Amino acid dipepetide frequency for Echinicola vietnamensis (strain DSM 17526 / LMG 23754 / KMM 6221)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.694AlaAla: 5.694 ± 0.082	0.642AlaCys: 0.642 ± 0.023	3.903AlaAsp: 3.903 ± 0.057	4.59AlaGlu: 4.59 ± 0.05	3.612AlaPhe: 3.612 ± 0.052	5.232AlaGly: 5.232 ± 0.071	1.43AlaHis: 1.43 ± 0.033	4.912AlaIle: 4.912 ± 0.062	4.356AlaLys: 4.356 ± 0.059	6.822AlaLeu: 6.822 ± 0.078	1.944AlaMet: 1.944 ± 0.036	3.219AlaAsn: 3.219 ± 0.043	2.571AlaPro: 2.571 ± 0.042	2.651AlaGln: 2.651 ± 0.045	2.477AlaArg: 2.477 ± 0.042	4.484AlaSer: 4.484 ± 0.061	3.536AlaThr: 3.536 ± 0.064	4.718AlaVal: 4.718 ± 0.057	0.892AlaTrp: 0.892 ± 0.026	2.978AlaTyr: 2.978 ± 0.041	0.0AlaXaa: 0.0 ± 0.0
Cys	0.46CysAla: 0.46 ± 0.018	0.121CysCys: 0.121 ± 0.01	0.375CysAsp: 0.375 ± 0.016	0.428CysGlu: 0.428 ± 0.024	0.43CysPhe: 0.43 ± 0.019	0.599CysGly: 0.599 ± 0.024	0.228CysHis: 0.228 ± 0.013	0.44CysIle: 0.44 ± 0.016	0.409CysLys: 0.409 ± 0.015	0.708CysLeu: 0.708 ± 0.022	0.171CysMet: 0.171 ± 0.011	0.3CysAsn: 0.3 ± 0.014	0.332CysPro: 0.332 ± 0.016	0.276CysGln: 0.276 ± 0.015	0.261CysArg: 0.261 ± 0.012	0.516CysSer: 0.516 ± 0.02	0.405CysThr: 0.405 ± 0.019	0.406CysVal: 0.406 ± 0.017	0.084CysTrp: 0.084 ± 0.007	0.254CysTyr: 0.254 ± 0.013	0.0CysXaa: 0.0 ± 0.0
Asp	3.723AspAla: 3.723 ± 0.053	0.354AspCys: 0.354 ± 0.015	2.874AspAsp: 2.874 ± 0.048	4.064AspGlu: 4.064 ± 0.055	3.396AspPhe: 3.396 ± 0.043	4.378AspGly: 4.378 ± 0.071	1.427AspHis: 1.427 ± 0.031	3.988AspIle: 3.988 ± 0.057	3.545AspLys: 3.545 ± 0.053	5.444AspLeu: 5.444 ± 0.06	1.441AspMet: 1.441 ± 0.029	2.502AspAsn: 2.502 ± 0.043	2.59AspPro: 2.59 ± 0.048	2.582AspGln: 2.582 ± 0.043	2.632AspArg: 2.632 ± 0.039	2.784AspSer: 2.784 ± 0.048	2.52AspThr: 2.52 ± 0.049	3.397AspVal: 3.397 ± 0.049	0.916AspTrp: 0.916 ± 0.028	2.721AspTyr: 2.721 ± 0.045	0.0AspXaa: 0.0 ± 0.0
Glu	5.257GluAla: 5.257 ± 0.069	0.323GluCys: 0.323 ± 0.016	3.905GluAsp: 3.905 ± 0.052	5.756GluGlu: 5.756 ± 0.069	2.64GluPhe: 2.64 ± 0.049	4.969GluGly: 4.969 ± 0.065	1.336GluHis: 1.336 ± 0.027	4.773GluIle: 4.773 ± 0.065	5.5GluLys: 5.5 ± 0.076	5.96GluLeu: 5.96 ± 0.065	1.965GluMet: 1.965 ± 0.037	3.889GluAsn: 3.889 ± 0.05	1.817GluPro: 1.817 ± 0.035	2.547GluGln: 2.547 ± 0.041	2.971GluArg: 2.971 ± 0.047	3.352GluSer: 3.352 ± 0.048	3.321GluThr: 3.321 ± 0.046	5.108GluVal: 5.108 ± 0.077	0.842GluTrp: 0.842 ± 0.027	2.29GluTyr: 2.29 ± 0.041	0.0GluXaa: 0.0 ± 0.0
Phe	2.911PheAla: 2.911 ± 0.044	0.426PheCys: 0.426 ± 0.015	3.206PheAsp: 3.206 ± 0.046	3.149PheGlu: 3.149 ± 0.047	2.435PhePhe: 2.435 ± 0.049	3.732PheGly: 3.732 ± 0.055	0.93PheHis: 0.93 ± 0.024	3.036PheIle: 3.036 ± 0.05	2.728PheLys: 2.728 ± 0.044	4.64PheLeu: 4.64 ± 0.062	1.252PheMet: 1.252 ± 0.028	2.435PheAsn: 2.435 ± 0.038	1.862PhePro: 1.862 ± 0.038	1.644PheGln: 1.644 ± 0.034	2.018PheArg: 2.018 ± 0.039	3.782PheSer: 3.782 ± 0.055	2.901PheThr: 2.901 ± 0.045	2.803PheVal: 2.803 ± 0.043	0.693PheTrp: 0.693 ± 0.022	2.078PheTyr: 2.078 ± 0.04	0.0PheXaa: 0.0 ± 0.0
Gly	4.729GlyAla: 4.729 ± 0.062	0.545GlyCys: 0.545 ± 0.022	4.05GlyAsp: 4.05 ± 0.073	4.714GlyGlu: 4.714 ± 0.066	3.714GlyPhe: 3.714 ± 0.049	5.21GlyGly: 5.21 ± 0.078	1.475GlyHis: 1.475 ± 0.032	5.223GlyIle: 5.223 ± 0.063	5.255GlyLys: 5.255 ± 0.059	6.755GlyLeu: 6.755 ± 0.074	2.095GlyMet: 2.095 ± 0.042	3.672GlyAsn: 3.672 ± 0.064	1.834GlyPro: 1.834 ± 0.035	2.718GlyGln: 2.718 ± 0.04	2.804GlyArg: 2.804 ± 0.046	4.253GlySer: 4.253 ± 0.061	4.238GlyThr: 4.238 ± 0.071	4.884GlyVal: 4.884 ± 0.059	1.048GlyTrp: 1.048 ± 0.03	3.243GlyTyr: 3.243 ± 0.05	0.0GlyXaa: 0.0 ± 0.0
His	1.304HisAla: 1.304 ± 0.029	0.199HisCys: 0.199 ± 0.012	1.04HisAsp: 1.04 ± 0.024	1.278HisGlu: 1.278 ± 0.03	1.284HisPhe: 1.284 ± 0.028	1.448HisGly: 1.448 ± 0.033	0.696HisHis: 0.696 ± 0.022	1.352HisIle: 1.352 ± 0.034	1.1HisLys: 1.1 ± 0.029	2.123HisLeu: 2.123 ± 0.037	0.441HisMet: 0.441 ± 0.019	0.845HisAsn: 0.845 ± 0.023	1.18HisPro: 1.18 ± 0.028	1.013HisGln: 1.013 ± 0.026	0.93HisArg: 0.93 ± 0.024	1.17HisSer: 1.17 ± 0.03	0.986HisThr: 0.986 ± 0.024	1.189HisVal: 1.189 ± 0.03	0.328HisTrp: 0.328 ± 0.016	1.031HisTyr: 1.031 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	4.888IleAla: 4.888 ± 0.057	0.572IleCys: 0.572 ± 0.022	3.972IleAsp: 3.972 ± 0.053	4.06IleGlu: 4.06 ± 0.056	2.853IlePhe: 2.853 ± 0.046	4.811IleGly: 4.811 ± 0.067	1.464IleHis: 1.464 ± 0.035	4.334IleIle: 4.334 ± 0.057	4.357IleLys: 4.357 ± 0.067	5.888IleLeu: 5.888 ± 0.082	1.41IleMet: 1.41 ± 0.034	3.546IleAsn: 3.546 ± 0.049	3.114IlePro: 3.114 ± 0.042	2.447IleGln: 2.447 ± 0.042	2.986IleArg: 2.986 ± 0.044	4.823IleSer: 4.823 ± 0.055	3.946IleThr: 3.946 ± 0.06	3.703IleVal: 3.703 ± 0.058	0.716IleTrp: 0.716 ± 0.021	2.439IleTyr: 2.439 ± 0.043	0.0IleXaa: 0.0 ± 0.0
Lys	4.98LysAla: 4.98 ± 0.063	0.336LysCys: 0.336 ± 0.016	3.919LysAsp: 3.919 ± 0.062	5.269LysGlu: 5.269 ± 0.077	2.299LysPhe: 2.299 ± 0.045	4.695LysGly: 4.695 ± 0.057	1.293LysHis: 1.293 ± 0.03	4.262LysIle: 4.262 ± 0.059	4.966LysLys: 4.966 ± 0.081	5.741LysLeu: 5.741 ± 0.064	1.844LysMet: 1.844 ± 0.035	3.338LysAsn: 3.338 ± 0.047	2.343LysPro: 2.343 ± 0.046	2.239LysGln: 2.239 ± 0.043	2.8LysArg: 2.8 ± 0.043	3.9LysSer: 3.9 ± 0.053	3.469LysThr: 3.469 ± 0.044	4.626LysVal: 4.626 ± 0.062	0.854LysTrp: 0.854 ± 0.025	2.388LysTyr: 2.388 ± 0.045	0.0LysXaa: 0.0 ± 0.0
Leu	6.772LeuAla: 6.772 ± 0.071	0.723LeuCys: 0.723 ± 0.023	5.61LeuAsp: 5.61 ± 0.066	6.58LeuGlu: 6.58 ± 0.063	4.527LeuPhe: 4.527 ± 0.066	6.408LeuGly: 6.408 ± 0.076	1.768LeuHis: 1.768 ± 0.036	5.954LeuIle: 5.954 ± 0.086	6.517LeuLys: 6.517 ± 0.077	8.944LeuLeu: 8.944 ± 0.102	2.489LeuMet: 2.489 ± 0.043	4.43LeuAsn: 4.43 ± 0.059	4.171LeuPro: 4.171 ± 0.055	3.402LeuGln: 3.402 ± 0.047	3.801LeuArg: 3.801 ± 0.056	6.74LeuSer: 6.74 ± 0.064	5.179LeuThr: 5.179 ± 0.063	5.97LeuVal: 5.97 ± 0.066	1.023LeuTrp: 1.023 ± 0.029	3.281LeuTyr: 3.281 ± 0.051	0.0LeuXaa: 0.0 ± 0.0
Met	2.236MetAla: 2.236 ± 0.038	0.119MetCys: 0.119 ± 0.008	1.724MetAsp: 1.724 ± 0.032	1.965MetGlu: 1.965 ± 0.035	0.83MetPhe: 0.83 ± 0.025	1.905MetGly: 1.905 ± 0.038	0.469MetHis: 0.469 ± 0.015	1.655MetIle: 1.655 ± 0.034	2.047MetLys: 2.047 ± 0.035	2.306MetLeu: 2.306 ± 0.044	0.731MetMet: 0.731 ± 0.024	1.25MetAsn: 1.25 ± 0.027	1.033MetPro: 1.033 ± 0.024	0.83MetGln: 0.83 ± 0.022	1.014MetArg: 1.014 ± 0.024	1.373MetSer: 1.373 ± 0.033	1.358MetThr: 1.358 ± 0.028	1.9MetVal: 1.9 ± 0.035	0.217MetTrp: 0.217 ± 0.012	0.711MetTyr: 0.711 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	3.26AsnAla: 3.26 ± 0.046	0.326AsnCys: 0.326 ± 0.014	2.534AsnAsp: 2.534 ± 0.052	2.97AsnGlu: 2.97 ± 0.05	2.336AsnPhe: 2.336 ± 0.05	3.898AsnGly: 3.898 ± 0.067	1.065AsnHis: 1.065 ± 0.027	3.482AsnIle: 3.482 ± 0.051	2.71AsnLys: 2.71 ± 0.042	4.541AsnLeu: 4.541 ± 0.059	1.214AsnMet: 1.214 ± 0.026	2.326AsnAsn: 2.326 ± 0.048	2.62AsnPro: 2.62 ± 0.048	1.993AsnGln: 1.993 ± 0.038	2.242AsnArg: 2.242 ± 0.04	2.762AsnSer: 2.762 ± 0.048	2.814AsnThr: 2.814 ± 0.064	3.029AsnVal: 3.029 ± 0.062	0.74AsnTrp: 0.74 ± 0.021	2.264AsnTyr: 2.264 ± 0.041	0.0AsnXaa: 0.0 ± 0.0
Pro	2.822ProAla: 2.822 ± 0.047	0.214ProCys: 0.214 ± 0.011	2.63ProAsp: 2.63 ± 0.039	3.457ProGlu: 3.457 ± 0.05	1.991ProPhe: 1.991 ± 0.035	2.78ProGly: 2.78 ± 0.052	0.836ProHis: 0.836 ± 0.026	2.424ProIle: 2.424 ± 0.041	2.383ProLys: 2.383 ± 0.041	3.551ProLeu: 3.551 ± 0.051	0.985ProMet: 0.985 ± 0.027	1.939ProAsn: 1.939 ± 0.037	1.118ProPro: 1.118 ± 0.027	1.375ProGln: 1.375 ± 0.031	1.299ProArg: 1.299 ± 0.032	2.727ProSer: 2.727 ± 0.041	1.999ProThr: 1.999 ± 0.037	2.988ProVal: 2.988 ± 0.045	0.503ProTrp: 0.503 ± 0.023	1.663ProTyr: 1.663 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	2.707GlnAla: 2.707 ± 0.04	0.18GlnCys: 0.18 ± 0.01	1.884GlnAsp: 1.884 ± 0.035	2.921GlnGlu: 2.921 ± 0.044	1.628GlnPhe: 1.628 ± 0.03	2.366GlnGly: 2.366 ± 0.04	0.85GlnHis: 0.85 ± 0.023	2.17GlnIle: 2.17 ± 0.035	2.65GlnLys: 2.65 ± 0.046	3.896GlnLeu: 3.896 ± 0.06	0.966GlnMet: 0.966 ± 0.03	1.869GlnAsn: 1.869 ± 0.039	1.402GlnPro: 1.402 ± 0.033	1.837GlnGln: 1.837 ± 0.045	1.621GlnArg: 1.621 ± 0.032	2.101GlnSer: 2.101 ± 0.036	1.856GlnThr: 1.856 ± 0.033	2.668GlnVal: 2.668 ± 0.04	0.517GlnTrp: 0.517 ± 0.018	1.499GlnTyr: 1.499 ± 0.03	0.0GlnXaa: 0.0 ± 0.0
Arg	2.586ArgAla: 2.586 ± 0.044	0.239ArgCys: 0.239 ± 0.012	2.161ArgAsp: 2.161 ± 0.035	2.91ArgGlu: 2.91 ± 0.052	2.209ArgPhe: 2.209 ± 0.038	2.494ArgGly: 2.494 ± 0.038	0.803ArgHis: 0.803 ± 0.023	2.917ArgIle: 2.917 ± 0.048	3.063ArgLys: 3.063 ± 0.046	4.042ArgLeu: 4.042 ± 0.055	1.169ArgMet: 1.169 ± 0.029	2.238ArgAsn: 2.238 ± 0.038	1.616ArgPro: 1.616 ± 0.032	1.547ArgGln: 1.547 ± 0.033	1.729ArgArg: 1.729 ± 0.036	2.368ArgSer: 2.368 ± 0.042	2.065ArgThr: 2.065 ± 0.034	2.543ArgVal: 2.543 ± 0.041	0.612ArgTrp: 0.612 ± 0.022	1.938ArgTyr: 1.938 ± 0.034	0.0ArgXaa: 0.0 ± 0.0
Ser	4.076SerAla: 4.076 ± 0.056	0.597SerCys: 0.597 ± 0.02	3.291SerAsp: 3.291 ± 0.043	3.725SerGlu: 3.725 ± 0.046	3.377SerPhe: 3.377 ± 0.047	4.995SerGly: 4.995 ± 0.076	1.289SerHis: 1.289 ± 0.029	4.261SerIle: 4.261 ± 0.057	3.727SerLys: 3.727 ± 0.054	6.311SerLeu: 6.311 ± 0.068	1.524SerMet: 1.524 ± 0.033	3.002SerAsn: 3.002 ± 0.052	2.677SerPro: 2.677 ± 0.042	2.205SerGln: 2.205 ± 0.037	2.591SerArg: 2.591 ± 0.049	4.23SerSer: 4.23 ± 0.055	3.424SerThr: 3.424 ± 0.049	3.757SerVal: 3.757 ± 0.054	0.842SerTrp: 0.842 ± 0.021	2.601SerTyr: 2.601 ± 0.046	0.0SerXaa: 0.0 ± 0.0
Thr	4.173ThrAla: 4.173 ± 0.068	0.361ThrCys: 0.361 ± 0.016	3.162ThrAsp: 3.162 ± 0.053	3.078ThrGlu: 3.078 ± 0.049	2.856ThrPhe: 2.856 ± 0.042	4.351ThrGly: 4.351 ± 0.064	1.031ThrHis: 1.031 ± 0.025	3.767ThrIle: 3.767 ± 0.056	2.916ThrLys: 2.916 ± 0.049	5.174ThrLeu: 5.174 ± 0.057	1.09ThrMet: 1.09 ± 0.025	2.407ThrAsn: 2.407 ± 0.049	2.442ThrPro: 2.442 ± 0.045	1.696ThrGln: 1.696 ± 0.042	1.772ThrArg: 1.772 ± 0.038	3.394ThrSer: 3.394 ± 0.053	2.987ThrThr: 2.987 ± 0.06	3.975ThrVal: 3.975 ± 0.084	0.673ThrTrp: 0.673 ± 0.023	2.282ThrTyr: 2.282 ± 0.054	0.0ThrXaa: 0.0 ± 0.0
Val	4.536ValAla: 4.536 ± 0.053	0.51ValCys: 0.51 ± 0.019	3.824ValAsp: 3.824 ± 0.057	4.118ValGlu: 4.118 ± 0.061	3.316ValPhe: 3.316 ± 0.051	4.238ValGly: 4.238 ± 0.054	1.224ValHis: 1.224 ± 0.029	4.342ValIle: 4.342 ± 0.053	4.248ValLys: 4.248 ± 0.061	6.256ValLeu: 6.256 ± 0.064	1.666ValMet: 1.666 ± 0.038	3.303ValAsn: 3.303 ± 0.053	2.777ValPro: 2.777 ± 0.048	2.124ValGln: 2.124 ± 0.039	2.638ValArg: 2.638 ± 0.051	4.534ValSer: 4.534 ± 0.062	3.752ValThr: 3.752 ± 0.102	4.421ValVal: 4.421 ± 0.076	0.704ValTrp: 0.704 ± 0.023	2.496ValTyr: 2.496 ± 0.044	0.0ValXaa: 0.0 ± 0.0
Trp	0.866TrpAla: 0.866 ± 0.026	0.101TrpCys: 0.101 ± 0.008	0.769TrpAsp: 0.769 ± 0.023	0.964TrpGlu: 0.964 ± 0.027	0.582TrpPhe: 0.582 ± 0.018	0.953TrpGly: 0.953 ± 0.026	0.285TrpHis: 0.285 ± 0.014	0.815TrpIle: 0.815 ± 0.028	0.946TrpLys: 0.946 ± 0.025	1.189TrpLeu: 1.189 ± 0.029	0.433TrpMet: 0.433 ± 0.016	0.674TrpAsn: 0.674 ± 0.021	0.405TrpPro: 0.405 ± 0.018	0.532TrpGln: 0.532 ± 0.02	0.567TrpArg: 0.567 ± 0.022	0.758TrpSer: 0.758 ± 0.025	0.678TrpThr: 0.678 ± 0.022	0.773TrpVal: 0.773 ± 0.024	0.217TrpTrp: 0.217 ± 0.015	0.521TrpTyr: 0.521 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.682TyrAla: 2.682 ± 0.044	0.317TyrCys: 0.317 ± 0.016	2.445TyrAsp: 2.445 ± 0.045	2.522TyrGlu: 2.522 ± 0.042	2.349TyrPhe: 2.349 ± 0.045	2.996TyrGly: 2.996 ± 0.048	1.04TyrHis: 1.04 ± 0.027	2.222TyrIle: 2.222 ± 0.037	2.139TyrLys: 2.139 ± 0.043	3.997TyrLeu: 3.997 ± 0.057	0.844TyrMet: 0.844 ± 0.022	1.939TyrAsn: 1.939 ± 0.042	1.783TyrPro: 1.783 ± 0.038	1.93TyrGln: 1.93 ± 0.037	2.096TyrArg: 2.096 ± 0.038	2.45TyrSer: 2.45 ± 0.044	2.154TyrThr: 2.154 ± 0.053	2.167TyrVal: 2.167 ± 0.043	0.607TyrTrp: 0.607 ± 0.021	1.953TyrTyr: 1.953 ± 0.048	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4509 proteins (1596854 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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