Amino acid dipepetide frequency for Monosporascus sp. mg162

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.925AlaAla: 10.925 ± 0.067	1.083AlaCys: 1.083 ± 0.013	4.876AlaAsp: 4.876 ± 0.031	5.88AlaGlu: 5.88 ± 0.041	3.152AlaPhe: 3.152 ± 0.027	6.51AlaGly: 6.51 ± 0.036	1.854AlaHis: 1.854 ± 0.017	4.121AlaIle: 4.121 ± 0.028	4.158AlaLys: 4.158 ± 0.031	8.071AlaLeu: 8.071 ± 0.05	2.005AlaMet: 2.005 ± 0.018	3.039AlaAsn: 3.039 ± 0.026	5.131AlaPro: 5.131 ± 0.044	3.425AlaGln: 3.425 ± 0.029	5.686AlaArg: 5.686 ± 0.033	7.348AlaSer: 7.348 ± 0.039	5.521AlaThr: 5.521 ± 0.033	6.006AlaVal: 6.006 ± 0.038	1.201AlaTrp: 1.201 ± 0.014	2.283AlaTyr: 2.283 ± 0.019	0.0AlaXaa: 0.0 ± 0.0
Cys	0.967CysAla: 0.967 ± 0.015	0.225CysCys: 0.225 ± 0.007	0.667CysAsp: 0.667 ± 0.012	0.6CysGlu: 0.6 ± 0.012	0.507CysPhe: 0.507 ± 0.01	0.956CysGly: 0.956 ± 0.016	0.309CysHis: 0.309 ± 0.008	0.64CysIle: 0.64 ± 0.01	0.47CysLys: 0.47 ± 0.009	1.171CysLeu: 1.171 ± 0.016	0.241CysMet: 0.241 ± 0.007	0.403CysAsn: 0.403 ± 0.009	0.627CysPro: 0.627 ± 0.011	0.418CysGln: 0.418 ± 0.008	0.779CysArg: 0.779 ± 0.013	0.828CysSer: 0.828 ± 0.015	0.625CysThr: 0.625 ± 0.011	0.77CysVal: 0.77 ± 0.012	0.206CysTrp: 0.206 ± 0.007	0.345CysTyr: 0.345 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	5.317AspAla: 5.317 ± 0.033	0.617AspCys: 0.617 ± 0.01	4.641AspAsp: 4.641 ± 0.043	4.709AspGlu: 4.709 ± 0.034	2.186AspPhe: 2.186 ± 0.021	4.611AspGly: 4.611 ± 0.032	1.237AspHis: 1.237 ± 0.019	3.02AspIle: 3.02 ± 0.03	2.391AspLys: 2.391 ± 0.028	5.093AspLeu: 5.093 ± 0.034	1.281AspMet: 1.281 ± 0.015	1.901AspAsn: 1.901 ± 0.017	3.564AspPro: 3.564 ± 0.027	1.838AspGln: 1.838 ± 0.019	3.382AspArg: 3.382 ± 0.033	4.069AspSer: 4.069 ± 0.031	2.866AspThr: 2.866 ± 0.025	3.919AspVal: 3.919 ± 0.032	0.926AspTrp: 0.926 ± 0.013	1.65AspTyr: 1.65 ± 0.018	0.0AspXaa: 0.0 ± 0.0
Glu	6.071GluAla: 6.071 ± 0.044	0.653GluCys: 0.653 ± 0.011	4.438GluAsp: 4.438 ± 0.035	5.589GluGlu: 5.589 ± 0.052	1.982GluPhe: 1.982 ± 0.017	4.11GluGly: 4.11 ± 0.03	1.428GluHis: 1.428 ± 0.016	2.964GluIle: 2.964 ± 0.024	3.631GluLys: 3.631 ± 0.034	5.432GluLeu: 5.432 ± 0.032	1.408GluMet: 1.408 ± 0.016	2.307GluAsn: 2.307 ± 0.019	3.058GluPro: 3.058 ± 0.03	2.465GluGln: 2.465 ± 0.022	4.308GluArg: 4.308 ± 0.029	4.208GluSer: 4.208 ± 0.031	3.541GluThr: 3.541 ± 0.027	3.746GluVal: 3.746 ± 0.029	0.909GluTrp: 0.909 ± 0.012	1.665GluTyr: 1.665 ± 0.019	0.0GluXaa: 0.0 ± 0.0
Phe	3.034PheAla: 3.034 ± 0.023	0.513PheCys: 0.513 ± 0.01	2.239PheAsp: 2.239 ± 0.021	2.207PheGlu: 2.207 ± 0.02	1.465PhePhe: 1.465 ± 0.02	2.83PheGly: 2.83 ± 0.028	0.833PheHis: 0.833 ± 0.012	1.548PheIle: 1.548 ± 0.016	1.441PheLys: 1.441 ± 0.017	3.219PheLeu: 3.219 ± 0.024	0.731PheMet: 0.731 ± 0.013	1.292PheAsn: 1.292 ± 0.015	1.846PhePro: 1.846 ± 0.019	1.286PheGln: 1.286 ± 0.015	2.084PheArg: 2.084 ± 0.019	2.719PheSer: 2.719 ± 0.022	2.002PheThr: 2.002 ± 0.02	2.325PheVal: 2.325 ± 0.022	0.612PheTrp: 0.612 ± 0.012	1.045PheTyr: 1.045 ± 0.014	0.0PheXaa: 0.0 ± 0.0
Gly	6.182GlyAla: 6.182 ± 0.034	0.884GlyCys: 0.884 ± 0.014	4.224GlyAsp: 4.224 ± 0.03	3.982GlyGlu: 3.982 ± 0.028	2.748GlyPhe: 2.748 ± 0.022	6.807GlyGly: 6.807 ± 0.055	1.861GlyHis: 1.861 ± 0.021	3.401GlyIle: 3.401 ± 0.027	3.422GlyLys: 3.422 ± 0.029	6.083GlyLeu: 6.083 ± 0.033	1.533GlyMet: 1.533 ± 0.017	2.69GlyAsn: 2.69 ± 0.025	3.728GlyPro: 3.728 ± 0.035	2.536GlyGln: 2.536 ± 0.021	4.81GlyArg: 4.81 ± 0.033	5.884GlySer: 5.884 ± 0.041	4.114GlyThr: 4.114 ± 0.026	4.547GlyVal: 4.547 ± 0.035	1.181GlyTrp: 1.181 ± 0.017	2.157GlyTyr: 2.157 ± 0.024	0.0GlyXaa: 0.0 ± 0.0
His	1.891HisAla: 1.891 ± 0.02	0.315HisCys: 0.315 ± 0.008	1.304HisAsp: 1.304 ± 0.016	1.349HisGlu: 1.349 ± 0.017	0.887HisPhe: 0.887 ± 0.015	1.803HisGly: 1.803 ± 0.022	0.877HisHis: 0.877 ± 0.018	1.137HisIle: 1.137 ± 0.014	0.873HisLys: 0.873 ± 0.014	2.114HisLeu: 2.114 ± 0.022	0.488HisMet: 0.488 ± 0.009	0.82HisAsn: 0.82 ± 0.013	1.668HisPro: 1.668 ± 0.02	0.972HisGln: 0.972 ± 0.014	1.599HisArg: 1.599 ± 0.019	1.692HisSer: 1.692 ± 0.019	1.137HisThr: 1.137 ± 0.016	1.47HisVal: 1.47 ± 0.018	0.342HisTrp: 0.342 ± 0.007	0.7HisTyr: 0.7 ± 0.011	0.0HisXaa: 0.0 ± 0.0
Ile	3.971IleAla: 3.971 ± 0.026	0.681IleCys: 0.681 ± 0.013	2.763IleAsp: 2.763 ± 0.021	2.789IleGlu: 2.789 ± 0.025	1.758IlePhe: 1.758 ± 0.021	2.955IleGly: 2.955 ± 0.026	1.08IleHis: 1.08 ± 0.014	2.177IleIle: 2.177 ± 0.021	1.997IleLys: 1.997 ± 0.021	4.15IleLeu: 4.15 ± 0.027	0.952IleMet: 0.952 ± 0.012	1.626IleAsn: 1.626 ± 0.016	2.827IlePro: 2.827 ± 0.026	1.705IleGln: 1.705 ± 0.019	2.91IleArg: 2.91 ± 0.025	3.399IleSer: 3.399 ± 0.026	2.618IleThr: 2.618 ± 0.022	2.96IleVal: 2.96 ± 0.023	0.707IleTrp: 0.707 ± 0.013	1.297IleTyr: 1.297 ± 0.016	0.0IleXaa: 0.0 ± 0.0
Lys	4.327LysAla: 4.327 ± 0.033	0.437LysCys: 0.437 ± 0.009	2.725LysAsp: 2.725 ± 0.028	3.256LysGlu: 3.256 ± 0.031	1.373LysPhe: 1.373 ± 0.015	3.033LysGly: 3.033 ± 0.025	1.047LysHis: 1.047 ± 0.014	2.07LysIle: 2.07 ± 0.022	3.132LysLys: 3.132 ± 0.042	4.007LysLeu: 4.007 ± 0.026	0.928LysMet: 0.928 ± 0.012	1.591LysAsn: 1.591 ± 0.018	2.718LysPro: 2.718 ± 0.025	1.77LysGln: 1.77 ± 0.019	3.36LysArg: 3.36 ± 0.029	3.189LysSer: 3.189 ± 0.027	2.689LysThr: 2.689 ± 0.022	2.755LysVal: 2.755 ± 0.023	0.63LysTrp: 0.63 ± 0.012	1.28LysTyr: 1.28 ± 0.015	0.0LysXaa: 0.0 ± 0.0
Leu	8.218LeuAla: 8.218 ± 0.041	1.15LeuCys: 1.15 ± 0.014	5.241LeuAsp: 5.241 ± 0.029	5.701LeuGlu: 5.701 ± 0.039	3.078LeuPhe: 3.078 ± 0.026	6.085LeuGly: 6.085 ± 0.039	2.081LeuHis: 2.081 ± 0.022	3.544LeuIle: 3.544 ± 0.032	4.054LeuLys: 4.054 ± 0.03	8.405LeuLeu: 8.405 ± 0.069	1.731LeuMet: 1.731 ± 0.018	2.954LeuAsn: 2.954 ± 0.023	5.354LeuPro: 5.354 ± 0.033	3.634LeuGln: 3.634 ± 0.033	6.246LeuArg: 6.246 ± 0.035	6.838LeuSer: 6.838 ± 0.043	4.565LeuThr: 4.565 ± 0.031	5.465LeuVal: 5.465 ± 0.039	1.243LeuTrp: 1.243 ± 0.018	2.228LeuTyr: 2.228 ± 0.021	0.0LeuXaa: 0.0 ± 0.0
Met	2.253MetAla: 2.253 ± 0.022	0.224MetCys: 0.224 ± 0.006	1.215MetAsp: 1.215 ± 0.015	1.25MetGlu: 1.25 ± 0.016	0.688MetPhe: 0.688 ± 0.012	1.404MetGly: 1.404 ± 0.018	0.469MetHis: 0.469 ± 0.009	0.874MetIle: 0.874 ± 0.013	0.942MetLys: 0.942 ± 0.014	1.801MetLeu: 1.801 ± 0.017	0.534MetMet: 0.534 ± 0.01	0.733MetAsn: 0.733 ± 0.012	1.257MetPro: 1.257 ± 0.017	0.797MetGln: 0.797 ± 0.014	1.356MetArg: 1.356 ± 0.013	1.701MetSer: 1.701 ± 0.016	1.275MetThr: 1.275 ± 0.015	1.286MetVal: 1.286 ± 0.015	0.265MetTrp: 0.265 ± 0.007	0.49MetTyr: 0.49 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	3.161AsnAla: 3.161 ± 0.022	0.432AsnCys: 0.432 ± 0.01	1.9AsnAsp: 1.9 ± 0.018	1.961AsnGlu: 1.961 ± 0.019	1.272AsnPhe: 1.272 ± 0.015	3.071AsnGly: 3.071 ± 0.028	0.827AsnHis: 0.827 ± 0.012	1.831AsnIle: 1.831 ± 0.02	1.454AsnLys: 1.454 ± 0.017	3.069AsnLeu: 3.069 ± 0.025	0.777AsnMet: 0.777 ± 0.013	1.503AsnAsn: 1.503 ± 0.021	2.444AsnPro: 2.444 ± 0.02	1.231AsnGln: 1.231 ± 0.017	2.025AsnArg: 2.025 ± 0.02	2.573AsnSer: 2.573 ± 0.025	1.995AsnThr: 1.995 ± 0.021	2.17AsnVal: 2.17 ± 0.021	0.559AsnTrp: 0.559 ± 0.009	1.017AsnTyr: 1.017 ± 0.013	0.0AsnXaa: 0.0 ± 0.0
Pro	5.648ProAla: 5.648 ± 0.045	0.503ProCys: 0.503 ± 0.008	3.506ProAsp: 3.506 ± 0.029	4.116ProGlu: 4.116 ± 0.032	1.959ProPhe: 1.959 ± 0.02	4.438ProGly: 4.438 ± 0.034	1.313ProHis: 1.313 ± 0.016	2.297ProIle: 2.297 ± 0.02	2.56ProLys: 2.56 ± 0.023	4.799ProLeu: 4.799 ± 0.027	1.056ProMet: 1.056 ± 0.014	2.139ProAsn: 2.139 ± 0.02	5.486ProPro: 5.486 ± 0.073	2.457ProGln: 2.457 ± 0.029	3.755ProArg: 3.755 ± 0.033	5.744ProSer: 5.744 ± 0.042	3.912ProThr: 3.912 ± 0.034	3.584ProVal: 3.584 ± 0.028	0.766ProTrp: 0.766 ± 0.012	1.531ProTyr: 1.531 ± 0.019	0.0ProXaa: 0.0 ± 0.0
Gln	3.452GlnAla: 3.452 ± 0.031	0.407GlnCys: 0.407 ± 0.01	2.033GlnAsp: 2.033 ± 0.021	2.398GlnGlu: 2.398 ± 0.021	1.213GlnPhe: 1.213 ± 0.015	2.459GlnGly: 2.459 ± 0.023	1.052GlnHis: 1.052 ± 0.018	1.714GlnIle: 1.714 ± 0.016	1.866GlnLys: 1.866 ± 0.021	3.369GlnLeu: 3.369 ± 0.026	0.808GlnMet: 0.808 ± 0.013	1.386GlnAsn: 1.386 ± 0.017	2.562GlnPro: 2.562 ± 0.027	2.549GlnGln: 2.549 ± 0.047	2.671GlnArg: 2.671 ± 0.023	2.797GlnSer: 2.797 ± 0.024	2.151GlnThr: 2.151 ± 0.019	2.111GlnVal: 2.111 ± 0.02	0.557GlnTrp: 0.557 ± 0.01	1.11GlnTyr: 1.11 ± 0.016	0.0GlnXaa: 0.0 ± 0.0
Arg	5.423ArgAla: 5.423 ± 0.032	0.747ArgCys: 0.747 ± 0.013	3.926ArgAsp: 3.926 ± 0.034	4.231ArgGlu: 4.231 ± 0.034	2.227ArgPhe: 2.227 ± 0.019	4.362ArgGly: 4.362 ± 0.033	1.729ArgHis: 1.729 ± 0.017	2.95ArgIle: 2.95 ± 0.024	3.386ArgLys: 3.386 ± 0.026	5.967ArgLeu: 5.967 ± 0.038	1.363ArgMet: 1.363 ± 0.016	2.387ArgAsn: 2.387 ± 0.022	3.839ArgPro: 3.839 ± 0.029	2.747ArgGln: 2.747 ± 0.025	5.839ArgArg: 5.839 ± 0.051	4.835ArgSer: 4.835 ± 0.04	3.464ArgThr: 3.464 ± 0.028	3.643ArgVal: 3.643 ± 0.023	1.026ArgTrp: 1.026 ± 0.015	1.74ArgTyr: 1.74 ± 0.018	0.0ArgXaa: 0.0 ± 0.0
Ser	6.775SerAla: 6.775 ± 0.04	0.793SerCys: 0.793 ± 0.012	4.098SerAsp: 4.098 ± 0.032	4.151SerGlu: 4.151 ± 0.033	2.743SerPhe: 2.743 ± 0.022	5.783SerGly: 5.783 ± 0.033	1.799SerHis: 1.799 ± 0.019	3.464SerIle: 3.464 ± 0.028	3.41SerLys: 3.41 ± 0.026	6.639SerLeu: 6.639 ± 0.041	1.593SerMet: 1.593 ± 0.018	2.724SerAsn: 2.724 ± 0.026	5.37SerPro: 5.37 ± 0.047	3.031SerGln: 3.031 ± 0.026	5.155SerArg: 5.155 ± 0.042	8.173SerSer: 8.173 ± 0.067	5.035SerThr: 5.035 ± 0.04	4.412SerVal: 4.412 ± 0.028	1.103SerTrp: 1.103 ± 0.015	2.017SerTyr: 2.017 ± 0.018	0.0SerXaa: 0.0 ± 0.0
Thr	5.453ThrAla: 5.453 ± 0.033	0.72ThrCys: 0.72 ± 0.012	2.792ThrAsp: 2.792 ± 0.023	3.154ThrGlu: 3.154 ± 0.024	2.05ThrPhe: 2.05 ± 0.022	4.283ThrGly: 4.283 ± 0.032	1.188ThrHis: 1.188 ± 0.015	2.777ThrIle: 2.777 ± 0.024	2.446ThrLys: 2.446 ± 0.02	4.875ThrLeu: 4.875 ± 0.03	1.168ThrMet: 1.168 ± 0.014	1.927ThrAsn: 1.927 ± 0.019	4.313ThrPro: 4.313 ± 0.032	1.948ThrGln: 1.948 ± 0.019	3.279ThrArg: 3.279 ± 0.022	4.956ThrSer: 4.956 ± 0.036	4.18ThrThr: 4.18 ± 0.038	3.735ThrVal: 3.735 ± 0.032	0.847ThrTrp: 0.847 ± 0.012	1.553ThrTyr: 1.553 ± 0.019	0.0ThrXaa: 0.0 ± 0.0
Val	5.722ValAla: 5.722 ± 0.031	0.784ValCys: 0.784 ± 0.011	3.912ValAsp: 3.912 ± 0.029	4.046ValGlu: 4.046 ± 0.032	2.35ValPhe: 2.35 ± 0.022	4.123ValGly: 4.123 ± 0.03	1.369ValHis: 1.369 ± 0.014	2.827ValIle: 2.827 ± 0.025	2.874ValLys: 2.874 ± 0.025	5.611ValLeu: 5.611 ± 0.037	1.277ValMet: 1.277 ± 0.016	2.188ValAsn: 2.188 ± 0.022	3.688ValPro: 3.688 ± 0.025	2.307ValGln: 2.307 ± 0.023	3.837ValArg: 3.837 ± 0.026	4.435ValSer: 4.435 ± 0.031	3.55ValThr: 3.55 ± 0.028	4.481ValVal: 4.481 ± 0.032	0.882ValTrp: 0.882 ± 0.013	1.726ValTyr: 1.726 ± 0.02	0.0ValXaa: 0.0 ± 0.0
Trp	1.244TrpAla: 1.244 ± 0.018	0.19TrpCys: 0.19 ± 0.006	0.987TrpAsp: 0.987 ± 0.016	0.895TrpGlu: 0.895 ± 0.015	0.531TrpPhe: 0.531 ± 0.01	0.966TrpGly: 0.966 ± 0.014	0.353TrpHis: 0.353 ± 0.008	0.727TrpIle: 0.727 ± 0.01	0.763TrpLys: 0.763 ± 0.011	1.374TrpLeu: 1.374 ± 0.018	0.346TrpMet: 0.346 ± 0.009	0.616TrpAsn: 0.616 ± 0.01	0.617TrpPro: 0.617 ± 0.009	0.538TrpGln: 0.538 ± 0.01	1.024TrpArg: 1.024 ± 0.013	0.984TrpSer: 0.984 ± 0.013	0.917TrpThr: 0.917 ± 0.013	0.925TrpVal: 0.925 ± 0.013	0.266TrpTrp: 0.266 ± 0.008	0.41TrpTyr: 0.41 ± 0.008	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.241TyrAla: 2.241 ± 0.021	0.395TyrCys: 0.395 ± 0.008	1.73TyrAsp: 1.73 ± 0.02	1.65TyrGlu: 1.65 ± 0.017	1.101TyrPhe: 1.101 ± 0.013	2.185TyrGly: 2.185 ± 0.022	0.732TyrHis: 0.732 ± 0.012	1.236TyrIle: 1.236 ± 0.015	1.047TyrLys: 1.047 ± 0.014	2.569TyrLeu: 2.569 ± 0.023	0.595TyrMet: 0.595 ± 0.01	1.045TyrAsn: 1.045 ± 0.015	1.469TyrPro: 1.469 ± 0.017	1.012TyrGln: 1.012 ± 0.013	1.727TyrArg: 1.727 ± 0.019	1.895TyrSer: 1.895 ± 0.02	1.489TyrThr: 1.489 ± 0.017	1.679TyrVal: 1.679 ± 0.016	0.448TyrTrp: 0.448 ± 0.009	0.922TyrTyr: 0.922 ± 0.019	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.006XaaXaa: 0.006 ± 0.006

Statistics based on 11877 proteins (5863050 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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