571 ± 0.053
1.991GluGln: 1.991 ± 0.039
5.069GluArg: 5.069 ± 0.062
2.114GluSer: 2.114 ± 0.04
2.469GluThr: 2.469 ± 0.037
4.375GluVal: 4.375 ± 0.057
0.627GluTrp: 0.627 ± 0.018
1.045GluTyr: 1.045 ± 0.027
0.0GluXaa: 0.0 ± 0.0
Phe
3.726PheAla: 3.726 ± 0.05
0.28PheCys: 0.28 ± 0.015
2.024PheAsp: 2.024 ± 0.034
1.174PheGlu: 1.174 ± 0.028
0.803PhePhe: 0.803 ± 0.024
3.055PheGly: 3.055 ± 0.042
0.529PheHis: 0.529 ± 0.019
0.708PheIle: 0.708 ± 0.022
0.376PheLys: 0.376 ± 0.015
2.485PheLeu: 2.485 ± 0.042
0.31PheMet: 0.31 ± 0.014
0.552PheAsn: 0.552 ± 0.018
1.33PhePro: 1.33 ± 0.027
0.672PheGln: 0.672 ± 0.023
1.807PheArg: 1.807 ± 0.034
1.265PheSer: 1.265 ± 0.025
1.755PheThr: 1.755 ± 0.036
2.318PheVal: 2.318 ± 0.035
0.43PheTrp: 0.43 ± 0.018
0.596PheTyr: 0.596 ± 0.022
0.0PheXaa: 0.0 ± 0.0
Gly
11.809GlyAla: 11.809 ± 0.104
0.954GlyCys: 0.954 ± 0.02
5.244GlyAsp: 5.244 ± 0.059
4.441GlyGlu: 4.441 ± 0.052
2.771GlyPhe: 2.771 ± 0.039
9.309GlyGly: 9.309 ± 0.106
2.156GlyHis: 2.156 ± 0.04
3.388GlyIle: 3.388 ± 0.046
1.597GlyLys: 1.597 ± 0.035
9.764GlyLeu: 9.764 ± 0.088
1.985GlyMet: 1.985 ± 0.036
1.749GlyAsn: 1.749 ± 0.041
6.172GlyPro: 6.172 ± 0.091
2.898GlyGln: 2.898 ± 0.043
8.962GlyArg: 8.962 ± 0.091
5.372GlySer: 5.372 ± 0.062
6.459GlyThr: 6.459 ± 0.079
7.691GlyVal: 7.691 ± 0.073
1.991GlyTrp: 1.991 ± 0.04
2.592GlyTyr: 2.592 ± 0.043
0.0GlyXaa: 0.0 ± 0.0
His
2.376HisAla: 2.376 ± 0.045
0.201HisCys: 0.201 ± 0.011
1.273HisAsp: 1.273 ± 0.028
1.024HisGlu: 1.024 ± 0.028
0.537HisPhe: 0.537 ± 0.017
2.146HisGly: 2.146 ± 0.039
0.607HisHis: 0.607 ± 0.021
0.53HisIle: 0.53 ± 0.019
0.207HisLys: 0.207 ± 0.011
2.415HisLeu: 2.415 ± 0.04
0.256HisMet: 0.256 ± 0.011
0.378HisAsn: 0.378 ± 0.016
1.792HisPro: 1.792 ± 0.039
0.553HisGln: 0.553 ± 0.02
2.322HisArg: 2.322 ± 0.045
0.813HisSer: 0.813 ± 0.019
1.068HisThr: 1.068 ± 0.024
1.545HisVal: 1.545 ± 0.028
0.323HisTrp: 0.323 ± 0.012
0.463HisTyr: 0.463 ± 0.017
0.0HisXaa: 0.0 ± 0.0
Ile
4.715IleAla: 4.715 ± 0.051
0.326IleCys: 0.326 ± 0.015
2.297IleAsp: 2.297 ± 0.038
1.998IleGlu: 1.998 ± 0.039
0.879IlePhe: 0.879 ± 0.022
3.661IleGly: 3.661 ± 0.051
0.55IleHis: 0.55 ± 0.018
0.971IleIle: 0.971 ± 0.031
0.591IleLys: 0.591 ± 0.02
2.467IleLeu: 2.467 ± 0.04
0.484IleMet: 0.484 ± 0.017
0.743IleAsn: 0.743 ± 0.023
1.653IlePro: 1.653 ± 0.035
0.732IleGln: 0.732 ± 0.023
2.67IleArg: 2.67 ± 0.042
1.696IleSer: 1.696 ± 0.032
2.021IleThr: 2.021 ± 0.034
2.804IleVal: 2.804 ± 0.044
0.439IleTrp: 0.439 ± 0.015
0.575IleTyr: 0.575 ± 0.021
0.0IleXaa: 0.0 ± 0.0
Lys
1.711LysAla: 1.711 ± 0.041
0.079LysCys: 0.079 ± 0.007
0.699LysAsp: 0.699 ± 0.028
0.633LysGlu: 0.633 ± 0.02
0.336LysPhe: 0.336 ± 0.017
1.033LysGly: 1.033 ± 0.032
0.285LysHis: 0.285 ± 0.013
0.706LysIle: 0.706 ± 0.025
0.386LysLys: 0.386 ± 0.017
1.456LysLeu: 1.456 ± 0.031
0.265LysMet: 0.265 ± 0.011
0.301LysAsn: 0.301 ± 0.015
0.94LysPro: 0.94 ± 0.027
0.502LysGln: 0.502 ± 0.02
1.089LysArg: 1.089 ± 0.031
0.726LysSer: 0.726 ± 0.023
0.866LysThr: 0.866 ± 0.023
1.29LysVal: 1.29 ± 0.033
0.187LysTrp: 0.187 ± 0.012
0.305LysTyr: 0.305 ± 0.014
0.0LysXaa: 0.0 ± 0.0
Leu
17.269LeuAla: 17.269 ± 0.122
0.793LeuCys: 0.793 ± 0.021
7.146LeuAsp: 7.146 ± 0.079
3.736LeuGlu: 3.736 ± 0.051
2.556LeuPhe: 2.556 ± 0.044
9.554LeuGly: 9.554 ± 0.08
2.294LeuHis: 2.294 ± 0.041
3.339LeuIle: 3.339 ± 0.054
1.183LeuLys: 1.183 ± 0.033
11.904LeuLeu: 11.904 ± 0.128
1.312LeuMet: 1.312 ± 0.031
1.608LeuAsn: 1.608 ± 0.03
6.832LeuPro: 6.832 ± 0.069
1.835LeuGln: 1.835 ± 0.038
9.667LeuArg: 9.667 ± 0.08
5.151LeuSer: 5.151 ± 0.055
6.35LeuThr: 6.35 ± 0.061
9.874LeuVal: 9.874 ± 0.084
1.264LeuTrp: 1.264 ± 0.023
1.729LeuTyr: 1.729 ± 0.032
0.0LeuXaa: 0.0 ± 0.0
Met
2.116MetAla: 2.116 ± 0.03
0.127MetCys: 0.127 ± 0.008
0.756MetAsp: 0.756 ± 0.021
0.518MetGlu: 0.518 ± 0.017
0.454MetPhe: 0.454 ± 0.015
1.046MetGly: 1.046 ± 0.025
0.301MetHis: 0.301 ± 0.012
0.67MetIle: 0.67 ± 0.019
0.289MetLys: 0.289 ± 0.014
1.731MetLeu: 1.731 ± 0.032
0.26MetMet: 0.26 ± 0.014
0.33MetAsn: 0.33 ± 0.014
1.035MetPro: 1.035 ± 0.024
0.409MetGln: 0.409 ± 0.015
1.353MetArg: 1.353 ± 0.028
1.169MetSer: 1.169 ± 0.024
1.388MetThr: 1.388 ± 0.03
1.314MetVal: 1.314 ± 0.031
0.183MetTrp: 0.183 ± 0.01
0.295MetTyr: 0.295 ± 0.014
0.0MetXaa: 0.0 ± 0.0
Asn
2.071AsnAla: 2.071 ± 0.043
0.171AsnCys: 0.171 ± 0.012
0.905AsnAsp: 0.905 ± 0.027
0.717AsnGlu: 0.717 ± 0.023
0.508AsnPhe: 0.508 ± 0.018
1.881AsnGly: 1.881 ± 0.044
0.364AsnHis: 0.364 ± 0.014
0.596AsnIle: 0.596 ± 0.022
0.295AsnLys: 0.295 ± 0.015
1.763AsnLeu: 1.763 ± 0.034
0.26AsnMet: 0.26 ± 0.012
0.428AsnAsn: 0.428 ± 0.02
1.424AsnPro: 1.424 ± 0.033
0.542AsnGln: 0.542 ± 0.02
1.395AsnArg: 1.395 ± 0.032
0.898AsnSer: 0.898 ± 0.025
0.984AsnThr: 0.984 ± 0.026
1.381AsnVal: 1.381 ± 0.028
0.314AsnTrp: 0.314 ± 0.015
0.458AsnTyr: 0.458 ± 0.018
0.0AsnXaa: 0.0 ± 0.0
Pro
11.287ProAla: 11.287 ± 0.133
0.319ProCys: 0.319 ± 0.013
5.256ProAsp: 5.256 ± 0.056
3.815ProGlu: 3.815 ± 0.057
1.447ProPhe: 1.447 ± 0.03
7.447ProGly: 7.447 ± 0.089
1.173ProHis: 1.173 ± 0.029
1.661ProIle: 1.661 ± 0.032
0.767ProLys: 0.767 ± 0.022
5.279ProLeu: 5.279 ± 0.06
0.954ProMet: 0.954 ± 0.024
0.954ProAsn: 0.954 ± 0.026
4.61ProPro: 4.61 ± 0.088
1.546ProGln: 1.546 ± 0.03
4.262ProArg: 4.262 ± 0.056
3.049ProSer: 3.049 ± 0.05
3.841ProThr: 3.841 ± 0.056
6.087ProVal: 6.087 ± 0.057
0.916ProTrp: 0.916 ± 0.024
1.282ProTyr: 1.282 ± 0.03
0.0ProXaa: 0.0 ± 0.0
Gln
3.453GlnAla: 3.453 ± 0.05
0.147GlnCys: 0.147 ± 0.01
1.185GlnAsp: 1.185 ± 0.029
1.144GlnGlu: 1.144 ± 0.028
0.702GlnPhe: 0.702 ± 0.018
1.789GlnGly: 1.789 ± 0.037
0.651GlnHis: 0.651 ± 0.019
1.088GlnIle: 1.088 ± 0.028
0.404GlnLys: 0.404 ± 0.016
3.219GlnLeu: 3.219 ± 0.042
0.412GlnMet: 0.412 ± 0.015
0.442GlnAsn: 0.442 ± 0.016
2.023GlnPro: 2.023 ± 0.039
1.142GlnGln: 1.142 ± 0.037
2.793GlnArg: 2.793 ± 0.043
1.127GlnSer: 1.127 ± 0.03
1.325GlnThr: 1.325 ± 0.032
2.731GlnVal: 2.731 ± 0.046
0.443GlnTrp: 0.443 ± 0.016
0.512GlnTyr: 0.512 ± 0.017
0.0GlnXaa: 0.0 ± 0.0
Arg
10.714ArgAla: 10.714 ± 0.112
0.749ArgCys: 0.749 ± 0.025
4.938ArgAsp: 4.938 ± 0.052
4.06ArgGlu: 4.06 ± 0.06
2.452ArgPhe: 2.452 ± 0.039
6.048ArgGly: 6.048 ± 0.072
2.255ArgHis: 2.255 ± 0.042
3.492ArgIle: 3.492 ± 0.049
1.078ArgLys: 1.078 ± 0.029
10.124ArgLeu: 10.124 ± 0.109
1.856ArgMet: 1.856 ± 0.031
1.487ArgAsn: 1.487 ± 0.032
6.196ArgPro: 6.196 ± 0.078
2.632ArgGln: 2.632 ± 0.036
9.659ArgArg: 9.659 ± 0.116
4.579ArgSer: 4.579 ± 0.055
5.258ArgThr: 5.258 ± 0.057
6.569ArgVal: 6.569 ± 0.063
1.729ArgTrp: 1.729 ± 0.031
2.273ArgTyr: 2.273 ± 0.032
0.0ArgXaa: 0.0 ± 0.0
Ser
6.561SerAla: 6.561 ± 0.063
0.404SerCys: 0.404 ± 0.015
2.358SerAsp: 2.358 ± 0.042
1.842SerGlu: 1.842 ± 0.031
1.446SerPhe: 1.446 ± 0.03
5.913SerGly: 5.913 ± 0.077
0.845SerHis: 0.845 ± 0.02
1.563SerIle: 1.563 ± 0.031
0.673SerLys: 0.673 ± 0.021
4.268SerLeu: 4.268 ± 0.047
0.986SerMet: 0.986 ± 0.023
0.879SerAsn: 0.879 ± 0.026
3.094SerPro: 3.094 ± 0.058
1.134SerGln: 1.134 ± 0.027
3.857SerArg: 3.857 ± 0.048
2.519SerSer: 2.519 ± 0.052
3.151SerThr: 3.151 ± 0.044
3.939SerVal: 3.939 ± 0.047
0.923SerTrp: 0.923 ± 0.024
1.211SerTyr: 1.211 ± 0.027
0.0SerXaa: 0.0 ± 0.0
Thr
8.76ThrAla: 8.76 ± 0.082
0.409ThrCys: 0.409 ± 0.017
3.678ThrAsp: 3.678 ± 0.043
2.783ThrGlu: 2.783 ± 0.041
1.574ThrPhe: 1.574 ± 0.033
7.055ThrGly: 7.055 ± 0.082
0.977ThrHis: 0.977 ± 0.024
1.937ThrIle: 1.937 ± 0.033
0.731ThrLys: 0.731 ± 0.021
5.533ThrLeu: 5.533 ± 0.059
0.946ThrMet: 0.946 ± 0.024
1.08ThrAsn: 1.08 ± 0.033
4.005ThrPro: 4.005 ± 0.056
1.165ThrGln: 1.165 ± 0.028
4.072ThrArg: 4.072 ± 0.049
2.897ThrSer: 2.897 ± 0.045
3.443ThrThr: 3.443 ± 0.064
6.011ThrVal: 6.011 ± 0.063
0.848ThrTrp: 0.848 ± 0.025
1.253ThrTyr: 1.253 ± 0.032
0.0ThrXaa: 0.0 ± 0.0
Val
12.471ValAla: 12.471 ± 0.107
0.712ValCys: 0.712 ± 0.021
5.573ValAsp: 5.573 ± 0.053
4.485ValGlu: 4.485 ± 0.06
2.299ValPhe: 2.299 ± 0.039
7.334ValGly: 7.334 ± 0.073
1.783ValHis: 1.783 ± 0.036
2.742ValIle: 2.742 ± 0.044
1.152ValLys: 1.152 ± 0.033
10.087ValLeu: 10.087 ± 0.093
1.102ValMet: 1.102 ± 0.025
1.651ValAsn: 1.651 ± 0.035
5.646ValPro: 5.646 ± 0.052
2.09ValGln: 2.09 ± 0.036
7.634ValArg: 7.634 ± 0.073
4.151ValSer: 4.151 ± 0.05
5.687ValThr: 5.687 ± 0.063
8.196ValVal: 8.196 ± 0.084
1.074ValTrp: 1.074 ± 0.026
1.472ValTyr: 1.472 ± 0.027
0.0ValXaa: 0.0 ± 0.0
Trp
1.697TrpAla: 1.697 ± 0.032
0.165TrpCys: 0.165 ± 0.01
0.7TrpAsp: 0.7 ± 0.024
0.565TrpGlu: 0.565 ± 0.02
0.489TrpPhe: 0.489 ± 0.017
0.933TrpGly: 0.933 ± 0.025
0.434TrpHis: 0.434 ± 0.016
0.53TrpIle: 0.53 ± 0.016
0.234TrpLys: 0.234 ± 0.013
2.0TrpLeu: 2.0 ± 0.042
0.266TrpMet: 0.266 ± 0.013
0.392TrpAsn: 0.392 ± 0.018
0.953TrpPro: 0.953 ± 0.026
0.647TrpGln: 0.647 ± 0.021
1.626TrpArg: 1.626 ± 0.034
1.05TrpSer: 1.05 ± 0.024
1.042TrpThr: 1.042 ± 0.029
1.036TrpVal: 1.036 ± 0.024
0.378TrpTrp: 0.378 ± 0.014
0.374TrpTyr: 0.374 ± 0.015
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.798TyrAla: 2.798 ± 0.035
0.185TyrCys: 0.185 ± 0.011
1.408TyrAsp: 1.408 ± 0.03
0.984TyrGlu: 0.984 ± 0.025
0.624TyrPhe: 0.624 ± 0.019
2.204TyrGly: 2.204 ± 0.043
0.447TyrHis: 0.447 ± 0.016
0.393TyrIle: 0.393 ± 0.015
0.269TyrLys: 0.269 ± 0.014
2.538TyrLeu: 2.538 ± 0.04
0.185TyrMet: 0.185 ± 0.01
0.419TyrAsn: 0.419 ± 0.019
1.294TyrPro: 1.294 ± 0.031
0.683TyrGln: 0.683 ± 0.021
1.994TyrArg: 1.994 ± 0.037
0.906TyrSer: 0.906 ± 0.027
1.064TyrThr: 1.064 ± 0.031
1.698TyrVal: 1.698 ± 0.036
0.365TyrTrp: 0.365 ± 0.016
0.434TyrTyr: 0.434 ± 0.017
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5179 proteins (1768842 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski