Amino acid dipepetide frequency for Butyrivibrio fibrisolvens 16/4

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.79AlaAla: 6.79 ± 0.1	1.027AlaCys: 1.027 ± 0.047	4.813AlaAsp: 4.813 ± 0.091	5.231AlaGlu: 5.231 ± 0.096	3.011AlaPhe: 3.011 ± 0.073	5.749AlaGly: 5.749 ± 0.088	1.101AlaHis: 1.101 ± 0.036	5.676AlaIle: 5.676 ± 0.097	5.311AlaLys: 5.311 ± 0.084	6.405AlaLeu: 6.405 ± 0.1	2.359AlaMet: 2.359 ± 0.056	3.291AlaAsn: 3.291 ± 0.072	2.024AlaPro: 2.024 ± 0.059	2.068AlaGln: 2.068 ± 0.052	2.507AlaArg: 2.507 ± 0.059	4.485AlaSer: 4.485 ± 0.132	4.196AlaThr: 4.196 ± 0.098	5.542AlaVal: 5.542 ± 0.09	0.583AlaTrp: 0.583 ± 0.025	2.769AlaTyr: 2.769 ± 0.061	0.0AlaXaa: 0.0 ± 0.0
Cys	0.893CysAla: 0.893 ± 0.036	0.233CysCys: 0.233 ± 0.019	0.966CysAsp: 0.966 ± 0.035	0.884CysGlu: 0.884 ± 0.039	0.596CysPhe: 0.596 ± 0.026	1.324CysGly: 1.324 ± 0.044	0.265CysHis: 0.265 ± 0.019	1.057CysIle: 1.057 ± 0.035	0.908CysLys: 0.908 ± 0.038	1.033CysLeu: 1.033 ± 0.037	0.391CysMet: 0.391 ± 0.023	0.607CysAsn: 0.607 ± 0.027	0.589CysPro: 0.589 ± 0.029	0.404CysGln: 0.404 ± 0.025	0.473CysArg: 0.473 ± 0.022	0.86CysSer: 0.86 ± 0.033	0.673CysThr: 0.673 ± 0.026	0.952CysVal: 0.952 ± 0.036	0.117CysTrp: 0.117 ± 0.012	0.601CysTyr: 0.601 ± 0.022	0.0CysXaa: 0.0 ± 0.0
Asp	4.629AspAla: 4.629 ± 0.081	0.815AspCys: 0.815 ± 0.034	4.071AspAsp: 4.071 ± 0.085	5.497AspGlu: 5.497 ± 0.101	3.113AspPhe: 3.113 ± 0.063	4.869AspGly: 4.869 ± 0.102	0.818AspHis: 0.818 ± 0.035	5.141AspIle: 5.141 ± 0.091	4.263AspLys: 4.263 ± 0.073	4.778AspLeu: 4.778 ± 0.078	2.002AspMet: 2.002 ± 0.047	3.051AspAsn: 3.051 ± 0.06	1.711AspPro: 1.711 ± 0.04	1.191AspGln: 1.191 ± 0.043	2.172AspArg: 2.172 ± 0.069	3.752AspSer: 3.752 ± 0.08	3.292AspThr: 3.292 ± 0.062	4.642AspVal: 4.642 ± 0.072	0.602AspTrp: 0.602 ± 0.027	3.45AspTyr: 3.45 ± 0.066	0.0AspXaa: 0.0 ± 0.0
Glu	5.74GluAla: 5.74 ± 0.1	0.857GluCys: 0.857 ± 0.035	4.665GluAsp: 4.665 ± 0.086	6.762GluGlu: 6.762 ± 0.12	2.819GluPhe: 2.819 ± 0.064	4.258GluGly: 4.258 ± 0.074	1.224GluHis: 1.224 ± 0.039	5.769GluIle: 5.769 ± 0.107	6.064GluLys: 6.064 ± 0.097	6.336GluLeu: 6.336 ± 0.095	2.283GluMet: 2.283 ± 0.051	4.282GluAsn: 4.282 ± 0.076	1.851GluPro: 1.851 ± 0.054	2.344GluGln: 2.344 ± 0.058	2.755GluArg: 2.755 ± 0.065	3.809GluSer: 3.809 ± 0.159	3.546GluThr: 3.546 ± 0.073	4.472GluVal: 4.472 ± 0.09	0.558GluTrp: 0.558 ± 0.025	3.28GluTyr: 3.28 ± 0.059	0.0GluXaa: 0.0 ± 0.0
Phe	2.974PheAla: 2.974 ± 0.072	0.637PheCys: 0.637 ± 0.028	3.044PheAsp: 3.044 ± 0.066	2.834PheGlu: 2.834 ± 0.064	1.9PhePhe: 1.9 ± 0.052	2.996PheGly: 2.996 ± 0.074	0.632PheHis: 0.632 ± 0.032	3.192PheIle: 3.192 ± 0.075	2.607PheLys: 2.607 ± 0.05	3.46PheLeu: 3.46 ± 0.075	1.287PheMet: 1.287 ± 0.039	2.122PheAsn: 2.122 ± 0.042	1.259PhePro: 1.259 ± 0.047	1.002PheGln: 1.002 ± 0.038	1.36PheArg: 1.36 ± 0.042	2.824PheSer: 2.824 ± 0.063	2.61PheThr: 2.61 ± 0.06	3.177PheVal: 3.177 ± 0.062	0.435PheTrp: 0.435 ± 0.025	1.76PheTyr: 1.76 ± 0.046	0.0PheXaa: 0.0 ± 0.0
Gly	4.889GlyAla: 4.889 ± 0.084	1.112GlyCys: 1.112 ± 0.04	3.983GlyAsp: 3.983 ± 0.077	4.442GlyGlu: 4.442 ± 0.077	3.247GlyPhe: 3.247 ± 0.067	4.609GlyGly: 4.609 ± 0.099	1.293GlyHis: 1.293 ± 0.044	5.861GlyIle: 5.861 ± 0.1	5.211GlyLys: 5.211 ± 0.091	5.732GlyLeu: 5.732 ± 0.088	2.183GlyMet: 2.183 ± 0.05	3.325GlyAsn: 3.325 ± 0.074	1.385GlyPro: 1.385 ± 0.04	2.081GlyGln: 2.081 ± 0.051	2.653GlyArg: 2.653 ± 0.067	3.894GlySer: 3.894 ± 0.08	4.127GlyThr: 4.127 ± 0.079	5.017GlyVal: 5.017 ± 0.09	0.744GlyTrp: 0.744 ± 0.032	3.217GlyTyr: 3.217 ± 0.065	0.0GlyXaa: 0.0 ± 0.0
His	0.916HisAla: 0.916 ± 0.033	0.291HisCys: 0.291 ± 0.018	0.913HisAsp: 0.913 ± 0.036	1.0HisGlu: 1.0 ± 0.038	0.833HisPhe: 0.833 ± 0.03	1.154HisGly: 1.154 ± 0.043	0.383HisHis: 0.383 ± 0.034	1.329HisIle: 1.329 ± 0.042	0.937HisLys: 0.937 ± 0.032	1.316HisLeu: 1.316 ± 0.043	0.515HisMet: 0.515 ± 0.027	0.804HisAsn: 0.804 ± 0.033	0.754HisPro: 0.754 ± 0.034	0.495HisGln: 0.495 ± 0.026	0.667HisArg: 0.667 ± 0.027	0.959HisSer: 0.959 ± 0.034	0.849HisThr: 0.849 ± 0.034	1.085HisVal: 1.085 ± 0.037	0.127HisTrp: 0.127 ± 0.013	0.784HisTyr: 0.784 ± 0.03	0.0HisXaa: 0.0 ± 0.0
Ile	5.862IleAla: 5.862 ± 0.1	1.289IleCys: 1.289 ± 0.043	5.018IleAsp: 5.018 ± 0.08	5.359IleGlu: 5.359 ± 0.086	3.03IlePhe: 3.03 ± 0.066	5.143IleGly: 5.143 ± 0.094	1.198IleHis: 1.198 ± 0.036	6.079IleIle: 6.079 ± 0.111	5.126IleLys: 5.126 ± 0.085	6.581IleLeu: 6.581 ± 0.108	2.116IleMet: 2.116 ± 0.049	4.032IleAsn: 4.032 ± 0.084	2.88IlePro: 2.88 ± 0.065	2.036IleGln: 2.036 ± 0.054	2.784IleArg: 2.784 ± 0.063	5.481IleSer: 5.481 ± 0.11	4.644IleThr: 4.644 ± 0.083	5.4IleVal: 5.4 ± 0.101	0.583IleTrp: 0.583 ± 0.027	2.997IleTyr: 2.997 ± 0.066	0.0IleXaa: 0.0 ± 0.0
Lys	5.433LysAla: 5.433 ± 0.104	0.77LysCys: 0.77 ± 0.035	4.511LysAsp: 4.511 ± 0.079	6.17LysGlu: 6.17 ± 0.095	2.194LysPhe: 2.194 ± 0.056	4.089LysGly: 4.089 ± 0.081	1.11LysHis: 1.11 ± 0.033	4.933LysIle: 4.933 ± 0.072	5.592LysLys: 5.592 ± 0.099	5.709LysLeu: 5.709 ± 0.084	2.206LysMet: 2.206 ± 0.054	4.109LysAsn: 4.109 ± 0.077	2.017LysPro: 2.017 ± 0.045	2.111LysGln: 2.111 ± 0.055	2.787LysArg: 2.787 ± 0.061	3.771LysSer: 3.771 ± 0.079	3.706LysThr: 3.706 ± 0.057	4.622LysVal: 4.622 ± 0.074	0.599LysTrp: 0.599 ± 0.029	3.261LysTyr: 3.261 ± 0.066	0.0LysXaa: 0.0 ± 0.0
Leu	6.381LeuAla: 6.381 ± 0.091	1.232LeuCys: 1.232 ± 0.04	5.295LeuAsp: 5.295 ± 0.094	5.642LeuGlu: 5.642 ± 0.082	3.598LeuPhe: 3.598 ± 0.082	5.675LeuGly: 5.675 ± 0.103	1.402LeuHis: 1.402 ± 0.042	6.081LeuIle: 6.081 ± 0.099	5.857LeuLys: 5.857 ± 0.095	7.328LeuLeu: 7.328 ± 0.118	2.634LeuMet: 2.634 ± 0.061	4.126LeuAsn: 4.126 ± 0.071	2.917LeuPro: 2.917 ± 0.064	2.402LeuGln: 2.402 ± 0.061	3.102LeuArg: 3.102 ± 0.067	6.045LeuSer: 6.045 ± 0.1	4.628LeuThr: 4.628 ± 0.081	5.458LeuVal: 5.458 ± 0.089	0.668LeuTrp: 0.668 ± 0.032	3.256LeuTyr: 3.256 ± 0.075	0.0LeuXaa: 0.0 ± 0.0
Met	2.551MetAla: 2.551 ± 0.062	0.364MetCys: 0.364 ± 0.022	1.985MetAsp: 1.985 ± 0.05	2.137MetGlu: 2.137 ± 0.054	1.105MetPhe: 1.105 ± 0.035	2.072MetGly: 2.072 ± 0.052	0.502MetHis: 0.502 ± 0.026	2.197MetIle: 2.197 ± 0.054	2.331MetLys: 2.331 ± 0.053	2.592MetLeu: 2.592 ± 0.06	0.926MetMet: 0.926 ± 0.035	1.655MetAsn: 1.655 ± 0.042	1.043MetPro: 1.043 ± 0.034	0.843MetGln: 0.843 ± 0.036	1.053MetArg: 1.053 ± 0.037	1.846MetSer: 1.846 ± 0.042	1.741MetThr: 1.741 ± 0.043	2.057MetVal: 2.057 ± 0.06	0.213MetTrp: 0.213 ± 0.017	1.03MetTyr: 1.03 ± 0.038	0.0MetXaa: 0.0 ± 0.0
Asn	3.47AsnAla: 3.47 ± 0.066	0.675AsnCys: 0.675 ± 0.034	2.882AsnAsp: 2.882 ± 0.063	3.424AsnGlu: 3.424 ± 0.067	1.781AsnPhe: 1.781 ± 0.051	3.89AsnGly: 3.89 ± 0.082	0.885AsnHis: 0.885 ± 0.032	4.085AsnIle: 4.085 ± 0.08	3.334AsnLys: 3.334 ± 0.06	4.096AsnLeu: 4.096 ± 0.076	1.508AsnMet: 1.508 ± 0.047	2.684AsnAsn: 2.684 ± 0.059	2.155AsnPro: 2.155 ± 0.055	1.57AsnGln: 1.57 ± 0.042	2.007AsnArg: 2.007 ± 0.056	2.992AsnSer: 2.992 ± 0.071	2.898AsnThr: 2.898 ± 0.068	3.456AsnVal: 3.456 ± 0.071	0.507AsnTrp: 0.507 ± 0.028	2.255AsnTyr: 2.255 ± 0.059	0.0AsnXaa: 0.0 ± 0.0
Pro	2.305ProAla: 2.305 ± 0.062	0.367ProCys: 0.367 ± 0.023	2.089ProAsp: 2.089 ± 0.052	3.016ProGlu: 3.016 ± 0.066	1.441ProPhe: 1.441 ± 0.047	2.009ProGly: 2.009 ± 0.055	0.489ProHis: 0.489 ± 0.023	2.274ProIle: 2.274 ± 0.049	1.936ProLys: 1.936 ± 0.049	2.402ProLeu: 2.402 ± 0.057	0.837ProMet: 0.837 ± 0.035	1.46ProAsn: 1.46 ± 0.044	0.542ProPro: 0.542 ± 0.026	0.885ProGln: 0.885 ± 0.031	0.835ProArg: 0.835 ± 0.034	1.831ProSer: 1.831 ± 0.053	1.899ProThr: 1.899 ± 0.077	2.581ProVal: 2.581 ± 0.057	0.301ProTrp: 0.301 ± 0.021	1.332ProTyr: 1.332 ± 0.042	0.0ProXaa: 0.0 ± 0.0
Gln	2.163GlnAla: 2.163 ± 0.055	0.32GlnCys: 0.32 ± 0.021	1.515GlnAsp: 1.515 ± 0.045	2.063GlnGlu: 2.063 ± 0.055	1.135GlnPhe: 1.135 ± 0.04	1.781GlnGly: 1.781 ± 0.049	0.439GlnHis: 0.439 ± 0.018	2.325GlnIle: 2.325 ± 0.054	2.042GlnLys: 2.042 ± 0.049	2.641GlnLeu: 2.641 ± 0.057	1.062GlnMet: 1.062 ± 0.036	1.377GlnAsn: 1.377 ± 0.053	0.849GlnPro: 0.849 ± 0.035	0.988GlnGln: 0.988 ± 0.039	1.104GlnArg: 1.104 ± 0.04	1.506GlnSer: 1.506 ± 0.056	1.375GlnThr: 1.375 ± 0.042	2.069GlnVal: 2.069 ± 0.046	0.29GlnTrp: 0.29 ± 0.022	1.13GlnTyr: 1.13 ± 0.039	0.0GlnXaa: 0.0 ± 0.0
Arg	2.476ArgAla: 2.476 ± 0.055	0.482ArgCys: 0.482 ± 0.024	2.17ArgAsp: 2.17 ± 0.067	2.718ArgGlu: 2.718 ± 0.068	1.635ArgPhe: 1.635 ± 0.047	2.191ArgGly: 2.191 ± 0.05	0.637ArgHis: 0.637 ± 0.035	3.142ArgIle: 3.142 ± 0.07	2.658ArgLys: 2.658 ± 0.067	3.09ArgLeu: 3.09 ± 0.066	1.314ArgMet: 1.314 ± 0.039	1.894ArgAsn: 1.894 ± 0.044	1.164ArgPro: 1.164 ± 0.05	1.188ArgGln: 1.188 ± 0.038	1.711ArgArg: 1.711 ± 0.052	1.724ArgSer: 1.724 ± 0.049	1.867ArgThr: 1.867 ± 0.054	2.473ArgVal: 2.473 ± 0.062	0.281ArgTrp: 0.281 ± 0.016	1.585ArgTyr: 1.585 ± 0.042	0.0ArgXaa: 0.0 ± 0.0
Ser	4.432SerAla: 4.432 ± 0.141	0.755SerCys: 0.755 ± 0.035	3.894SerAsp: 3.894 ± 0.085	4.332SerGlu: 4.332 ± 0.166	2.949SerPhe: 2.949 ± 0.063	4.703SerGly: 4.703 ± 0.082	0.978SerHis: 0.978 ± 0.034	4.752SerIle: 4.752 ± 0.093	4.135SerLys: 4.135 ± 0.08	5.217SerLeu: 5.217 ± 0.097	1.726SerMet: 1.726 ± 0.045	2.954SerAsn: 2.954 ± 0.063	1.5SerPro: 1.5 ± 0.045	1.87SerGln: 1.87 ± 0.061	2.279SerArg: 2.279 ± 0.059	4.006SerSer: 4.006 ± 0.116	3.302SerThr: 3.302 ± 0.106	4.327SerVal: 4.327 ± 0.1	0.568SerTrp: 0.568 ± 0.031	2.604SerTyr: 2.604 ± 0.06	0.0SerXaa: 0.0 ± 0.0
Thr	4.171ThrAla: 4.171 ± 0.079	0.645ThrCys: 0.645 ± 0.032	3.435ThrAsp: 3.435 ± 0.07	3.667ThrGlu: 3.667 ± 0.075	2.373ThrPhe: 2.373 ± 0.057	4.376ThrGly: 4.376 ± 0.083	0.839ThrHis: 0.839 ± 0.032	4.47ThrIle: 4.47 ± 0.076	3.513ThrLys: 3.513 ± 0.066	4.617ThrLeu: 4.617 ± 0.085	1.472ThrMet: 1.472 ± 0.04	2.597ThrAsn: 2.597 ± 0.057	2.194ThrPro: 2.194 ± 0.088	1.375ThrGln: 1.375 ± 0.045	1.767ThrArg: 1.767 ± 0.052	3.415ThrSer: 3.415 ± 0.106	3.198ThrThr: 3.198 ± 0.081	4.593ThrVal: 4.593 ± 0.086	0.498ThrTrp: 0.498 ± 0.028	2.247ThrTyr: 2.247 ± 0.058	0.0ThrXaa: 0.0 ± 0.0
Val	5.562ValAla: 5.562 ± 0.094	1.158ValCys: 1.158 ± 0.039	4.866ValAsp: 4.866 ± 0.077	4.983ValGlu: 4.983 ± 0.098	2.915ValPhe: 2.915 ± 0.056	4.61ValGly: 4.61 ± 0.078	0.972ValHis: 0.972 ± 0.036	5.525ValIle: 5.525 ± 0.088	4.57ValLys: 4.57 ± 0.074	6.053ValLeu: 6.053 ± 0.086	1.956ValMet: 1.956 ± 0.053	3.444ValAsn: 3.444 ± 0.072	2.416ValPro: 2.416 ± 0.062	1.708ValGln: 1.708 ± 0.048	2.403ValArg: 2.403 ± 0.056	4.802ValSer: 4.802 ± 0.101	4.026ValThr: 4.026 ± 0.084	5.51ValVal: 5.51 ± 0.09	0.559ValTrp: 0.559 ± 0.027	2.794ValTyr: 2.794 ± 0.067	0.0ValXaa: 0.0 ± 0.0
Trp	0.568TrpAla: 0.568 ± 0.031	0.15TrpCys: 0.15 ± 0.013	0.599TrpAsp: 0.599 ± 0.033	0.528TrpGlu: 0.528 ± 0.029	0.401TrpPhe: 0.401 ± 0.021	0.633TrpGly: 0.633 ± 0.027	0.168TrpHis: 0.168 ± 0.015	0.632TrpIle: 0.632 ± 0.03	0.543TrpLys: 0.543 ± 0.028	0.779TrpLeu: 0.779 ± 0.032	0.311TrpMet: 0.311 ± 0.019	0.559TrpAsn: 0.559 ± 0.032	0.243TrpPro: 0.243 ± 0.021	0.337TrpGln: 0.337 ± 0.023	0.272TrpArg: 0.272 ± 0.02	0.48TrpSer: 0.48 ± 0.028	0.488TrpThr: 0.488 ± 0.028	0.523TrpVal: 0.523 ± 0.029	0.115TrpTrp: 0.115 ± 0.013	0.406TrpTyr: 0.406 ± 0.024	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.735TyrAla: 2.735 ± 0.068	0.648TyrCys: 0.648 ± 0.03	3.143TyrAsp: 3.143 ± 0.069	2.984TyrGlu: 2.984 ± 0.068	2.037TyrPhe: 2.037 ± 0.053	2.872TyrGly: 2.872 ± 0.067	0.775TyrHis: 0.775 ± 0.034	3.118TyrIle: 3.118 ± 0.064	2.76TyrLys: 2.76 ± 0.068	3.563TyrLeu: 3.563 ± 0.065	1.156TyrMet: 1.156 ± 0.042	2.181TyrAsn: 2.181 ± 0.053	1.341TyrPro: 1.341 ± 0.046	1.277TyrGln: 1.277 ± 0.04	1.709TyrArg: 1.709 ± 0.048	2.797TyrSer: 2.797 ± 0.065	2.395TyrThr: 2.395 ± 0.06	2.876TyrVal: 2.876 ± 0.061	0.39TyrTrp: 0.39 ± 0.024	2.131TyrTyr: 2.131 ± 0.078	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2904 proteins (797346 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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