Amino acid dipepetide frequency for Streptococcus satellite phage Javan324

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.993AlaAla: 0.993 ± 0.626
0.331AlaCys: 0.331 ± 0.281
2.648AlaAsp: 2.648 ± 0.947
2.979AlaGlu: 2.979 ± 0.895
2.648AlaPhe: 2.648 ± 0.896
1.655AlaGly: 1.655 ± 0.541
0.662AlaHis: 0.662 ± 0.61
2.979AlaIle: 2.979 ± 1.371
7.613AlaLys: 7.613 ± 1.508
3.641AlaLeu: 3.641 ± 1.037
0.993AlaMet: 0.993 ± 0.488
2.979AlaAsn: 2.979 ± 0.609
0.662AlaPro: 0.662 ± 0.452
1.655AlaGln: 1.655 ± 0.811
2.648AlaArg: 2.648 ± 0.794
1.986AlaSer: 1.986 ± 0.977
3.972AlaThr: 3.972 ± 0.97
2.317AlaVal: 2.317 ± 1.023
0.331AlaTrp: 0.331 ± 0.326
3.641AlaTyr: 3.641 ± 0.842
0.0AlaXaa: 0.0 ± 0.0
Cys
0.331CysAla: 0.331 ± 0.326
0.0CysCys: 0.0 ± 0.0
0.331CysAsp: 0.331 ± 0.287
0.331CysGlu: 0.331 ± 0.339
0.0CysPhe: 0.0 ± 0.0
0.993CysGly: 0.993 ± 0.582
0.0CysHis: 0.0 ± 0.0
0.331CysIle: 0.331 ± 0.326
0.662CysLys: 0.662 ± 0.434
0.993CysLeu: 0.993 ± 0.565
0.331CysMet: 0.331 ± 0.42
0.0CysAsn: 0.0 ± 0.0
0.662CysPro: 0.662 ± 0.39
0.0CysGln: 0.0 ± 0.0
0.331CysArg: 0.331 ± 0.305
0.331CysSer: 0.331 ± 0.281
0.331CysThr: 0.331 ± 0.275
0.331CysVal: 0.331 ± 0.287
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
1.324AspAla: 1.324 ± 0.72
0.662AspCys: 0.662 ± 0.46
4.965AspAsp: 4.965 ± 1.522
1.986AspGlu: 1.986 ± 0.693
4.965AspPhe: 4.965 ± 1.09
2.979AspGly: 2.979 ± 0.879
0.331AspHis: 0.331 ± 0.275
5.296AspIle: 5.296 ± 1.453
7.944AspLys: 7.944 ± 1.551
8.606AspLeu: 8.606 ± 1.63
0.662AspMet: 0.662 ± 0.444
3.972AspAsn: 3.972 ± 0.641
0.662AspPro: 0.662 ± 0.394
0.993AspGln: 0.993 ± 0.546
2.317AspArg: 2.317 ± 0.906
6.289AspSer: 6.289 ± 1.275
4.303AspThr: 4.303 ± 0.983
2.648AspVal: 2.648 ± 0.865
0.331AspTrp: 0.331 ± 0.287
2.979AspTyr: 2.979 ± 1.079
0.0AspXaa: 0.0 ± 0.0
Glu
3.31GluAla: 3.31 ± 1.03
1.324GluCys: 1.324 ± 0.474
5.296GluAsp: 5.296 ± 2.01
3.972GluGlu: 3.972 ± 1.117
2.979GluPhe: 2.979 ± 0.801
2.317GluGly: 2.317 ± 1.0
0.331GluHis: 0.331 ± 0.306
7.944GluIle: 7.944 ± 1.293
9.599GluLys: 9.599 ± 1.863
9.599GluLeu: 9.599 ± 2.08
0.662GluMet: 0.662 ± 0.497
4.965GluAsn: 4.965 ± 1.437
1.324GluPro: 1.324 ± 0.79
4.303GluGln: 4.303 ± 0.877
2.648GluArg: 2.648 ± 0.864
4.634GluSer: 4.634 ± 0.975
5.296GluThr: 5.296 ± 1.122
3.31GluVal: 3.31 ± 1.089
0.993GluTrp: 0.993 ± 0.529
3.641GluTyr: 3.641 ± 1.115
0.0GluXaa: 0.0 ± 0.0
Phe
0.993PheAla: 0.993 ± 0.623
0.331PheCys: 0.331 ± 0.287
4.303PheAsp: 4.303 ± 1.042
3.641PheGlu: 3.641 ± 1.011
2.648PhePhe: 2.648 ± 0.74
1.986PheGly: 1.986 ± 0.7
0.662PheHis: 0.662 ± 0.361
1.986PheIle: 1.986 ± 0.787
4.965PheLys: 4.965 ± 1.458
4.965PheLeu: 4.965 ± 1.32
0.662PheMet: 0.662 ± 0.455
1.324PheAsn: 1.324 ± 0.747
0.993PhePro: 0.993 ± 0.631
1.324PheGln: 1.324 ± 0.66
1.324PheArg: 1.324 ± 0.503
3.972PheSer: 3.972 ± 1.229
2.317PheThr: 2.317 ± 0.979
2.648PheVal: 2.648 ± 1.076
0.993PheTrp: 0.993 ± 0.372
1.324PheTyr: 1.324 ± 0.671
0.0PheXaa: 0.0 ± 0.0
Gly
2.317GlyAla: 2.317 ± 0.781
0.331GlyCys: 0.331 ± 0.275
2.317GlyAsp: 2.317 ± 1.038
1.324GlyGlu: 1.324 ± 0.781
2.648GlyPhe: 2.648 ± 0.706
2.648GlyGly: 2.648 ± 1.175
1.324GlyHis: 1.324 ± 0.702
2.648GlyIle: 2.648 ± 0.836
6.289GlyLys: 6.289 ± 1.674
3.641GlyLeu: 3.641 ± 0.915
0.662GlyMet: 0.662 ± 0.387
2.317GlyAsn: 2.317 ± 0.822
0.0GlyPro: 0.0 ± 0.0
1.324GlyGln: 1.324 ± 0.51
1.655GlyArg: 1.655 ± 0.667
3.641GlySer: 3.641 ± 1.227
2.317GlyThr: 2.317 ± 0.898
2.317GlyVal: 2.317 ± 0.655
0.993GlyTrp: 0.993 ± 0.482
4.634GlyTyr: 4.634 ± 1.343
0.0GlyXaa: 0.0 ± 0.0
His
1.655HisAla: 1.655 ± 0.787
0.0HisCys: 0.0 ± 0.0
0.331HisAsp: 0.331 ± 0.281
0.331HisGlu: 0.331 ± 0.29
0.662HisPhe: 0.662 ± 0.61
0.331HisGly: 0.331 ± 0.305
0.662HisHis: 0.662 ± 0.449
0.662HisIle: 0.662 ± 0.418
0.993HisLys: 0.993 ± 0.545
2.317HisLeu: 2.317 ± 1.084
0.0HisMet: 0.0 ± 0.0
0.993HisAsn: 0.993 ± 0.61
0.662HisPro: 0.662 ± 0.429
0.662HisGln: 0.662 ± 0.387
0.0HisArg: 0.0 ± 0.0
1.324HisSer: 1.324 ± 0.504
2.648HisThr: 2.648 ± 0.823
0.331HisVal: 0.331 ± 0.306
0.0HisTrp: 0.0 ± 0.0
0.993HisTyr: 0.993 ± 0.675
0.0HisXaa: 0.0 ± 0.0
Ile
2.979IleAla: 2.979 ± 1.024
0.0IleCys: 0.0 ± 0.0
4.634IleAsp: 4.634 ± 0.83
5.958IleGlu: 5.958 ± 1.826
1.986IlePhe: 1.986 ± 0.855
1.986IleGly: 1.986 ± 0.729
1.324IleHis: 1.324 ± 0.594
4.965IleIle: 4.965 ± 1.166
8.606IleLys: 8.606 ± 1.512
7.613IleLeu: 7.613 ± 0.893
0.331IleMet: 0.331 ± 0.281
5.627IleAsn: 5.627 ± 1.217
2.317IlePro: 2.317 ± 0.701
4.303IleGln: 4.303 ± 0.97
1.986IleArg: 1.986 ± 0.705
5.958IleSer: 5.958 ± 1.104
3.972IleThr: 3.972 ± 1.352
2.317IleVal: 2.317 ± 0.926
0.0IleTrp: 0.0 ± 0.0
2.317IleTyr: 2.317 ± 0.826
0.0IleXaa: 0.0 ± 0.0
Lys
5.958LysAla: 5.958 ± 1.712
0.993LysCys: 0.993 ± 0.541
6.289LysAsp: 6.289 ± 1.486
11.255LysGlu: 11.255 ± 1.742
3.31LysPhe: 3.31 ± 1.079
6.289LysGly: 6.289 ± 1.502
1.986LysHis: 1.986 ± 0.679
7.944LysIle: 7.944 ± 1.154
10.262LysLys: 10.262 ± 1.593
6.62LysLeu: 6.62 ± 1.034
3.641LysMet: 3.641 ± 1.323
6.289LysAsn: 6.289 ± 1.157
2.979LysPro: 2.979 ± 1.075
4.965LysGln: 4.965 ± 1.116
7.944LysArg: 7.944 ± 1.174
7.282LysSer: 7.282 ± 1.312
6.951LysThr: 6.951 ± 1.981
5.627LysVal: 5.627 ± 1.17
0.662LysTrp: 0.662 ± 0.372
3.972LysTyr: 3.972 ± 1.345
0.0LysXaa: 0.0 ± 0.0
Leu
6.951LeuAla: 6.951 ± 1.592
0.331LeuCys: 0.331 ± 0.42
8.275LeuAsp: 8.275 ± 1.575
10.924LeuGlu: 10.924 ± 1.398
3.641LeuPhe: 3.641 ± 1.053
6.62LeuGly: 6.62 ± 0.953
1.986LeuHis: 1.986 ± 0.772
6.951LeuIle: 6.951 ± 1.597
8.275LeuLys: 8.275 ± 1.668
8.937LeuLeu: 8.937 ± 2.45
2.317LeuMet: 2.317 ± 0.657
5.958LeuAsn: 5.958 ± 1.453
2.317LeuPro: 2.317 ± 0.654
3.972LeuGln: 3.972 ± 0.944
3.641LeuArg: 3.641 ± 0.837
5.958LeuSer: 5.958 ± 0.921
4.965LeuThr: 4.965 ± 1.068
5.296LeuVal: 5.296 ± 1.47
0.0LeuTrp: 0.0 ± 0.0
2.317LeuTyr: 2.317 ± 0.907
0.0LeuXaa: 0.0 ± 0.0
Met
0.662MetAla: 0.662 ± 0.47
0.0MetCys: 0.0 ± 0.0
2.317MetAsp: 2.317 ± 0.785
2.317MetGlu: 2.317 ± 1.052
0.662MetPhe: 0.662 ± 0.543
0.331MetGly: 0.331 ± 0.34
0.0MetHis: 0.0 ± 0.0
0.993MetIle: 0.993 ± 0.527
1.986MetLys: 1.986 ± 0.58
1.324MetLeu: 1.324 ± 0.56
0.0MetMet: 0.0 ± 0.0
1.986MetAsn: 1.986 ± 0.813
0.331MetPro: 0.331 ± 0.326
0.331MetGln: 0.331 ± 0.326
1.324MetArg: 1.324 ± 0.709
0.662MetSer: 0.662 ± 0.394
2.648MetThr: 2.648 ± 1.292
0.662MetVal: 0.662 ± 0.448
0.0MetTrp: 0.0 ± 0.0
0.331MetTyr: 0.331 ± 0.364
0.0MetXaa: 0.0 ± 0.0
Asn
3.31AsnAla: 3.31 ± 0.901
0.331AsnCys: 0.331 ± 0.275
1.655AsnAsp: 1.655 ± 0.724
2.648AsnGlu: 2.648 ± 1.001
2.979AsnPhe: 2.979 ± 0.814
3.31AsnGly: 3.31 ± 1.065
0.993AsnHis: 0.993 ± 0.477
3.31AsnIle: 3.31 ± 1.711
5.296AsnLys: 5.296 ± 1.169
6.289AsnLeu: 6.289 ± 1.102
1.986AsnMet: 1.986 ± 0.951
5.627AsnAsn: 5.627 ± 2.13
0.993AsnPro: 0.993 ± 0.47
2.979AsnGln: 2.979 ± 1.009
2.648AsnArg: 2.648 ± 0.816
3.641AsnSer: 3.641 ± 0.811
5.627AsnThr: 5.627 ± 1.564
1.986AsnVal: 1.986 ± 0.981
0.993AsnTrp: 0.993 ± 0.631
4.634AsnTyr: 4.634 ± 1.289
0.0AsnXaa: 0.0 ± 0.0
Pro
0.662ProAla: 0.662 ± 0.418
0.0ProCys: 0.0 ± 0.0
1.986ProAsp: 1.986 ± 0.8
1.986ProGlu: 1.986 ± 1.007
1.655ProPhe: 1.655 ± 0.932
0.331ProGly: 0.331 ± 0.326
0.662ProHis: 0.662 ± 0.449
0.993ProIle: 0.993 ± 0.506
5.296ProLys: 5.296 ± 1.635
0.662ProLeu: 0.662 ± 0.429
0.0ProMet: 0.0 ± 0.0
1.324ProAsn: 1.324 ± 0.444
0.331ProPro: 0.331 ± 0.29
0.993ProGln: 0.993 ± 0.654
0.662ProArg: 0.662 ± 0.38
0.993ProSer: 0.993 ± 0.472
0.662ProThr: 0.662 ± 0.513
1.324ProVal: 1.324 ± 0.549
0.331ProTrp: 0.331 ± 0.369
0.993ProTyr: 0.993 ± 0.428
0.0ProXaa: 0.0 ± 0.0
Gln
4.634GlnAla: 4.634 ± 1.241
0.662GlnCys: 0.662 ± 0.434
1.655GlnAsp: 1.655 ± 0.668
3.641GlnGlu: 3.641 ± 0.751
1.324GlnPhe: 1.324 ± 0.657
0.662GlnGly: 0.662 ± 0.519
1.324GlnHis: 1.324 ± 0.562
2.648GlnIle: 2.648 ± 0.874
4.303GlnLys: 4.303 ± 0.692
3.31GlnLeu: 3.31 ± 1.047
0.662GlnMet: 0.662 ± 0.565
2.317GlnAsn: 2.317 ± 0.826
0.662GlnPro: 0.662 ± 0.454
0.993GlnGln: 0.993 ± 0.538
2.317GlnArg: 2.317 ± 0.736
1.655GlnSer: 1.655 ± 0.737
2.979GlnThr: 2.979 ± 0.907
2.648GlnVal: 2.648 ± 0.674
0.331GlnTrp: 0.331 ± 0.306
1.986GlnTyr: 1.986 ± 0.563
0.0GlnXaa: 0.0 ± 0.0
Arg
0.993ArgAla: 0.993 ± 0.577
0.0ArgCys: 0.0 ± 0.0
3.972ArgAsp: 3.972 ± 0.835
3.972ArgGlu: 3.972 ± 1.037
1.986ArgPhe: 1.986 ± 0.905
1.986ArgGly: 1.986 ± 0.844
0.662ArgHis: 0.662 ± 0.387
2.648ArgIle: 2.648 ± 0.791
6.951ArgLys: 6.951 ± 1.374
3.641ArgLeu: 3.641 ± 0.917
1.324ArgMet: 1.324 ± 0.457
2.648ArgAsn: 2.648 ± 0.925
0.993ArgPro: 0.993 ± 0.506
2.979ArgGln: 2.979 ± 0.813
1.655ArgArg: 1.655 ± 0.954
1.655ArgSer: 1.655 ± 0.809
3.641ArgThr: 3.641 ± 1.069
0.662ArgVal: 0.662 ± 0.418
0.0ArgTrp: 0.0 ± 0.0
2.648ArgTyr: 2.648 ± 1.225
0.0ArgXaa: 0.0 ± 0.0
Ser
3.31SerAla: 3.31 ± 1.441
0.331SerCys: 0.331 ± 0.326
4.303SerAsp: 4.303 ± 0.835
7.944SerGlu: 7.944 ± 1.203
2.979SerPhe: 2.979 ± 1.171
3.31SerGly: 3.31 ± 0.747
1.324SerHis: 1.324 ± 0.643
3.641SerIle: 3.641 ± 1.324
7.282SerLys: 7.282 ± 1.728
5.958SerLeu: 5.958 ± 1.289
0.331SerMet: 0.331 ± 0.426
2.317SerAsn: 2.317 ± 0.833
2.317SerPro: 2.317 ± 0.617
2.317SerGln: 2.317 ± 0.945
1.986SerArg: 1.986 ± 0.717
2.979SerSer: 2.979 ± 1.29
4.303SerThr: 4.303 ± 1.329
3.641SerVal: 3.641 ± 1.103
0.662SerTrp: 0.662 ± 0.488
2.317SerTyr: 2.317 ± 0.805
0.0SerXaa: 0.0 ± 0.0
Thr
2.648ThrAla: 2.648 ± 0.808
0.0ThrCys: 0.0 ± 0.0
1.655ThrAsp: 1.655 ± 0.803
4.965ThrGlu: 4.965 ± 1.427
1.655ThrPhe: 1.655 ± 0.659
4.965ThrGly: 4.965 ± 0.934
1.324ThrHis: 1.324 ± 0.617
5.627ThrIle: 5.627 ± 1.149
4.965ThrLys: 4.965 ± 1.162
8.937ThrLeu: 8.937 ± 1.379
1.324ThrMet: 1.324 ± 0.502
3.641ThrAsn: 3.641 ± 0.816
0.993ThrPro: 0.993 ± 0.438
2.979ThrGln: 2.979 ± 1.315
4.303ThrArg: 4.303 ± 1.608
4.303ThrSer: 4.303 ± 1.343
4.965ThrThr: 4.965 ± 1.438
5.296ThrVal: 5.296 ± 1.275
0.331ThrTrp: 0.331 ± 0.364
2.317ThrTyr: 2.317 ± 1.343
0.0ThrXaa: 0.0 ± 0.0
Val
1.986ValAla: 1.986 ± 0.749
0.331ValCys: 0.331 ± 0.287
4.634ValAsp: 4.634 ± 1.533
3.641ValGlu: 3.641 ± 1.262
1.986ValPhe: 1.986 ± 0.657
0.662ValGly: 0.662 ± 0.396
0.0ValHis: 0.0 ± 0.0
3.972ValIle: 3.972 ± 0.892
4.634ValLys: 4.634 ± 1.432
4.303ValLeu: 4.303 ± 1.154
0.662ValMet: 0.662 ± 0.448
3.641ValAsn: 3.641 ± 1.066
1.655ValPro: 1.655 ± 0.682
1.986ValGln: 1.986 ± 0.77
1.655ValArg: 1.655 ± 0.755
3.31ValSer: 3.31 ± 1.052
3.641ValThr: 3.641 ± 0.931
2.648ValVal: 2.648 ± 0.994
0.331ValTrp: 0.331 ± 0.339
2.317ValTyr: 2.317 ± 0.669
0.0ValXaa: 0.0 ± 0.0
Trp
0.993TrpAla: 0.993 ± 0.438
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
1.655TrpGlu: 1.655 ± 0.807
0.0TrpPhe: 0.0 ± 0.0
0.331TrpGly: 0.331 ± 0.369
0.0TrpHis: 0.0 ± 0.0
0.331TrpIle: 0.331 ± 0.42
0.331TrpLys: 0.331 ± 0.326
0.993TrpLeu: 0.993 ± 0.752
0.662TrpMet: 0.662 ± 0.394
0.331TrpAsn: 0.331 ± 0.306
0.0TrpPro: 0.0 ± 0.0
0.331TrpGln: 0.331 ± 0.275
0.331TrpArg: 0.331 ± 0.339
0.331TrpSer: 0.331 ± 0.275
0.0TrpThr: 0.0 ± 0.0
0.662TrpVal: 0.662 ± 0.475
0.0TrpTrp: 0.0 ± 0.0
0.331TrpTyr: 0.331 ± 0.305
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.324TyrAla: 1.324 ± 0.752
0.331TyrCys: 0.331 ± 0.339
2.648TyrAsp: 2.648 ± 0.838
2.979TyrGlu: 2.979 ± 0.886
2.648TyrPhe: 2.648 ± 1.026
1.655TyrGly: 1.655 ± 0.663
0.0TyrHis: 0.0 ± 0.0
3.31TyrIle: 3.31 ± 1.02
4.965TyrLys: 4.965 ± 1.327
7.282TyrLeu: 7.282 ± 1.532
1.324TyrMet: 1.324 ± 0.674
2.979TyrAsn: 2.979 ± 1.243
0.993TyrPro: 0.993 ± 0.579
1.324TyrGln: 1.324 ± 0.44
3.641TyrArg: 3.641 ± 1.49
2.979TyrSer: 2.979 ± 1.105
1.655TyrThr: 1.655 ± 0.852
1.324TyrVal: 1.324 ± 0.559
0.331TyrTrp: 0.331 ± 0.287
1.655TyrTyr: 1.655 ± 0.912
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 19 proteins (3022 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski